Glycan Renew

SKU: 2816
Supportive Function: Immune System, Multiple Organ Systems, Healthy Cell Proliferation and General Well- Being and Homeostasis (they are adaptogenic).

When is Mushroom Glycan Support Helpful? Immune conditions, aging process, joint/structural issues, energy, and much more.
Clinical Applications Research: Coriolus Versicolor (high in PSK): Chu, K. et al. report that the a wide array of coriolus versicolor biological activities has been extensively demonstrated, including stimulatory effects on different immune cells (Chu KK, et al. Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values. J Clin Pharmacol. 2002 Sep;42(9):976-84).

PSK (polysaccharide K), one of the substances that can be extracted from Coriolus Versicolor has several properties that support immune cell activity and normal cell turnover. PSK is believed to be a strong antioxidant, a compound that blocks the action of free radicals (activated oxygen molecules that can damage cells). More than 2 dozen human studies of PSK have been reviewed by experts at the University of Texas, who concluded that PSK is excellent immune support. Researchers hoping to provide clear evidence of augmentation of immune responses demonstrated that PSK was “surprisingly active” (Ragupathi G, et al. Evaluation of widely consumed botanicals as immunological adjuvants. Vaccine. 2008 Sep 2;26(37):4860-5.)
A systematic review and meta-analysis (a meta-analysis drawing from several randomized, placebo-controlled, double-blind trials is considered the strongest evidence to support a theory) assessed the efficacy of coriolus versicolor. After reviewing 13 of these clinical trials, findings showed that coriolus was a strong herbal support factor (Eliza WL, et al. Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87).

Reishi Mushroom: has a multitude of benefits; it is known in ancient Eastern medicine as the "mushroom of immortality" and the "medicine of kings." Health issues mean that the body is out of balance, which is why an equilibrium-enhancing formula with an adaptogenic herb such as reishi in it can help in so many ways. Reishi’s high content of substances like sterols, ganoderic acids, coumarin, mannitol and polysaccharides support heart health and rhythms, including healthy cholesterol and triglyceride levels, and normal blood pressure. Reishi is good support for the liver, and is reported in the International Journal of Medicinal Mushrooms as a “wellknown traditional medicinal mushroom” that has been shown to have obvious beneficial effects on the liver (Wu X, et al. Int J Med Mushrooms. 2013;15(4):383-91).
The International Journal of Medicinal Mushrooms also reports that “bioactive components found in the G. lucidum mushroom have numerous health properties” and is used to support liver health (Batra P, et al. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43). Reishi affects survival and proliferative signaling pathways that act on translation, and this method of action enhances its support effects (Suarez-Arroyo IJ, et al. PLoS One. 2013;8(2):e57431).

Maitake Mushroom, described as immunomodulatory, is noted to have an effect on maintaining the homeostasis of normal blood sugar levels, which might be related to the fact that it decreases levels of factors that destroy pancreatic β-cells, such as oxidative stress” (Lei H, et al. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-81).

Maitake was on a list from the Clinical Practice Committee of The Society of Integrative Oncology, of leading supplements that have “the best suggestions of benefit” when it came to recommending complementary therapies (Frenkel M, et al. Integr Canc Ther. 2013 Feb 25). One research group reported on the antioxidant and immunomodulatory effects of two of the polysaccharides in maitake, saying that the activity to support normal cell proliferation may result from the improved immune response (Bi Y, et al. Biological and physicochemical properties of two polysaccharides from the mycelia of Grifola umbellate. Carbohydr Polym. 2013 Jun 20;95(2):740-5).

Scientists refer to maitake as a “high value medicinal mushroom”, and describe it as being popularly consumed, especially for supporting immune functions (Wu SJ, et al. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. Am J Chin Med. 2013;41(1):131-44). In one study, the bioactive compound ergosterol peroxide (EPO), found in maitake, was discovered to offer full protection against induced cell toxicity. Researchers concluded that EPO may play an important role in the immunomodulatory activity of maitake, by inhibiting both the production of pro-inflammatory mediators and activation of the NF-κB signaling pathway (Ibid, Wu).

