Product:

#1-AD (T-1)

Supportive Function: Eleuthero, containing biologically active constituents known as ginsenosides, teams up with Gotu Kola, Licorice and Parsley in a complementary herbal formula that supports the energy-producing adrenal glands.
Ingredients: Contains: Pure tincture extract of Eleuthero (root), Gotu Kola (herb), Licorice (root), Parsley (leaf).
Vegetarian: Yes
Pack: 1oz Herbal Tincture
Product:

Adreno Plus (T-44)

Supportive Function: Support for the adrenal system during both hypo and hyper adrenal periods. Creates synergy within the entire endocrine system. When is Adrenal Support Effective? Stress and conditions caused by stress, fatigue, lethargy, weakness, mental fuzziness, irritability, and inability to handle everyday tasks.
Clinical Applications Research: Eleuthero (12%) : Supports the adrenal glands and acts as an energy tonic adaptogen. Increases resistance to stress. Licorice Root (12%) : Increases the effectiveness of the adrenal hormones. Helps overcome adrenal fatigue. Fo-Ti (12%) : Provides support for the kidneys, liver, blood, pancreas and spleen. Helps restore energy. Korean Ginseng : Strengthens the immune system and decreases fatigue. Gota Kola : A neural tonic that slowly builds mental stamina and neural health. Helps liver and gallbladder congestion. Ginger : Aids in digestions and enhances the effectiveness of other herbs. Ginger is also a potent antiinflammatory product. Ginkgo Biloba : Cerebral stimulant. Relaxes blood flow and increases brain circulation.
Contraindications: Contraindicated in pregnancy, hypertension, and with blood-thinning drugs. The combination of herbs in this herbal tincture work together in creating synergistic effects, and smaller amounts of the herbs are utilized for optimal effects.
Ingredients: Ingredients: Pure Tincture Extract of: Eleuthero (root), Licorice (root), Fo-Ti (root), Asian Ginseng (root), Gotu Kola (herb), Ginger (root), Ginkgo Biloba (leaf).
Vegetarian: Yes
Suggested Dosage: 5-20 drops or as directed
Pack: 1 oz Herbal Tincture
Product:

Allerhale (0003)

Supportive Function: Allergy Support. For the temporary relief of itching, burning watery eyes, sneezing associated with inhaled allergens or hay fever.
Clinical Applications Research: ARSENICUM ALBUM 12X: watery discharges, sneeaing, stuffed up nose, burning eyes with acrd lachrymation, asthma PHOSPHORUS 12X: Epistaxi, redness of eyes, difficult breathing NUX VOMICA 12X: Watery discharge from the nose, sneezing, dry obstruction, photophobia, dry sensation of eyes, asthma, difficult breathing ALLIUM CEPA 12X: Watery discharge from the nose that is acrid, balnd discharge from the eyes AMBROSIA ARTEMISIAEFOLIA 12X: Lachrymation, intolerable itching of the eyelid, watery discharge of the nose, sneezing, nose bleeds, respiratory tract congested, irrtation of the trachea and bronchial tubes, wheezing cough PULSATILLA 12X: Discharge from the eyes, thick profuse yellow, itching and burning of the eyes, lachrymation, lids inflamed, coryza, yellow discharge, dry cough eveining and night SULPHUR 12X: Burning of the margins of the lids, heat and burning of the eyes, nose stuffed indoors, pressing and burning in the chest, difficult respiration, shortness of breath EUPHRASIA 12X: Profuse fluent coryza conjunctivitis, lachrymation acrid and burning, sticky mucous on the cornea, swelling of eyelids, coughing and expectoration SOLIDAGO 12X: Irritation from pollen inhalation, nasal pharyngeal catarrh, burning in the throat, bronchitis, oppressed breathing, shortness of breath, asthma ECHINACEA 3X: Full feeling in the upper part of the lungs, constant clearing mucous from the throat, full feeling in the nostrils, eyes ache and tire easily ALLIUM SATIVUM 3X: rattling mucous in the bronchi, cough in the morning, mucous expectoration BAPTISIA 3X: Beathing difficult, constriction of the chest
Contraindications: WARNING: STOP USE AND CALL A DOCTOR IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN. CONTAINS ALCOHOL: IN CASE OF ACCIDENTAL OVERDOSE, CONSULT A POISON CONTROL CENTER IMMEDIATELY.
Ingredients: Active Ingredients: Allium cepa 12X, Allium sat 3X, Ambrosia 12X, Arsenicum Alb 12X, Baptisia 3X, Echinacea 3X, Euphrasia 12X, Nux Vom 12X, Phosphorus 12X, Pulsatilla 12X, Solidago 12X, Sulphur 12X. Contains equal volumes of each ingredient. Inactive Ingredients: Alcohol (20% v/v), Purified water.
Vegetarian: No
Suggested Dosage: 4-6 drops, 4x per day. Acute situations: 4-6 drops every 15-30 minutes until symptoms subside.
Product:

Amino All (1415F)

Supportive Function: A comprehensive line-up of amino acids from natural hydrolyzed protein provides the building blocks for many of the body’s essential tissues, such as enzymes, hormones, antibodies, blood clotting factors, and muscle. Some may choose this supplement to increase the protein- to-carbohydrate ratio in a meal, aiding in achievement of a healthy blood sugar zone. Protein elicits glucagon secretion (the opposing hormone to insulin), which functions in times of low blood sugar to contribute to sugar homeostasis. When is Amino Acid Support helpful? Compromised immune systems, rheumatoid and osteoarthritis, degenerative diseases, psoriasis, mononucleosis, herpes, allergies, muscle/nerve health, hypoglycemia, pre and post surgery, amino acid nutrition for athletes and weight loss.
Clinical Applications Research: Amino-All is a source for condroitin sulfate, which has received a lot of attention for its role in cartilage regeneration and arthritis relief. Pioneering studies by J. F. Prudden have shown it may be one of the most important upcoming nutrients used to boost the immune system. Keats Publishing now offers a text (April 1998), devoted solely to bovine cartilage, entitled: “Boost your health with bovine cartilage," by Sally Eauclaire Osborne, MS. From the book, Sally says, “Paradoxically, it stimulates the immune system to fight cancer and viral diseases but suppresses it when necessary, as with allergies and rheumatoid arthritis.” Immune Support: Antibodies and enzymes are made up of proteins. Joint Support: Bovine cartilage has a high content of tracheal cartilage in it, which has received attention for its role in cartilage regeneration. The cartilage provides all of the right precursors to help the cellular growth and repair process. Weight Loss: Protein can be very helpful when added to foods and shakes, because the protein content will lower the glycemic index of a carbohydrate meal. The glycemic index rates carbohydrates for their ability to turn to sugar in the body and stimulate insulin secretion, which can start a roller coaster of carbohydrate cravings.
Contraindications: People taking MAO inhibiting drugs have to avoid tyramine-containing foods and have to be careful with protein supplements. Do not take in PKU (contains phenylalanine). People taking MAO-inhibitors should not supplement with tyrosine.
Ingredients: Each Tablet Contains: Protein 1000 mg. Each 2 tablets supply Proprietary blend 1000 mg* of: Natural Hydrolyzed protein (bovine). Which contains the following Amino Acids: L-Alanine 80 mg, L-Arginine 75 mg, L-Aspartic Acid 45 mg, L-Glutamic Acid 100 mg, L-Glycine 190 mg, L-Histidine 10 mg, L-Hydroxylysine 10 mg, L-Hydroxyproline 120 mg, L-Isoleucine 20 mg, L-Leucine 30 mg, L-Lysine 38 mg, L-Methionine 6 mg, LOrnithine 2 mg, L-Phenylalanine 20 mg, L-Proline 157 mg, L-Serine 35 mg, L-Threonine 20 mg, L-Tyrosine 6 mg, L-Valine 28 mg.
Vegetarian: No
Suggested Dosage: 2 tablets daily or as directed
Pack: 240 Tablets
Product:

Aspartic-Multi-Min (1346)

Supportive Function: A good choice for those wishing to supplement with higher amounts of magnesium and a higher Mg/Ca ratio than usually found. Contains a balance of synergistic minerals.
Contraindications: Some people experience diarrhea at doses of magnesium > 1,000 mg/day. Chronic large doses could possibly upset the mineral balance, especially calcium.
Ingredients: Each Tablet Contains: Calcium (as aspartate) 30 mg, Magnesium (as aspartate) 100 mg, Zinc (as aspartate) 3 mg, Selenium (as chelate) 25 mcg, Manganese (as aspartate) 3 mg, Chromium (as aspartate) 10 mcg, Molybdenum (as chelate) 10 mcg, Potassium (as aspartate) 95 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

B-Complex (1205)

Supportive Function: A total (hypoallergenic) formula that employs the synergistic action of all the B vitamins; additionally, it is boosted with choline and inositol, which are vitamin-like substances that participate in fat metabolism. People who are exposed to stressful situations or who have a poor dietary intake may choose to supplement with B-Complex. When is a B-Complex Formula helpful? Fatigue, depression, stress, glucose control, skin/hair/eyes/ and mouth problems, anxiety, insomnia, hyperactivity, PMS, menopausal symptoms, alcohol withdrawal, and long-term antibiotic application.
Clinical Applications Research: The B vitamins help give us the energy to function. They are known as the "catalytic spark plugs" of the body; they catalyze many biochemical reactions because of their role as Coenzymes. The B vitamins are water-soluble (easily eliminated from the body) and must be constantly replenished. Bacteria in the large intestine can make most B vitamins in the body. A refined diet high in sugar, coffee, alcohol and refined flour can deplete the B vitamins, and long-term antibiotic therapy can reduce the population of beneficial bacteria that normally makes B vitamins in the large intestine. Brain Food: The B vitamins are also important for the synthesis of our brain neurotransmitters, which are chemical signals that our brain uses to carry out physiological functions. The B vitamins are needed, for instance, for the synthesis of the neurotransmitters dopamine, norepinephrine, and serotonin. Administration of B vitamins B-1, B-2, and B-6, in a 4-week randomized, placebo-controlled, double-blind study resulted in trends of greater improvement in scores on ratings of mental well-being and cognitive tasks, and researchers suggested the results "offer preliminary support for further investigation of B-complex vitamin augmentation” in addressing mental well-being (Bell IR et al. J Am Coll Nutr. 1992; 11(2): 159-63) . Glands/Organs: The B vitamins are also essential for the proper functioning of the endocrine glands, most notably the adrenals and the thyroid. The B vitamins are needed for healthy liver functioning, and the liver is one of the highest concentrated areas of B vitamins. The organ we know as the skin depends on B vitamins for its healthy appearance. The B’s are also essential for hair, eyes and mouth; a deficiency of the B’s can manifest in patchy scaly skin around the mouth area. They are also necessary for normal functioning of the nervous system, and essential for maintenance of muscle tone in the gastrointestinal tract. Glucose Control: Just as the B vitamins are used to make ATP (energy) from glucose, they are involved in every step of glucose metabolism, and are therefore helpful in regulating blood glucose levels.
Contraindications: Vitamin B-6 in amounts > 200 mg/day can possibly cause symptoms of neuropathy.
Ingredients: Each Tablet Contains: Thiamine (as hydrochloride) 50 mg, Riboflavin 50 mg, Niacin (as niacinamide) 50 mg, Vitamin B-6 (as pyridoxine hydrochloride) 25 mg, Folate (as L-5 methyltetrahydrofolate) 165 mcg, Vitamin B- 12 (as methylcobalamin) 50 mcg, Biotin 50 mcg, Pantothenic Acid (as calcium pantothenate) 50 mg, Choline (as bitartrate) 49 mg. Proprietary blend 75 mg* of: Inositol, Para Amino Benzoic Acid (PABA).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Beta-C-TR (1215AF)

Supportive Function: Time Released Beta Carotene & Vitamin C A high dose formula of the popular antioxidant vitamins C and beta carotene, augmented with synergistic bioflavonoids (plant phytochemicals with biological activity). Incorporated into a time-release tablet to maximize total absorption of the vitamin over a period of time, in a gentle, natural manner. This makes it an ideal supplement to be chosen by anyone wishing to get an amount of vitamin C equivalent to approximately 1,000 mg in one dose. SPECIAL PROMOTION - PRICE REDUCED TO SAME AS C-1000TR WHILE STOCKS LAST. GET THE BENEFIT OF C-1000TR WITH ADDED BETA CAROTENE!
Contraindications: There is a possible interaction with beta-carotene and smoking that has not been determined as of yet. Beta carotene is a powerful antioxidant, but until more is determined, it is wise not to take it in combination with smoking. Since it is only converted to vitamin A as needed, beta carotene does not have the associated toxicity of high doses. High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Vitamin A (as beta carotene) 18,000 mcg, Vitamin C (as ascorbic acid) 1000 mg, Lemon Bioflavonoid 100 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Biostress-B (1353)

Supportive Function: Biostress-B provides all of the B vitamins, just the way they appear in nature! Natural sources of primary yeast and rice bran offer an ample supply of the B vitamins, which are essential to optimize our biological defenses against stress.
Ingredients: Each Tablet Contains: Thiamine (as pyrophosphate) 1 mg. Proprietary blend 300 mg* of: Primary Yeast, Rice Bran.
Vegetarian: Yes
Pack: 100 Tablets
Product:

Black Currant Seed Oil (1506A)

Supportive Function: The use of black currant seed oil has been well researched for its benefits. In addition to being a rich source of the popular gamma linolenic acid, it supplies a balanced amount of all the essential fatty acids (preserved with natural vitamin E). When is Black Currant Seed Oil helpful? Chronic inflammatory conditions, dermatitis, eczema, rheumatoid arthritis, PMS, menstrual cramps, immune effects, and cardiovascular conditions, poor wound healing, sparse hair growth, dry eyes.
Clinical Applications Research: Immune effects: Black currant seed oil (BCSO) has a profound effect on the immune system, and a correlation was found between the oil and the degree of developing resistance to infection and virus accumulation (Vopr Virusol 1993; 38:170-3) .  Rheumatoid arthritis (RA): A study on rheumatoid arthritis patients showed, "A significant improvement in morning stiffness was noted in the rheumatoid arthritis patients receiving black currant seed oil" (British J Rheumatology 1993; 32:1055-8) . A clinical trial with 37 RA patients showed such positive results that the authors concluded that gamma-linolenic acid, "is a well-tolerated and effective treatment for active RA"  (Ann Int Med 1993; 119(9): 867-73) . The beneficial effects of BCSO on RA may result from its ability to decrease inflammatory cytokine production, which would explain why it is so effective in RA. In a clinical trial where BCSO demonstrated improvement of RA symptoms, "The results suggest that the numerous beneficial effects of (BCSO) in inflammatory diseases such as RA may be due to a reduction in the secretion of the inflammatory cytokines Il-1 and TNF-alpha..." (Br J Rheumtol 1993; 32(12): 1055-8) .  Cardiovascular effects: The prostaglandins made by black currant seed oil counteract vessel constriction. Vessel wall thrombus formation (i.e. atherosclerotic lesions) was decreased when a diet rich in black currant seed oil was fed. This latter effect was better obtained when gamma linolenic acid was present suggesting a secondary effect of this fatty acid...We conclude that both fish oil and black currant seed oil rich diets inhibit platelet/vessel wall adhesion (Thromb Res 1990; 59(5): 819-30) .  Female conditions: Anti-inflammatory substances produced by black currant seed oil, along with the beneficial immune effects, can have a favorable influence on many female conditions.  Dermatitis: Supplementation of oil containing 10% gamma linolenic acid was tested on dermatitis, and anti-inflammatory substances were increased. In another study of 12 volunteers, gamma linolenic acid-enriched oil not only inhibited the inflammatory substance LTB4, but the larger dose (1.5g) had a greater inhibition than the .5 g dose (AJCN 1992; 55:39-45) . If biliary colic (digestive upset) is present, check gallbladder function.
Contraindications: None known
Ingredients: Each Capsule Contains: Vitamin E (as d-alpha tocopherol) 5 IU. Proprietary blend 250 mg* of: Black Currant (seed) Oil, (which contains Gamma Linolenic Acid).
Vegetarian: No
Suggested Dosage: 1 capsule daily or as directed
Pack: 120 Capsules
Product:

BP Renew (2826)

Supportive Function: BP Renew was formulated with strong nutrients and outstanding antioxidants to support lipid homeostasis, heart, arteries,kidneys, nervous system,and many other areas of the body. When is BP Renew helpful? Lipid Homeostasis, Heart, Arteries, Artery Muscles Circulation, Vasoactivity, Blood Flow, Heart, Kidneys, Nervous System, Blood Sugar, Pollutant Detoxification, Stress, Healthy Aging, NOS (Nitric Oxide System), Angiotensin System, GABA Production, Water/Electrolyte Balance, Endothelial Function, Mitochondrial Function, Neurotransmitter Signalling, and any situation of oxidation since the combination of ingredients has outstanding antioxidant qualities.
Clinical Applications Research: Magnesium (as glycinate) is an essential mineral that has many roles, including co-factor for over 200 biochemical reactions, however one of the most important roles that magnesium plays is in the contraction-relaxation cycles of muscles. Calcium is essential mostly for the contraction phase, and magnesium is essential mostly for the relaxation phase. Magnesium is thus critical for proper muscle function, including the muscles that line our arteries and veins. In addition to working synergistically with calcium, magnesium helps to maintain the right balance of phosphates in the body; phosphates can be responsible for calcification of tissue (PLoS One. 2014 Dec 29;9(12):e116273. Magnesium … hyperphosphatemia in patients undergoing hemodialysis: a cohort study.Sakaguchi Y et al). Magnesium’s contribution to endothelial function and nerve function helps to maintain homeostasis of those cells (Johnson AC. Et al. Magnesium sulfate treatment…PLoS One. 2014 Nov 19;9(11):e113670). Magnesium is noted as one of the minerals that guards against oxidative damage to mitochondria and neuronal circuits associated with cognitive/affective behaviors (Du J. et al. The Role of Nutrients in Mitochondrial Function& Neurotransmitter Signaling… Crit Rev Food Sci Nutr.2014 Nov 3:0). L-Taurine is an amino acid (required block of protein) and a powerful antioxidant. Taurine “supports neurological development and helps regulate the level of water and mineral salts in the blood” (www.mayoclinic.org) . Taurine plays an important role in cardiovascular function by acting not only within the brain but also within peripheral tissues. Taurine acts on GABA receptors; it is commonly supplemented during stress and supports normal relaxation of the arterial muscularis (El Idrissi A. et al. Taurine regulation... AdvExp Med Biol. 2013;775:407-25). L-Taurine conjugates bile acids, and while unconjugated bile acids are relatively insoluble in water, the conjugated forms with Taurine are much more water soluble and much more able to fulfill their physiologic function of emulsifying fats. This is one of the mechanisms by which taurine gained its reputation for supporting lipid homeostasis. Grape Seed Extract (95% proanthocyanidins) is amazing for supporting the homeostasis of vasoactivity, along with various organs like the kidney. It is such a potent antioxidant that it is normally associated with numerous health benefits for a multitude of systems. “Grape seed proanthocyanidin extract (GSPE) is known to be an effective natural polyphenol capable of removing free radicals in the body”, and research confirms that it raises activity of antioxidant enzymes and reduces levels of c-reactive proteins, the expression of the cytokineTNF-α, and an intercellular adhesion molecule-1 in the kidney (Bao L. et al. Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats. Mol Med Rep. 2015 Jan;11(1):645-52) . R-Alpha Lipoic Acid is a pure form of alpha lipoic acid and is well known for its remarkable bioavailability. It is excellent support for the body’s organ systems and biochemical pathways, especially the brain, heart, kidneys, blood sugar, pollutant detoxification, and healthy aging. R-alpha lipoic acid boosts the sirtuin 1 gene that is associated with healthy aging. R-alpha Lipoic acid is an Nrf2 activator. Nrf2 is a potent protein that is present in every cell in the body; however it needs to be “turned on” by an Nrf2 activator. Once it is “turned on”, the Nrf2 activator moves into the cell nucleus and bonds to the DNA, right where the Antioxidant Response Element (ARE) is located. The ARE is the master regulator of the total antioxidant system available in all of the body’s cells (Rücker H, et al…. tuning the Michael acceptor site.Org Biomol Chem. 2015 Jan 26). R-Alpha Lipoic Acid has been identified as a potent booster of glutathione, the major antioxidant in the body (Steele ML. et al. Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells.Redox Biol. 2013 Sep 12;1:441-5). Catechol-O-Methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, which some researchers report that, “In conclusion, the ability of natural mineral-rich waters to increase hepatic COMT activity may eventually explain the positive … effects associated with the consumption of some natural mineral-rich waters (Bastos P et al. Effect of a natural mineral-rich water on catechol-O-methyltransferase function.Magnes Res. 2014 Jul- Sep;27(3):131-41).
Contraindications: None known
Ingredients: Each Tablet Contains: Magnesium (as glycinate) 50 mg. Proprietary blend 550 mg* of: L-Taurine, Grape Seed Extract (95% proanthocyanidins), R-Alpha Lipoic Acid.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Brain Plus (T-46)

Supportive Function: Nutritional support for the brain and its supporting systems.
Contraindications: Do not take in pregnancy. Ginkgo biloba is an anticoagulant and should not be used in large amounts with anticoagulant drugs such as coumadin. Eleuthero supports the adrenals, but in extremely high doses, can cause side effects of hypertension, irritability, sadness, anxiousness, and insomnia. St. John's wort should not be taken with antidepressant drugs which also raise neurotransmitter levels. Hawthorn berries can be given with ACE-inhibiting drugs and cardiac glycosides, however large amounts need to be monitored by a doctor (there are small amounts in this formula). The combination of herbs in this formula work together in creating synergistic effects, and does not contain large amounts of any of the herbs mentioned above.
Ingredients: Ingredients: Pure tincture extract of: Ginkgo Biloba (leaf), Eleuthero (root), Gotu Kola (herb), Skullcap (herb), Valerian (root), Hawthorne (fruit), Marshmallow (root), Cayenne (fruit).
Vegetarian: Yes
Suggested Dosage: 5-20 drops per day or as directed
Pack: 1 oz Herbal Tincture
Product:

C-1000 TR (1220F)

Supportive Function: High-potency vitamin C is boosted by bioflavonoids and slowly released over time for maximum absorption. When is Vitamin C helpful? Common cold, respiratory infections, hayfever, flu, antioxidant function, immune enhancement, adrenal and thyroid support, viral infections, inflammation, asthma, post-surgical support, substance addiction, heavy metal toxicities, infertility, diabetes, eye problems (antioxidant effect), hypertension and heart disease.
Clinical Applications Research: Vitamin C (as ascorbic acid): Ascorbic acid was discovered in the 1700s when many British sailors died from scurvy. James Lind discovered that the juice of lemons and limes could prevent scurvy, and from that point on, the sailors were known as "limeys" because the ships were required to carry British West Indies limes to prevent scurvy. That is where ascorbic acid got its name, from its antiscorbutic properties. Vitamin C has many functions. It maintains collagen, wound healing, formation of red blood cells (RBCs), aids in absorption of iron, fights bacterial infections, enhances white blood cell (WBC) production, and promotes thymic hormone secretion. In addition to all of that, it is an antioxidant, aids in the metabolism of tyrosine, folic acid and tryptophan, stimulates adrenal function, aids in thyroid hormone production and cholesterol metabolism, acts as a detoxifier of certain metals and drugs, recycles other hydrogen donors such as vitamin E, and aids in phagocytosis (digestion of damaged, dead or foreign cells). Vitamin C is necessary for the enzyme reactions of many physiological processes, including collagen synthesis. Unless vitamin C is present, a bridge forms in the collagen-building enzyme and inactivates it. If vitamin C is deficient, the collagen that is synthesized can't form fibers properly, resulting in skin lesions, blood vessel fragility, and poor wound healing - in other words, the symptoms of scurvy. Bioflavonoids are found in plants; they are closely associated with vitamin C, and they boost the therapeutic effect of vitamin C, helping to build strong connective tissue, and create a protective barrier to infection. Heart Disease: The presence of hypercholesterolemia, hypertension, and atherosclerosis is more frequent in humans with a low intake of vitamin C. Administration of gram doses of vitamin C have led to substantial decreases in circulating triglycerides (Sokoloff, B, Hori, M, Saelhof, CC et al. J Am Geriatr Soc. 14:1239-60, 1966; Ginter, E, N Engl J Med. 294:559-60, 1976. Gooly, KL, Diamond, LH. Ann Intern Med. 93:511, 1980) . Vitamin C's antioxidant function prevents the oxidation of LDL (the bad cholesterol), which has been shown to be instrumental in heart disease. Chronic subclinical deficiency of vitamin C may result in progressive oxidative damage, which may lead to permanent degenerative diseases in the heart (Mol Cell Biochem 1992 111:41-7) . One puff on a cigarette can deplete the plasma vitamin C content by as much as 50%. This is why the RDA for vitamin C intake for smokers is six times that for non-smokers (Efstratopoulos AD & Voyaki SM J of Hypertension 1993 11(suppl 5): S112-113) . Immune System: One group, taking 600 mg supplements, had upper respiratory tract infections reduced by 50% (Amer. J. Clin. Nutr. 57:170-74) . Asthma: Vitamin C is a potent antioxidant which guards against the oxidant stress involved in the cause and progression of asthma (Hatch GE Am J of Clin Nutr 1995; 61(suppl): p. 628S) . Vitamin C decreases histamine secretion and also blocks production of the potent vasoconstrictive leukotrienes, which are known to be involved in asthma (Werbach, M, MD. Healing through nutrition, Harper Collins Publishers, NY. p. 37) . General Well-being: A UCLA researcher, James Enstrom, says that 300 mg of vitamin C a day (half from supplements) will extend the life of men 5 or 6 years longer than those getting only 25 mg. Enstrom claims that the same amount will add two years to a woman's life (Fort Collins Coloradoan USA Weekend, Sept 30, 1994 p. 10) .
Contraindications: High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 1,000 mg. Proprietary blend 110 mg* of: Lemon Bioflavonoids
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

