Product:

Nitric Oxide Formula

SKU: 2840F
Supportive Function: Nitric Oxide (NO) Formula balances NO whether high or low, contributing to circulation support and the optimal functioning of many pathways, especially when genetic mutations impede the process.

Nitric Oxide (NO) plays a very important role in relationship to cardiovascular health. It also participates in virtually every cellular function in the body. Since NO is a vasodilator, its benefits are also noted for contributing to sexual health in males. Low levels are associated with health imbalances, so for optimal functioning, we should be sure to maintain sufficient levels in the bloodstream. Genetics can greatly influence NO metabolism, and since the importance of nitric oxide production and management in the human body can appear complicated, a clarified overview will help.

Increasing levels of NO must be done safely, because NO can form dangerous peroxynitrites (potent free radicals) in the absence of nutritional support (antioxidants). Peroxynitrite is a very damaging molecule that is produced when the body tries to fight infections. It damages the cells of bacteria, viruses and other foreign invaders however if this molecule is not broken down well, it can attack our own tissues through the production of free radicals. This may lead to chronic inflammation, imbalances, and cell membrane damage.

In addition to environmental and dietary imbalances contributing to low levels, genetic variants can also affect circulating NO levels. Genetic variants in the SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase) and NOS (nitric oxide synthase) genes can have a profound effect on nitic oxide levels in the body. These enzymes may affect NO levels by using up nitric oxide to quench free radicals or by decreasing production of nitric oxide.
Clinical Applications Research: Nutritional interventions can be a tremendous help to balancing out these critical metabolites. By adding antioxidants to quench free radical production and adding in potent precursors to NO, we can optimize levels in the body and reduce risks of imbalances that can lead to many health risks.

There are three types of NO in the body; neuronal, endothelial, and inducible. These three types of NO have very different roles in the body. The neuronal form (nNOS) is involved in cell to cell communication; the endothelial form (eNOS) is involved in arterial health, vascular tone and blood flow; and the inducible form (iNOS) is involved in immune system response.

Genetic variants in the nNOS, eNOS and iNOS genes can cause low levels to be produced. In the past, arginine was used to raise NO levels without tremendous success due to the fact that variants in one or more of these genes it can block the conversion of arginine to NO. Evidence suggests that the conversion of arginine to NO occurs in the arterial system but the arginine molecule can have difficulty passing into the circulation system from the digestive system. Citrulline, on the other hand, can pass through into the circulation much more easily. This makes converting citrulline to arginine in the system the best way to raise NO more successfully.

This is especially true when the genetic variants are slowing that conversion down (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.00 37439 http://www.biochemj.org/content/281/1/45).

NO production requires several cofactors, including tetrahydrobiopterin (BH4). This molecule is produced when the methylation cycle is functioning correctly. FAD (flavin adenine dinucleotide) is another important cofactor (a product of the Krebs cycle) as is FMN (flavin mononucleotide) a riboflavin derivative. Lastly, the heme molecule in red blood cells is also a cofactor.

Nitric Oxide can be reduced to the superoxide molecule (another damaging free radical) in the case of a deficiency of arginine or BH4. This so called “uncoupling” has been known to occur in sugar, pressure and fat imbalances.

Optimal levels of NO can lead to tremendous changes in cardiovascular profiles. It has been shown to help health imbalances by dilating blood vessels. In addition, it supports an anti-inflammatory environment by clearing up free radical damage. It also supports the immune system response by cleaning up chronic immune attacks that can lead to inflammation. It has even been shown to support the elimination of parasitic infections (Norris, et al, Infect. and Immun. July 1995 vol. 63 no. 7 2793-2796).

L-Citrulline (comes from watermelon) has been shown to be a major precursor to NO production in the body. High levels have been shown to support vasodilation and arterial pressure. L-Citrulline supplementation restores NO formation, while also reducing free radicals in the body (Clinical & Experimental Allergy Volume 47, Issue 2, pages 190–199, February 2017).

Citrulline has recently received a great deal of attention for its potent antioxidant effect (Akashi et al. 2001). Additional studies demonstrate many effects, including an important role in the cardiovascular system (Romero et al. 2006), as a regulator of immunity (Norris et al. 1995), and in the regulation of nitrogen balance (Osowska et al. 2004, 2006).

