Product:

Hydroxo B-12 Lozenge

SKU: 2834
Supportive Function: Together with folic acid, cobalamins are essential cofactors required for DNA synthesis in cells, for maintaining the methylation cycle, for producing glutathione in detoxification, and for producing precursors for the citric acid cycle and energy production.

When is Hydroxocobalamin Support helpful? The blood, digestive system, vision, and the nervous system.
Clinical Applications Research: Vitamin B-12 is a member of a group of vitamins called cobalamins. B-12 is a cofactor for many reactions in the body. It helps support the health of the blood, digestive system, vision, and the nervous system. Together with folic acid, cobalamins are essential cofactors required for DNA synthesis in cells, for maintaining the methylation cycle, for producing glutathione in detoxification, and for producing precursors for the citric acid cycle and energy production.

The main dietary sources of vitamin B-12 are meat (especially liver), eggs, and dairy products. Given these food sources, vegetarians are at risk of inadequate B-12 levels. Only bacteria and archaea (single-celled microorganisms) have the enzymes required for the synthesis of B-12. Shortages commonly occur in adults as they age due to changes in absorption. In addition, genetic variations (or SNiPs) can lead to inadequate levels of this vital nutrient. The prevalence of these variations was determined by the American Journal of Epidemiology to affect an average of 46.9% of people in the United States. (Man-huei Chang, et. al, Am J Epidemiol. Jan 1, 2009; 169(1): 54–66.)

With the presence of the genetic variations in the methylation cycle, the absorption of B-12 can be significantly reduced. (Watkins, David, and Rosenblatt, David S(Feb 2010) Vitamin B12: Disorders of Absorption and Metabolism. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0002267.pub2]).

While there are many types of vitamin B-12 or “cobalamins,” only the following four are generally used as dietary ingredients.
  •  Hydroxocobalamin
  •  Cyanocobalamin
  •  Methylcobalamin
  •  Adenosylcobalamin
All four are considered “Vitamin B-12”; however, choosing the correct one for a patient can be a critical decision as each one functions in different ways.

Cyanocobalamin is probably most commonly used in supplementation. However, it may not be the best choice for some people. Cyanocobalamin is a cheaper form, but it requires a higher dosage for the same effectiveness as the active hydroxycobalamin. Cyanocobalamin must be converted in the liver to methylcobalamin or adenosylcobalamin before it can be utilized.

Methylcobalamin is considered by many practitioners to be a good choice. It helps protect the nervous system by promoting nerve cell regeneration. People who get jittery from caffeine, coke, or tea may react better to Hydroxo B-12 than to Methyl B-12.

Adenosylcobalamin (dibencozide), another highly-active form of vitamin B-12, is essential for energy metabolism and is required for myelin sheath formation and RNA/DNA synthesis which has been associated with maintenance of nerve and spinal cord health.

Hydroxocobalamin is mainly produced by bacteria and can be converted in the body to useable coenzyme forms of B-12. Hydroxocobalamin is a unique form of B-12 that participates in detoxification and is a scavenger of nitric oxide. Hydroxocobalamin may be a preferred choice of B-12 for some because it is more highly protein-bound and therefore remains longer in the circulation. (Hall, Charles A., James A. Begley, and Pamela D. Green-Colligan. "The availability of therapeutic hydroxocobalamin to cells." Blood 63.2 (1984): 335-341).

Methylation
Methylation is a critical function in the body and one of the main ways the body detoxifies itself. One of the most important cofactors in the methylation process is cobalamin. Our exposure to environmental pollutants, excess consumption of sugars and caffeine, and stress in our lives will cause us to deplete our stores of this nutrient.

The “methyl” group needed for this important process is supplied by methylcobalamin. However, for some people the hydroxo form of B-12 works better for them; the hydroxyl form of B-12, hydroxocobalamin, is able to slow the process down by incorporating an additional step in its conversion to methylcobalamin. Understanding the differing needs of individuals and their genetic patterns will go a long way toward determining the optimal form of B-12 supplementation to choose for your patient.
Contraindications: Vitamin B-12 is non-toxic. Being water soluble, excesses are excreted in the urine.
Ingredients: Vitamin B-12 (as hydroxocobalamin) 1000 mcg
Vegetarian: Yes
Suggested Dosage: 1 lozenge daily or as directed
Pack: 120 Lozenges
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