CAL/MAG 1:1 (2706)

Supportive Function: Calcium and magnesium act synergistically in hundreds of reactions in the body, and they must both be respected and taken in balance. Magnesium is called the forgotten mineral by some. For instance, as important as calcium is in muscle function, the contraction-relaxation phase cannot operate without magnesium. Bones also need healthy balances of both calcium and magnesium.
Clinical Applications Research: Calcium (as aspartate, citrate): In addition to maintaining healthy bones, calcium maintains healthy tissues also, and functions as a natural tranquilizer, aids certain colon conditions, relieves cramps, and acts as a cofactor in many enzyme reactions (Hendlor, Sheldon. The Doctor’s Vitamin and Mineral Encyclopedia. 1990. Simon and Schuster, NY. Pp. 116-123) . Calcium also plays a role in the intricate balance of ion transport, muscle contraction, heartbeat maintenance, nerve impulses, and muscle tone (Whitney E.R. and Nunnelley, E.M. Understanding Nutrition. 4th ed. 1987. West Publishing, NY. p. 390) . Inflammation: Calcium helps transport essential minerals to the site of inflammation. After periods of trauma, the system tends to be alkaline, and it is important for an acid-calcium to deliver healing nutrients to binding sites. Calcium significantly improves symptoms of pouchitis (chronic and/or acute inflammation of the ileal reservoir) (Ann Chiro 1993; 47(10): 1049-53) . An acid environment solubilizes and ionizes the insoluble calcium salts in the body (calcium has to be ionized in the intestines in order to be absorbed). Hydrochloric acid (Hcl) is needed for proper calcium absorption. Vitamin D also increases calcium absorption. Calcium Balance: Eating a red meat/high protein diet may leach calcium from the system (controversial). Sodium and the phosphoric acid in soda drinks also leach calcium. High fiber foods may increase calcium excretion and should be taken into consideration, especially when assessing requirements for the elderly. Inflammation: Magnesium increases the solubility and retention of calcium. Magnesium gets depleted in conditions of inflammation, and is integral to the healing process. Injury: Very important in preventing infection after trauma. Magnesium’s function in protein metabolism and rebuilding after injury makes it useful in providing ligamental nutrient support. Heart Problems and Other Conditions: Besides having a favorable effect on blood pressure, magnesium fights chronic fatigue syndrome, slows bone loss, strengthens muscles, reduces kidney stone formation, and helps in diabetes (Wright, Jonathan V. M.D. Healing with Nutrition. 1990. Keats Publishing, Inc. New Canaan, Conn. p. 205) . PMS: “Magnesium deficiency is strongly implicated as a causative factor in premenstrual syndrome...The deficiency is characterized by excessive nervous sensitivity, with generalized aches and pains and a lower premenstrual pain threshold. In a study cited in Obstetrics and Gynecology, women were given 350 mg 3x/day during last two weeks of cycle, and experienced less moodiness, bloating, aches and pains (cited in Mindell, E. Earl Mindell’s Food as Medicine. Simon & Schuster, NY, NY. 1994, p.78) . 200 mg Mg/day reduced headaches in women, especially before/during their period (Mindell, p. 78).  Kidney Stones: Magnesium supplementation can help decrease the occurrence of kidney stones and will help breakdown gallstones, to help aid their passage through the bile duct. Use magnesium 1-2 weeks prior to a gallbladder flush to help breakdown stone formation. (A gallbladder flush should only be attempted under the supervision of a licensed professional, as bilary colic can ensue if the stones are too large to pass through the duct. Ultrasound can help determine gallstone size.)
Contraindications: Magnesium in amounts over 1,000 mg/day may cause diarrhea in some people.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 25 mg, Vitamin D3 (as cholecalciferol) 0.6 mcg, Calcium (as aspartate, citrate) 70 mg, Magnesium (as aspartate, glycinate) 56 mg, Betaine (as hydrochloride) 20 mg.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Calac (1358A)

Supportive Function: Provides calcium lactate and magnesium in a 5:1 ratio.
Ingredients: Calcium (as lactate) 41 mg, Magnesium (as citrate) 8.2 mg.
Vegetarian: Yes
Pack: 250 Tablets
Product:

Calc Acid (1355)

Supportive Function: An acidifying calcium formula often chosen to support inflammatory conditions.
Clinical Applications Research: May symtomatically help patients with low stomach acid and or GURD with the absorbtion and utilization of calcium and magnesium.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin C (as calcium ascorbate) 45 mg, Calcium (as phosphate, ascorbate, aspartate) 50 mg, Proprietary blend 241 mg* of: L-Glutamic Acid (as hydrochloride), Ammonium Chloride, Betain (as hydrochloride).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Carbo-Met (2206)

Supportive Function: Nutritional support for blood sugar balance; glandulars support pancreas function, and various herbs, minerals and vitamins (especially the natural B vitamins from primary yeast) are vital to carbohydrate metabolism. Chromium functions as part of the body’s glucose tolerance factor (GTF), which serves to enhance normal insulin sensitivity. When are Chromium and B Vitamins helpful? Diabetes (mostly type II because of insulin sensitivity), hypoglycemia, refined carbohydrate diet
Clinical Applications Research: Chromium (as picolinate) is one of the biggest nutrients to be in short supply in the American diet. Chromium has been shown to be beneficial in persons suffering from diabetes, hyperlipidemia and obesity. Chromium has been shown to have an anabolic (muscle building) effect in athletes. Chromium, which is part of the “glucose tolerance factor”, is a needed potentiator of insulin function. Zinc (as chelate): Found in the islets of Langerhans (distal tail of the pancreas) in large amounts; zinc is released with insulin from the beta cells of the pancreas. Primary Yeast: High in natural B vitamins, which are necessary for carbohydrate metabolism. Herbs: Studies have demonstrated that cinnamon, cloves, turmeric and bay leaves have affected insulin sensitivity.
Contraindications: Do not take in pregnancy. Some people may be allergic to yeast.
Ingredients: Each Tablet Contains: Zinc (as chelate) 4 mg, Chromium (as picolinate) 150 mcg. Proprietary blend 266.25 mg* of: Primary Yeast, Pancreas (bovine), Cinnamon (bark), Turmeric (rhizome), Cloves (stem), Parotid (bovine), Cayenne (fruit).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Chloroplex (1520A)

Supportive Function: A soothing, water-soluble formula with vitamin-packed chlorella, chlorophyll, phytochemically rich plant nutrients, and immune-supporting Lactobacillus probiotics; soothing to the gastrointestinal area. When is Chlorella Helpful? Increased energy, immune system repair and restoration, irritated ileocecal valves, ulceration’s and other intestinal irritations including ulcerative colitis
Clinical Applications Research: Chlorella is known as a potent detoxifier and promoter of beneficial bacteria growth in the intestinal tract. Chlorella is also very effective in removing heavy metals from the body and provides relief for intestinal gas and chronic constipation. Tidbit: Chloroplex is excellent for patients with chronic digestive complaints. This formula soothes and comforts the whole digestive tract.
Contraindications: Alfalfa contains L-canavanine, which is suspected of causing allergic reactions in some people. Chlorella is considered to be non-toxic, but if taken in severely excess dosages (greater than 60 grams per day for long periods of time), it may cause vitamin A toxicity. Medicinal amounts of any vitamin, mineral or specialty nutrient should only be taken with the advice of a trained licensed healthcare professional.
Ingredients: Each Tablet Contains: Vitamin E (as succinate) 2 mg. Proprietary blend 495.3 mg* of: Alfalfa (stem, leaf), Chlorella (plant), Parsley (leaf), Apple Pectin, Deglycyrrhizinated Licorice (root), Yogurt Powder, Lemon Bioflavonoid, Cabbage (leaf), Chlorophyll (water soluble), Lactobacillus Acidophilus, Bifidobacterium Bifidum, Lactobacillus Bulgaricus.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

CLM-NRV (T-38)

Supportive Function: A calming and relaxing tonic for the entire body. When are Calming Herbs helpful? Nervous tension, emotional stress, insomnia, panic attacks, hysteria.
Clinical Applications Research: Passion Flower (flower): Acts as an antispasmodic, mild sedative and is helpful for insomnia, nervousness, anxiety and neuralgia. Scullcap (herb): A sedative and antispasmodic that helps relax nervous tension and induce inner calm. Valerian (root): Helps with insomnia, stress, nervousness and pain and assists in balancing the nervous system. Wood Betony (herb): Used for chronic headaches and nervousness, neuralgia and anxiety. Balances the nerves. Black Cohosh (root): Used for all nervous conditions. Relieves nerve pain, numbness and neuralgia. Wild Yam (root): Antispasmodic and anti-inflammatory. Blue Cohosh (root): Antispasmodic.  Milk Thistle (seed): Liver protector and regenerator. Eleuthero (root): Antispasmodic properties; supports the adrenal glands.
Contraindications: Contraindicated in pregnancy. Ginseng should not be taken in high doses (this formula does not contain a high dose). St. John's Wort should not be taken with antidepressant drugs; concerns about sun sensitivity only exist with high doses. Cautions of MAO-inhibiting effects appear to be unfounded.
Ingredients: Ingredients: Pure Tincture Extract Of: Passion Flower (flower), Skullcap (herb), Valerian (root), Wood Betony (herb), Black Cohosh (root), Wild Yam (root), Blue Cohosh (root), Milk Thistle (seed), Eleuthero (root).
Vegetarian: Yes
Suggested Dosage: 5-20 drops per day or as directed
Pack: 1 oz Herbal Tincture
Product:

CLN-Zym (1455F)

Supportive Function: Enzymes, extracts and mucilaginous plant substances which historically support the upper gastrointestinal tract.
Contraindications: No known contraindications.
Ingredients: Each Tablet Contains: Vitamin E (as succinate) 5 IU. Proprietary blend 375 mg* of: Okra (leaf), Bromelain, Licorice (root), Pepsin, Slippery Elm (bark), Cabbage (leaf), Duodenum (porcine), Stomach (porcine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Co-Q-10 Plus (1528F)

Supportive Function: A potent antioxidant, co-enzyme Q-10 is one of the electron carriers in the energyproducing mitochondria. Its many effects include support of cardiac function. When is Co-Enzyme Q-10 helpful? Heart disease, periodontal disease, antioxidant properties, increasing blood flow and oxygen delivery to tissues, brain function, hypertension, mitral valve prolapse, angina, cardiomyopathy, congestive heart failure, mitochondrial encephalomyopathy, mitochondrial function, exercise performance and post surgical healing.
Clinical Applications Research: Co-Enzyme Q-10: a vitamin-like nutrient that is vital to the production of energy. As one of the electron carriers in the electron transport system, it helps cells utilize oxygen. If you have ever wondered how we get energy from food, or why we have to breathe oxygen, it is because the body strips food of electrons and transports them to an electron acceptor, which is oxygen. Co-Q-10 facilitates this process, providing one of the “spark plugs” for the creation of cellular energy. Without Co-Q-10, we would not have enough energy to fuel the physiological reactions we need to survive (Folkers K & Wolaniuk A. Drugs Exp Clin Res. 1985; 11(8): 539-45) . Dr. Folkers notes that Co-Q-10 levels falling to 75% may cause illness, whereas falling to 25% may cause death (Folkers, ibid) . Co-enzyme Q-10 concentration in the mitochondria (which are sometimes called the “powerhouses” of the cell) is not believed to be saturated, which is one of the reasons researchers think that supplementation is having beneficial effects (Clin Investig 1993; 71(8 Suppl): S66-70) . Numerous therapeutic effects of Co-enzyme Q-10 have been reported, most notably in areas where oxygen transport is critical, for instance heart disease, aging and periodontal disease. Since an adequate supply of oxygen is necessary for tissue repair and immune function, many applications have been reported in these areas. Additionally, Co-enzyme Q-10 has therapeutic potential because of its antioxidant properties (fights damaging free radicals). Co-enzyme Q-10 has a wide variety of functions and applications in the body.
Contraindications: High doses of Co-enzyme Q-10 may interfere with the effectiveness of anticoagulant drugs such as coumadin. In one study, Swedish researches have observed that patients taking Co-enzyme Q-10 and Coumadin at the same time had their bleeding time changed, and the Coumadin was less effective.
Ingredients: Each Tablet Contains: Vitamin E (as succinate) 6 mg. Proprietary blend 61 mg* of: Co-En-Zyme Q-10, Olive Oil, Quercetin, Alpha Lipoic Acid.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Complete Brain Charge (1540F)

Supportive Function: The new designer cholines are available in effective synergy for charging the brain with necessary building blocks and essential nutrients to power brain support, with sufficient lipid mobilizers for increased absorption (phosphatidyl serine and choline). When is Brain Support helpful? Brain function; healthy aging; cognitive function; acetylcholine & neurotransmitter production; energy; general well-being.
Clinical Applications Research: Turmeric (95% curcuminoids) is one of the most studied herbs for  cognitive support ( Planta Med. 2014 Oct;80(15):1249-58. Mechanisms of action of phytochemicals from medicinal herbs ....Kim MH, et al. ) Curcumin boosts DHA in the brain (BiochimBiophysActa. 2014 Dec 27;1852(5):951-961. Curcumin boosts DHA in the brain: Implications...Wu A, et al.) DHA is the long chain fatty acid that is essential for brain development and has been found in numerous clinical trials and observational studies to support cognitive function ( Yurko-Mauro K. et al. Docosahexaenoic Acid ...: a systematic review and meta-analysis.PLoS One. 2015 Mar 18;10(3):e0120391 ). Curcumin demonstrated support for both nerve and glial cells (glial cells are non-neuronalcells that maintain homeostasis, form myelin, and provide support for neurons in the brain and peripheral nervous system) and axonal microenvironment ( J Surg Res. 2015 Jan 7. pii: S0022-4804(15)00006-2. Curcumin...Yuan J, et al ). One review searched the literature (including PubMed, Science Direct, Scopus, and Cochrane Library) and found mechanisms of action to explain why the constituents of plants have support potential for neurotransmitters,  including curcumin ( Rev Neurosci. 2015 Feb 14. Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.Farahani MS, et al ) . Curcumin from Curcuma longa interact with D1 and D2 receptors as well as elevate the brain dopamine level. Mechanism of support seems to be through Vitamin D receptors. Turmeric (95% curcuminoids): Some scientists recognize the huge impact that a dietary component like curcumin can have: “The development of curcumin for clinical use as a regulator of epigenetic changes needs further investigation to determine novel and effective strategies, either alone or in combination with other agents, for improving outcomes” (Simone Reuter et al. Genes Nutr. 2011 May; 6(2): 93–108 ) . Ginkgo Biloba Extract (24% ginkgosides, 6% terpene lactones): Clinical trials report outcomes documenting  brain support in patients ( J Stroke Cerebrovasc Dis. 2013 Nov;22(8):e557-63. The effect of Ginkgo biloba...: a double-blind, placebo- controlled, randomized clinical trial.Oskouei DS1, et al ) . In an open clinical pilot study, GBE was administered to 20 children over 3 to 5 weeks. Ginkgo was found to have ideal characteristics to support the brain and behavior in children ( Z Kinder JugendpsychiatrPsychother. 2014 Sep;42(5):337-47. Ginkgo biloba extract in children with ADHD.Uebel-von Sandersleben H. et al ) . Ginkgo , along with  phosphatidyl choline (as sunflower lecithin) and phosphatidyl serine are the most frequently recommended nutritional substances for cognitive support, “often in combinations with many other substances” ( J Neuropsychiatry ClinNeurosci. 2010 Summer;22(3):345-7. A study of herbal remedies for memory complaints.Serby MJ, et. al ) . Phosphatidyl Serine or phosphatidyl choline combined with ginkgo biloba appears to potentiate the effects of a low dose of ginkgo biloba (Hum Psychopharmacol. 2007 Jun;22(4):199-210. Acute cognitive effects of standardized Ginkgo biloba extract complexed with phosphatidylserine.Kennedy DO et al). The data suggest that combining standardized Ginkgo biloba extract (GBE) with soy-derived phospholipids enhances the bioavailability of GBE's active components. The current study therefore aimed to assess the comparative effects of a low dose of GBE with either phosphatidyl serine or phosphatidyl choline. The study utilized a placebo-controlled, multi-dose, double-blind, balanced-crossover design. Twenty-eight healthy young participants received either GBE, GBE with phosphatidylserine, or GBE with phosphatidylcholine or placebo. Ginkgo together with phosphatidylserine had the biggest effect, followed by ginkgo with phosphatidyl choline. We have always recognized the essential role for choline. Choline (as bitartrate) is a necessary element and building block for the structural components of cell membranes and helps account for fluidity and communication within those membranes. Choline is essential for phosphatidyl choline and sphingomyelin, which are the two major phospholipids in cell walls. Choline is the precursor molecule for the neurotransmitter acetylcholine, which is involved in many functions of the brain and muscles. Choline has many forms, several of which have been called “designer cholines” because they exhibit properties  above and beyond regular choline. Two of these designer cholines are known as alpha-GPC, or Glycerolphosphorylcholine, and CDP choline, or Cytidine 5'-diphosphocholine. CHOLINE INCREASES ABSORPTION! Additionally, phosphtidyl choline and phosphatidyl serine have been discovered as nutritional additions to help boost the absorptive power of other ingredients that are given in conjunction with them, such as ginkgo  and curcumin for instance (Drug Deliv. 2014 Nov 4:1-9. Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study.Madane RG, Mahajan HS.; Hum Psychopharmacol. 2007 Jun;22(4):199-210. Acute effects of standardized Ginkgo biloba extract complexed with phosphatidylserine.Kennedy DO et al.; Planta Med. 2001 Jun;67(4):326-30. Complexation of Ginkgo biloba extract with phosphatidylcholine improves activity and increases the plasma antioxidant capacity in the rat.Carini M, et al.; Phytother Res. 2006 Oct;20(10):901-5.Neuropharmacological evaluation of Ginkgo bilobaphytosomes...Naik SR, et al.) DESIGNER CHOLINES: Alpha GPC and CDP-Choline Alpha glycerolphosphorylcholine (Alpha GPC demonstrated a support benefit for patients in a number of clinical studies conducted on the brain and maintenance of brain function. In fact, the researchers, “being impressed not only with results but in lack of side effects, recommended that it is desirable to reconsider alpha  glycerolphosphorylcholine in larger carefully controlled studies ... for the maintenance of brain function” (Scapicchio PL. Revisiting choline alphoscerate profile: a new, perspective, role...Int J Neurosci. 2013 Jul;123(7):444-9.) “Supplementation with alpha-GPC and CDP choline (cytidine 5'-diphosphocholine) has proven to be much superior to supplementation with just basic choline for brain support and normal neurotransmitter production. It is theorized that these designer cholines are able to be better incorporated and stored into the phospholipids in the brain, and therefore make better precursors for acetylcholine” - Amenta F, Tayebati SK. Pathways of acetylcholine synthesis, transport and release. Curr Med Chem. 2008;15(5):488-98. More on Alpha GPC: A multicenter, randomized, controlled study compared the efficacy (for brain support) of alpha-GPC among 126  patients, and found that alpha GPC provides excellent support (Drugs Aging. 1993 Mar-Apr;3(2):159-64.Multicentre study of l- alpha-glyceryl-phosphorylcholine. Parnetti L. et al). “Alpha- glycerolphosphorylcholine, (alpha-GPC) is a derivative of phosphatidyl choline known to support the parasympathetic nervous system. Alpha-GPC demonstrated benefit for patients in a number of clinical studies conducted on the brain and maintenance of brain function. The researchers, being impressed not only with results but in lack of side effects, recommended that “it is desirable to reconsider alpha-GPC in larger carefully controlled studies”, ... for the maintenance of brain function. Scapicchio PL. Revisiting choline alphoscerate profile: a new, perspective, role...?Int J Neurosci. 2013 Jul;123(7):444-9. CDP Choline undergoes quick hydrolysis and dephosphorylation after ingestion to yield cytidine and choline, which then enter the brain separately and are used to resynthesize CDP-choline inside brain cells. A research paper reviews the roles of choline and of choline-containing phospholipidson brain metabolism, stating that (CCPLs) are safe, effective compounds developed a long time ago thathave a place in this support category and should be further investigated by new appropriate clinical studies. They also report that CDP-choline has displayed interesting effects documented in preclinical studies and limited clinical trials for its neurotransmission support (ClinChem Lab Med. 2013 Mar 1;51(3):513-21. Choline-containing phospholipids: relevance to brain functional pathways.Tayebati SK1, Amenta F.) In an open, multicenter trial, CDP choline supported biosynthesis of phospholipids in neuronal membranes, brain metabolism, neurotransmitters, and the central nervous system ( ClinInterv Aging. 2013;8:131-7. Effectiveness and safety of citicoline...: the IDEALE study.Cotroneo AM1, et al ).
Contraindications: Some ingredients in Complete Brain Charge are derived from soy, but they do not  contain the soy protein (amino acid sequence).
Ingredients: Each Tablet Contains: Choline (as bitartrate) 24 mg, Proprietary blend 143.2 mg* of: Ginkgo Biloba Extract  (24% ginkgosides, 6% terpene lactones), Phosphatidyl Choline (as sunflower lecithin), Phosphatidyl Serine, Alpha Glycerolphosphorylcholine, Turmeric (95% curcuminoids), Cytidine 5-diphosphocholine.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Product:

Complete Children's Co-Factors (Chewable Tablets) (1519F)