Citrulline seems to work in a different way than arginine and increases levels of NO in the bloodstream more effectively than arginine. Several studies support the idea that citrulline has a more potent therapeutic effect than arginine in increasing NO production (http://www.sciencedirect.com/science/article/pii/S1096719212000200).

Citrulline could be helpful in pregnancy related imbalances (Lassala et al. 2009), in cardiovascular imbalances (Romero et al. 2006; Wu and Meininger 2000), in weight issues and/or sugar imbalances (Jobgen et al. 2006; Wu et al. 2007), in intestinal imbalances, (Elwafi et al. 2012; Osowska et al. 2004; Wijnands et al. 2012) and in critically ill patients (Hao et al. 2004).

L-citrulline supplementation may help reduce ammonia levels through assistance in the urea cycle. It has also been shown to reduce lactic acid levels and levels of fatigue during workouts as well.

Citrulline can be recycled to arginine in macrophages. “The citrulline-arginine cycle may contribute to the regulation of intracellular availability of arginine and thus the prolonged production of NO by macrophages” (http://www.biochemj.org/content/281/1/45).

Cranberry Powder (fruit) is another natural source of nitric oxide precursors. In addition to its high levels of antioxidants and polyphenols, cranberries have been shown to have numerous health benefits, including their antioxidant properties (Yan et al. 2002; Bagchi et al. 2004; Ferguson et al. 2004; Seeram et al. 2004; Neto 2007; Zafra-Stone et al. 2007).

Cranberry extract has been shown to significantly reduce levels of TNFα, CAT, and SOD1 mRNA. This action secondarily reduces free radical activation and increases NO production (http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A249).

Quercetin is a potent antioxidant that reduces free radicals and preserves the NO produced, helping to maintain its cardiovascular and other health effects (1998 British Journal of Surgery Society Ltd).

Vitamin C (as ascorbic acid) is another source of free radical quenching antioxidant that helps keep NO in the beneficial form. Vitamin C has been shown to enhance NO bioactivity by increasing intracellular BH4 (tetrahydrobiopterin) levels (http://www.jbc.org/content/275/23/17399.short).

Resveratrol is a polyphenol that is found in red wine; “it increases the activity of nitric oxide synthase, this increases the production of NO especially in cultured pulmonary artery endothelial cells” (Cancer Research 59, 2596 – 2601, June 1, 1999).

In addition, resveratrol helps prevent eNOS uncoupling and production of peroxynitrites. It has been shown to reduce levels of superoxide molecules as well both mechanisms preserve the NO molecule needed for cardiovascular health. (http://www.sciencedirect.com/science/article/pii/S0014299911005942).

Huperzine A reduces the overexpression of proinflammatory enzymes such as NF Kappa-B, and decreases the overproduction of NO, thereby reducing cell damage. (http://www.sciencedirect.com/science/article/pii/S0047637412001820 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2008.05504.x/full).

Beet Powder (root) - contains high levels of nitrites, which are converted into nitric oxide through the action of bacteria in the mouth and gastrointestinal system. Inorganic nitrate and beetroot juice supplementation was associated with a significant benefit is arterial pressure support (http://jn.nutrition.org/content/143/6/818.short).

Fruits and vegetables rich in nitrate/nitrite added to the diet help balance blood sugar and vascular endothelial imbalances by increasing the NO levels. It may also help prevent other lifestyle-related problems, including bone density imbalances, respiratory imbalances and free radical pathologies (Nutrients 2015, 7(6), 4911-4937; doi:10.3390/nu7064911).

In summary, in order to balance nitric oxide levels in the body, it is important to first make sure to clean up or prepare for extra free radical production. The new Nitric Oxide Formula does both, by providing antioxidant support and also supplying precursors to nitric oxide production itself. Adding the NO product in a regimen with SOD lozenges can increase the benefits of this product.
Contraindications: When there is a shortage of the enzyme required to catalyze the citrulline-arginine urea cycle (not common), ammonia can accumulate in the blood. Research indicates, however, that supplementation with zinc can improve the conversion of citrulline-arginine in the liver and at the same time keep the levels of NH3 (ammonia) in the blood low. Some people avoid large doses of arginine when they have the herpes virus.
Ingredients: Each tablet contains: Vitamin C (as ascorbic acid) 50 mg. Proprietary blend 817.025 mg* of: L-Citrulline, Beet Powder (root), Cranberry Powder (fruit), Quercetin, Resveratrol, Huperzine A
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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