Product:

DIM Renew

SKU: 2810
Supportive Function: To promote the balance of male and female organs (particularly breast, uterine and prostate) and hormonal health, while supporting the immune system, cell regulation and liver function.

When is DIM Support helpful? Hormonal Health, Sleep, Brain Function, Immune Activity, Gene Regulation.
Clinical Applications Research: DIM is a strong product that was formulated to promote the balance of male and female organs (particularly breast, uterine and prostate) and hormonal health, while supporting the immune system, cell regulation and liver function. Metabolized estrogen by-products can have oxidative effects in the body. DIM (Di-Indole Methane), one of the best antioxidant ingredients in cruciferous vegetables, detoxifies estrogen by-products properly, and encourages a healthy balance of the right estrogens and their metabolites. Synergistic factors in DIM RENEW boost the effect of DIM and contribute to the energetic influence in many areas, including sleep, brain function, immune activity, gene regulation etc. Each Tablet Contains: Proprietary blend 390 mg* of: DIM (diindolylmethane), Olive Leaf Extract (20% oleuropein), Green Tea Extract (decaffeinated), Calcium D-Glucarate, Lecithin (sunflower), Broccoli Sprouts (4% sulforaphane), Grape Seed Extract (95% proanthones), Mangosteen (90% xanthones), Apigenin.

Estrogen needs to be in balance for optimal health. Excess estrogen has a place for beneficial effects in the body, but it can get out of balance with other hormones easily and the estrogen metabolites can get out of balance very easily as well. This can be responsible for sluggish metabolism, fatigue, weight gain, mood swings, bloating, occasional sleeplessness, decreased sex drive, etc. Without trying to oversimplify, there are “good” estrogens and “not so good” estrogens (considering side effects), and while you do not want total estrogen to be out of balance with other hormones, particularly progesterone and testosterone, the ratios of these estrogens and their by- products is critically important. Inflammation and Oxidation pathways have a detrimental effect on these ratios, so it is important to keep optimal ratios of estrogen and its metabolites. Estrogen methylation is an important step involved in beneficial estrogen mechanisms, and also in successful detoxification of oxidative estrogen metabolites.

The Lowdown on Estrogens: E1 (Estrone); E2 (Estradiol); and E3 (Estriol)

Estrone (E1) is not considered a “good” estrogen. It is derived from the hormones that are stored in body fat and is found in increased amounts in postmenopausal women. Estrone is similar to estradiol but is much weaker in its effects. Estrone is rarely used in estrogen replacement therapy.

Estradiol (E2) is the strongest estrogen believed to be responsible for most of the side effects/risk factors, and a lot of the benefits (mostly for bones, the cardiovascular system, relief of menopausal symptoms) that are attributed to estrogen. Estradiol is made in the ovaries and is the principal estrogen found in a woman's body during the reproductive years Because of the down side of estradiol, it is considered not the best estrogen; functional health focuses on achieving balance of estradiol (and estrone) with the “good” estrogen, E3 (Estriol).

Estriol (E3) is considered the “good” estrogen; estriol is much weaker than estradiol and in fact is the weakest of the three major estrogens. It is 1,000 times weaker in its effect on breast tissue. Estriol is the estrogen that is made in large quantities during pregnancy and has potential health properties.

Estriol derives a lot of its benefit from blocking estrone (for instance occupying the estrogen receptor sites on the breast cells), and for helping to achieve good ratios of the three estrogens, and also good ratios of the metabolites of the estrogens. Vegetarians and Asian women are known to have high levels of estriol. Estriol is the estrogen that may be most beneficial to the vagina, cervix and vulva. Many people believe that relatively higher levels of estriol should be sought after, and that the higher levels are beneficial for achieving an optimal health profile (especially concerning hormone balance) while providing some of the symptomatic benefits as well. Bioidentical estrogen therapy involves a higher ratio of estriol to estradiol for this reason (usually 80:20).

Bottom Line for Type of Estrogen: You want a healthy balance of estriol without an overload of either estradiol or estrone.

The Estrogen By-Products or Metabolites:

The other critical factor needing to be in balance is the metabolites of the different estrogens. The hydroxyestrones or methoxyestrones are metabolites of these estrogens, (which for simplicity will just be referred to by their numbers, 2, 4 and 16), determine a health profile, backed by a lot of research. Again, without trying to oversimplify, 2 is referred to as a good metabolite, 16 is not so good, and the 4 depends on whether it’s methoxy (good) or hydroxy (fairly innocuous). High levels of 4 hydroxy can cause issues, so low levels of 4 hydroxy are best.

The ratio of one metabolite over the other represents the relative dominance of one pathway over the other and is believed to be modifiable by diet. The main ratio is represented as the 2/16 ratio. It has been hypothesized that women who have a higher estrogen metabolite ratios (high 2/16) tend to be healthier.

Bottom Line for Type of Metabolite: You want a higher number for 2 and a lower number of 16, and a higher ratio overall of 2:16 to be considered in the healthiest profile group.