Supportive Function: Children’s Co-Factors provide for the proper absorption and utilization of Omega 3 fatty acids. Also supports the heart and mitochondria, in addition to being an excellent anti-oxidant formula. Recommendation: Take with Complete Children’s DHA/EPA for best results. When are Complete Children’s Co-Factors helpful? Co-factors help the absorption and utilization of omega 3 fish oils. Additionally, the co-factors offer protection against cell damage, and optimize the nutritional protection that vitamins, minerals and anti-oxidants can provide to growing children. Vitamins and minerals are vital to all biochemical functions in the body, and therefore are helpful in most things related to health; beneficial in impaired immune status and vitamin/mineral deficiencies. Magnesium is a co-factor in a multitude of enzymatic reactions.
Clinical Applications Research: The B vitamins are water-soluble, necessary for many biochemical reactions, and are essential for energy, mental well-being, and the health of hair, skin, eyes, mouth, liver, etc . Most of them are made by the intestinal flora of the gut. They are particularly important for nervous system function and adrenal/thyroid glands in infants/children. They are destroyed by heat and microwaving, making it even more difficult to extract them from food. Stress and sugar are both notorious for robbing the body of necessary B vitamins. Thiamine (as hydrochloride) (Vitamin B-1) is associated with proper growth and energy production in children, and contributes to normal Hcl production. Riboflavin (Vitamin B-2) is important for the production of two Co-enzymes that are essential to many reactions, including metabolism of food macronutrients, energy production, and normal cell growth. Vitamin B-6 (as pyridoxine hydrochloride) is especially correlated with normal function of the nervous system, fluid balance, and synthesis of red blood cells, antibodies, and DNA. Vitamin B-6 can lower homocysteine levels, a toxic substance that is increasingly noticed in children, and indeed, “Risk factors established at young ages may set the stage for later cardiovascular disease (CVD)” (Papoutsakis C, et al. Plasma homocysteine concentrations in Greek children. J Nutr. 2005 Mar; 135(3): 383-8) . Folate (as folic acid) is needed for all dividing cells (especially RNA/DNA), it helps prevent neural tube birth defects, and it also lowers homocysteine levels. Vitamin B-12 (as methylcobalamin) is also essential to nervous system and energy function, and lowers homocysteine levels, too. Deficiencies in folic acid or vitamin B-12 can manifest in anemias. Vitamin C (as ascorbic acid) is necessary for a lot of processes, but it is most widely known for its integral function in the development of collagen (strong tissues) and its effect on the immune system. It is a powerful antioxidant and protects cells from oxidative destruction. Typical overconsumption of carbonated drinks can crowd out much needed fruits and vegetables from the diet that provide a good source of vitamin C. Eating inadequate amounts of fresh fruit or vegetables can cause symptoms of asthenia (lack of energy), weak blood vessels, bleeding, and gum abnormalities. Musculoskeletal symptoms can consist of arthralgia, myalgia, hemarthrosis (blood in a joint or synovial cavity), and muscular hematomas. Vitamin C depletion is responsible for structural collagen alterations, defective bone matrix formation, and increased bone resorption. Imaging studies may show osteolysis, osteoporosis, joint space loss, bone cell death, and osteopenia. Children can experience severe lower limb pain related to subperiosteal bleeding (bleeding under the periosteum, specialized connective tissue covering all bones). Alpha Lipoic Acid (ALA): ALA enhances glucose conversion for cell protection, maintenance, and rebuilding. In diabetes, cells starve from unconverted glucose, resulting in diabetic complications to tissues and organs. Lipoic Acid protects against capillary damage. Lipoic Acid helps regenerate and recycle other antioxidants, especially C, E, and glutathione. It protects against arterial plaque and oxidative damage to LDL cholesterol. It helps neutralize toxins in alcohol and tobacco smoke, mobilize and detoxify heavy metals. Lipoic Acid protects liver from damage, enhances glucose disposal in Type II diabetes, improves insulin sensitivity; and protects against diabetic complications of nerve damage. It has been shown to improve nerve blood flow, reduce oxidative stress, improve distal nerve conduction, and improve reduced levels of deficient glutathione and deficient E in the nerves of diabetics. It binds with the DNA of some viruses and prevents replication. Viral causes are implicated in some cases of diabetes. Supplements have been shown to improve neuropathy and reduce nerve pain. Co-Enzyme Q-10: Co-Q-10 is a vitamin-like nutrient that is vital to the production of energy. As one of the electron carriers in the electron transport system, it helps cells utilize oxygen. If you have ever wondered how we get energy from food, or why we have to breathe oxygen, it is because the body strips food of electrons and transports them to an electron acceptor, which is oxygen. Co-Q-10 facilitates this process, providing one of the “spark plugs” for the creation of cellular energy. Without Co-Q-10, we would not have enough energy to fuel the physiological reactions we need to survive (Folkers K & Wolaniuk A. Drugs Exp Clin Res. 1985; 11(8): 539-45) . Dr. Folkers notes that Co-Q-10 levels falling to 75% may cause illness, whereas falling to 25% may cause death (Folkers, ibid) . Co-enzyme Q-10 concentration in the mitochondria (which are sometimes called the “powerhouses” of the cell) is not believed to be saturated, which is one of the reasons researchers think that supplementation is having beneficial effects (Clin Investig 1993; 71(8 Suppl): S66-70). Numerous therapeutic effects of Co-enzyme Q-10 have been reported, most notably in areas where oxygen transport is critical, for instance heart disease, aging and periodontal disease. Since an adequate supply of oxygen is necessary for tissue repair and immune function, many applications have been reported in these areas. Additionally, Co-enzyme Q-10 has therapeutic potential because of its antioxidant properties (fights damaging free radicals). Co-enzyme Q-10 has a wide variety of functions and applications in the body. L-Glutathione is a potent antioxidant, conjugator (detoxer) and cell protector, especially in the liver. Glutathione is most powerful in a reduced or non-oxidized form. Glutathione is a major protector of microglial cells resident immune cells of the central nervous system. These cells defend the central nervous system against invading microorganisms and clear the debris from damaged cells helping to repair damaged brain cells. (Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid Redox Signal. 2005 Sep- Oct; 7(9-10): 1223-33). Xylitol is a naturally occurring sweetener, present in some fruits, that exhibits the ability to act as a sweetener and actually reduce dental caries (Catillo JL et al. Children's acceptance of milk with xylitol or sorbitol for dental caries prevention BMC Oral Health. 2005 Jul 22; 5(1): 6). Xylitol has antibacterial characteristics, and may increase saliva production, enhancing its usefulness for dental applications; researchers believe that xylitol is “not only a means of stabilizing some pathologies (diabetes, obesity) but also a weapon in the prevention of dental caries ” (Grillaud, M. The polyols in pediatric dentistry: advantages of xylitol. Arch Pediatr. 2005 Jul; 12(7): 1180-6).
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 25 mg, Thiamine (as hydrochloride) 4 mg, Riboflavin 4 mg, Vitamin B-6 (as pyridoxine hydrochloride) 4 mg, Folate (as folic acid) 75 mcg, Vitamin B-12 (as methylcobalamin) 25 mcg. Proprietary blend 5.5 mg* of: L-Glutathione, Co-Enzyme-Q-10, Alpha Lipoic Acid.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Chewable Tablets
Product:

Complete Children's DHA/EPA (1521F)

Supportive Function: Nutritional support for a healthy immune system and also supports brain and nervous system development/ the cardiovascular system, the kidney, provides nutritional support for vaccination, behavior, cholesterol/triglycerides, autoimmune scenarios, etc. Presented in chewable fish shaped capsules. Take with Complete Children’s Co-Factors for best results. When is Complete Children’s DHA helpful? Nutritional support for a healthy immune system. Also supports brain and nervous system development/ the cardiovascular system, the kidney, vaccination, behavior, cholesterol/triglycerides, autoimmune scenarios, etc.
Clinical Applications Research: Allergy: Many believe that changes in the typical diet, that include decreased consumption of omega 3 fatty acids, may explain the increase in the prevalence of atopic diseases, such as asthma, eczema and allergic rhinitis (Black PN, Sharpe S. Dietary fat and asthma: is there a connection? Eur Respir J. 1997 Jan; 10(1): 6- 12). Dietary intake of the omega 6’s (arachidonic acid) was positively associated with seasonal allergic rhinoconjunctivitis (Wakai, K. et al. seasonal allergic rhinoconjunctivitis and fatty acid intake: A cross-sectional study in Japan. Ann Epidemiol 2001 Jan; 11(1): 59-64). Omega 3’s from fish oil competitively inhibit the production of all the inflammatory modulators from omega 6’s. Other atopic diseases such as bronchial asthma and atopic dermatitis are characteristically associated with an imbalance between different types of T cells and cytokines, leading to an increase of IgE and histamine, which gives rise to allergic symptoms (Strannegard O and Strannegard I.L. Allergy 2001; 56(2): 91-102) . Omega-3 polyunsaturated fatty acid supplementation “may reduce omega-6-derived allergic inflammation and inflammation-perpetuated sensitization to multiple allergens, and may be beneficial in the prevention of allergy” (Dietary Fatty Acids and Allergy, Kankaanpaa P, et al, Ann Med, 1999; 31:282-287). Asthma: Fish oils make anti-inflammatory substances. Fish oil can block some of the inflammatory leukotrienes, and leukotrienes are responsible for most of the inflammation that is involved in asthma attacks. Leukotrienes are 1,000 times more potent as stimulators of bronchial constriction than histamine (Murray M and Pizzorno J, Encyclopedia of Natural Medicine, Prima Publishing, CA. p. 152) . It is believed that asthma sufferers may have an imbalance in fatty acid metabolism, subjecting them to risk for elevated leukotriene production (Yen SS and Morris HG. Biochem Biophys Res Com 1981; 103:774-79) . Fish oil is a competitive substrate for arachidonic acid, thereby reducing inflammatory mediators (Oily fish and asthma - A fishy story? Thien, F et al., Medical Journal of Australia, February 5, 1996; 164:135-36) . A study on children found that those eating fresh, oily fish had ¼ the risk of asthma as children who did not eat oily fish (Hodge et al., Consumption of oily fish and childhood asthma risk. Med J Australia 1996; 164:137-40) . Canned fish, non-oily fish, and total fish intake were not found to be protective against asthma. Oily fish include Atlantic salmon, anchovy, sardine, blue mackerel, rainbow trout, cod, yellowtail, and several others with greater than 2% fat content. Aside from the production of anti-inflammatory substances, the reported effects of fish oil and omega 3’s on the immune system could also be playing a role in ameliorating symptoms. Eczema and other inflammatory conditions: Dietary supplements ranging 1-8 g per day of omega 3 fatty acids have been reportedly beneficial in the treatment of eczema, psoriasis, IBD (inflammatory bowel disease) and rheumatoid arthritis... treatment with omega-3 long-chain PUFA reduces mucosal damage (Gil A. Polyunsaturated fatty acids and inflammatory diseases. Biomed Pharmacother. 2002 Oct; 56(8): 388-96; Jensen RG Possible alleviation of atopic eczema in a breast fed infant by maternal supplementation with a fish oil concentrate. J Pediatr Gastroenterol Nutr. 1992 May; 14(4): 474-5). Bipolar Disorder/Depression: Omega 3 fatty acids improved the short-term course of illness in a preliminary study of patients with bipolar disorder. The omega 3 group performed better for nearly every outcome measure (Stoll, A.L. et al. Omega 3 fatty acids in bipolar disorder: a preliminary double blind, placebo-controlled trial. Arch Gen Psychiatry 56(5): 407-12) . “Fish oil blocked the abnormal signaling in the brain which we think is present in mania and depression” – Andrew Stoll, lead researcher in a study published by the Am Med Assoc Arch Gen Psychiatry (Fatty oil in fish eases depression. Reuters May 14, 1999) . Also, “Stoll said omega 3 fatty acids boost levels of the neurotransmitter serotonin in the brain – similar to the effect of popular anti-depressants such as Prozac”. One of the mechanisms may be that the omega 3’s replenish the lipid bilayer surrounding brain cells that receive signals from chemical transmitters. As Dr. Murphy points out, the fat we eat affects the ability of neurotransmitters like serotonin and dopamine to dock on membrane receptor sites and initiate their respective physiological functions. Brain Development/Regeneration of Nerve Cells: Consumption of omega 3’s by eating fish once a week significantly reduces risk of Alzheimer’s (Barberger-Gateau, P. et al. British Medical Journal 2002; 325 Oct 26:932-933) . This article also noted a specific role of the omega 3 fatty acids in the regeneration of nerve cells. General Immune System: The fatty acids in fish oil can influence the immune system by their effect on cytokines, macrophages, and other immune molecules. Cytokines and macrophages are immune defense molecules highly involved in the inflammatory response (Kremer, JM (ed.) Progress in Inflammation Research: Medicinal fatty acids in inflammation. Birkhauser Verlag, 1998. Autoimmune Disease: The fatty acids in fish oil can influence the autoimmune system by their effect on cytokines, macrophages, and the MHC II complex. The MHC class II complex is a genetically set cell coding system that determines susceptibility to autoimmune disease. Fish oil affects T-cells, adhesion molecule expression, signal transduction and MHC class II expression (reduces the expression of these autoimmunesusceptible cells) (Immunoregulatory and anti-inflammatory effects of omega 3 polyunsaturated fatty acids. Brazilian Journal of Medical and Biological Research 1998 Apr;31(4):467-90, as cited by Dan Murphy, DC, DABCO) . Omega 3-induced effects may be of use as a therapy for “disorders which involve an inappropriately-activated immune response” (Kremer, JM (ed.) Progress in Inflammation Research: Medicinal fatty acids in inflammation. Birkhauser Verlag, 1998, as sited by Dan Murphy, DC, DABCO) . ADD/ADHD: It is believed that ADD patients may suffer from altered fatty acid metabolism. For instance, one well controlled clinical trial found that 53 subjects with ADHD had significantly lower concentrations of key fatty acids in their plasma, and in red blood cell lipids, than did the 43 control subjects (Stevens LJ et al. AJCN 1995; 62:761-768) . In the same study, a subgroup of 21 subjects with ADHD exhibited symptoms of actual essential fatty acid deficiency. All ADHD subjects were lower than controls in the long chain omega 3 fatty acids (EPA and DHA found in fish oil). Autism: “Phospholipid fatty acids are major structural components of neuronal cell membranes, which modulate membrane fluidity and hence function. Evidence from clinical and biochemical sources have indicated changes in the metabolism of fatty acids in several psychiatric disorders. We examined the phospholipid fatty acids in the plasma of a population of autistic subjects compared to mentally retarded controls. Our results showed a marked reduction in the levels of DHA (23%) in the autistic subjects, resulting in significantly lower levels of total omega 3 polyunsaturated fatty acids (PUFA) (20%), without significant reduction in the omega 6 series, and consequently a significant increase in the omega-6/omega-3 ratio (25%)” (Vancassel S. et.al. Plasma fatty acid levels in autistic children. Prostaglandins Leukot Essent Fatty Acids. 2001 Jul; 65(1): 1-7). Vaccination: Vaccination has been observed to increase the expression of cells, which code for autoimmune susceptibility (Koppang EO et. al. Vaccination induces major histocompatibility complex class II expression in the Atlantic salmon eye. Scand J Immunol. 2003 Jul; 58(1): 9-14) , and fish oil has been observed to decrease expression (Immunoregulatory and anti-inflammatory effects of omega 3 polyunsaturated fatty acids. Brazilian Journal of Medical and Biological Research 1998 Apr;31(4):467-90, as cited by Dan Murphy, DC, DABCO) . Fish oil may be able to reduce harmful effects of vaccination by its influence on the immune system. *Please Note: Dr. Murphy recommends that you also take the sister product COMPLETE CHILDREN’S COFACTORS ™
Contraindications: (* Note that generally, the dose is so low on the children’s fish oils that the contraindications do not apply, and generally children are not on blood thinners, however the contraindications are listed here for safety purposes): Fish oil can thin the blood and should not be combined with blood thinning drugs. Thinning the blood is normally considered to be advantageous because of the effect on reduced risk for blood clots/heart attack. Although blood thinning can hypothetically raise risk for hemorrhage/stroke, fish intake has been associated with reduced risk for stroke (Hiroyasu I, et al. Intake of fish and omega 3 fatty acids and risk of stroke in women. JAMA 2001; 285(3) Jan 17:304-312). Refrigerate after opening for best results
Ingredients: Each Capsule Contains: Vitamin E (as D-Alpha Tocopherol) 15 IU. Proprietary blend 445 mg* of: Omega 3 Fish Oil, providing a dietary source of: Eicosapentaenoic Acid (EPA) (as fish oil) 33 mg, Docosahexaenoic Acid (DHA) (as fish oil) 85.5 mg, Alpha-Linolenic Acid (ALA) (as flax seed oil) 12 mg, Gamma Linolenic Acid (GLA) (as black currant seed oil) 6.5 mg.
Vegetarian: No
Suggested Dosage: 1 capsule daily or as directed.
Pack: 60 Chewable Capsules
Product:

Complete Essentials 2:1(Adult formula) (1514F)

Supportive Function: Nutritional support for inflammatory environments, healthy immune system, normal brain and nervous system development/function and kidneys. Use as part of the diet to help maintain healthy cholesterol and triglyceride levels. When is Complete Omega 3 Essentials helpful? Complete Omega 3 Essentials 2:1 gets incorporated into all of the body’s cell membranes, accounting for a wide variety of health benefits. The capsules are dark to prevent oxidation, and they contain concentrated EPA/DHA, the sought after fatty acids in fish oil responsible for most of its effects. Take with Complete Omega 3 Co-Factors for best results.
Clinical Applications Research: Health Benefits: One long detailed article (23 pages), containing 172 references, touts some of the many health benefits of fish oil. The benefits include positive influences on: Inflammation, pain, swelling, kidney function, MS, rheumatoid arthritis, psoriasis, autoimmune diseases, cardiovascular disease, organ transplant, asthma, diabetes, inflammatory bowel, hypersensitivity/allergy, nonrheumatoid joint inflammation, gene expression, immune cells, fever, erythma, vascular permeability, edema, and others (Calder PC. Immunoregulatory and Anti-inflammatory Effects of n-3 Polyunsaturated Fatty acids. Brazilian J Med and Biol Res 1998; 31(4): 467-90). This article also pointed out that fish oil acts on receptor operated calcium channels. Calcium channel blocker drugs, used to regulate high blood pressure, operate on a similar mechanism. Additionally, the effect on gene expression, of factors such as cytokines, adhesion molecules, and nitric oxide synthase, can affect cell membrane receptor proteins which alters the membrane’s sensitivity to inflammatory mediators. This is yet another way in which fish oil can modulate the inflammatory response. “Chronic inflammation, which is detrimental to tissues, is the basic pathogenic mechanism of hypersensitivity reactions against xenobiotics. Other frequent pathologies, for instance atherosclerosis, chronic hepatitis, inflammatory bowel disease (IBD), liver cirrhosis, lung fibrosis, psoriasis, and rheumatoid arthritis are also chronic inflammatory diseases…. Dietary supplements ranging 1-8 g per day of omega 3 fatty acids have been reportedly beneficial in the treatment of IBD (inflammatory bowel disease), eczema, psoriasis and rheumatoid arthritis... treatment with omega-3 long-chain PUFA reduces mucosal damage (Gil A. Polyunsaturated fatty acids and inflammatory diseases. Biomed Pharmacother. 2002 Oct; 56(8): 388-96). Fibromyalgia/Chronic Fatigue: Patients with Fibromyalgia/chronic fatigue are suspected of having blood coagulation defects, where their blood is too thick and not able to deliver nutrients appropriately, or remove toxins efficiently. Blood coagulation has been tied to the fatigue experienced by these patients (Kop WJ et. al. Relationship of blood coagulation and fibrinolysis to vital exhaustion. Psychosom Med 1998 May-Jun; 60(3): 352-8) . The blood thinning effect of fish oil allows more oxygen delivery to the tissues and therefore more support for tissue repair. “Most symptoms of Gulf War Illness (GWI) are similar to Chronic Fatigue Syndrome (CFS) and/or Fibromyalgia (FM). We investigated whether these symptoms are associated with an activated coagulation system as has been reported in some cases of CFS/FM. … Our findings show activation of the coagulation system in GWI. 69 This evidence of a hypercoagulable state suggests that symptoms may be due to poor blood flow and, therefore, a basis for the potential utility of anticoagulant therapy” (Hannan KL, et. al. Activation of the coagulation system in Gulf War Illness: a potential pathophysiologic link with chronic fatigue syndrome. A laboratory approach to diagnosis. Blood Coagul Fibrinolysis 2000 Oct; 11(7): 673-8) . Symptoms of fatigue, myalgia and depression improved in another study after supplementation with fish oil (Horrobin, D.F., BCh, Essential Fatty Acids, Immunity and Viral Infections. Journal of Nutritional Medicine, 1990; 1:145-151) . Allergy: Dietary intake of the omega 6’s (arachidonic acid) was positively associated with seasonal allergic rhinoconjunctivitis (Wakai, K. et al. Seasonal allergic rhinoconjunctivitis and fatty acid intake: A cross-sectional study in Japan. Ann Epidemiol 2001 Jan; 11(1): 59-64). Omega 3’s from fish oil competitively inhibit the production of all the inflammatory modulators from omega 6’s. Other atopic diseases such as bronchial asthma and atopic dermatitis are characteristically associated with an imbalance between different types of T cells and cytokines, leading to an increase of IgE and histamine, which gives rise to allergic symptoms (Strannegard O and Strannegard I.L. Allergy 2001; 56(2): 91-102) . Asthma: Fish oils make anti-inflammatory substances. Fish oil can block some of the inflammatory leukotrienes, and leukotrienes are responsible for most of the inflammation that is involved in asthma attacks. Leukotrienes are 1,000 times more potent as stimulators of bronchial constriction than histamine (Murray M and Pizzorno J, Encyclopedia of Natural Medicine, Prima Publishing, CA. p. 152) . It is believed that asthma sufferers may have an imbalance in fatty acid metabolism, subjecting them to risk for elevated leukotriene production (Yen SS & Morris HG. Biochem Biophys Res Com 1981; 103:774-79) . Stroke: In a study of almost 80,000 women in the Nurses’ Health Study, those with higher intakes of fish had a lower risk of stroke. In a subgroup of the study, significantly reduced risk of thrombotic infarction was found in the women who ate fish 2 or more times per week. Mechanisms may include: inhibition of platelet aggregation, lowered blood viscosity, suppressed formation of leukotrienes, reduction of plasma fibrinogen blood pressure levels, and reduction of insulin resistance (Hiroyasu I, et al. Intake of fish and omega 3 f.a. and risk of stroke in women (JAMA 2001; 285(3) Jan 17:304-312) . Bipolar Disorder/Depression: Omega 3 fatty acids improved the short-term course of illness in a preliminary study of patients with bipolar disorder. The omega 3 groups performed better for nearly every outcome measure (Stoll, A.L. et al. Omega 3 fatty acids in bipolar disorder: a preliminary double blind, placebo-controlled trial. Arch Gen Psychiatry 56(5): 407-12) . “Fish oil blocked the abnormal signaling in the brain which we think is present in mania and depression” – Andrew Stoll, lead researcher in a study published by the Am Med Assoc Arch Gen Psychiatry (Fatty oil in fish eases depression. Reuters May 14, 1999) . Also, “Stoll said omega 3 fatty acids boost levels of the neurotransmitter serotonin in the brain – similar to the effect of popular anti-depressants such as Prozac”. One of the mechanisms may be that the omega 3’s replenish the lipid bilayer surrounding brain cells that receive signals from chemical transmitters. As Dr. Murphy points out, the fat we eat affects the ability of neurotransmitters like serotonin and dopamine to dock on membrane receptor sites and initiate their respective physiological functions. Brain Development/Regeneration of Nerve Cells: Consumption of omega 3’s by eating fish once a week significantly reduces risk of Alzheimer’s (Barberger-Gateau, P. et al. BMJ 2002; 325 Oct 26:932-933) . This article also noted a specific role of the omega 3 fatty acids in the regeneration of nerve cells. Sudden Death/Arrhythmia: A randomized trial suggested that dietary supplements of omega 3’s might reduce the risk of sudden death among survivors of a heart attack. The main cause of sudden death among these men in the study was cardiac arrhythmia. Other evidence supports the association of the omega 3’s with reduced risk of sudden death among men who have not experienced prior cardiovascular disease (Albert, C. et al. Blood levels of long chain n-3 fatty acids and the risk of sudden death. NEJM Apl 11, 2002; 346(15): 1113-118). The DHA in fish oil could have a positive influence in heart failure by increasing efficiency of camp and increasing the force of contraction (Grynberg A et. al. Effect of docosahexaenoic acid and eicosapentaenoic acid in the phospholipids of rat heart muscle cells on adrenoceptor responsiveness and mechanism. J Mol Cell Cardiol 1995 Nov; 27(11): 2507-20) . Cholesterol/Triglycerides: Omega 3’s lower LDL cholesterol, and also have a favorable effect on reducing triglycerides (Hu, F.B. JAMA 2002; 288(20): 2569-2578) . Since hormone replacement therapy (HRT) can raise triglycerides significantly, “Taking omega-3 supplements might be good co-therapy for women taking HRT" says Ken D. Stark, a doctoral candidate at the University of Guelph, in Canada and lead researcher of a study published in the American Journal of Clinical Nutrition. The 35 women in the study, half of whom were on HRT, each were given a daily dose of fish oil concentrate containing 4 grams of omega-3 fatty acids. Osteoarthritis: Supplementation with omega 3’s reduced the release of proteoglycan metabolites from articular cartilage and abolished aggrecanase and collagenase activity (Curtis, C.L. Arthritis and Rheumatism 2002; 46(6): 1544-1553) . Also, as Dr. Murphy points out, supplementation of omega 3’s can be important in both quiescent and active osteoarthritis. Back Pain/Disc Herniation: PGE2 is the principal mediator related to the induction of sciatica and low back pain. It provokes ectopic firing of nerve roots, indicating that it may play a part in the chemical irritation of nerve roots. Dorsal root ganglion neurons can be sensitized by PGE2. “PGE2 possesses the capability of causing pain, or enhancing pain-inducing substances such as bradykinin…it is suggested that COX-2 may be involved in the pathogenesis of lumbar disc herniation through upregulation of PGE2 production” (Miyamoto, H et al. Spine 2002; 27(22): 2477-2483). C Reactive Protein: DHA is associated with reduced C reactive protein, which is an independent risk factor for heart disease, and an important marker of inflammation that is being related to several diseases with suspected inflammation etiology. “The inverse correlation between CRP and DHA may reflect an anti-inflammatory effect of DHA in patients with stable coronary artery disease and suggest a novel mechanism by which fish consumption may decrease the risk of coronary artery disease” (Madsen T et al. C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol 2001 Nov 15; 88(10): 1139-42) . General Immune System: The fatty acids in fish oil can influence the immune system by their effect on cytokines, macrophages, and other immune molecules. Cytokines and macrophages are immune defense molecules highly involved in the inflammatory response. “Inclusion in the diet of high levels of omega 3’s significantly reduces the movement of human monocytes towards chemotactic agents and the production of proinflammatory cytokines by human mononuclear phagocytes… Such omega 3-induced effects may be of use as a therapy for acute and chronic … disorders” (Kremer, JM (ed.) Progress in Inflammation Research: Medicinal fatty acids in inflammation. Birkhauser Verlag, 1998, as sited by Dan Murphy, DC, DABCO) . Autoimmune Disease: The fatty acids in fish oil can influence the autoimmune system by their effect on cytokines, macrophages, and the MHC II complex. The MHC class II complex is a genetically set cell coding system that determines susceptibility to autoimmune disease. Fish oil affects T-cells, adhesion molecule expression, signal transduction and MHC class II expression (reduces the expression of these autoimmune-susceptible cells) (Immunoregulatory and anti-inflammatory effects of omega 3 polyunsaturated fatty acids. Brazilian Journal of Medical and Biological Research 1998 Apr;31(4):467-90, as cited by Dan Murphy, DC, DABCO) . Omega 3-induced effects may be of use as a therapy for “disorders which involve an inappropriately-activated immune response” (Kremer, JM (ed.) Progress in Inflammation Research: Medicinal fatty acids in inflammation. Birkhauser Verlag, 1998, as cited by Dan Murphy, DC, DABCO) . Part of a non-pharmacological approach to SLE (lupus) is to “treat both symptoms and the underlying inflammation”, and a diet high in fish oil is part of the recommended protocol (Ioannou Y, Isenberg DA. Current concepts for the management of systemic lupus erythematosus in adults: a therapeutic challenge. Postgrad Med J. 2002 Oct; 78(924): 599-606).
Contraindications: Fish oil can thin the blood and should not be combined with blood thinning drugs. Thinning the blood is normally considered to be advantageous because of the effect on reduced risk for blood clots/heart attack. Although blood thinning can hypothetically raise risk for hemorrhage/stroke, fish intake has been associated with reduced risk for stroke (Hiroyasu I, et al. Intake of fish and omega 3 fatty acids and risk of stroke in women. JAMA 2001; 285(3) Jan 17:304-312).
Ingredients: Each Capsule Contains: Total Fat 1 g, Cholesterol <4 mg, Vitamin E (as D-Alpha Tocopherol) 50 mg. Other Dietary Ingredients 550 mg* of: Eicosapentaenoic Acid (EPA) (as fish oil) 300 mg*, Docosahexaenoic Acid (DHA) (as fish oil) 150 mg*, Flax Seed Oil (ALA) 50 mg*, Black Currant Seed Oil (GLA) 50 mg*. Product of Canada
Vegetarian: No
Suggested Dosage: 1 capsule daily or as directed
Pack: 90 Capsules
Product:

Complete FM (1522)

Supportive Function: Nutritional support for healthy muscles and joints, especially those with fibromyalgia.
Contraindications: No known contraindications.
Ingredients: Each Two Tablets Supply: Magnesium (as malate, citrate) 118 mg, Calcium (as citrate) 20 mg, Zinc (as malate) 12 mg, Malic Acid 588 mg, Grapeseed Extract 8 mg, Betaine HCL 13 mg, Silymarin Extract (20% Silybin) 8 mg, Bromelain 24 mg, Papain 24 mg, Trypsin (chymotrypsin) 4 mg, Lipase 12 mg, Amylase 16 mg, Pancreatin 6X 44 mg, Lecithin (Phosphytidal Choline 12 mg) 26 mg, L-Leucine 22 mg, L-Valine 22 mg, Glucosamine Sulfate 50 mg, N-Acetyl Glucosamine 20 mg, Ornithine Alpha Ketoglutarate 20 mg.
Vegetarian: No
Pack: 120 Tablets
Product:

Complete Gluco-D (1518F)

Supportive Function: Use as part of the diet to help maintain healthy blood sugar levels, normal nerve growth and maintenance. When is Complete Gluco-D Helpful? Blood Sugar Maintenance; insulin homeostasis; tissue damage (especially kidney, nerve, eye etc.; provides antioxidant/cell protection).
Clinical Applications Research: Benfotiamine (lipid soluble derivative of Vitamin B-1): Exciting research on a new form of an old nutrient (vitamin B-1) has ben putting benfotiamine in the spotlight. There are three major biochemical pathways implicated in the pathogenesis of hyperglycemia induced vascular damage: 1. the advanced glycation end product (AGE) formation pathway; 2. The hexosamine pathway and 3. The diacylglycerol (DAG)- protein kinase C (PKC) pathway. They are all activated by increased availability of sugar metabolites. Researchers have discovered that, “the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways by activating the pentose phosphate pathway enzyme transketolase. In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and also prevented experimental diabetic retinopathy ”. Accumulation of sugar by-products called triosephosphates resulting from high glucose concentrations is a trigger for biochemical dysfunction leading to the development of diabetic nephropathy - a common complication of diabetes associated with a high risk of cardiovascular disease and mortality. By stimulating the pentose phosphate pathway with benfotiamine, the accumulation of triosephosphates was countered, and development of nephropathy was inhibited. This inhibition “was associated with decreased activation of protein kinase C and decreased protein glycation and oxidative stress - three major pathways of biochemical dysfunction in hyperglycemia . Benfotiamine also inhibited diabetes-induced hyperfiltration… benfotiamine therapy is a potential novel strategy for the prevention of clinical diabetic nephropathy .” Why is it important to think of benfotiamine and not just thiamine? In a rat study, nerve conduction velocity was nearly normalized after six months of benfotiamine application but not with thiamine. “Furthermore, benfotiamine induced a major inhibition of neural imidazole-type AGE formation and completely prevented diabetes induced glycoxidation products…Unlike treatment with water soluble thiamine, timely administration of liposoluble benfotiamine was effective in the prevention of functional damage and of AGE formation in nerves of diabetic rats .” Vitamin B-6 (as pyridoxine hydrochloride): The B vitamins are involved in all aspects of glucose metabolism. Vitamin B-6 in particular prevents the glycation process. Solomon and co-workers determined that administration of high dose B-6 for six weeks decreased levels of hemoglobin 1Ac and that, “B-6 supplementation has a beneficial role for persons with diabetes”. Zinc (as chelate) is involved in all aspects of insulin metabolism - synthesis, secretion, and utilization. “Zinc can help prevent diabetes complications through its intracellular activation of the enzyme sorbitol dehydrogenase (SDH)”. Manganese (as chelate): Minerals can be depleted in diabetes. Manganese is an important cofactor in key enzymes of glucose metabolism. A deficiency has resulted in diabetes in animals, and many human diabetics have ½ the manganese levels of non-diabetics. Chromium (as chelate): Chromium is part of the GTF, or Glucose Tolerance Factor; it helps to regulate insulin utilization and blood sugar levels. Chromium has been shown in studies to improve insulin sensitivity…“Accordingly, ingestion of chromium and antioxidants which improve insulin sensitivity and/or lessen free radical formation could theoretically ameliorate these basic disorders and lessen signs and symptoms of chronic age-related disorders.” Gymnema (leaf): Gymnema sylvestre is native to the Indian tropical forests. Studies on Type 2 diabetics indicate that gymnema sylvestre “significantly reduced blood glucose, glycosylated hemoglobin, and glycosylated proteins. These data suggest that the beta cells (that produce insulin in the pancreas) may be regenerated/repaired in Type 2 diabetic patients on supplementation” Animal studies indicate that gymnema sylvestre may also stimulate insulin production in type I diabetics. Eleuthero (root): Siberian ginseng is known as an adaptogen, which means it works to stabilize and bring the body into homeostasis, especially in stress-related incidences. Siberian ginseng is thought to enhance mental acuity, and possibly improve the use of oxygen by the working muscle. Healthy people supplementing with Siberian ginseng have been shown to have increased numbers of immune cells (T4 lymphocytes). Bitter Melon (fruit): People in tropical regions have utilized bitter melon for nutritional support of diabetes for many years, and beneficial results have been reported in some clinical trials. At least three sets of constituents in bitter melon have been reported to have potential benefit. These include steroidal saponins known as charantin, insulin like peptides, and alkaloids. Researchers report that, “ Components of bitter melon extract appear to have structural similarities to animal insulin. Antiviral and antineoplastic activities have also been reported in vitro. Four clinical trials found bitter melon juice, fruit, and dried powder to have a moderate hypoglycemic effect.” Asian Ginseng: Panax ginseng is another “adaptogenic” herb, which is also commonly used for mental and physical vitality. Ginseng is composed of ginsenosides, and also “panaxans”, which may help lower blood sugar, and the polysaccharides (complex sugar molecules), which are believed to support immune function. A double-blind trial found that Panax ginseng improved blood sugar levels in people with type 2 (non-insulindependent) diabetes. Fenugreek (seed): Fenugreek seeds contain alkaloids (mainly trigonelline) and protein (it is high in lysine and L-tryptophan). The steroidal saponins (diosgenin, yamogenin, tigogenin, and neotigogenin) and mucilaginous fiber are believed to account for many of the beneficial effects. The ingredients in fenugreek, especially the soluble fiber, may help lower blood sugar levels. One human study discovered that fenugreek can help lower cholesterol and blood sugar levels in people with moderate atherosclerosis and non-insulin-dependent (type 2) diabetes. Preliminary and double-blind trials have found that fenugreek helps improve blood sugar control in both patients with insulin-dependent (type 1) and non-insulin-dependent (type 2) diabetes. Double-blind trials have shown that fenugreek lowers elevated cholesterol and triglyceride levels in the blood and this has also been found in a controlled clinical trial with diabetic patients exhibiting elevated cholesterol. Additionally, fenugreek does not lower the good cholesterol (HDL). Acetyl-L-Carnitine: Carnitine is known for its ability to bring fats across the mitochondrial membrane to be oxidized for energy. A deficiency in carnitine has been associated with impaired ability to utilize these fats, and may even result in accumulation of fatty acids, which is detrimental to nerve health. Acetyl-L-carnitine has been researched for potential neuroprotective characteristics. “In the prevention study, the nerve-conduction defect was 73% prevented and structural abnormalities attenuated. Intervention with acetyl-L-carnitine resulted in 76% recovery of the conduction defect and corrected neuropathologic changes characteristic of 4 mo. diabetic rats. Acetyl-Lcarnitine treatment promoted nerve fiber regeneration, which was increased two-fold, compared to nontreated diabetic rats. These results demonstrate that acetyl-L-carnitine has a preventive effect on the acute Na+/K+- ATPase defect and a preventive and corrective effect on PGE1”. Treatment with acetyl-L-carnitine “reduces the functional, structural, and biochemical changes associated with hyperglycemia that occur in the myelin sheath.” The acetyl group that is part of acetyl-L-carnitine contributes to the production of the nerve transmitter acetylcholine, which is required for mental function. Several double blind clinical trials suggest that acetyl-Lcarnitine delays the progression of Alzheimer’s disease. One double-blind trial has found that acetyl-L-carnitine may be helpful for people with degenerative cerebellar ataxia, a loss of muscular coordination affecting the hind part of the brain that controls muscle tone and balance. Co-Enzyme-Q-10: Co-Q-10 stimulates insulin production. It has been shown to reduce fasting blood sugar levels and ketone bodies by 30%. References available on request.
Contraindications: Contraindicated in hypoglycemia (low blood sugar) and pregnancy. Use caution with other diabetic drugs (i.e. glipizide); monitor for hypoglycemia. Fenugreek and ginseng are used synergistically in small amounts to enhance this formula.
Ingredients: Each Tablet Contains: Thiamine (as hydrochloride) 15 mg, Niacin (as niacinamide) 30 mg, Vitamin B-6 (as pyridoxine hydrochloride) 15 mg, Folate (as folic acid) 100 mcg, Vitamin B-12 (as methylcobalamin) 100 mcg, Biotin 30 mcg, Pantothenic Acid (as calcium pantothenate) 30 mg, Zinc (as chelate) 1.5 mg, Selenium (as chelate) 20 mcg, Manganese (as chelate) 500 mcg, Chromium (as chelate) 50 mcg. Proprietary blend 305.5 mg* of: Gymnema (leaf), Benfotiamine (lipid soluble derivative of Vitamin B-1), Eleuthero (root), L-Glutamine, LTaurine, Bitter Melon (fruit), Inositol, Asian Ginseng (root), Fenugreek (seed), Acetyl L-Carnitine, Amylase (vegetable), Lipase (vegetable), Protease (vegetable), Quercetin, Alpha Lipoic Acid, Co-Enzyme-Q-10, Vanadium (as vanadyl sulfate).
Vegetarian: Yes
Suggested Dosage: One tablet daily or as directed.
Pack: 90 Tablets
Product:

Complete Glutathione (1529)

Supportive Function: Glutathione is a powerful antioxidant, immune nutrient, and detoxifier. Complete glutathione is the nutritional answer for raising glutathione in the cells without a whey source. In convenient tablet form. When is Glutathione Support helpful? Helpful for general health, stress, athletic performance, skin and hair health, detoxification, fatigue, digestion, pregnancy/lactation, sleep, psychoneurobiology, stomach/bowel dysfunction, prostate health, kidney issues, eyesight, hearing, sinusitis, lung problems, ...and many other areas where decreased levels of glutathione are suspected of being a problem.
Clinical Applications Research: N-acetyl cysteine raises glutathione levels in the body by increasing cellular cysteine, the rate-limiting step to glutathione synthesis: Glutathione (GSH) is a potent intracellular antioxidant that is backed by strong research describing its dramatic health benefits. The biggest roadblock in glutathione supplementation is the breakdown of glutathione in the digestive tract (it is quickly broken down and eliminated), lowering the efficiency of glutathione supplementation. However, many nutrients, such as the glutathione precursor N-acetyl cysteine (NAC), are able to bypass the normal roadblocks to successful cellular glutathione production by increasing glutathione production once it reaches the cell. NAC is a readily absorbable building block for glutathione, and since cysteine is the rate-limiting amino acid in glutathione, NAC supplementation increases the glutathione concentration. Supplementation of the glutathione precursor cysteine in several clinical trials improved skeletal muscle functions, decreased the body fat/lean, body mass ratio, decreased inflammatory cytokines, and improved immune functions. “As all these parameters degenerate with age, these findings suggest: (i) that loss of youth, health and quality of life may be partly explained by a deficit in cysteine and (ii) that the dietary consumption of cysteine is generally suboptimal and everybody is likely to have a cysteine deficiency sooner or later ” ( Droge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29; 360(1464): 2355-72) . Supplementation with N-acetyl cysteine is more efficient and absorbable than cysteine supplementation, and some people are sensitive to straight cysteine supplementation – it can be toxic and not easily transported into cells. When patients suffer from Tylenol poisoning, they are given N-acetyl cysteine, the best known and fastest way to raise cellular glutathione levels; the glutathione in turn binds to the toxic by-products of the excess Tylenol and prevents tissue damage. N-Acetyl Cysteine is well known as a life-saving nutrient when it comes to acetaminophen (Tylenol) poisoning. If someone takes excessive acetaminophen and they are rushed to the hospital, they are immediately administered n-acetyl cysteine, because n-acetyl cysteine is the fastest, most effective way to raise intracellular levels of glutathione. It is a membrane-permeable precursor to cysteine and glutathione. Being membranepermeable, N-acetyl cysteine is more readily absorbed than either cysteine by itself, or glutathione. As the rate-limiting amino acid in glutathione synthesis, it readily provides the necessary building block to the cells, and glutathione concentrations are increased. Excessive acetaminophen burdens the liver’s ability to remove the toxic by-products, and extensive cell damage or even death may occur. As long as there is enough glutathione in the liver to take care of this damaging intermediate product of acetaminophen, the glutathione will hook onto it and draw it out of the system. This happens in what is called phase II detoxification in the liver. Glutathione binds many toxic substances in this way and targets them for removal from the body. In phase II, where the body is preparing to make the toxin water-soluble, a highly toxic, reactive substance is formed as an intermediary by-product, and it is much more toxic than the original form of acetaminophen. As the quantity of acetaminophen increases, the amount that is detoxified in this pathway increases, and the highly toxic, reactive by-products are left unbound, depleting the body’s stores of glutathione and causing extensive major cell damage and liver injury. NAC has been reported to have many benefits, from antioxidant properties to restoration of nitric oxide bioavailability in the circulation (Xia Z, Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats. Free Radic Res. 2006 Feb; 40(2): 175-84). NAC has a very strong protective effect on cell health . Brain neurons with reduced glutathione content were found to have increased oxidant levels and increased susceptibility to injury, however this situation was reversed with NAC supplementation (Aoyama K, et al. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci. 2006 Jan; 9(1): 119-26).  NAC has a reputation as being a nutrient that prevents the toxic assault from many strong chemicals. The scientific literature is full of documentation for this protection (Olanders K. et al. Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. Scand J Gastroenterol. 2003 Jun; 38(6): 618-25; Isoniemi H, Poyhia R. N-Acetylcysteine--a new possibility in the therapy of hepatic failure. Duodecim. 1999; 115(4): 361-2; Muldoon LL, et al. Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants. J Pharmacol Exp Ther. 2001 Mar; 296(3): 797-805; setting if chemotherapy and chemoprotectant can be physically and/or temporally separated; Karg E, et al. Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester. : J Dermatol Sci. 1990 Jan; 1(1): 39-45). NAC and Neuronal Health: In an interesting study conducted by brain researchers, they noted “Oxidative stress caused by various stimuli lead to oxidation of glutathione (GSH), the major redox (antioxidant) power of the cell. Amyloid beta is one of the key components of senile plaques surrounding nerves, and is involved in the initiation and triggers of Alzheimer's disease (AD). Lower GSH levels correlated with the activation of protein kinases (enzymes) have been demonstrated in AD, Parkinson's disease (PD) and other neurodegenerative disorders and have been proposed to play a central role in the deterioration of the aging and neurodegenerative brain.” The same study concluded that N-acetyl cysteine replenished GSH levels, and the cell death induced by amyloid beta in primary neuronal cells was reversed by N-acetyl cysteine. “Likewise, protein oxidation, loss of mitochondrial function and DNA fragmentation all returned to control levels by pretreatment” (Bartov O, et al. Low molecular weight thiol amides attenuate MAPK activity... Brain Res. 2005 Dec 28).  Selenium (as chelate) is an integral nutrient for the production of glutathione peroxidase, an important antioxidant enzyme that also contains glutathione . Acting as a component in this enzyme is the main biological function of selenium in our bodies. Many of the health characteristics of selenium and glutathione are actually attributed to the glutathione peroxidase enzyme. Supplementation of selenium is reported to have many benefits, including an ability to promote cell-mediated immunity in humans (Yu B, Wang M, Li D. Zhonghua Wai Ke Za Zhi. 1996 Jan; 34(1): 50-3. (The relationship between selenium and immunity in large bowel cancer) . Alpha Lipoic Acid, like many of the antioxidants, works synergistically with glutathione to protect the body from oxidative stress, elevates the GSH-peroxidase enzyme, and specifically prevents the depletion of GSH (Shila s. et al. Arsenic intoxication-induced reduction of glutathione level and of the activity of related enzymes in rat brain regions: reversal by DL-alphalipoic acid. Arch Toxicol. 2005 Mar; 79(3): 140-6.) Alpha lipoic acid and N-acetyl cysteine have been shown to reverse oxidative damage caused by zinc deficiency (Mackenzie GG et al. alpha-Lipoic acid and N-acetyl cysteine... Free Radic Res. 2006 Jan; 40(1): 75-84). Additionally, alpha lipoic acid contains precursors for cysteine and glutathione. Kwashiorkor is a severe form of malnutrition and has been reported to be associated with oxidative stress. Even though the therapy of kwashiorkor is still ineffective, a pilot study tested the hypothesis that raising glutathione status would be beneficial for the clinical recovery of kwashiorkor patients. “Both glutathione and alpha lipoic acid supplementation had positive effects on survival… The data strongly suggest that a therapy restoring the antioxidative capacity by applying cysteine equivalents in the form of glutathione and/or alpha lipoic acid is beneficial for biochemical and clinical recovery of kwashiorkor patients” (Becker K, Redox Rep. 2005;10(4):215-26). L-Glutamine is an amino acid that can balance pH, protect the intestinal lining, and exhibit strong antioxidant properties. Research has shown that glutamine can entirely prevent the decrease in glutathione, which normally happens after an oxidative stress challenge (Gonzales S, et al. World J Gastroenterol. 2005 Jun 21; 11(23): 3533-8). Milk Thistle (seed) is an herb historically known for cleansing and supporting the liver. One of its main components, silybin, is a highly active ingredient that has been shown to increase patient serum levels of glutathione and glutathione peroxidase, while protecting against glutathione depletion (Wellington K, Jarvis B. Silymarin…BioDrugs. 2001; 15(7): 465-89.) and protect against GSH depletion; Campos R, et al. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 1989 Oct; 55(5): 417-9). Vitamin C (as ascorbic acid), Vitamin E (as succinate), Zinc (as chelate), and the B Vitamins all work together in the synthesis and maintenance of sufficient amounts of antioxidants, including active, reduced glutathione (Sprietsma JE. Med Hypotheses. 1999 Jul; 53(1): 6-16. Modern diets and diseases) . Magnesium deficiency is known to affect the glutathione peroxidase enzyme and the ability to respond to oxidative stress (Vernet P, et al. Biochim Biophys Acta. 2004 Nov 18; 1675(1-3): 32-45) . Superoxide Dismutase Type G (glutathione) is a natural free-radical scavenging enzyme. It mops ups the superoxide free radical, and works synergistically with many of the antioxidants in the oxidative defense system of the body, particularly glutathione. The superoxide radical produces oxidative stress associated with tissue damage and dysfunction of physiological signals. Molecular studies reveal that insulin receptor activity (associated with aging) is increased by this oxidative stress, and decreased by certain antioxidants such as glutathione (Droge W. Oxidative stress and ageing: is aging a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29; 360(1464): 2355-72). Catalase is a radical fighting enzyme that turns potentially dangerous hydrogen peroxide into harmless water and oxygen. Anti-Inflammatory, Natural Cox-2 Inhibitors: The Cox 2 enzyme causes inflammatory substances to be produced in the body and is also the enzyme targeted by the cox-2 inhibitor drugs such as Vioxx and Celebrex. Raising glutathione has the ability to modulate cox-2 gene expression and prostaglandin (inflammatory substance) synthesis (Chen JX et al. Glutathione mediates LPS-stimulated COX-2 expression. J Cell Physiol. 2003 Oct; 197(1): 86-93). Glutathione (GSH) functions as a natural cox-2 inhibitor because adequate levels of glutathione affect this gene expression of the cox-2 enzyme. Reduced Glutathione is the preferred form of glutathione, because it is the active form. When glutathione is oxidized, it needs to be recycled into its reduced form. As a supplement, GSH breaks down in digestion and is not the most effective way to raise glutathione in the cells, HOWEVER, oral glutathione supplementation has been shown to have some effect on GSH concentration in the liver because of the efficient extraction by the liver of the cysteine that originated from the breakdown of GSH in the gut (Grattagliano I, et al. Effect of oral glutathione monoethyl ester and glutathione on circulating and hepatic sulfhydrils in the rat. Pharmacol Toxicol. 1994 Dec; 75(6): 343-7). Glutathione protects not only individual cells but also the tissues of the arteries, brain, heart, immune cells, kidneys, lenses of the eyes, liver, lungs, and skin. In addition to glutathione, the following nutrients ALSO inhibit inflammatory cox-2 naturally, and they have been added to the Nutri-West Complete Glutathione formula because their high antioxidant activity protects glutathione levels, plus they boost the anti-inflammatory support of the formula: Turmeric (rhizome) is a spice with high antioxidant activity, and possesses the ability to preserve glutathione levels and to recycle oxidized glutathione. The curcumin in turmeric plays a particularly important regulatory role in this process (Dickinson DA Biol Chem. 2003 Apr; 384(4): 527-37. Cytoprotection against oxidative stress and the regulation of glutathione synthesis) . Curcumin also possesses powerful cox-2 inhibiting activity. “Curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis… All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer” (Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: pre-clinical and clinical studies. Anticancer Res. 2003 Jan-Feb; 23(1A): 363-98). It has also been suggested that curcumin’s “anti-inflammatory and anti-oxidant actions may be useful in the prevention-treatment of neurodegenerative diseases, e.g. Alzheimer's and Parkinson's Diseases” (Ambegaokar SS, et al. Neuroendocrinol Lett. 2003 Dec; 24(6): 469-73) . Rosemary (herb) contains carnosol, rosmanol, and epirosmanol, which all demonstrate high antioxidant activity (Zeng HH, et al. 2001), and additionally, carnasol is a potent inhibitor of cox 2 (Subbaramaiah K. et al. 2002). Rosemary reduces pathogenic substances such as bacteria, raises detoxification enzymes in the liver, and decreases inflammation and liver cell injury (Ahn J. et al. 2004; Sotelo-Felix JI, et al. 2002). Rosemary can specifically raise glutathione levels.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 75 mg, Vitamin E (as succinate) 10 IU, Thiamine (as hydrochloride) 10 mg, Riboflavin 10 mg, Vitamin B-6 (as pyridoxine hydrochloride) 5 mg, Folate (as folic acid) 50 mcg, Vitamin B-12 (as cyanocobalamin) 50 mcg, Zinc (as chelate) 0.500 mg, Selenium (as chelate) 10 mcg. Proprietary blend 280 mg* of: Rosemary (herb), N-Acetyl Cysteine, Milk Thistle (seed), Super Oxide Dismutase Type-G (glutathione), Catalase, L-Glutamine, Alpha Lipoic Acid, Silybin (seed), Turmeric (rhizome), Glutathione (reduced).
Vegetarian: No
Suggested Dosage: One tablet daily or as directed.
Pack: 60 Tablets
Product:

Complete Glutathione Lozenge (1558)

Supportive Function: Glutathione, a powerful antioxidant and detoxifier, is now available in a highly absorbable sublingual lozenge that bypasses the digest system and delivers this potent nutrient straight into the bloodstream. Energy, Detox, Heavy metal removal, Sleep, Trauma, Digestion, Kidney, Eyes, Lungs, Skin, Oxidative stress, Cell injury, The Brain, Glucose homeostasis and overall health. When is Sublingual Glutathione Support Helpful? By slowly dissolving under the tongue and absorbing into the bloodstream where it is carried to the cells to act as a powerful antioxidant, detoxifier, energy booster, and support for aging and the immune system, amongst many other benefits.
Clinical Applications Research: Glutathione , sometimes described as the body’s “most powerful protector”, is now available in a highly absorbable sublingual lozenge that bypasses the digestive system and delivers this potent nutrient straight into the bloodstream. Since glutathione is broken down by enzymes in the digestive system, it is usually recommended to take oral N-acetyl cysteine as a building block to overcome that roadblock, however this new lozenge overcomes that roadblock easily by slowly dissolving under the tongue and absorbing into the bloodstream where it is carried to the cells to act as a powerful antioxidant, detoxifier, energy booster, and support for aging and the immune system, amongst many other benefits. Additionally, glutathione is the most active and powerful when it is in its non-oxidized, reduced form. Complete Sublingual Glutathione supplies that reduced form to the body. Glutathione is present in many cells; however, it is utilized mainly in the liver. It functions as the most important binder of toxins that the body possesses. When toxic substances enter Phase II of liver detoxification, they have to be “conjugated” or hooked onto something that will aid elimination. The main conjugator for these toxins is a nutrient, namely glutathione. Complete Sublingual Glutathione is good support for: Energy, detox, heavy metal removal, sleep, trauma, digestion, kidney, eyes, lungs, skin, oxidative stress, cell injury, the brain, glucose homeostasis, etc. etc. and overall health. Glutathione raises ATP levels and ATP is the currency our body needs for various biochemical reactions. Increasing ATP increases our body’s ability to heal itself. Also, oxidative stress, or free radical damage, is responsible for a whole host of health dysfunctions. Glutathione destroys free radicals and prevents oxidative cell injury. Along with providing this essential health nutrient, the sublingual lozenge also provides the synergistic factors that enhance the efficacy, absorption, and utilization of the glutathione. These synergistic factors are: N Acetyl Cysteine, Seleno-methionine, and Acerola. NAC: Cysteine is the most important amino acid building block used in the production of glutathione in the cell. The other two amino acids that contribute to the production of glutathione occur with abundance in the body. For that reason, the presence of cysteine in the cell is known as the “rate-limiting” step because glutathione can’t be manufactured in the cell without it. The N-acetyl form of cysteine (NAC) is a safe, effective way to get cysteine into the cell so that glutathione production can occur. NAC supplementation is an ideal way to bypass the digestive roadblock to successful cellular glutathione (GSH) production by getting inside the cells as a precursor. Once NAC is inside the cell, it combines with the other two amino acids, glutathione increases and is then available for the many reactions for which glutathione is needed. NAC supports the glutathione making ability of the body and keep stores of this versatile nutrient high . For this reason, NAC makes an excellent, synergistic addition to the sublingual lozenge. NAC and the liver/detox: As mentioned, glutathione is essential for eliminating toxins from the body and depletion of glutathione can be life threatening if the toxic load surpasses the body’s reserve of glutathione to deal with the situation. Hospitals typically administer N-acetyl cysteine to patients with depleted glutathione levels, as an efficient method to bring levels of glutathione back to normal (Amathieu R, et al., 2013; Elshazly SM 2014) . NAC is an excellent heavy metal chelator with special affinity for mercury and arsenic. NAC as an antioxidant: NAC is a potent antioxidant even before it is used as a building block for glutathione. In a model of rats prone to cell injury in the liver, those given N-acetyl cysteine showed a decrease in congestion, polymorphonuclear leukocytes, mononuclear leukocytes, vacuolar degeneration of hepatocytes, and hepatocellular necrosis. Researchers hypothesized that the antioxidant properties of N-acetyl cysteine were responsible for the favorable effect on liver health (Sahin S&Alatas O. 2013) . Selenomethionine: Seleno-methionine is another synergistic nutrient in the Sub-Glutathione lozenge. Selenium is combined with a naturally occurring amino acid to provide a highly absorbable form of selenium .The selenium is a necessary co-factor for the compounded selenium glutathione peroxidase enzyme (SeGSHPx), an enzyme whose main biological role is to initiate the glutathione chemical reaction and protect the organism from oxidative damage. The integrity of the cellular and subcellular membranes depends heavily on SeGSH-Px. The sole reason that selenium is considered an essential mineral is for this reason; without it we would not have the antioxidant enzyme SeGSH-Px. Selenium also acts as an antioxidant even before it is incorporated into SeGSH-Px. Acerola: Aside from adding a pleasant taste, acerola is high in vitamin C content. Vitamin C serves to preserve glutathione, recycling it from an oxidized state back to a usable, reduced state. Acerola is very synergistic in this lozenge, because the lozenge not only provides glutathione; it provides vitamin C to recycle the glutathione back to the reduced active form after it gets oxidized.
Contraindications: None known
Ingredients: Selenium (as L-Selenomethionine) 10 mcg. Proprietary blend 85 mg* of: Glutathione (reduced), N-Acetyl Cysteine, Acerola (fruit).
Vegetarian: Yes
Suggested Dosage: 1 lozenge daily or as directed
Pack: 90 Lozenges
Product:

Complete Hi-Potency Omega-3 Liquid (Adult Formula) (1541PF)

Supportive Function: Nutritional support for chronic pain, inflammation, depression, osteoarthritis, and a healthy immune system. Also supports the cardiovascular system, normal brain and nervous system development/function, kidneys, and the body
Clinical Applications Research: Health Benefits: One long detailed article (23 pages), containing 172 references, touts some of the many health benefits of fish oil. The benefits include positive influences on: Inflammation, pain, swelling, kidney function, MS, rheumatoid arthritis, psoriasis, autoimmune diseases, cardiovascular disease, organ transplant, asthma, diabetes, inflammatory bowel, hypersensitivity/allergy, nonrheumatoid joint inflammation, gene expression, immune cells, fever, erythma, vascular permeability, edema, and others (Calder PC. Immunoregulatory and Anti-inflammatory Effects of n-3 Polyunsaturated Fatty acids. Brazilian J Med and Biol Res 1998; 31(4): 467-90). This article also pointed out that fish oil acts on receptor operated calcium channels. Calcium channel blocker drugs, used to regulate high blood pressure, operate on a similar mechanism. Additionally, the effect on gene expression, of factors such as cytokines, adhesion molecules, and nitric oxide synthase, can affect cell membrane receptor proteins which alters the membrane’s sensitivity to inflammatory mediators. This is yet another way in which fish oil can modulate the inflammatory response. “Chronic inflammation, which is detrimental to tissues, is the basic pathogenic mechanism of hypersensitivity reactions against xenobiotics. Other frequent pathologies, for instance atherosclerosis, chronic hepatitis, inflammatory bowel disease (IBD), liver cirrhosis, lung fibrosis, psoriasis, and rheumatoid arthritis are also chronic inflammatory diseases…. Dietary supplements ranging 1-8 g per day of omega 3 fatty acids have been reportedly beneficial in the treatment of IBD (inflammatory bowel disease), eczema, psoriasis and rheumatoid arthritis... treatment with omega-3 long-chain PUFA reduces mucosal damage (Gil A. Polyunsaturated fatty acids and inflammatory diseases. Biomed Pharmacother. 2002 Oct; 56(8): 388-96). Fibromyalgia/Chronic Fatigue: Patients with Fibromyalgia/chronic fatigue are suspected of having blood coagulation defects, where their blood is too thick and not able to deliver nutrients appropriately, or remove toxins efficiently. Blood coagulation has been tied to the fatigue experienced by these patients (Kop WJ et. al. Relationship of blood coagulation and fibrinolysis to vital exhaustion. Psychosom Med 1998 May-Jun; 60(3): 352-8) . The blood thinning effect of fish oil allows more oxygen delivery to the tissues and therefore more support for tissue repair. “Most symptoms of Gulf War Illness (GWI) are similar to Chronic Fatigue Syndrome (CFS) and/or Fibromyalgia (FM). We investigated whether these symptoms are associated with an activated coagulation system as has been reported in some cases of CFS/FM. … Our findings show activation of the coagulation system in GWI. 69 This evidence of a hypercoagulable state suggests that symptoms may be due to poor blood flow and, therefore, a basis for the potential utility of anticoagulant therapy” (Hannan KL, et. al. Activation of the coagulation system in Gulf War Illness: a potential pathophysiologic link with chronic fatigue syndrome. A laboratory approach to diagnosis. Blood Coagul Fibrinolysis 2000 Oct; 11(7): 673-8) . Symptoms of fatigue, myalgia and depression improved in another study after supplementation with fish oil (Horrobin, D.F., BCh, Essential Fatty Acids, Immunity and Viral Infections. Journal of Nutritional Medicine, 1990; 1:145-151) . Allergy: Dietary intake of the omega 6’s (arachidonic acid) was positively associated with seasonal allergic rhinoconjunctivitis (Wakai, K. et al. Seasonal allergic rhinoconjunctivitis and fatty acid intake: A cross-sectional study in Japan. Ann Epidemiol 2001 Jan; 11(1): 59-64). Omega 3’s from fish oil competitively inhibit the production of all the inflammatory modulators from omega 6’s. Other atopic diseases such as bronchial asthma and atopic dermatitis are characteristically associated with an imbalance between different types of T cells and cytokines, leading to an increase of IgE and histamine, which gives rise to allergic symptoms (Strannegard O and Strannegard I.L. Allergy 2001; 56(2): 91-102) . Asthma: Fish oils make anti-inflammatory substances. Fish oil can block some of the inflammatory leukotrienes, and leukotrienes are responsible for most of the inflammation that is involved in asthma attacks. Leukotrienes are 1,000 times more potent as stimulators of bronchial constriction than histamine (Murray M and Pizzorno J, Encyclopedia of Natural Medicine, Prima Publishing, CA. p. 152) . It is believed that asthma sufferers may have an imbalance in fatty acid metabolism, subjecting them to risk for elevated leukotriene production (Yen SS & Morris HG. Biochem Biophys Res Com 1981; 103:774-79) . Stroke: In a study of almost 80,000 women in the Nurses’ Health Study, those with higher intakes of fish had a lower risk of stroke. In a subgroup of the study, significantly reduced risk of thrombotic infarction was found in the women who ate fish 2 or more times per week. Mechanisms may include: inhibition of platelet aggregation, lowered blood viscosity, suppressed formation of leukotrienes, reduction of plasma fibrinogen blood pressure levels, and reduction of insulin resistance (Hiroyasu I, et al. Intake of fish and omega 3 f.a. and risk of stroke in women (JAMA 2001; 285(3) Jan 17:304-312) . Bipolar Disorder/Depression: Omega 3 fatty acids improved the short-term course of illness in a preliminary study of patients with bipolar disorder. The omega 3 groups performed better for nearly every outcome measure (Stoll, A.L. et al. Omega 3 fatty acids in bipolar disorder: a preliminary double blind, placebo-controlled trial. Arch Gen Psychiatry 56(5): 407-12) . It is generally believed that liquid fish oil is the best form of support for depression, because researchers believe that “Studies likely will require escalating doses of DHA, eventually reaching high levels so as to ensure that patients will avoid a potentially ineffective subclinical dose” (Mischoulon D & Fava M. Docosahexanoic acid and omega-3 fatty acids in depression. Psychiatr Clin North Am. 2000 Dec; 23(4): 785-94) . A typical dose would start in the vicinity of 10 g per day. “Fish oil blocked the abnormal signaling in the brain which we think is present in mania and depression” – Andrew Stoll, lead researcher in a study published by the Am Med Assoc Arch Gen Psychiatry (Fatty oil in fish eases depression. Reuters May 14, 1999) . Also, “Stoll said omega 3 fatty acids boost levels of the neurotransmitter serotonin in the brain – similar to the effect of popular anti-depressants such as Prozac”. One of the mechanisms may be that the omega 3’s replenish the lipid bilayer surrounding brain cells that receive signals from chemical transmitters. As Dr. Murphy points out, the fat we eat affects the ability of neurotransmitters like serotonin and dopamine to dock on membrane receptor sites and initiate their respective physiological functions. Brain Development/Regeneration of Nerve Cells: Consumption of omega 3’s by eating fish once a week significantly reduces risk of Alzheimer’s (Barberger-Gateau, P. et al. BMJ 2002; 325 Oct 26:932-933) . This article also noted a specific role of the omega 3 fatty acids in the regeneration of nerve cells. Sudden Death/Arrhythmia: A randomized trial suggested that dietary supplements of omega 3’s might reduce the risk of sudden death among survivors of a heart attack. The main cause of sudden death among these men in the study was cardiac arrhythmia. Other evidence supports the association of the omega 3’s with reduced risk of sudden death among men who have not experienced prior cardiovascular disease (Albert, C. et al. Blood levels of long chain n-3 fatty acids and the risk of sudden death. NEJM Apl 11, 2002; 346(15): 1113-118). The DHA in fish oil could have a positive influence in heart failure by increasing efficiency of camp and increasing the force of contraction (Grynberg A et. al. Effect of docosahexaenoic acid and eicosapentaenoic acid in the phospholipids of rat heart muscle cells on adrenoceptor responsiveness and mechanism. J Mol Cell Cardiol 1995 Nov; 27(11): 2507-20) . Cholesterol/Triglycerides: Omega 3’s lower LDL cholesterol, and also have a favorable effect on reducing triglycerides (Hu, F.B. JAMA 2002; 288(20): 2569-2578) . Since hormone replacement therapy (HRT) can raise triglycerides significantly, “Taking omega-3 supplements might be good co-therapy for women taking HRT" says Ken D. Stark, a doctoral candidate at the University of Guelph, in Canada and lead researcher of a study published in the American Journal of Clinical Nutrition. The 35 women in the study, half of whom were on HRT, each were given a daily dose of fish oil concentrate containing 4 grams of omega-3 fatty acids. Osteoarthritis: Supplementation with omega 3’s reduced the release of proteoglycan metabolites from articular cartilage and abolished aggrecanase and collagenase activity (Curtis, C.L. Arthritis and Rheumatism 2002; 46(6): 1544-1553) . Also, as Dr. Murphy points out, supplementation of omega 3’s can be important in both quiescent and active osteoarthritis. Back Pain/Disc Herniation: PGE2 is the principal mediator related to the induction of sciatica and low back pain. It provokes ectopic firing of nerve roots, indicating that it may play a part in the chemical irritation of nerve roots. Dorsal root ganglion neurons can be sensitized by PGE2. “PGE2 possesses the capability of causing pain, or enhancing pain-inducing substances such as bradykinin…it is suggested that COX-2 may be involved in the pathogenesis of lumbar disc herniation through upregulation of PGE2 production” (Miyamoto, H et al. Spine 2002; 27(22): 2477-2483). C Reactive Protein: DHA is associated with reduced C reactive protein, which is an independent risk factor for heart disease, and an important marker of inflammation that is being related to several diseases with suspected inflammation etiology. “The inverse correlation between CRP and DHA may reflect an anti-inflammatory effect of DHA in patients with stable coronary artery disease and suggest a novel mechanism by which fish consumption may decrease the risk of coronary artery disease” (Madsen T et al. C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol 2001 Nov 15; 88(10): 1139-42) . General Immune System: The fatty acids in fish oil can influence the immune system by their effect on cytokines, macrophages, and other immune molecules. Cytokines and macrophages are immune defense molecules highly involved in the inflammatory response. “Inclusion in the diet of high levels of omega 3’s significantly reduces the movement of human monocytes towards chemotactic agents and the production of proinflammatory cytokines by human mononuclear phagocytes… Such omega 3-induced effects may be of use as a therapy for acute and chronic … disorders” (Kremer, JM (ed.) Progress in Inflammation Research: Medicinal fatty acids in inflammation. Birkhauser Verlag, 1998, as sited by Dan Murphy, DC, DABCO) . Autoimmune Disease: The fatty acids in fish oil can influence the autoimmune system by their effect on cytokines, macrophages, and the MHC II complex. The MHC class II complex is a genetically set cell coding system that determines susceptibility to autoimmune disease. Fish oil affects T-cells, adhesion molecule expression, signal transduction and MHC class II expression (reduces the expression of these autoimmune-susceptible cells) (Immunoregulatory and anti-inflammatory effects of omega 3 polyunsaturated fatty acids. Brazilian Journal of Medical and Biological Research 1998 Apr;31(4):467-90, as cited by Dan Murphy, DC, DABCO) . Omega 3-induced effects may be of use as a therapy for “disorders which involve an inappropriately-activated immune response” (Kremer, JM (ed.) Progress in Inflammation Research: Medicinal fatty acids in inflammation. Birkhauser Verlag, 1998, as cited by Dan Murphy, DC, DABCO) . Part of a non-pharmacological approach to SLE (lupus) is to “treat both symptoms and the underlying inflammation”, and a diet high in fish oil is part of the recommended protocol (Ioannou Y, Isenberg DA. Current concepts for the management of systemic lupus erythematosus in adults: a therapeutic challenge. Postgrad Med J. 2002 Oct; 78(924): 599-606).
Contraindications: Fish oil can thin the blood and should not be combined with blood thinning drugs. Thinning the blood is normally considered to be advantageous because of the effect on reduced risk for blood clots/heart attack. Although blood thinning can hypothetically raise risk for hemorrhage/stroke, fish intake has been associated with reduced risk for stroke (Hiroyasu I, et al. Intake of fish and omega 3 fatty acids and risk of stroke in women. JAMA 2001; 285(3) Jan 17:304-312). REFRIGERATE AFTER OPENING TO PRESERVE UNIQUE FRESHNESS.
Ingredients: Each Teaspoon Contains: Total Fat 3.86 g, Vitamin E (as D-Alpha Tocopherol) 23 mg. Other Dietary Ingredients 1490 mg* of: Eicosapentaenoic Acid (EPA) (as fish oil) 880 mg*, Docosahexaenoic Acid (DHA) (as fish oil) 420 mg*, Black Currant Seed Oil (GLA) 100 mg*, Flax Seed Oil (ALA) 90 mg*. Total Calories 41, Calories from fat 41, Polyunsaturated fat (not less than) 3 grams, Monosaturated fat (not less than) 0.45 grams. Product of Canada
Vegetarian: No
Suggested Dosage: 1 tsp per day or as directed
Pack: 8 oz./236 ml Brown glass bottle
Product:

Complete Immuno D3 (1548)

Supportive Function: Research is telling us that more people than not are deficient in vitamin D, and that we are not getting enough for optimal health. Vitamin D is quickly becoming known for its positive influences on immune system support (and support for autoimmune activity as well). This formula is boosted by other wellresearched immune ingredients, such as beta-sitosterol, probiotics, and quercetin. When is Vitamin D and Synergistic Immune-Support helpful? For maintenance and optimal function of the immune system, and for autoimmune activity.
Clinical Applications Research: Vitamin D is a versatile nutrient. We’ve known for many years that vitamin D increases calcium absorption and helps develop strong bones and teeth, and that it is highly important for proper muscle function. However, vitamin D’s role in more diverse health-related issues has become apparent, such as inflammation (suspected to be at the root of many diseases), peripheral neuropathies, autism, heart activity, insulin resistance, polycystic ovarian syndrome (PCOS), depression, skin rejuvenation, brain health, dementia-related conditions, bone fracture repair , and many others. UV rays from the sun are necessary for synthesis of vitamin D in the skin, but many don’t get the sunlight exposure to maintain adequate vitamin D levels. Vitamin D deficiency is widespread, and in fact, it is estimated that half of all white and two thirds of all black adults have low D levels below 70 nm/L (Between 90-100 nmol/L is ideal). Blood levels of vitamin D can be raised with supplementation; ideally, the form used should be active vitamin D3 and not vitamin D2, which may not be as effective. In recent years, in addition to all of the versatile uses for vitamin D, scientists have uncovered some of the profound effects that Vitamin D has on the immune system and autoimmune disorders . In particular, vitamin D positively affects T cell-mediated immunity and the dendritic cells ( dendritic cells, or DCs, serve up foreign antigens on a silver platter to the T cells ). Both Dr. Dan Murphy and Dr. Don Bellgrau have thoroughly researched vitamin D and its effects on the immune system; T cell immunity and dendritic cell immunotherapy are the primary areas of Dr. Bellgrau’s research. Vitamin D and Dendritic Cells: Vitamin D has a very dramatic influence on these dendritic cells of the immune system, but why is this important? In the words of European Molecular Biology Organization scientists, “DCs are indispensable for the initiation of the primary immune response, but now it is well established that these cells are able to orchestrate the entire immune response , including the regulation of peripheral immune tolerance .” Vitamin D and Immune Conditions: Vitamin D deficiency is associated with numerous immune conditions and diseases, and vitamin D supplementation is associated with beneficial effects in a multitude of conditions, from influenza to cancer/chemotherapy . Some of the immune conditions correlated to vitamin D intake include, but are not limited to: rheumatoid arthritis, multiple sclerosis, lupus (SLE), fibromyalgia, dermatological indications (i.e. psoriasis), diabetes type 1 and type 2, infectious disease and many others. Beta sitosterol is a phytosterol (a good plant fat), reported in the research to “possess anti-inflammatory, antipyretic, antineoplastic, and immune-modulating properties”; it has also “ shown promise in normalizing Tcell function, dampening overactive antibody responses, and normalizing DHEA:cortisol ratios ”. Researchers also state that “commercial phytosterols may be of benefit in re-establishing optimal immune parameters . Restoring balance to the immune system may be of therapeutic benefit in disease processes such as chronic viral infections, stress-induced immune suppression, tuberculosis, allergies, cancer, rheumatoid arthritis and other autoimmune conditions”.   Quercetin has potent immune properties, and has even been called by some “the most important flavonoid”. Quercetin has been named for its anti- inflammatory and antioxidant effects, and has been investigated for a wide range of potential health benefits. The Journal of Immunology, June 15, 2010, describes dendritic cells as a major target for the control of harmful immune responses, and points out that quercetin reduced production of proinflammatory cytokine and chemokine signals. Additionally, researchers reported in the journal that quercetin “ could be used in the prevention and therapy of chronic inflammation, autoimmunity, and transplantation ”. Lactobacillus Acidophilus, Lactobacillus Bifidus, and Lactobacillus Reuteri: Probiotics are not just for replacing imbalances caused by antibiotic drugs, they can be proactive in strengthening the immune system. A study published in Nutrition Research verifies this, and suggests that even the immune systems of healthy adults benefit from probiotic supplementation. A significant increase in the percentage of phagocytosing monocytes and neutrophils was observed over the trial period. Thus, the authors of this study concluded that, “ nutritional supplementation with probiotics has the potential to improve innate immune function in healthy adults ". Interest in probiotics has been spurred on by the growing abundance of civilization disorders that include atherosclerosis, heart disease, hypertension and many others. Researchers of a peer-reviewed journal noted that, “ probiotics are potentially capable of annihilating these disorders ”. Additionally, lactobacillus reuteri administered in low doses has demonstrated a hypocholesterolemic effect both therapeutically and preventively. REFERENCES AVAILABLE UPON REQUEST
Contraindications: Generally speaking, high dose vitamin D is becoming increasingly common (especially since many are deficient) with no side effects. Of all published cases of vitamin D toxicity for which a vitamin D amount is known, only one occurred at a level of intake under 40,000 IU per day. Caution is advised for sarcoidosis, hyperparathyroidism, and hypercalcemia, as vitamin D can raise calcium levels, which is considered a good thing unless levels are already high. It is probably prudent to take medications away from supplementation. Lab tests are always ideal to monitor individual situations.
Ingredients: Each Tablet Contains: Vitamin D3 (as cholecalciferol) 62 mcg. Proprietary blend 20.6 mg* of: Quercetin, Beta Sitosterol, Lactobacillus Acidophilus, Bifidobacterium Bifidum, Lactobacillus Reuteri.
Vegetarian: No
Suggested Dosage: One tablet daily or as directed.
Pack: 60 tablets
Product:

Complete K (1556)

Supportive Function: Essential in directing calcium to the proper tissue, such as bone, and needed as well in the blood coagulation process. When is Vitamin K helpful? Proper Blood Coagulation, Maintaining Strong Bones and Teeth, Supporting the Cardiovascular System, Blood Sugar and Reducing free radical oxidation.
Clinical Applications Research: Vitamin K is the term given to a group of related compounds. There are three main forms of vitamin K: K1, K2, and K3. There are also subtypes of these different forms of K. Vitamin K1 is found primarily in green leafy vegetables. K2, or menaquinone, is mainly found in the forms of MK4 and MK7. MK4 is primarily found in animal and dairy products, while MK7 is produced by intestinal bacteria and is also found in the Japanese soy product, Natto. K3 is a synthetic form of vitamin K and may have side effects when consumed. MK7 has been shown to stay in the body longer than other forms of vitamin K. Its half-life is three days, which allows it to build to a more consistent level in the blood stream, in contrast to MK4 or vitamin K1. MK7 is more effective than other forms of vitamin K in both catalyzing osteocalcin carboxylation in bone and in counteracting coumarin anticoagulants in the liver. This is likely due to MK7’s much longer half-life and it’s reported sixfold higher cofactor activity than found in K1. (Schurgers, Leon J., et al. "Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone- 7." Blood 109.8 (2007): 3279-3283). Typical diets generally contain up to ten times more K1 than K2, so researchers sometimes dismiss the importance of vitamin K2. These two substances may be better understood as two different vitamins: Whereas K1 is mainly used by the liver to activate blood clotting proteins, K2 is used by other tissues to place calcium in the bones and teeth where it belongs, and keep it out of soft tissues such as joints, arteries and kidneys. Although the body can convert vitamin K1 into vitamin K2, there is evidence suggesting that humans require K2 in the diet for optimal health. Causes and Symptoms of Deficiency: Inadequate vitamin K levels may result from antibiotic use, vitamin D deficiency, liver damage, chronic alcoholism, or kidney disease. Other causes include intestinal disorders such as celiac disease, cystic fibrosis, or removal of part of the intestines. Vitamin K has been shown to play a role in: • Proper blood coagulation • Maintaining strong bones and teeth • Supporting the cardiovascular system • Protecting the brain and other cells against free radical oxidation • Blood sugar balance Bone Mineral Density Support: Vitamin K2 has recently gotten a reputation for its role in bone metabolism. Several studies have demonstrated that low dietary vitamin K2 intake is associated with decreased bone mineral density. (Bügel, Susanne. "Vitamin K and bone health." Proceedings of the Nutrition Society 62.04 (2003): 839-843.) Vitamin K2 may be more effective than K1 in converting the inactive to the active form of glutamate residues involved in bone building. There is a synergy between the action of vitamin D and vitamin K, particularly in terms of bone strength and cardiovascular health. Vitamin D provides improved bone development by helping you absorb calcium. Vitamin K2 directs the calcium to the bones, while preventing the calcium from being deposited in arteries, joints, and kidneys. The protein, osteocalcin, is responsible for organizing the deposition of calcium and phosphorus in bones and teeth. Cells produce this protein in the presence of both vitamins A and D, but only when activated by vitamin K. (Oliva A, Ragione FD, Fratta M, Marrone G, Palumbo R, Zappia V. Effect of retinoic acid on osteocalcin gene expression in human osteoblasts. Biochem Biophys Res Commun. 1993; 191(3): 908-14).
Contraindications: Caution is indicated with blood-thinning drugs.
Ingredients: Vitamin K (as K-1 500 mcg, K2-4 1000 mcg, K2-7 200 mcg) 1700 mcg
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Complete MG (1570F)

Supportive Function: Magnesium is necessary to activate the ATP for energy in every cell of our body. It is involved in more than 700 metabolic reactions. It can determine optimal performance of every cell in bone, muscle and organ system. It is important to both physical and mental health. When is Magnesium helpful? Energy, muscle cramps, muscle relaxation, nerve conduction, normal heart rhythm, DNA synthesis; protein synthesis, immune system, healthy bones, mental health, restful sleep, healthy blood pressure maintenance, blood glucose homeostasis, activation of vitamin D, headache, attention span.
Clinical Applications Research: Magnesium is necessary to activate the ATP for energy in every cell of our body. It is involved in more than 700 metabolic reactions. It can determine optimal performance of every cell in bone, muscle and organ system. It is important to both physical and mental health. Yet, many foods are depleted of magnesium; many dietary components and drugs interfere with magnesium absorption; many people suffer from deficiency; intake & absorption decrease as we age; and urinary excretion increases with age. An estimated 75% of Americans have daily magnesium intakes less than the RDA (World Health Organization. Calcium and Magnesium in Drinking Water: Public health significance. Geneva: World Health Organization Press; 2009). Also, blood tests of magnesium (serum magnesium) can be inaccurate unless the red blood cell magnesium is measured directly. Magnesium (as malate, citrate and glycinate) . Malate, citrate and glycinate are exceptional carriers for magnesium that greatly increase the absorption rate of magnesium into the system. Utilizing all three of these carriers takes advantage of the nutritional benefits of each one. Choosing these forms over other, less absorbable forms can make a big difference in overall magnesium absorption. Synergistic ingredients, such as Caprillic Acid (mct-medium chain triglycerides), Inulin (soluble fiber), Coconut Fiber and Taurine contribute to a proprietary formula that optimizes the delivery and efficacy of one of our most vital minerals. In a nutshell, SL Volpe describes some of the attributes of magnesium by saying: “Magnesium helps maintain normal nerve and muscle function, heart rhythm (cardiac excitability), vasomotor tone, blood pressure, immune system, bone integrity, and blood glucose levels and promotes calcium absorption” (Curr Sports Med Rep. 2015 Jul- Aug;14(4):279-83. Magnesium and the Athlete. Volpe SL). Magnesium is needed for many, many reactions and organ systems. We have included some of them in this booklet so that you can view some of the various facets by which magnesium supports our goals for health and happiness. For instance … Energy (Mg-ATP) - Energy is impossible without ATP, and ATP is useless without magnesium, because the synthesis of the Mg-ATP complex is one of the over 200 enzymatic reactions requiring magnesium. What many people do not realize is that ATP needs to bind with magnesium to be active; the binding process actually changes the shape and the charge of the ATP, such that energy can be accessed. Every one of our 100 trillion cells needs activated ATP to conduct its biochemical processes. Without magnesium, ATP cannot be activated and used as an energy source. Since malate is also good support for energy, magnesium malate makes an excellent combination formula. The enzyme succinyl-CoA synthetase (from the citric acid cycle/ Kreb’s cycle/energy producing cycle) is specific for succinate and does not react appreciably with citrate nor with the other acids in the cycle, such as fumarate and oxaloacetate, but it does show some activity with malate (Acta Crystallogr D Struct Biol. 2016 Aug;72(Pt 8):912-21. Structural basis for the binding of succinate to succinyl-CoA synthetase. Huang J & Fraser ME) . In a randomized, double blind, placebo controlled, crossover pilot study published in the Journal of Rheumatology, 1200 mg of malic acid was administered daily for fatigue support and determined to be safe and beneficial (Russell IJ et al. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol. 1995 May;22(5):953-8). “Because of magnesium's role in energy production and storage, normal muscle function, and maintenance of blood glucose levels, it has been studied as an ergogenic aid for athletes” (Curr Sports Med Rep. 2015 Jul-Aug;14(4):279-83. Magnesium and the Athlete. Volpe SL). Glutathione Production – One of the many co-factor properties that magnesium exhibits is that it is needed for the synthesis of glutathione, the most powerful antioxidant in the body. Glutathione fights free radical damage, and also hooks onto toxins to remove them from the body. When dysfunctional livers were examined, “all magnesium supplements revealed normalization of oxidant and antioxidants parameters. Histopathological examination supported the biochemical and molecular findings” (Drug Chem Toxicol. 2016 May 5:1-10. Comparative study of antifibrotic activity of some magnesium-containing supplements on experimental liver toxicity. Molecular study. El-Tantawy WH et al). Detoxification - Magnesium facilitates detoxification, not only by increasing glutathione synthesis, but by being a chelator for environmental toxins/metals (i.e. lead, aluminum, mercury), and by nourishing the cell so that metals are less likely to enter. Magnesium is a “critical component of the antioxidant system” that is crucial in detoxification (Pharmacol Rep. 2015 Oct;67(5): 914-20. Pretreatment with magnesium ameliorates lipopolysaccharide-induced liver injury in mice. El-Tanbouly DM et al). Magnesium allows ions and nutrients to enter the cell, and at the same time allows toxic waste to be removed from the cell. This contributes to the key role that magnesium plays in maintaining the structure and integrity of the cell. Nerve Impulse Conduction – Because of its ability to regulate ion exchange in nerve cells, magnesium can optimize impulse transmission. Additionally, one article cited the power of combining taurine with magnesium (i.e. in the Complete MG formula) to achieve multiple mechanisms of action, which included inhibition of NMDA (N-methyl-Daspartate) receptors, antioxidant effects, and activation of BDNF (brain-derived neurotropic factor)-related mechanisms (Neurotox Res. 2016 Aug 27. Effect of Magnesium... Lambuk L et al). Muscle Function – Maintenance of healthy muscles is one of the most important facets of magnesium. Calcium and magnesium regulate the contraction/relaxation cycle of the muscle, with magnesium being responsible for relaxation. Magnesium is excellent support for muscle cramps. Immune System – Magnesium is involved in the production and activation of white blood cells. Inflammatory bowel disease, because of the nature of the condition, predisposes to multiple deficiencies, and among them is magnesium (World J Gastroenterol. 2016 Jan 21;22(3):895-905. Owczarek D et al. Diet and nutritional factors in inflammatory bowel diseases). Healthy Bones and Teeth – One of the main purposes of magnesium is to help build strong bones but exact mechanisms by which magnesium influences osteogenesis has been unclear. In October 2016, researchers published data showing that magnesium increases neuronal calcitonin gene-related polypeptide-α (CGRP), and this is a likely mechanism by which implants containing only magnesium have been used for fracture support “with considerable efficacy” and, “Taken together, these findings reveal a previously undefined role of magnesium in promoting CGRP-mediated osteogenic differentiation, which suggests the therapeutic potential of this ion in orthopedics” (Nat Med. 2016 Oct;22(10):1160-1169. Implant-derived magnesium induces local neuronal production of CGRP …. Zhang Y et al). Magnesium is needed for the reactions involved in bone and tooth health. This need has spurred various online articles to appear such as “Magnesium - The Forgotten Nutrient For Dental Health”. In one study, magnesium ions reacted with human tooth enamel. The researchers reported that,”In this study we showed that treatment of human tooth enamel with solutions saturated with magnesium induced changes in the nanocrystals at the outer surface of the protective enamel layer. The physical properties of the tooth were modified; tooth microhardness increased and the color shade became whiter, thus suggesting that this method could be used as a clinical treatment to improve dental mechanical properties and esthetics” (Acta Biomater. 2016 Jun;37:174-83. Diagenesis-inspired reaction of magnesium ions with surface enamel mineral modifies properties of human teeth. Abdallah MN et al). Heart Health & Rhythm – Magnesium is essential for heart health. Magnesium balances calcium and counters unhealthy calcium buildup (calcification) in tissues. It also has a beneficial, stabilizing effect on mitochondrial membrane potential, which is important to maintain normal rhythm (Biochem Biophys Res Commun. 2016 Sep 9;478(1):314-22. Magnesium inhibits the calcification of the extracellular matrix in tendon-derived stem cells via the ATP-P2R and mitochondrial pathways. Yue J et al). A comprehensive review in the Am J Clin Nutr 2012 examined studies including more than 241,000 people, and found that those with higher magnesium levels were much more likely to be heart healthy (Larsson, S et al. Dietary magnesium intake…: a meta-analysis of prospective studies. AJCN 2012; 95(2):269-270). DNA Synthesis; Protein Synthesis – Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis, and imbalances in magnesium status can result in unwanted neuromuscular, cardiac or nervous system dysfunction (disruption in homeostasis of essential organ systems) (Nutrients. 2015 Sep 23;7(9):8199- 226. Magnesium… Gröber U et al). Magnesium is not only involved in DNA/RNA synthesis, it is the crucial element that cinches the deal, as demonstrated by the title of a research article in Science (June 2016), “Capture of a third Mg²⁺ is essential for catalyzing DNA synthesis” (Science. 2016 Jun 10;352(6291):1334-7). In the article, Gao Y and Yang W report that, “It is likely that the third cation (of magnesium) provides the ultimate boost over the energy barrier to catalysis of DNA synthesis.” Inflammation Support – We have seen that magnesium is correlated with stress, and it has been reported that a moderate deficiency of Mg may increase chronic inflammatory stress. Low levels of magnesium were associated with a much higher CRP (C - Reactive protein) concentration (CRP is a by-product of inflammation) in a study published in Sleep Breath (Sleep Breath. 2016 Sep 6. [Epub ahead of print] Serum levels of magnesium and their relationship with CRP in patients with OSA. Karamanli H et al). Supplementation with magnesium improved hematologic and metabolic inflammatory markers in another study as well (J Diet Suppl. 2016 Jul 26:1-13. [Epub ahead of print] Ige AO & Adewoye EO). “The results of our study have indicated, to our knowledge for the first time, that IL-33/ST2 (an interleukin immune system player) pathway plays a role in enhancing inflammation and tissue damage at the site of acute inflammation by affecting the concentration of magnesium and GSH (glutathione),” important for antioxidative capacity, as well as gene expression of supportive cytokines (Exp Mol Pathol. 2016 Aug;101(1):31-7. Effects of IL-33/ST2 pathway in acute inflammation on tissue damage, antioxidative parameters, magnesium concentration and cytokines profile. Stankovic MS et al). Kidney Stone Support – Because one of the roles of magnesium is to balance calcium and counter unhealthy calcium buildup (calcification), magnesium is excellent support for kidney stones. The National Kidney and Urologic Diseases Information Clearinghouse estimates the yearly cost of kidney stones in the United States to be 5 billion dollars. High urinary calcium can be the cause of kidney stones in upwards of 80% of cases. The most prevalent stone composition is calcium oxalate. The general rule is that a diet with adequate calcium is better than a diet too low in calcium intake, which allows preferential absorption of oxalate in the gut and increases the risk of calcium oxalate stones. The key, is seems, is to avoid calcium oxalate binding, and one of the ways to achieve this is to supplement with magnesium citrate. Magnesium balances calcium, and citrate “acts to stabilize crystal formation rate and can be used to adjust urinary pH in the appropriate clinical setting. Specifically, citrate is theorized to act by binding with calcium in a soluble complex, thus reducing the amount of calcium available for binding to oxalate” (Lee YH, Huang WC. The efficacy of potassium citrate based medical prophylaxis for preventing upper urinary tract calculi; a midterm follow up study. J Urol. 1999;161:1453-1457). Mental Health – Magnesium may favorably affect mental status (J La State Med Soc. 2015 May-Jun;167(3):151. Kaiksow FA & Bhatnagar D). The regulatory effects of magnesium on N-methyl-D-aspartate (NMDA) channels make it a factor in protocols for depression. Depressed patients are more likely to have low magnesium levels, and there was a significant relationship between hypomagnesemia and intensity of depression that “suggests a role for this element in the pathogenesis of the disorder” (Biol Trace Elem Res. 2016 Jun;171(2):275-82. Serum Magnesium Status in Patients Subjects with Depression in the City of Yazd in Iran 2013-2014. Rajizadeh A. et al). Restful Sleep - Sleep allows us to rest and repair. GH Stress disrupts circadian rhythms that affect sleep, body temperature and hormone concentrations. If magnesium can’t buffer stress, sleep gets disrupted. Cortisol is one of the hormones controlled by the circadian rhythm, and when its secretion is thrown off by lack of magnesium and disrupted circadian cycles, it can cause wakefulness at night, when cortisol is supposed to ebb and drowsiness in the morning, when cortisol is supposed to peak. Melatonin is also important. There are four steps to metabolizing melatonin, and they all require magnesium. A study with 100 men and women (ages 51-85) who suffered from poor quality sleep were given 320 mg (half) and the other half received placebo. The magnesium group had lower C reactive protein and quality, restful normal sleep. Magnesium increases deep levels of sleep, regulates brain wave patterns, improves abnormal brain wave patterns associated with insomnia, reduces the time it takes to fall asleep, and helps sleep apnea and restless leg (Nielson, FH et al. Mag sup improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res 2010;23(4):158-168). Healthy Blood Pressure - In a 2016 meta-analysis of well-controlled magnesium and blood pressure studies, researchers found that “Mg supplementation with a dose of 300 mg/d or duration of 1 month is sufficient to elevate serum Mg” and have a favorable effect on blood pressure homeostasis (Hypertension. 2016 Aug;68(2):324-33. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Zhang X. et al). Blood Glucose Homeostasis – “Magnesium has been reported to improve glucose utilization” and contribute to the homeostasis of a healthy blood glucose level (J Diet Suppl. 2016 Jul 26:1-13. Oral Magnesium Treatment Reduces Anemia and Levels of Inflammatory Markers in Experimental Diabetes. Ige AO & Adewoye EO.) Magnesium also improved anemic state and reduced inflammatory markers in the same study. Headache - “The serum level of magnesium is an independent factor for migraine headaches and patients with migraine have lower serum levels of magnesium during the migraine attacks and between the attacks compared with healthy individuals” (Int Clin Psychopharmacol. 2016 Sep;31(5):287-92. Serum concentration of magnesium as an independent risk factor in migraine attacks: a matched case-control study and review of the literature. Assarzadegan F et al). Magnesium is a supplement with “good evidence for improvement of migraine symptoms” (Curr Treat Options Neurol. 2016 Nov;18(11):48. Diagnosis and Treatment of Childhood Migraine. Merison K & Jacobs H). Stress – Magnesium buffers the stress hormones, and can reduce damaging effects, however stress depletes magnesium. In fact, every time the stress hormones are released, they draw on magnesium stores and deplete them. A lot of things can generate stress, both psychological and physical. Mental factors, environmental toxins, internal dysbiosis/candida, GMO/non-nutritious food, drug side effects, nutrient deficiencies, etc. etc. are all stressors. Good stressors, like weddings and new babies, still release stress hormones that can deplete magnesium. Herbicides not only add to physiological stress, they deplete the magnesium stores of the plant on which they are used. Synergy - Included in the Complete MG formula are: Caprillic Acid (mct-medium chain triglycerides), inulin and coconut fiber (both soluble fiber), which all increase absorption of magnesium, and also taurine, which supports the brain and complements the activity of magnesium (Neurotox Res. 2016 Aug 27. … Effect of Magnesium Acetyltaurate Against NMDA-Induced Excitotoxicity... Lambuk L et al). Vitamin D – Magnesium activates vitamin D. Vitamin D can increase magnesium absorption, so if one is supplementing with vitamin D, it may be beneficial to take at the same time as magnesium (ScientificWorldJournal. 2015:318595. Vitamin D, Essential Minerals, and Toxic Elements... Schwalfenberg GK & Genuis SJ). Foods that are Highest in Magnesium , for example almonds, has only 20% of the RDA of magnesium per serving. Other magnesium containing foods are: other nuts (especially cashews), avocado, seeds, sprouts, dark leafy greens and vegetables (especially artichoke), fish (especially salmon), beans, yogurt and goat cheese (many avoid dairy), bananas, dark chocolate (without sugar) and dried fruit (watch the concentrated sugar content). Spinach has magnesium, but it also has oxalate that interferes with absorption. Edamame, black beans and whole grains contain magnesium, but can contain phytates and absorption blockers. It is not necessary to avoid these foods, but be aware that they should be balanced. Remember also that foods with magnesium come from soils containing magnesium, and many of our soils have been depleted. The result of oil refining is a removal of magnesium. Safflower seeds, for example, contain 680 mg of magnesium per 1,000 calories. Refined safflower oil lacks magnesium entirely. Organic, cold pressed, unrefined oils will contain magnesium. Items that deplete or interfere with magnesium absorption: alcohol, soda, tea (not herbal), coffee, chocolate, sugar, herbicides, antibiotics, diuretics, and medications that affect kidney function. Impaired digestion, aging, disease, stress, intense exercise, surgery drinks, diarrhea, vomiting, and illness (especially affecting the digestive/intestinal area) can also reduce magnesium absorption. Calcium is an important mineral, but it’s just as important not to let Ca++ overshadow Mg++; balance is critical - In one study, addition of 300 to 1000 mg of Ca++ to the diet decreased Mg++ absorption significantly in participants consuming an average of 370 of dietary Mg++ daily (Bohn T. Dietary Factors Influencing Magnesium Absorption in Humans. Current Nutrition & Food Science. 2008;4:53-72). Many believe that negative traits recently attributed to calcium are due to non-absorbable forms, and also to the “crowding out” of Mg++, leading to insufficiencies and deficiencies.
Contraindications: Excess magnesium (everyone’s bowel tolerance will be different) can cause diarrhea and cramping. Contraindications (from p. 240 of The Magnesium Miracle by Carolyn Dean, MD): kidney failure; myasthenia gravis; excessively slow heart rate; bowel obstruction.
Ingredients: Magnesium (as malate, citrate, glycinate) 300 mg. Proprietary blend: 85 mg* Caprillic Acid (mct-medium chain triglycerides), Inulin, L-Taurine, Coconut Fiber.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Complete Neuro (1549F)

