St. John's-DEP

SKU: 1717
Supportive Function: Mood support

When is St. John’s Wort helpful? Disruption of the feeling of well-being, low serotonin levels.
Clinical Applications Research: St. John’s Wort (herb): St. John’s wort has been used extensively for mood support for ages. Many clinical trials have been conducted to confirm the efficacy of the herb in this area. One study, which listed some of the active ingredients in the herb, such as mucilage, anthraquinones, oils, catechins, etc... was carried out “to study the elemental, nutritional, phytochemical and biological evaluation” of this herb (Pak J Pharm Sci. 2016 Mar;29(2):547-55. Elemental, nutritional, phytochemical and biological evaluation of Hypericum perforatum Linn. Dastagir G et al). The efficacy of St. John’s wort may be attributed to properties that prevent oxidation, glycation, and cell toxicity (Pak J Pharm Sci. 2016 Mar;29(2):397-405. Pharmacological screening of Hypericum androsaemum extracts for antioxidant, anti-lipid peroxidation, antiglycation and cytotoxicity activity. Saddiqe Z. et al).

B Vitamins: B vitamins are essential to our energy making processes, and some B vitamins are especially critical to those processes. Folate (as folic acid) and Vitamin B-12 (as cyanocobalamine), for instance, are very important. They are necessary to stimulate tetrahydrobiopterin (BH4). BH4 is a vitamin- like compound which functions as an essential co-enzyme in the synthesis of several neurotransmitters. Low levels of tetrahydrobiopterin (BH4) in the brain can elicit many symptoms associated with mood imbalance. Folic acid deficiency is the most common nutrient deficiency in the world. Supplemen-0tation has proven useful for feelings of well-being (J Neurosci Rural Pract. 2016 Jul-Sep;7(3):362-7. Effect of Vitamin B12 and folic acid supplementation…Adhikari PM et al).

Thiamine (as hydrochloride) (B-1): A thiamine deficiency may result in metabolic acidosis, changes in the peripheral nervous system, gastric upset and altered brain chemistry. Low thiamine levels can contribute to the symptoms of mood imbalance. Efficacy of supplementation is evidenced by clinical trials, and results were reported in six weeks time in one study. (Eur Arch Psychiatry Clin Neurosci. 2016 Mar 16. Adjuvant thiamine:… results from a randomized, double-blind, and placebo-controlled clinical trial. Ghaleiha A et al).

Niacin (as niacinamide): Niacinamide is the form of niacin that does not cause vasodilatory flushing: Deficiencies can cause insomnia, irritability, strain, tension, and affect mood. Niacinamide is very important for brain metabolism. Nicotinamide may act in part by preventing NADH hyperoxidation (Neurobiol Dis. 2014 Feb;62:469-78. Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation … Shetty PK et al).

Calcium (as citrate) and Magnesium (as citrate): Calcium and magnesium are two minerals that are essential for normal metabolic functioning. They both affect multiple organ systems, like the muscular system and the neuronal system. They work synergistically to provide the needed support for optimal well-being. They both act as co-enzymes in many metabolic functions, and both are extremely integral nutrients for mental well-being (BMC Psychiatry. 2016 Jun 8;16:192. … rationale and design of the MooDFOOD prevention trial. Roca M et al).

Ginkgo (leaf) and Gingko Extract (leaf): Ginkgo biloba is a well known herb, studied for its support of circulation, brain plasticity and mood support. The various phenols in ginkgo may be responsible for its efficacy. (Oxid Med Cell Longev. 2015;2015:248529. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy? Trebatická J, Ďuračková Z. et al).

Damiana (leaf): Damiana has been used traditionally for years as a tonic for the nervous system. The plant contains thymol, flavonoids (such as 5 hydroxy-7,3",4-trimeathoxyflavone) and the hydroquinone arbutin, that may be responsible for its efficacy.

Blue Vervain (herb): The uses of vervain are varied, including as a tonic for the nervous system. Vervain contains iridoids, verbenin, verbenalin and bastatoside with numerous essential oils, which may be responsible for its effects.

Eleuthero (root): The eleutherosides contained in Eleuthero (called Siberian ginseng) have been shown to be responsible for the adaptogenic properties of this plant. Eleutherosides are a range of glycosides with aromatic alcohol aglycones. The glycosides appear to act on the adrenal glands, helping to prevent adrenal hyper-trophy and excess response to stress. The eleutherosides additionally help reduce the exhaustion phase of the stress response and support adrenal homeostasis (Roca M et al. ibid).

Pyridoxal-5-Phosphate (P-5-P): P-5-P is the active form of vitamin B-6. Vitamin B-6 (and thus P-5-P) helps to metabolize brain neurotransmitters, especially the monoamines, like dopamine, epinephrine, norepinephrine and serotonin. A reduction in the availability of the active form of this vitamin is known to affect tryptophan hydroxylase, the enzyme leading to serotonin synthesis (J Physiol Parmacol. 2016 Feb;67 (1):3-19. Overview of the role vitamins and minerals on the kynurenine pathway in health and disease. Majewski M. et al).
Contraindications: Do not take while taking any mood-altering drugs, or drugs that raise neurotransmitters, unless monitored by a physician. Do not take with drugs metabolized by cytochrome P450, as decreased drug effectiveness may occur. Cautions to avoid tyramine-containing foods because St. John’s wort is a possible MAO inhibitor, etc., have not been substantiated. Hypericin, the concentrated extract, can cause sun sensitivity, however there is not as much concern with the whole herb. Use caution in pregnancy. None of the herbs in this formula are directly contraindicated in pregnancy; however, it is a good idea to check with a licensed professional when contemplating the use of herbs during pregnancy.
Ingredients: Each Tablet Contains: Calcium (as citrate) 20 mg, Thiamine (as hydrochloride) 10 mg, Niacin (as niacinamide) 50 mg, Folate (as folic acid) 100 mcg, Vitamin B-12 (as cyanocobalamine) 250 mcg, Magnesium (as citrate) 16 mg. Proprietary blend 520 mg* of: St. Johns Wort (herb), Ginkgo (leaf), Damiana (leaf), Blue Vervain (herb), Hyssop (leaf), Eleuthero (root), Pyridoxal-5-Phosphate, Riboflavin-5-Phosphate, Gingko Extract (leaf).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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