SKU: 1542
Supportive Function: Helps maintain healthy cholesterol; works as an antioxidant; helps maintain and stabilize capillary walls and cell membranes; prevents proteins, lipids, hormones (such as pituitary, thyroid and adrenal hormones as well as the sex hormones), and other substances from being oxidized.

When is Vitamin E and Tocotrienol Support Useful? Vitamin E and the tocotrienols are helpful in supporting the skin and heart health, and conditions either caused by free radical damage or resulting in free radical damage (including blood sugar maintenance and eyesight).
Clinical Applications Research: Vitamin E is involved in maintaining the integrity, function, and flexibility of all cell membranes. It stabilizes the cell membrane, which is a necessary feature for ensuring cell health. The natural, d-alpha tocopherol portion of vitamin E serves an important antioxidant function in the body, which means that it prevents free radicals (harmful substances with unstable electron structure) from attacking and damaging the cell membrane. There are also synergistic, naturally occurring tocotrienols (alpha, beta, gamma, and delta) that are members of the natural vitamin E family, which all contribute to the health benefits of this essential vitamin. This formula is boosted by rice bran, which additionally contains fiber, gamma-oryzanol and tocotrienols.

D-Alpha Tocopherol (Alpha tocopherol is used synonymously with vitamin E in the literature) is the natural form of this major lipid antioxidant, and there are many reports in the literature of health benefits.

Vitamin E and the Immune System: Vitamin E “was capable of restoring mucosal and systemic humoral immune responses to mature adult levels” after vaccine-induced immune depression (Enioutina EY, et al. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Vaccine. 2000 May 8;18(22):2381-93). Vitamin E is described as having a positive influence on age-related immune and inflammatory changes, and also as having an ability to reduce the suppressive factor (PGE2), (which is a pro-inflammatory factor and an immune-activating factor), and in fact, the researchers were quoted as saying, “Vitamin E reverses an ageassociated defect in T cells, particularly naïve T cells” (Wu D. & Meydani SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol. 2008 Oct;84(4):900-14). This effect of vitamin E was also reflected in support for the upper respiratory tract, especially in the elderly.

Vitamin E and the Eye: Several studies have found that micronutrients (including vitamin E) support the homeostasis of eye health, and slow down the onset and progression of age-related disruption of that homeostasis; also that vitamin E has specific potential to support retina health (Kowluru RA, et al. Arch Ophthalmol. 2008 Sep;126(9):1266-72). Additionally, antioxidative agents (including vitamin E) may play a role in keeping the eye in good health free from obstructive film (Nourmohammadi I, et al. Ann Nutr Metab. 2008;52(4):296-8).

Vitamin E and the Nervous System: Vitamin E levels are decreased in nerve dysfunction. “Increased oxidative stress contributes to neuronal dysfunction... We investigated whether the pathological changes in (these) brains may also be present in peripheral tissues… These results suggest increased oxidative damage and decreased antioxidant capacity in peripheral blood” (there was also a significant correlation between oxidation and severity of nerve dysfunction) (Chen CM, et al. Increased oxidative damage in peripheral blood correlates with severity... Neurobiol Dis. 2009 Mar;33(3):429-35).

The Tocotrienols: While d-alpha tocopherol gets most of the limelight for its antioxidant properties, the tocotrienols are being researched for their synergistic and stand-alone properties. It has been suggested that the vitamin E research done only with the alpha tocopherol portion of vitamin E does not do justice to the properties of the vitamin. Besides the fact that the tocotrienols balance the alpha tocopherol portion of the vitamin E molecule and work in synergy with it, the tocotrienols have emerged as vitamin E moieties with functions in health and disease that are clearly distinct from that of alpha tocopherol.

Tocotrienols possess powerful neural, lipid and cell-regulating properties that are often not exhibited by tocopherols. Current developments in vitamin E research clearly indicate that members of the vitamin E family are not redundant with respect to their biological functions” (Sen CK. Et al. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 2006 Mar 27;78(18):2088-98.

Another study reported that tocotrienols “possess potent antioxidant activities”, and they additionally reported that they possess activity to promote a healthy, non-inflammatory cellular environment, probably by inhibiting substances like nitric oxide, cox 2, and NF-kappaB expression (Wu SJ, et al. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators…. Mol Nutr Food Res. 2008 Aug;52(8):921-9).

Tocotrienols have been found to function as efficacious support for nerves and the nervous system (Das S, et al. …Palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H970-8). Another study confirms the neural support qualities of the tocotrienols, and reports that oral tocotrienol maintains brain neural health, and that “taken orally, tocotrienols are bioavailable to all vital organs” (Sen CK, et al. Tocotrienols in health and disease. Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728).

Tocotrienols are reported to be useful in maintaining healthy cholesterol levels (Ajuluchukwu JN, et al. Comparative study of the effect of tocotrienols and -tocopherol on fasting serum lipid profiles … a preliminary report. Niger Postgrad Med J. 2007 Mar;14(1):30- 3); in providing heart support (Das S, et al. Cardioprotection with palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H970-8); and in guarding against biochemical and molecular changes associated with glucose maintenance (Kuhad A, Chopra K. Life Sci. 2009 Feb 27;84(9-10):296-301).
Contraindications: Large doses of vitamin E are contraindicated with blood thinners (>1200 IUs).
Ingredients: Each Tablet Contains: Vitamin E (as d-alpha tocopherol) 125 mg. Proprietary blend 130 mg* of: Tocotrienols (mixed-alpha, beta, gamma, delta), Rice Bran (with naturally occurring tocotrienols).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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