Supportive Function: Supports the entire nervous system, the health of neurons, neuronal components, surrounding tissue, and communication with other organ systems. Many nerve problems are attributed to mitochondrial dysfunction, and to toxic assaults (including environmental toxins and oxidizing substances) that damage nerve function. Antioxidants and potent nutrients like resveratrol, curcumin, quercetin, and sulforaphane from organic broccoli sprouts, etc. are combined into a formula for optimal support of the nerves and the entire nervous system. When is Neural Support helpful? Nerve health; in addressing the aging of the nervous system; cognitive/brain functions.
Clinical Applications Research: There are many nutrients that help support nerve cell growth, function, and repair. The mitochondria of nerve cells are particularly susceptible to attack. Age and disease are also major contributing factors to nerve damage. Nutritional support has been demonstrated in the scientific literature to make a difference. Antioxidant protection has proven to be indispensable for proper nerve health and function. Synergy is a key factor in providing support, and as researchers have observed, to be able to achieve “ neuroprotection ” and “ neurorescue ,” “multiple neuroprotective agents may be more effective than the current treatment with extremely high doses of a single antioxidative agent ”. Niacin is one of the nutrients that provides mitochondrial support and conserves growth factor receptors, and nicotinamide adenine dinucleotide (made from niacin) has proven to be of clinical benefit in dementias and nerve disorders. Chromium (as chelate) supports nerve growth and has also been reported to be “one of the most researched nutritional supplements in conjunction with peripheral neuropathy”.   Turmeric (extract)(rhizome)(Curcumin) activates defensive genes in the body and “ protects neurons against oxidative stress ”. Administration of curcumin in one study significantly reduced neuronal death caused by oxidation, and also reduced mitochondrial dysfunction . Another study suggested that “ curcumin is a promising agent for the prevention and treatment ” of some neurodegenerative disorders . Garlic (root): The Journal of Neuroscience reported that an ingredient in garlic enhances the antioxidant system responsible for protecting against neuronal loss. Since oxidative damage is suspected of being a major cause of neuronal loss in Parkinson’s disease (PD), the researchers suggested that this antioxidant system may “represent a new prevention and therapeutic approach for PD and potentially for other neurodegenerative diseases involving oxidative stress”. Even though there is currently no clinically accepted treatment to stop the progression of Alzheimer’s, “its risk is known to reduce with increased consumption of antioxidant agents”. The amyloid beta mentioned earlier that is implicated in Alzheimer’s disease can cause nerve cell death, and a “component present in garlic is known to prevent cognitive decline by protecting neurons from amyloid beta induced neuronal apoptosis (cell death)”. The Journal of Nutrition published a study titled, “Garlic reduces dementia and heart-disease risk,” where it was noted that garlic “may help prevent cognitive decline by protecting neurons from amyloid beta neurotoxicity,” thereby “improving learning and memory retention”. Resveratrol is one of the best nerve support nutrients, having a favorable effect on the mitochondria and serving to protect all tissues, including nervous tissue, from oxidative damage. There are reports of the potential of resveratrol to mediate neurodegeneration that has been caused by oxidative mechanisms. Scientists have explored indirect pathways by which resveratrol “can exert its neuroprotective abilities ,” and they have discovered that, using primary neuronal cultures, resveratrol affects an important enzyme and is a “unique pathway by which this compound can exert its neuroprotective action s”. Researchers have stated that nutrition can modify neuronal dysfunction, and that nutritional modifiers “may provide an alternative and early intervention approach that may prevent further damage ,” including resveratrol as one of the nutritional modifiers. In a publication from the Annals of the NY Academy of Sciences called “ Potential mechanism by which resveratrol, a red wine constituent, protects neurons ,” researchers report that, “Resveratrol is known to protect against cardiovascular diseases and cancers, as well as to promote antiaging effects in numerous organisms. It also modulates pathomechanisms of debilitating neurological disorders, such as strokes, ischemia, and Huntington's disease”. There is evidence suggesting that resveratrol acts as a signaling molecule within tissues and cells to modulate the expression of genes and proteins. This modulation could explain the cell protective actions of resveratrol, as well as its influence on blood flow and inflammatory cascades. Benfotiamine protects neurons by way of at least three mechanisms. Benfotiamine is a lipid soluble form of the B vitamin thiamin with very powerful antioxidant capabilities . Benfotiamine has many protective qualities. In fact, benfotiamine is “one of the most researched nutritional supplements in conjunction with peripheral neuropathy”. Ginkgo Biloba Extract (leaf) was one the agents named as being a promising candidate for further study as a neuroprotective agent in Parkinson’s disease and Alzheimer’s disease. Ginkgo has a long reputation as a cognitive enhancer (one recent peer-reviewed article title is “Ginkgo biloba as a cognitive enhancer”), and that is confirmed by numerous experimental observations and clinical results.  Researchers call ginkgo a “neuroprotector,” and explain that the action of protection is based on the ability of ginkgo to detoxify, to act as an antioxidant, and to normalize energy transfer in brain neurons. Quercetin has been called the most important flavonoid by some. In addition to many other biological benefits, quercetin “contributes significantly to the protective effects of neuronal cells from oxidative stressinduced neurotoxicity, such as Alzheimer’s disease”. Quercetin’s radical-scavenging ability is so great that it, like some other nutrients mentioned here, is neuroprotective and has potential use for Parkinson’s and Alzheimer’s. Rhodiola Rosea (root) has been found to have effects on the brain and nervous system, attributed to the ability of Rhodiola to influence the levels and activity of monoamine neurotransmitters. REFERENCES AVAILABLE UPON REQUEST
Contraindications: Consult a practitioner if on blood thinners.
Ingredients: Niacin 5 mg, Chromium (as chelate) 25 mcg. Proprietary blend 175 mg* of: Turmeric (extract)(rhizome), Broccoli (sprouts), Garlic (root), Resveratrol, Benfotiamine, Ginkgo Biloba Extract(leaf), Quercetin, Rhodiola Rosea (root).
Vegetarian: Yes
Suggested Dosage: One tablet daily or as directed.
Pack: 60 Tablets
Product:

Complete Omega 3 Co-Factors (1517F)

Supportive Function: Co-Factors provide for the proper absorption and utilization of Omega 3 fatty acids. Cofactors also support the heart and the mitochondria, in addition to being an excellent anti-oxidant/aging formula. Take with Complete Omega-3 Essentials 2:1 for best results. When are Complete Omega 3 Co-Factors helpful? Co-factors help support the absorption and utilization of the fish oils. Additionally, co-factors are necessary for the antioxidant protection of the double bonds in the fish oil and they offer protection against health risk factors.
Clinical Applications Research: Policosanol: A randomized, double blind study was undertaken to compare the efficacy and tolerability of policosanol (10 mg/day) and lovastatin (20 mg/day) in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus. After 6 weeks on a lipid lowering diet, 53 patients were randomized to receive either policosanol or lovastatin tablets that were taken for 12 weeks under double-blind conditions. Both groups significantly (p < 0.001) lowered low-density lipoprotein (LDL)-cholesterol, total cholesterol and the ratio of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol. Comparison between groups showed that changes in HDL-cholesterol induced by policosanol were significantly greater (p < 0.01) than those induced by lovastatin. Lovastatin significantly (p < 0.05) increased levels of aminotransferase, creatine phosphokinase and alkaline phosphatase. Adverse reactions were more frequent in the lovastatin group (p < 0.01) than in the policosanol group. In conclusion, policosanol administered at 10 mg/day produces more advantageous changes in HDL-cholesterol and has a better safety and tolerability profile than lovastatin 20 mg/day (Crespo N et al. Int J Clin Pharmacol Res 1999; 19(4): 117-27 Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus) . Alpha Lipoic Acid: ALA enhances glucose conversion for cell protection, maintenance, and rebuilding. In diabetes, cells starve from unconverted glucose, resulting in diabetic complications to tissues and organs. Lipoic Acid protects against capillary damage and cataract formation. Lipoic Acid helps regenerate and recycle other antioxidants, especially C, E, and glutathione. It protects against arterial plaque and oxidative damage to LDL cholesterol. It helps neutralize toxins in alcohol and tobacco smoke, mobilize and detoxify heavy metals. Lipoic Acid protects liver from alcohol damage, enhances glucose disposal in adult onset, Type II diabetes, improves insulin sensitivity; and protects against diabetic complications of nerve damage. It has been shown to improve nerve blood flow, reduce oxidative stress, improve distal nerve conduction, and improve reduced levels of deficient glutathione and deficient E in the nerves of diabetics. Lipoic Acid prevents cataracts in animals by increasing levels of C, E, and glutathione in the lens. It binds with the DNA of some viruses and prevents replication. Viral causes are implicated in some cases of diabetes. Supplements have been shown to improve neuropathy and reduce nerve pain.  Co-Enzyme Q-10: Co-Q-10 is a vitamin-like nutrient that is vital to the production of energy. As one of the electron carriers in the electron transport system, it helps cells utilize oxygen. If you have ever wondered how we get energy from food, or why we have to breathe oxygen, it is because the body strips food of electrons and transports them to an electron acceptor, which is oxygen. Co-Q-10 facilitates this process, providing one of the “spark plugs” for the creation of cellular energy. Without Co-Q-10, we would not have enough energy to fuel the physiological reactions we need to survive (Folkers K & Wolaniuk A. Drugs Exp Clin Res. 1985; 11(8): 539-45) . Dr. Folkers notes that Co-Q-10 levels falling to 75% may cause illness, whereas falling to 25% may cause death (Folkers, ibid) . Co-Enzyme Q-10 concentration in the mitochondria (which are sometimes called the “powerhouses” of the cell) is not believed to be saturated, which is one of the reasons researchers think that supplementation is having beneficial effects (Clin Investig 1993; 71(8 Suppl): S66-70) . Numerous therapeutic effects of Co-enzyme Q-10 have been reported, most notably in areas where oxygen transport is critical, for instance heart disease, aging and periodontal disease. Since an adequate supply of oxygen is necessary for tissue repair and immune function, many applications have been reported in these areas. Additionally, Co-enzyme Q-10 has therapeutic potential because of its antioxidant properties (fights damaging free radicals). Co-enzyme Q-10 has a wide variety of functions and applications in the body. Vitamin B-12 (as methylcobalamin) and Folate (as folic acid) are B vitamins associated with lowering homocysteine levels, and hence lowering the risk for complications of high homocysteine levels (heart disease, osteoporosis, placental abruption, weak capillaries, etc.) (Vitamin therapy may reduce hip fracture risk. Folate, B12 appear to reduce homocysteine levels. Health News. 2005 Jun; 11(6): 8). Glutathione (reduced) is a potent antioxidant, conjugator (detoxer) and cell protector, especially in the liver. Glutathione is most powerful in a reduced or non-oxidized form. Glutathione is a major protector of microglial cells, resident immune cells of the central nervous system. These cells defend the central nervous system against invading microorganisms and clear the debris from damaged cells helping to repair damaged brain cells. (Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid Redox Signal. 2005 Sep-Oct; 7(9-10): 1223-33). Vitamin C (as ascorbic acid) is an antioxidant, an immune nutrient, a chelator (especially metals), a detoxer, and possesses many healthful characteristics, including an ability to keep glutathione in a reduced form. It has protective qualities, and has been associated in the literature with favorable effects on many conditions, ranging from heart disease (Knekt P et al. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr. 2004 Dec; 80(6): 1508-20). Osteoporosis (Nieves JW. Osteoporosis: the role of micronutrients. Am J Clin Nutr. 2005 May; 81(5): 1232S-1239S) and degenerative joint disease (Goggs R. Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr. 2005; 45(3): 145-64). To photoaging and dermatological indications (Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg. 2005 Jul; 31(7 Pt 2): 814-7; discussion 818) , among others. Magnesium (as chelate) helps calcium absorption, regulates muscle relaxation cycles, and is important as a protective factor in heart disease; magnesium has been described as having an “anti-infarct characteristic” (Ebrahimi S. Anti-infarct effect of magnesium is not mediated by adenosine A1 receptors in rat globally ischaemic isolated hearts. Clin Exp Pharmacol Physiol. 2004 Dec; 31(12): 868-72). Magnesium intake deficiency increases not only vaso-spasms of the coronary artery, but also exacerbates several coronary risk factors such as hypertension, diabetes mellitus, and mental stress (Ueshima K. Magnesium and ischemic heart disease. Clin Calcium. 2005 Feb; 15(2): 175-80) . Deficiency also decreases ATPase. It is not unusual for magnesium intake to be below the recommended dietary allowance.
Contraindications: Large amounts of Co-Enzyme Q-10 may interfere with the efficacy of blood thinners, however only small amounts are utilized in this formula.
Ingredients: Vitamin C (as ascorbic acid) 250 mg, Riboflavin 25 mg, Vitamin B-6 (as pyridoxine hydrochloride) 25 mg, Folate (as folic acid) 400 mcg, Vitamin B-12 (as methylcobalamin) 200 mcg, Magnesium (as chelate) 75 mg. Proprietary blend 32.5 mg* of: Glutathione (reduced), Policosanol, Co- Enzyme-Q-10, Alpha Lipoic Acid.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Complete Synapse (1544)

Supportive Function: The ultimate support for brain, nerve cell and nerve synapse function to optimize cellular communication, utilizing heavily researched brain nutrients like bacopa, glucoraphanin, ashwagandha, and many others. When is Brain Support helpful? Brain Function; Healthy Aging; Nerve cell / Glial cell function; Nerve Synapse function; Nerve cell to nerve cell communication; Nerve cell to other receptor cell communication; Cognitive function; Normal HPA axis function; Communication within brain areas: Hypothalamus, Amygdala, etc., Stress, Antioxidant status, General well-being, Mental health.
Clinical Applications Research: Bacopa (bacopamonniera) is one of the herbs in a category known as adaptogens. A systematic review of six randomized, controlled human clinical trials was conducted on cognitive domains and the herb “Bacopa (bacopamonniera)”. Scientists recognized that traditional knowledge suggests bacopa is well known for supporting cognitive function in the brain, and they concluded that bacopa definitely supports cognition. They noted that research on bacopa and cognitive support is in its infancy “with research still yet to investigate the effects of Bacopa across all human cognitive abilities” (Pase MP, et al. Effects of Bacopamonnieri: a systematic review of randomized, controlled human clinical trials.J Altern Complement Med. 2012 Jul;18(7):647-52). In a randomized, placebo-controlled, double-blind trial involving 98 healthy older persons (over 55 years in age) in Australia, audioverbal and visual tests were used to assess performance over 12 weeks. Researchers believed that bacopa offers significant support and that their results concur “with previous findings and traditional use (Morgan A, &Stevens J. Bacopamonnieri … Results of a randomized, placebo-controlled, double-blind trial.J Altern Complement Med. 2010 Jul;16(7):753-9). Another randomized, placebo-controlled, double-blind trial evaluated 54 healthy elderly people 65 or older from Portland, OR. Similar results were obtained, and researchers concluded that bacopa had a good safety and tolerability profile (Calabrese C et al. Effects of a standardized Bacopamonnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.J Altern Complement Med. 2008 Jul;14(6):707- 13). Trans Pterostilbene: Multiple studies have demonstrated the antioxidant activity of pterostilbene, a natural dietary compound (related to resveratrol) and the primary antioxidant component of blueberries. The pterostilbene found in plants like blueberries acts as part of its defense system.Trans-pterostilbene is the pure form, and it has increased bioavailability in comparison to other stilbene compounds, which may enhance its dietary benefit and possibly contribute to a valuable clinical effect (McCormack D, McFadden D.A review of pterostilbene antioxidant activity ….Oxid Med Cell Longev. 2013;2013:575482). The unique structure of pterostilbene makes it oil-soluble and more bioavailable than resveratrol, another type of stilbene, resulting in greater metabolic stability which lasts longer in the blood (Ferrer P. et al. Association between pterostilbene and quercetin….Neoplasia. 2005 Jan;7(1):37-47). Nutakul W et al.(2011) also referred to the “superior bioavailability of pterostilbene to resveratrol” (Nutakul W et al.Inhibitory effects of resveratrol and pterostilbene… a side-by-side comparison.J Agric Food Chem. 2011 Oct 26;59(20):10964-70). McCormack & McFadden noted that the clinical effects can be particularly supportive of neuronal and vascular health. Other researchers of stilbenes (Kasiotis KM. et al. 2013) describe the “significant biological activities of medicinal interest”, calling the antioxidant properties “well established and subjects of numerous research endeavors.” The mini-review focused on research findings, the mechanisms underlying their effects, and respective signaling pathways. This blueberry-derived compound exerts supportive effects on neurons by crossing the blood brain barrier and maintaining central nervous system signals (Andres-Lacueva, C. et al. Anthocyanins in aged blueberry-fed rats …,” Nutritional Neuroscience, vol. 8, no. 2, pp. 111–120, 2005). No wonder we are told to eat blueberries for brain function! Blueberry (fruit) have other active ingredients besides pterostilbene. Blueberry phytochemicals were first found to cross the blood brain barrier by Andres-Lacueva C. et al. (2005) and localize in various brain regions. Correlational analyses revealed a relationship between test performance in BBS rats and the total number of blueberry compounds. Their findings suggest “that these compounds may deliver their antioxidant and signaling modifying capabilities centrally” (Andres-Lacueva C. et al. Anthocyanins in aged blueberry-fed rats are found …NutrNeurosci. 2005 Apr;8(2):111-20). Glucoraphanin (as broccoli seed extract) (sulforaphane) comes from cruciferous vegetables (broccoli, kale, cabbage, cauliflower etc.), and results in sulforaphane production. Both glucoraphanin and sulforaphane are well known for their antioxidant, high-powered phytochemical activity. Glucoraphanin “may target epigenetic alterations” and optimize our health status by providing these vegetable extracts that have such a wide reputation for health benefits (Antioxid Redox Signal. 2014 Nov 3. Dietary Sulforaphane…: The Role of Epigenetic Regulation and HDAC Inhibition.Tortorella SM. et al). The powerful support that glucoraphanin has on epithelial cells is evidenced by the effect it has on supporting the integrity of the blood brain barrier (Giacoppo S. et al. The … effects of bioactive (RS)-glucoraphanin on the permeability of the mice bloodbrain barrier...Eur Rev Med Pharmacol Sci. 2014;18(2):194-204). Researchers determined that a 10% broccoli diet was supportive in some areas for brain neurons, but that broccoli by-products like sulforaphane, which are more concentrated, “would need to be provided in supplement form” in order to support a normal non-inflammatory environment (Townsend BE. et al. Dietary broccoli in aged mice…. Nutr Res. 2014 Nov;34(11):990-9). Ashwagandha (root) (Withaniasomnifera) contains many extracts and bioactive components, including arabinogalactan, withanone and withanolide A. Ashwaganda is considered to be an ayurvedicadaptogen, a substance that supports physiological functions disturbed by chronic stress.The ability it has to act as a free radical scavenger helps cells during toxic insult; ashwaganda significantly raised antioxidant enzymes like catalase and superoxide dismutase in brain tissue (Kumar P. Glio… effects of Ashwagandha leaf extract …Biomed Res Int. 2014;2014:182029). One scientific review described ashwaganda as “the best known and most scientifically investigated” of Indian ayurvedic herbs (Ven Murthy MR. et al. Scientific basis for the use of Indian ayurvedic medicinal plants…: ashwagandha.Cent NervSyst Agents Med Chem. 2010 Sep 1;10(3):238-46). The mechanisms are wide and diverse, but some include opioid receptor pathways, oxidative pathways,and neuronalpathways (Nosálová G. et al. Antitussive activity of Withaniasomnifera and opioid receptors. AdvExp Med Biol. 2015;838:19-25). N. Shah et al. (2015) found these extracts to possess activities very supportive of glial and neuronal cells, especially in the midst of oxidative insult; they not only found low doses to be effective, the combinations of different ashwaganda extracts were “highly potent” and caused them to endorse the therapeutic merit of the combinational approach”. These researchers also described the potential of ashwaganda for neuronal support and declared that it “may serve as a supplement for brain health” (Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation.PLoS One. 2015 Mar 19;10(3):e0120554. Shah N.et al). Another study also suggests that properties of ashwaganda may provide explanation for the uses of it in traditional medicine for cognitive support (Kurapati KR. et al. Human neuronal cells and … effects of ashwagandha (Withaniasomnifera) and its constituent Withanolide A.PLoS One. 2014 Nov 21;9(11):e112818). DHEA - 3-acetyl-7-oxo-dehydroepiandrosterone (or 7-Keto DHEA) is a metabolite of DHEA, however it possesses unique qualities because of its oxygenated 7-position . One of the qualities is to support the thyroid, especially T-3, which is the active thyroid hormone (Kalman, DS. et al. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research 61(7), July 2000). DHEA is synthesized in the brain, has long had a traditional reputation for brain support, and decreases with age. DHEA metabolizes to other steroids and can carry side effects, however 3-acetyl-7-oxo has been described as “possibly more effective than (DHEA) without the prohormonal effects” (Goncharov NP, Katsia GV.Neurosteroiddehydroepiandrosterone and brain function. FiziolCheloveka. 2013 Nov-Dec;39(6):120- 8;Worrel ME et al.Alcohol. 2011 Jun;45(4):349-54). Unlike DHEA, this derivative of DHEA is not converted to steroid hormones and does not increase the level of steroid hormones in the blood (Web MD 2015).It has been found to be safe and well tolerated (no adverse effects in any of the studies), rapidly absorbed and excreted (half-life of 2.17 hours) and there is no accumulation with repeated dosing (Davidson, M. et al. "Safety and Pharmacokinetic Study with Escalating Doses of 3-acetyl-7-oxo-dehydroepiandrosterone in Healthy Male Volunteers". Clin. Invest. Med. 2000; 23 (5): 300–310). DHA (as spirulina): A systematic literature search was conductedof clinical trials and observational studies that examined the relationship between long chain omega 3 fatty acids on cognitive support in healthy adults. Scientists reported that DHA (docosahexaenoic acid) alone (or in combination with EPA) contributed to the supportive effect on the brain of long chain omega 3’s (Yurko-Mauro K. et al. Docosahexaenoic Acid and adult memory: a systematic review and meta-analysis.PLoS One. 2015 Mar 18;10(3):e0120391). Microglial cells can have both direct and indirect effects on synaptic structures and functions. Glial cells are non-neuronalcells that maintain homeostasis , form myelin , and provide support for neurons in the brain and peripheral nervous system . The integrity of dendritic spines, the postsynaptic component of excitatory synapses, dictates synaptic efficacy. It is very important to support glial, microglial, and dendritic spines to ensure proper support of brain and nerve communication support, and DHA is reported to do just that (Chang PK. Et al. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology.J Neuroinflammation.; 2015 Feb 22.12(1):244). One factor evidently important for neuronal health and function is the optimal supply of nutrients necessary for maintaining normal functioning of the brain; mechanistic studies, epidemiologic analyses, and randomized controlled intervention trials provide insight to the positive effects of docosahexaenoic acid (DHA) in helping neurons to “cope with aging” (Mohajeri MH. Et al. Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia.Nutrition. 2015 Feb;31(2):261-75). Alpha Keto-glutaric Acid, or α ketoglutarate , is a key intermediate in the Kreb’s Cycle, a biochemical reaction that constantly transpires within our cells to make energy (ATP). Two thirds of the brain's energy is utilized to help nerve cells "fire'' or send signals. The remaining third is used for cell-health maintenance. One of alpha ketoglutarate’s physiological purposes is to be a carrier of nitrogen to the urea cycle in the liver, where ammonia is detoxified, and indeed alpha ketoglutarate has demonstrated the ability to detoxify ammonia accumulation in the brain (Ott, P. et al. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis.". Neurochemistry international 2005 47 (1-2): 13–8; Hares, P. et al. Effect of ornithine alpha ketoglutarate (OAKG) on the response of brain metabolism to hypoxia in the dog. Stroke; a journal of cerebral circulation. 1978;9 (3): 222–4). Another interesting physiological purpose of alphaketoglutarate is that it is required for the hydroxylation of proline to hydroxyproline in the production of collagen . Vitamin B-6, Vitamin B-12 (as methylcobalamin) and Folate (as L-5 methyltetrahydrofolate): B vitamin support has been extensively studied and it is well-known that B vitamins, specifically three B vitamins in particular, help maintain methylation pathways and provide support for the brain. In a groundbreaking two year randomized controlled trial of 156 subjects, Douaud G. et al. published a report on May 20, 2013 in the journal Proc Natl AcadSci U S A. that named three major B vitamins for supporting brain activity and cognitive processes. Those B vitamins were: Vitamin B-6, vitamin B- 12, and folic acid. Although the study did not distinguish between the active forms of the vitamins, the active form of folic acid (5 MTH Folate) is powerful and beneficial to people who are impeded in their methylation capabilities (about 50% of the population), methyl B-12 is the active form of vitamin B-12, and Pyridoxal-5-Phosphate is the active form of vitamin B-6. The study determined that daily amounts of folic acid (800 mcg) along with vitamin B-12 (500 mcg) and vitamin B-6 (20 mg) provided excellent support for brain function, brain volume, and normal cognitive processes. Their recommendation, in approaching effective brain support, was to utilize a supplement plan containing these amounts of those three B vitamins. Berberine augments the antioxidant defense system and helps maintain nerve health; researchers believed that their study provided evidence that it has potential as a neuro-supportive agent (Abdel Moneim AE et al. The …effect of berberine in mercury-induced neurotoxicity in rats.MetabBrain Dis. 2015 Jan 21). Additional studies bolster the notion that berberine is good support for brain/nerve function, healthy cell communication, motor balance, neurotransmitter balance, and nerve integrity (Kim M. et al. Berberine ...Int J Mol Med. 2014 Apr;33(4):870-8; Wang CM. et al. Comparison of Two Old Phytochemicals versus Two Newly Researched Plant-Derived Compounds: Potential for Brain...; Evid Based Complement Alternat Med. 2014;2014:682717). L-Theanine is the amino acid in green tea responsible for some of its effects. L-theanine and green tea were discovered (in a double blinded placebo controlled trial of 91 people) to support healthy brain function, especially in the temporal, frontal, parietal, and occipital areas of the brain (Park SK, et al. A combination of green tea extract and l-theanine… a double-blind placebo-controlled study.J Med Food. 2011 Apr;14(4):334-43) Kim TI et al. (2009) suggest that some of the effects of L-theanine are due to the influence on ERK/p38 kinase and NF-kappaB pathways (Kim TI et al. L-Theanine, an amino acid in green tea … reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways.Free RadicBiol Med. 2009 Dec 1;47(11):1601-10). Phosphatidyl Choline (as sunflower Lecithin) is an emulsifier, high in phosphatidyl choline, that is beneficial for increasing the absorption and bioavailability of many nutrients. Lecithin is also known for fostering a normal non-inflammatory state, and has been researched for its favorable effects in supporting health. Lecithin has lowered C-reactive protein in some studies (CRP is an inflammatory marker). Black Pepper (Piper nigrum) is a spice referred to by many as a “functional food” ; the bioactive components present in it “are of considerable significance owing to their potential” (Butt MS. et al. Black pepper and health: a comprehensive treatise.Crit Rev Food SciNutr. 2013;53(9):875-86.) Butt MS. Et al. (2013) wrote a “comprehensive treatise” (by their own description), of health associations to piper nigrum, and point out that the widespread recognition of diet-health linkages bolsters the dietary importance of spices, calling piper nigrum “an important healthy food” owing, in part, to its antioxidant, gastro- and cognitive supportive qualities. Piperine is the main active ingredient, rich in the phytochemistry of black pepper that also includes volatile oil, oleoresins, and alkaloids. Piper nigrum attenuated oxidative stress in the rat hippocampus, helping to achieve brain health homeostasis (Hritcu L. et al. Methanolic extract of Piper nigrum… decreasing brain oxidative stress in… rat model ….Cell MolNeurobiol.2014 Apr;34(3):437-49). Piper nigrum also supports neurotransmitter production and postsynaptic currents (ProgNeuropsychopharmacolBiol Psychiatry. 2011 Jun 1;35(4):1144-7. Involvement of serotonergic system in the …effect of piperine.Mao QQ et al.; Food ChemToxicol. 2008 Sep;46(9):3106-10. Piperine, the potential functional food.Wattanathorn J. et al.; Biol Pharm Bull. 2010;33(4):598-603. …Effect of piperine on primarily cultured hippocampal neurons.Fu M. et al.) Thyme (leaf) and Oregano (leaf) are also spices, and they are rich in active substances like carvacrol ; carvacrol is a “brain-active” molecule that supports brain neurochemistry , the central nervous system, neuronal activity and neurotransmitters, and “if regularly ingested in low concentrations, it might determine feelings of well-being” (Zotti M. et al. Carvacrol: from ancient flavoring to neuromodulatory agent.Molecules. 2013 May 24;18(6):6161-72). Cinnamon, a widely-used food spice and flavoring material, was investigated for its supportive effect on levels of nerve messengers such as brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the central nervous system (CNS). Scientists reported that their results highlight a novel property of cinnamon to help maintain homeostasis of nerve factors in the CNS (Jana A. et al. Up-regulation of neurotrophic factors by cinnamon … implications.J NeuroimmunePharmacol. 2013 Jun;8(3):739-55). Other evidence also contributes to the theory that cinnamon is a highly beneficial spice and supports brain, cognitive function, and the nervous system (Anderson RA et al. Cinnamon counteracts the negative effects of a high fat/high fructose diet...PLoS One. 2013 Dec 13;8(12):e83243). For optimal brain function, we must nourish the varied areas of the brain and spinal cord that contribute to the smooth operation of all brain components. Nerve cells release neurotransmitters (NTs), and those neurotransmitters communicate with receptors via nerve synapses. Nerve synapses are junctions between the release and the receptor (the receptor can be another nerve cell) that allow the neurotransmitter to reach its goal and effect change. The synapse in essence permits a nerve cell (neuron) to pass an electrical or chemical signal to the other cell (receptor). Neurotransmitters like dopamine, serotonin, acetylcholine, epinephrine and norepinephrine have the ability to emit those signals to their receptors. There are also neurotransmitters released in the gut which communicate with the brain via neuronal pathways to the brain, including the vagal pathway, emphasizing the importance of a healthy gut as well.
Contraindications: Minor GI side-effects have been observed at relatively high doses of 300 mg bacopa every day for 12 weeks; Complete Synapse contains < 55 mg per serving. Bacopa might increase levels of thyroid hormone or slow heart rate (Web MD). Not recommended for pregnancy or lactation.
Ingredients: Folate (as L-5 methyltetrahydrofolate) 275 mcg, Vitamin B-12 (as methylcobalamin) 200 mcg. Proprietary blend 254.8 mg* of: DHA (as spirulina) Phosphatidyl Choline (as sunflower lecithin), Bacopa (monniera) Extract (root), Ashwagandha (root), Glucoraphanin (as broccoli seed extract), DHEA, Alpha Ketoglutaric Acid, Trans Pterostilbene, Berberine, L-Theanine, Thyme (leaf), Oregano (leaf), Blueberry (fruit), Cinnamon (bark), Trimethylglycine, Pyridoxal 5 Phosphate, Black Pepper (piper nigrum).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Complete Whey-G (Protein Powder) (1526PF)