Aromatase, or “estrogen synthase”, is an enzyme that catalyzes the last steps of estrogen biosynthesis from androgens (specifically it transforms androstenedione to estrone (bad) and testosterone to estradiol (bad, especially for men). So aromatase is bad, and aromatase homeostasis is good. Some natural ingredients have the power to affect this enzyme, and that is a good thing. When the following ingredients are described as affecting aromatase, the description means that they help to maintain a favorable balance of estrogens and their metabolites.

Low Testosterone: High aromatase activity converts too many androgens to estrogens, and can be responsible for throwing off the homeostasis of testosterone balance. This is important for both males and females.

SUPPORT CATEGORIES:

DIM Renew is great support for: estrogen and estrogen metabolite balance, testosterone balance; breast health; uterine health; prostate health; healthy female and male function; premenopausal symptoms; menopausal symptoms.

DIM, or di-indole methane, is one of the biggest reasons we get encouraged to eat our cruciferous vegetables. This nutritional ingredient is well known for its health properties and its ability to facilitate liver clearance of oxidizing substances (including estrogenic metabolites); these metabolites can be epigenetic influences. DIM provides powerful natural support for healthy, balanced estrogen/estrogen metabolite ratios.

Olive Leaf Extract (20% oleuropein) is one of the most powerful antioxidants available. Olive leaf is extremely effective against oxidation. It is a putative secretagogue of Glucagon-like peptide-1 (GLP-1), which means that it mimicks the action of an intestinal peptide involved in glucose regulation. It also has a stimulatory effect on the thyroid.

Green Tea Extract (decaffeinated) is another powerful antioxidant. The research supports the theory that green tea extract (GTE) is a key ingredient for healthy cell cycle regulation (Hu G. et al. 2014).
GTE has been studied for many years, and found to be excellent support for cell cyclye regulation in a wide variety of tissues, including breast, prostate, uterine, genito-urinary, etc.; green tea affect cell cycle signaling pathways. Z. Wang et al. 2013 point out that a number of nutraceuticals serve as candidates for development of agents “because of promising epidemiological, preclinical and pilot clinical findings,” adding that their mechanisms of action may involve an ability to target multiple molecular pathways without eliciting toxic side effects. Green tea extracts have been discovered to decrease the expression of genes (epigenetic influence) that promote dysregulated cell cycles (Mineva ND. et al. 2013).

Calcium D-Glucarate is the calcium salt of D-glucaric acid, found in high concentrations in cruciferous vegetables. Supplementation of calcium D-glucarate has been shown to inhibit beta-glucuronidase. Beta glucaronidase is an enzyme responsible for releasing estrogen into the system after it has already been conjugated (not a good thing). High levels of this enzyme are associated with unbalanced estrogen levels. Calcium D-glucarate helps to maintain a good balance of this enzyme, and contributes to estrogen metabolism regulation.

Lecithin is an emulsifier that is beneficial for increasing the absorption and bioavailability of many nutrients. Lecithin has been researched for its favorable effect in supporting prostate health.

Broccoli Sprouts (4% sulforaphane) have been noted by Gerhauser (2013) as being a strong epigenetic influence for induction and translational areas, and that the influence on oxidative pathways (among others) makes broccoli sprouts an interesting candidate for future research. Sulforaphane (contained in broccoli sprouts) may exert its effect in part via epigenetic modifications of the Nrf2 gene (a key regulator of cellular antioxidant defense systems), with subsequent induction of its downstream anti-oxidative stress pathway.

Grape Seed Extract (95% proanthones) has a high concentration of proanthocyanidins and is believed to keep aromatase expression in homeostasis. Its high antioxidant activity makes it a helpful addition for regulating everything involved with oxidative pathways. Ting, H. et al (2014) suggest that grape seed extract is one of the promising botanical extracts to support prostate health. A meta-analysis by Carlson, S. et al (2008) listed grape seed extract and its high phenol content to have several beneficial effects on metabolic homeostasis.

Mangosteen (90% xanthones), favorably affects aromatase homeostasis. Shen Q. (2014) note the favorable affect on Nrf2 (antioxidant power) that mangosteen brings about, to support healthy cell environments.

Apigenin is one of the citrus bioflavonoids; it has high antioxidant activity, and it can be very helpful in creating a healthy cellular environment. Apigenin also helps maintain healthy uric acid levels. It is also believed to have a favorable effect on central noradrenergic, dopaminergic and serotonergic activities. Apigenin is another nutrient believed to contribute to normal cell cycle regulation and an optimal health risk profile.
Contraindications: None known
Ingredients: Propriety blend 390 mg* of: Dim (diindolylmethane), Olive Leaf Extract (20% oleuropein), Green Tea Extract (decaffeinated), Calcium D-Glucarate, Lecithin (sunfl ower), Broccoli Sprout (4% sulforaphane), Grape Seed Extract (95% proanthones), Mangosteen (90% xanthones), Apigenin.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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