Product:

Complete Whey-G (Protein Powder)

SKU: 1526PF
Supportive Function: Undenatured whey is indicated wherever it is helpful to raise glutathione. General support for immune health, surgery recovery, inflammatory environment, detox, bone support, weight management, protein boosting (needed for hormones, immune antibodies, enzymes, neurotransmitters, muscles, surgery recovery, etc)

When is Glutathione helpful? Helpful Helpful for general health, stress, athletic performance, skin disorders, detoxification, fatigue, digestion, pregnancy/lactation, sleep, psychoneurobiology, stomach/bowel dysfunction, prostate health, kidney issues, eyesight, hearing, sinus, lung problems, ...and many other areas where decreased levels of glutathione are suspected of being a problem.
Clinical Applications Research: Undenatured whey efficiently raises glutathione levels in the body: One of the reasons that undenatured whey is getting so much press is because it raises glutathione levels in the cells. Glutathione (GSH) is a potent intracellular antioxidant that is backed by strong research describing its dramatic health benefits. Undenatured whey, which avoids heat processing, is able to bypass the normal roadblocks to successful cellular glutathione production. The biggest roadblock is the breakdown of glutathione in the digestive tract (it is quickly broken down and eliminated), lowering the efficiency of glutathione supplementation.

Enter undenatured whey. The whey has bioactive proteins and contains cystine, which is two cysteine molecules held together by a bond that is resistant to digestion. Cysteine, being one of the three amino acids that make up glutathione, facilitates the production of glutathione inside the body’s cells because it is the limiting building block. It is deficient in many diets. It does not travel to the cell well unless it is part of a larger protein, and that’s where cystine comes in. Being a larger protein, the cystine in whey travels quickly to the cell and then splits into the two-cysteine molecules to provide the necessary precursor for glutathione production.

The whey also contains an efficient delivery system to transport the cystine to the cells. Moreover, whey contains additional building blocks for glutathione. These building blocks, and the delivery system, are heatsensitive, however the undenatured whey eliminates this roadblock since it has not been exposed to heat. Glutathione must be manufactured in the cells. Because of this, and because the optimal production of GSH is provided by transportation of these heat-sensitive precursors (cystine and glutamylcystine residues) by other heat-sensitive molecules (albumin, lactoferrin and alpha lactalbumin) all contained in whey, undenatured, unheated whey protein is THE best nutritional source for glutathione production.

There are reports of a wide range of health benefits to be gained from whey. In addition to being a good source of protein, whey demonstrates a multitude of “immune-enhancing properties” and “has the ability to act as an antioxidant, antihypertensive, antitumor, hypolipidemic, antiviral, antibacterial, and chelating agent

A number of clinical trials have successfully been performed using whey in the treatment of cancer, HIV, hepatitis B, cardiovascular disease, osteoporosis, and as an antimicrobial agent. Whey protein has also exhibited benefit in the arena of exercise performance and enhancement(Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004 Jun; 9(2): 136-56).

Whey has been utilized to help reduce the inflammation in critically ill trauma patients receiving nutritional support; C-reactive protein concentrations (marker of inflammation) and total inflammatory index dramatically fell in one study (Vehe KL et al. The prognostic inflammatory and nutritional index in traumatized patients receiving enteral nutrition support. J Am Coll Nutr. 1991 Aug; 10(4): 355-63).

WHEY (Undenatured) contains glycomacropeptide: Glycomacropeptide (GMP) has anti-inflammatory, immunomodulatory and bacterial toxin binding effects. The intestinal anti-inflammatory activity of glycomacropeptide was assessed in colitis in a rat model. Pretreatment with glycomacropeptide had an antiinflammatory effect, characterized by less colonic damage (65%). “The magnitude of the anti-inflammatory effect was generally comparable to that of sulfasalazine, an established drug used in the treatment of inflammatory bowel disease. It may play a role in the management of patients with inflammatory bowel disease” (Daddaoua A et al. Bovine glycomacropeptide is anti-inflammatory in rats with hapten-induced colitis. J Nutr. 2005 May; 135(5): 1164- 70). Research on GMP has focused on its ability to bind toxins, inhibit bacteria and viruses adhesion, promote growth of good gut bacteria, inhibit proliferation of pathogens and modulate immune system responses (Brody E.P. Biological activities of bovine glycomacropeptide. Br J Nutr. 2000 Nov; 84 Suppl 1:S39-46). Researchers have found GMP to be a potent immunoenhancer even at low concentrations (Li EW, Mine Y. Immunoenhancing effects of bovine glycomacropeptide and its derivatives on the proliferative response and phagocytic activities of human macrophagelike cells, U937. J Agric Food Chem. 2004 May 5; 52(9): 2704-8).