Shiitake Mushroom: Researchers demonstrated that a novel polysaccharide from shiitake mushroom stimulates the differentiation of myeloid-derived suppressor cells (MDSCs) and supports homeostasis, shedding new light on developing strategies related to those cells (Wu H, et al. PLoS One. 2012;7(12):e51751). Shiitake is purported to have potent properties due to the presence of many bioactive compounds such as ergothioneine, and it has demonstrated an antioxidant activity “through the regulation of nitric oxide concentration and thiol redox status” (Zembron-Lacny A, et al. Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. J Physiol Pharmacol. 2013 Apr;64(2):249-54).In a clinical trial of 45 subjects, shiitake beta glucans increased the number of circulating B cells (Gaullier JM, et al. Supplementation with a soluble β-glucan exported rom Shiitake medicinal mushroom: a crossover, placebo-controlled study in healthy elderly. Int J Med Mushrooms. 2011;13(4):319-26).

Activated hexose correlated compound (AHCC), derived from shiitake mushrooms has positive effects on dendritic cells, natural killer cell function and interleukin 12 production. It may also be affecting a systemic response by regulating the secretion of cortisol and norepinephrine (NE) (Love KM, et al. A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis. J Trauma Acute Care Surg. 2013 Jun;74(6):1411-8). The researchers theorized that the immune function could be due, in part, to the effect on the stress hormones. Another potent ingredient in shiitake is lentinan.

Lentinan, the backbone of β-(1, 3)-glucan with β-(1, 6) branches, is one of the active ingredients purified from shiitake mushrooms and “has been approved as a biological response modifier” in Japan. Lentinan supports the repair of DNA damage and lessens cell death that resides, at least in part, on “its ability to modulate the cellular antioxidant levels” (Attia SM. Et al. J Biochem Mol Toxicol. 2013 Jul;27(7):370-7).

One publication noted that “These results suggest that lentinan exhibits intestinal support for gut inflammation activity through inhibition of IL-8 mRNA expression associated with the inhibition of NF-κB. (Nishitani Y, et al. Intestinal anti-inflammatory activity of lentinan: PLoS One. 2013 Apr 22;8(4):e62441).

Cordyceps: WebMD describes cordyceps as a tonic and an adaptogen used to strengthen the immune system, increase energy, and support liver function ( cordyceps overview). Modern applications for cordyceps include increased production of ATP, support for brain, heart, lung and mitochondria, heavy metal detoxification, and improving the integrity of the HPA (Hypothalamus/pituitary) axis, thus affecting the nervous system and supporting restful sleep (“this experiment can provide basic evidence that cordycepin may be helpful for sleep-disturbed subjects”) – (Hu Z, et al. Evid Based Complement Alternat Med. 2013;2013:840134). It possesses antioxidant properties, and is known for its ability to support kidney function (Yuan M, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 May;38(5):448-57). A study from Int Immunopharmacol states that many studies have shown that cordyceps sinensis has immunoregulatory activity in many models” (Shi B, et al. Int Immunopharmacol. 2009 May;9(5):582- 6).

A study which noted that cordyceps has benefits in immunoregulation attempted to clarify some of the mechanisms by looking at the influence of cordyceps on gene expression in immature dendritic cells. They looked specifically at genes that participate in the adjustment of immune response and the regulation of cell proliferation and death. They discovered that cordyceps specifically regulates the gene expression of genes involved in the regulation of the focal adhesion pathway, ECM-receptor interaction pathway, and hematopoietic cell lineage pathway. When studied in combination with lipopolysaccharide, cordyceps affected genes that were significantly involved in the regulation of oxidative phosphorylation pathway (Kreb’s cycle) (Li CY, et al. Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment. PLoS One. 2012;7(7):e40824). 

Lion’s Mane Mushroom is one of the mushrooms that are considered nutritionally functional foods and a source of physiologically beneficial effects. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is reported to be rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for immune support, lipid support, antioxidant support and nerve support. Lion’s mane has also been reported to have many other therapeutic potentials (Khan MA, et al. Hericium erinaceus: an edible mushroom with medicinal values. J Complement Integr Med. 2013 May 24;10).
Contraindications: High doses of mushrooms might increase the risk of bleeding in some people with thrombocytopenia. This product may lower blood pressure and/or thin the blood, which is ordinarily a good thing, however it means that caution should be exercised when on drugs that lower blood pressure or thin the blood, or if one has thrombocytopenia (clotting disorder).
Ingredients: Proprietary blend 725 mg* of: Coriolus Versicolor, Reishi Mushroom, Maitake Mushroom, Shiitake Mushroom, Cordyceps Sinensis, Lions Mane Mushroom, 1,3 Beta Glucans, Lentinan.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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