Serene Renew

SKU: 2806F
Supportive Function: Supportive Function: Sleep, relaxation, calmness, mood support and focus.

When is Calming Support helpful? Stressful or anxious times, busy schedules, sleepless nights.
Clinical Applications Research: Kava Kava (root) (70% kavalactones) is an herb used for relaxation and sleep support. Many studies (including a meta-analysis) confirm that kava is safe (Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 2013; Pittler, MH et al. 2003, Kava. Cochrane Database Syst Rev.). The various mechanisms of action for kava contribute to its effect on neurotransmitter homeostasis (and adrenal insufficiency) and its ability to support energy levels and stress reactions (Blumenthal, Mark. The ABC Clinical Guide to Herbs. American Botanical Council. 2003).

Valerian (root)(0.8% valerenic acid) has been used for centuries an herbal support for stress homeostasis. Its effects are suspected to be mediated through the GABA receptor. The amino acid valine is named after this plant. The valerenic acids and sesquiterpenoids in valerian are considered to be the highly active components. Valerian supports neuronal and heart health in addition to the effects normally attributed to this anti-stress herb.

Passion Flower (4% flavonoid): Numerous pharmacological effects of Passiflora incarnata are mediated via modulation of the GABA system (Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011). The same two-year multicenter, prospective observational study on St. John's Wort, valerian root, and Passion Flower mentioned above (involving 115 children between 6 and 12 years) was well tolerated and found to be beneficial (Herbal triplet in treatment of nervous agitation in children. Wien Med Wochenschr. 2013 Feb).

Inositol is used to stabilize cell structures thereby enhancing cell signaling and cell communication. It helps the second messenger system and aids in the production of ATP.

L-Theanine: Web MD describes theanine as an amino acid found in green tea that has a chemical structure similar to a naturally occurring amino acid in the body that helps to transmit nerve impulses in the brain. It is a powerful amino acid with amazing properties. It raises glutathione, which is the body’s main antioxidant and cell stabilizer. L-Theanine has a homeostatic effect on the calming neurotransmitters, as well as balancing the homeostasis of excitatory neurotransmitters. It is through this neurotransmitter pathway that L-theanine may be exerting its effects of counteracting the results of too much caffeine.

Phenibut (beta-phenyl-gamma-aminobutyric acid) is also a powerful antioxidant, and unlike GABA (gammaaminobutyric acid), it is able to cross the blood barrier to promote its effects. GABA is a natural neurotransmitter produced in the body. The proposed mechanisms of phenibut are aimed at neuronal responses, learning centers, and normal dopamine production.

St. John’s Wort (herb)(0.3% hypericin) has historically been utilized as support for mood homeostasis. St. John’s Wort, valerian and passion flower were investigated in a multicenter, prospective observational study (2008) with 115 children between 6 and 12 years, and found to be safe, well tolerated, and good support. 191 St. John’s Wort was studied with kava kava in a systematic review that was conducted using the electronic databases MEDLINE, CINAHL, and The Cochrane Library during late 2008 and those results also supported the historical use of St. John’s Wort. (Kava and St. John's Wort: current evidence for use in mood and anxiety disorders. J Altern Complement Med. 2009).

Lecithin (sunflower) is an emulsifier that is beneficial for increasing the absorption and bioavailability of many nutrients. Lecithin is also known for fostering a normal non-inflammatory state, and has been researched for its favorable effects in supporting health. Lecithin has lowered C-reactive protein in some studies (CRP is an inflammatory marker).
Contraindications: The ingredients in this formula have a good safety profile. Use caution when used concomitantly with other drugs, especially benzodiazepines, and CNS depressants as they sometimes affect similar biochemical pathways, and statins/acetaminophen which lower liver function. Possible interaction with goldenseal supplements. St. John’s Wort can interact (usually slow the metabolism of) some drugs. Consult with your practitioner if in doubt.
Ingredients: Proprietary blend 590 mg* of: Kava Kava (root)(70% kavalactones), Valerian (root)(0.8% valerenic acid), Passionflower (4% flavonoid), Inositol, L-Theanine, Phenibut, St. Johns Wort (herb)(0.3% hypericin), Lecithin (sunflower).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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