Whey supplies cysteine to the cells, and supplementation of the glutathione precursor cysteine in several clinical trials improved skeletal muscle functions, decreased the body fat/lean body mass ratio, decreased inflammatory cytokines, and improved immune functions. “As all these parameters degenerate with age, these findings suggest: (i) that loss of youth, health and quality of life may be partly explained by a deficit in cysteine and (ii) that the dietary consumption of cysteine is generally suboptimal and everybody is likely to have a cysteine deficiency sooner or later(Droge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29; 360(1464): 2355-72). 

Superoxide Dismutase Type G (glutathione) is a natural free-radical scavenging enzyme. It mops ups the superoxide free radical, and works synergistically with many of the antioxidants in the oxidative defense system of the body, particularly glutathione. The superoxide radical produces oxidative stress associated with tissue damage and dysregulation of physiological signals. Molecular studies reveal that insulin receptor activity (associated with aging) is increased by this oxidative stress, and decreased by certain antioxidants (Droge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29; 360(1464): 2355-72). 

Luo Han Guo (fruit), or Lo Han Kuo (from the Momordicia grosvenori fruit) is a novel, natural sweetener that has many beneficial, health-promoting properties. The sweet elements, called triterpene glycosides, actually suppress the rise in blood glucose after a meal! (Suzuki YA t. al. 2005). Researchers have found the natural sweetener to exhibit significant anti-tumor activity by decreasing both initiation and promotion (Ukiya M. et al. 2002). Additionally, it prevents the oxidation of LDL (bad cholesterol) and may reduce the risk of heart disease by reducing the atherogenicity of the LDL (Takeo E. et al. 2002). Researchers have determined that it possesses many advantages, such as having high sweetness capability with low adherence (good news for the teeth!) (Mu, J. 1998).

Anti-Inflammatory, Natural Cox-2 Inhibitors:

Undenatured Whey Inhibits cox-2 by raising GSH levels: As mentioned above, whey possesses many properties, including anti-inflammatory characteristics. One of the ways in which whey demonstrates antiinflammatory effects is by inhibiting the cox-2 enzyme. The Cox 2 enzyme causes inflammatory substances to be produced in the body and is also the enzyme targeted by the cox-2 inhibitor drugs such as Vioxx and Celebrex. Raising glutathione (for example by utilizing undenatured whey) has the ability to modulate cox-2 gene expression and prostaglandin (inflammatory substance) synthesis (Chen JX et al. Glutathione mediates LPS-stimulated COX-2 expression. J Cell Physiol. 2003 Oct; 197(1): 86-93).

The following nutrients ALSO inhibit inflammatory cox-2 naturally, and they have been added to the Complete Whey-G formula to boost its anti-inflammatory support:

Ginger has 477 documented active ingredients, including several cox-2 inhibitors such as kaempferol. A moderate dose of ginger has been found to stop the formation of inflammatory and pain-causing prostaglandins, and a University of Miami study demonstrated that 63 percent of patients with knee osteoarthritis showed improvement after taking ginger for just six weeks (Altman, RD & Marcussen, KC. Effects of a ginger extract on knee pain inpatients with osteoarthritis. Arthritis Rheum 2001 Nov).

T
urmeric (Curcumin) (rhizome) is an ingredient in the spice turmeric that possesses powerful cox-2 inhibiting activity. Curcumin and ginger were among the spices researched by the MD Anderson Cancer Center at the U of Texas that were determined to possess the ability to “inhibit the activation of a transcription factor linked with a variety of inflammatory diseases, including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma, arthritis, Crohn's disease, multiple sclerosis, Alzheimer's disease, osteoporosis, psoriasis, septic shock, and AIDS” (Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004 Dec; 1030:434-41). “Curcumin has been described as a potent antioxidant and antiinflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis… All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer” (Aggarwal BB, et al. Anti-cancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 Jan-Feb; 23(1A): 363-98).

Indian Frankincense (boswellia) (gum) has been used as a traditional remedy in Ayurvedic medicine in India for the treatment of inflammatory diseases, and a strong inhibitor of the cox-2 enzyme. When boswellia was used in clinical trials, “promising results were observed in patients with rheumatoid arthritis, chronic colitis, ulcerative colitis, Crohn's disease, bronchial asthma and peritumoral brain edemas” (Ammon HP. Boswellic acids as the active principle in treatment of chronic inflammatory diseases Wien Med Wochenschr. 2002; 152(15-16): 373-8). The same researchers point out that boswellia can inhibit elastase (an enzyme that breaks down connective tissue).

Quercetin is a powerful bioflavonoid and antioxidant that has been found to “effectively suppress the COX-2 promoter activity(Bagga D et al. Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci 2003 Feb 18; 100(4): 1751-6). 

Curcumin, Boswellia and Quercetin are all among the natural agents described by researchers that “may advance the efficacy of cancer therapy… One key new approach appears to be modulation of the inflammatory cascade, as research is expanding that links cancer initiation, promotion, progression, angiogenesis, and metastasis to inflammatory events” (Wallace JM. Nutritional and botanical modulation of the inflammatory cascade as an adjunct in cancer therapy. Integr Cancer Ther. 2002 Mar; 1(1): 7-37).

Chamomile (flower) contains bioactive flavonoids such as apigenin that are powerful cox 2 inhibitors, and “may be important in the prevention of carcinogenesis and inflammation” – in fact, apigenin was more powerful than genistein and kaempferol in inhibiting cox 2 (Liang YC, et al. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 1999 Oct; 20(10): 1945-52). The apigenin in chamomile has effectively suppressed inflammatory substances in scientific studies (Smolinski AT, Pestka JJ. Modulation of lipopolysaccharide-induced proinflammatory cytokine production by herbal constituents. Food Chem Toxicol. 2003 Oct; 41(10): 1381-90).

Glutathione (GSH) also inhibits the inflammatory cox-2 enzyme (Chen JX et al. Glutathione mediates LPS-stimulated COX-2 expression via early transient p42/44 MAPK activation. J Cell Physiol. 2003 Oct; 197(1): 86-93). As a supplement, GSH breaks down in digestion and is not the most effective way to raise glutathione in the cells, HOWEVER, oral glutathione supplementation has been shown to have some effect on GSH concentration in the liver because of the efficient extraction by the liver of the cysteine that originated from the breakdown of GSH in the gut (Grattagliano I, et al. Effect of oral glutathione monoethyl ester and glutathione on circulating and hepatic sulfhydryls in the rat. Pharmacol Toxicol. 1994 Dec; 75(6): 343-7). This makes it an excellent synergistic addition to a formula for glutathione support. Glutathione protects not only individual cells but also the tissues of the arteries, brain, heart, immune cells, kidneys, lenses of the eyes, liver, lungs, and skin against oxidant damage.
Contraindications: The components of whey include lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, bovine serum albumin and immunoglobulins. Those sensitive to dairy may be sensitive to the whey portion, however, that does not mean that all of those sensitive to dairy will necessarily be sensitive to the whey portion. Should not be used by whey-sensitive people.
Ingredients: Each Scoop* Contains: Calories: 37; Total Fat: 0.085 gms; Total Carbohydrate: 0.269 gms; Protein 8.89 gms. Proprietary blend 985 gms* of: Whey (undenatured), Rice Bran, Chamomile (flower), Ginger (root), Indian Frankincense (boswellia) (gum), Quercetin, Superoxide Dismutase Type G (glutathione), Turmeric (curcumin) (rhizome), Luo Han Guo (fruit), Glutathione. With Natural French Vanilla Flavoring.
Vegetarian: No
Suggested Dosage: 1 scoop in juice or water or as directed. Do not over mix. 34 servings per container.
Pack: 12 oz Powder
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