Supportive Function: Undenatured whey is indicated wherever it is helpful to raise glutathione. General support for immune health, surgery recovery, inflammatory environment, detox, bone support, weight management, protein boosting (needed for hormones, immune antibodies, enzymes, neurotransmitters, muscles, surgery recovery, etc) When is Glutathione helpful? Helpful Helpful for general health, stress, athletic performance, skin disorders, detoxification, fatigue, digestion, pregnancy/lactation, sleep, psychoneurobiology, stomach/bowel dysfunction, prostate health, kidney issues, eyesight, hearing, sinus, lung problems, ...and many other areas where decreased levels of glutathione are suspected of being a problem.
Clinical Applications Research: Undenatured whey efficiently raises glutathione levels in the body: One of the reasons that undenatured whey is getting so much press is because it raises glutathione levels in the cells. Glutathione (GSH) is a potent intracellular antioxidant that is backed by strong research describing its dramatic health benefits. Undenatured whey, which avoids heat processing, is able to bypass the normal roadblocks to successful cellular glutathione production. The biggest roadblock is the breakdown of glutathione in the digestive tract (it is quickly broken down and eliminated), lowering the efficiency of glutathione supplementation. Enter undenatured whey. The whey has bioactive proteins and contains cystine, which is two cysteine molecules held together by a bond that is resistant to digestion. Cysteine, being one of the three amino acids that make up glutathione, facilitates the production of glutathione inside the body’s cells because it is the limiting building block. It is deficient in many diets. It does not travel to the cell well unless it is part of a larger protein, and that’s where cystine comes in. Being a larger protein, the cystine in whey travels quickly to the cell and then splits into the two-cysteine molecules to provide the necessary precursor for glutathione production. The whey also contains an efficient delivery system to transport the cystine to the cells. Moreover, whey contains additional building blocks for glutathione. These building blocks, and the delivery system, are heatsensitive, however the undenatured whey eliminates this roadblock since it has not been exposed to heat. Glutathione must be manufactured in the cells. Because of this, and because the optimal production of GSH is provided by transportation of these heat-sensitive precursors (cystine and glutamylcystine residues) by other heat-sensitive molecules (albumin, lactoferrin and alpha lactalbumin) all contained in whey, undenatured, unheated whey protein is THE best nutritional source for glutathione production. There are reports of a wide range of health benefits to be gained from whey. In addition to being a good source of protein, whey demonstrates a multitude of “immune-enhancing properties” and “has the ability to act as an antioxidant, antihypertensive, antitumor, hypolipidemic, antiviral, antibacterial, and chelating agent … A number of clinical trials have successfully been performed using whey in the treatment of cancer, HIV, hepatitis B, cardiovascular disease, osteoporosis, and as an antimicrobial agent . Whey protein has also exhibited benefit in the arena of exercise performance and enhancement ” (Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004 Jun; 9(2): 136-56). Whey has been utilized to help reduce the inflammation in critically ill trauma patients receiving nutritional support; C-reactive protein concentrations (marker of inflammation) and total inflammatory index dramatically fell in one study (Vehe KL et al. The prognostic inflammatory and nutritional index in traumatized patients receiving enteral nutrition support. J Am Coll Nutr. 1991 Aug; 10(4): 355-63) . WHEY (Undenatured) contains glycomacropeptide: Glycomacropeptide (GMP) has anti-inflammatory, immunomodulatory and bacterial toxin binding effects. The intestinal anti-inflammatory activity of glycomacropeptide was assessed in colitis in a rat model. Pretreatment with glycomacropeptide had an antiinflammatory effect, characterized by less colonic damage (65%). “The magnitude of the anti-inflammatory effect was generally comparable to that of sulfasalazine, an established drug used in the treatment of inflammatory bowel disease. It may play a role in the management of patients with inflammatory bowel disease” (Daddaoua A et al. Bovine glycomacropeptide is anti-inflammatory in rats with hapten-induced colitis. J Nutr. 2005 May; 135(5): 1164- 70). Research on GMP has focused on its ability to bind toxins, inhibit bacteria and viruses adhesion, promote growth of good gut bacteria, inhibit proliferation of pathogens and modulate immune system responses (Brody E.P. Biological activities of bovine glycomacropeptide. Br J Nutr. 2000 Nov; 84 Suppl 1:S39-46) . Researchers have found GMP to be a potent immunoenhancer even at low concentrations (Li EW, Mine Y. Immunoenhancing effects of bovine glycomacropeptide and its derivatives on the proliferative response and phagocytic activities of human macrophagelike cells, U937. J Agric Food Chem. 2004 May 5; 52(9): 2704-8) . Whey supplies cysteine to the cells, and supplementation of the glutathione precursor cysteine in several clinical trials improved skeletal muscle functions, decreased the body fat/lean body mass ratio, decreased inflammatory cytokines, and improved immune functions. “As all these parameters degenerate with age, these findings suggest: (i) that loss of youth, health and quality of life may be partly explained by a deficit in cysteine and (ii) that the dietary consumption of cysteine is generally suboptimal and everybody is likely to have a cysteine deficiency sooner or later ” (Droge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29; 360(1464): 2355-72).  Superoxide Dismutase Type G (glutathione) is a natural free-radical scavenging enzyme. It mops ups the superoxide free radical, and works synergistically with many of the antioxidants in the oxidative defense system of the body, particularly glutathione. The superoxide radical produces oxidative stress associated with tissue damage and dysregulation of physiological signals. Molecular studies reveal that insulin receptor activity (associated with aging) is increased by this oxidative stress, and decreased by certain antioxidants (Droge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29; 360(1464): 2355-72).  Luo Han Guo (fruit) , or Lo Han Kuo (from the Momordicia grosvenori fruit) is a novel, natural sweetener that has many beneficial, health-promoting properties. The sweet elements, called triterpene glycosides, actually suppress the rise in blood glucose after a meal! (Suzuki YA t. al. 2005) . Researchers have found the natural sweetener to exhibit significant anti-tumor activity by decreasing both initiation and promotion (Ukiya M. et al. 2002) . Additionally, it prevents the oxidation of LDL (bad cholesterol) and may reduce the risk of heart disease by reducing the atherogenicity of the LDL (Takeo E. et al. 2002) . Researchers have determined that it possesses many advantages, such as having high sweetness capability with low adherence (good news for the teeth!) (Mu, J. 1998) . Anti-Inflammatory, Natural Cox-2 Inhibitors: Undenatured Whey Inhibits cox-2 by raising GSH levels: As mentioned above, whey possesses many properties, including anti-inflammatory characteristics. One of the ways in which whey demonstrates antiinflammatory effects is by inhibiting the cox-2 enzyme. The Cox 2 enzyme causes inflammatory substances to be produced in the body and is also the enzyme targeted by the cox-2 inhibitor drugs such as Vioxx and Celebrex. Raising glutathione (for example by utilizing undenatured whey) has the ability to modulate cox-2 gene expression and prostaglandin (inflammatory substance) synthesis (Chen JX et al. Glutathione mediates LPS-stimulated COX-2 expression. J Cell Physiol. 2003 Oct; 197(1): 86-93). The following nutrients ALSO inhibit inflammatory cox-2 naturally, and they have been added to the Complete Whey-G formula to boost its anti-inflammatory support: Ginger has 477 documented active ingredients, including several cox-2 inhibitors such as kaempferol. A moderate dose of ginger has been found to stop the formation of inflammatory and pain-causing prostaglandins, and a University of Miami study demonstrated that 63 percent of patients with knee osteoarthritis showed improvement after taking ginger for just six weeks (Altman, RD & Marcussen, KC. Effects of a ginger extract on knee pain inpatients with osteoarthritis. Arthritis Rheum 2001 Nov). T urmeric (Curcumin) (rhizome) is an ingredient in the spice turmeric that possesses powerful cox-2 inhibiting activity. Curcumin and ginger were among the spices researched by the MD Anderson Cancer Center at the U of Texas that were determined to possess the ability to “inhibit the activation of a transcription factor linked with a variety of inflammatory diseases, including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma, arthritis, Crohn's disease, multiple sclerosis, Alzheimer's disease, osteoporosis, psoriasis, septic shock, and AIDS” (Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004 Dec; 1030:434-41). “Curcumin has been described as a potent antioxidant and antiinflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis… All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer” (Aggarwal BB, et al. Anti-cancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 Jan-Feb; 23(1A): 363-98) . Indian Frankincense (boswellia) (gum) has been used as a traditional remedy in Ayurvedic medicine in India for the treatment of inflammatory diseases, and a strong inhibitor of the cox-2 enzyme. When boswellia was used in clinical trials, “promising results were observed in patients with rheumatoid arthritis, chronic colitis, ulcerative colitis, Crohn's disease, bronchial asthma and peritumoral brain edemas” (Ammon HP. Boswellic acids as the active principle in treatment of chronic inflammatory diseases Wien Med Wochenschr. 2002; 152(15-16): 373-8). The same researchers point out that boswellia can inhibit elastase (an enzyme that breaks down connective tissue). Quercetin is a powerful bioflavonoid and antioxidant that has been found to “effectively suppress the COX-2 promoter activity ” (Bagga D et al. Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci 2003 Feb 18; 100(4): 1751-6).  Curcumin, Boswellia and Quercetin are all among the natural agents described by researchers that “may advance the efficacy of cancer therapy… One key new approach appears to be modulation of the inflammatory cascade, as research is expanding that links cancer initiation, promotion, progression, angiogenesis, and metastasis to inflammatory events” (Wallace JM. Nutritional and botanical modulation of the inflammatory cascade as an adjunct in cancer therapy. Integr Cancer Ther. 2002 Mar; 1(1): 7-37) . Chamomile (flower) contains bioactive flavonoids such as apigenin that are powerful cox 2 inhibitors, and “may be important in the prevention of carcinogenesis and inflammation” – in fact, apigenin was more powerful than genistein and kaempferol in inhibiting cox 2 (Liang YC, et al. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 1999 Oct; 20(10): 1945-52). The apigenin in chamomile has effectively suppressed inflammatory substances in scientific studies (Smolinski AT, Pestka JJ. Modulation of lipopolysaccharide-induced proinflammatory cytokine production by herbal constituents. Food Chem Toxicol. 2003 Oct; 41(10): 1381-90). Glutathione (GSH) also inhibits the inflammatory cox-2 enzyme (Chen JX et al. Glutathione mediates LPS-stimulated COX-2 expression via early transient p42/44 MAPK activation. J Cell Physiol. 2003 Oct; 197(1): 86-93). As a supplement, GSH breaks down in digestion and is not the most effective way to raise glutathione in the cells, HOWEVER, oral glutathione supplementation has been shown to have some effect on GSH concentration in the liver because of the efficient extraction by the liver of the cysteine that originated from the breakdown of GSH in the gut (Grattagliano I, et al. Effect of oral glutathione monoethyl ester and glutathione on circulating and hepatic sulfhydryls in the rat. Pharmacol Toxicol. 1994 Dec; 75(6): 343-7). This makes it an excellent synergistic addition to a formula for glutathione support. Glutathione protects not only individual cells but also the tissues of the arteries, brain, heart, immune cells, kidneys, lenses of the eyes, liver, lungs, and skin against oxidant damage.
Contraindications: The components of whey include lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, bovine serum albumin and immunoglobulins. Those sensitive to dairy may be sensitive to the whey portion, however, that does not mean that all of those sensitive to dairy will necessarily be sensitive to the whey portion. Should not be used by whey-sensitive people.
Ingredients: Each Scoop* Contains: Calories: 37; Total Fat: 0.085 gms; Total Carbohydrate: 0.269 gms; Protein 8.89 gms. Proprietary blend 985 gms* of: Whey (undenatured), Rice Bran, Chamomile (flower), Ginger (root), Indian Frankincense (boswellia) (gum), Quercetin, Superoxide Dismutase Type G (glutathione), Turmeric (curcumin) (rhizome), Luo Han Guo (fruit), Glutathione. With Natural French Vanilla Flavoring.
Vegetarian: No
Suggested Dosage: 1 scoop in juice or water or as directed. Do not over mix. 34 servings per container.
Pack: 12 oz Powder
Product:

Core Level Bone Matrix (1634)

Supportive Function: Core Level Bone Matrix is made up of veal bone and the essential vitamins and minerals involved in maintaining bone health. This product contains calcium, phosphorus, manganese and vitamin D, which all play various key roles in bone metabolism. Veal bone makes bioavailable the natural ratios of nutrients necessary for bone health. When is Bone Matrix helpful? Broken bones, osteoporosis, and overall bone health.
Contraindications: High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease. Vitamin D is fat-soluble but not toxic in amounts less than 2400 IU/day. Female/male glandulars are contraindicated in cancers of the reproductive organs. Hyperparathyroidism or sarcoidosis patients should avoid vitamin D supplementation.
Ingredients: Each 2 Tablets Contains: Vitamin A (as palmitate) 1500 IU, Vitamin C (as sago palm), 1200 mg, Calcium (as aspartate, gluconate, chelate) 35.5 mg, Vitamin D3 (as cholecalciferol) 400 IU, Riboflavin 6 mg, Niacin 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Pantothenic Acid (as calcium pantothenate) 25 mg, Zinc (as sulfate) 3.6 mg, Manganese (as chelate) 0.500 mg, Molybdenum (as chelate) 2 mcg. Proprietary blend 807 mg* of: Bone Meal, Adrenal (bovine), Kidney (bovine), Rutin, Betaine (as hydrochloride), L-Cystine, Liver (bovine), Devils Claw (root), DL-Methionine, Stomach (porcine), Ovary (bovine), Orchic (bovine), Parathyroid (bovine).
Vegetarian: No
Suggested Dosage: 2 tablets daily or as directed
Pack: 60 Tablets
Product:

Core Level D-Tox (1609)

Supportive Function: Core Level D-Tox is a special formulation of vitamins, minerals, herbs and glandulars--a combination that aids the body in the detoxification process. Contains several powerful binders of metals and toxins. When is Detoxification helpful? Numerous conditions including hay fever, allergies, digestive problems, skin problems, asthma, autoimmune diseases, chronic diseases, overall ill health, fatigue, constipation, liver problems . . .
Clinical Applications Research: Apple Pectin: Apple pectin helps bind unwanted metals and toxins, and lowers cholesterol levels by binding the cholesterol and bile acids in the gut, which aids in excretion. Apples are high in malic acid content, which is used therapeutically for treating the symptoms of chronic fatigue syndrome. Sodium Alginate (from brown seaweed): Sodium alginate is a highly viscous polysaccharide with a high fiber content (J Nutr 1990; 120(4): 353-60). It is derived from a seaweed compound. Sodium alginate “offers incredible protection from many kinds of modern day pollutants, carcinogens and toxins. Algin, though non-digestible, can prevent living tissue from absorbing radioactive materials, including strontium-90, barium, mercury, tin, and cadmium” (Mowrey, D. Ph.D. The Scientific Validation of Herbal Medicine. Keats Publishing. New Canaan, CT, 1986, p. 88). Garlic (root): Garlic has been used for cholesterol/triglyceride reduction, candida, sinusitis, diabetes, antihypertensive, anticarcinogenic, antibacterial, antimicrobial, antifungal, anthelmintic (expels worms), antiviral, anti-inflammatory, immune-enhancing (esp. colds/flu), asthma, fever, flatulence, nausea, vomiting, colic, indigestion. Allicin is the molecule responsible for the odor of garlic, and also for many of the purported benefits it offers as an herb. There are many documented effects of garlic in the literature. Rice Bran and Oat Bran: Fiber produces butyric acid, a short chain fatty acid that is manufactured by the intestines through bacterial fermentation of fiber. Butyric acid is the main energy source for the large intestine epithelial cells and helps repair and regenerate damaged cells. Many fibers can absorb 7-8 times their weight in water, which softens stools and decreases transit time. Fiber may decrease the size of hemorrhoids and prevent hemorrhoidal bleeding. It also is said to “lower cholesterol levels and slow the absorption of sugar in diabetics, which may decrease the need for insulin in some people with diabetes" (Larson, D. Mayo Clinic Family Health Book, 1990. William Morrow & Co. Inc. NY, NY. p. 635). Chlorophyll: Chlorophyll provides intestinal nourishment and has a soothing effect on the lining of the mucosa. Chlorophyll acts as an effective natural healer and cleanser for chronic conditions internally and externally. It retards growth and development of toxic bacteria (Keith, V., and Gordon, M., The How To Herb Book, Mayfield Publications, Pleasant Grove, Utah, 1988, pg. 22). It is an intestinal detoxifier due to its neutralizing effects on guanidine, an intense alkaline substance found in the intestines caused by constipation or cell trauma. It can also bind heavy metals and prevent the adverse effects from them. Beet (root): Beets aid in gallbladder function, lymphatic function, and digestion (Balch JF, Prescription for Nutritional Healing, p. 39). Stone Root (root): Collinsonia stimulates, tones and cleanses the mucous membranes of the gastrointestinal tract. It is referred to in herbal literature as a “vascular astringent." In most patients with hemorrhoids or varicose vein problems, the patient has a congested liver. Bile salts can be combined with collinsonia because bile salts alone may be irritating.
Contraindications: High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease. Female/male Glandulars are contraindicated in cancers of the reproductive organs. In large amounts, garlic is contraindicated with anticoagulant drugs. The combination of herbs in this formula work together in creating synergistic effects, and smaller amounts of the herbs are utilized for optimal results.
Ingredients: Vitamin C (as ascorbic acid) 100 mg, Vitamin E (as succinate) 5 IU, Thiamine (as hydrochloride) 2 mg, Niacin 5 mg, Vitamin B-12 (as cyanocobalamin) 20 mcg, Pantothenic Acid (as calcium pantothenate) 35 mg, Magnesium (as chelate) 8 mg, Manganese (as chelate) 0.500 mg. Proprietary blend 598 mg* of: Rice Bran, Oat Bran, Sodium Alginate (from brown seaweed), Apple Pectin, Pancreatin (porcine), Beet (root), Garlic (root), Pancreas (bovine), Adrenal (bovine), Liver (bovine), Orchic (bovine), Spleen (bovine), Duodenum (porcine), L-Lysine, Chlorophyll, Stone Root (root), Parathyroid (bovine), L-Ornithine, Cabbage (leaf), L-Glycine, Ox Bile, Pepsin.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Core Level Health Reserve (120) (1621A)

Supportive Function: Packed with a powerhouse of essential vitamins and minerals, this formula provides a true, "core level" answer to full and balanced nutritional support. This formula provides high amounts of the antioxidant nutrients, i.e. vitamin C, vitamin E, selenium, zinc, and the bioflavonoids. In addition to the long list of concentrated essential nutrients, Core Level Health Reserve also contains well-known herbs such as Eleuthero, and garlic. Plant constituents such as the balancing chlorophyll and phytochemicals (lemon bioflavonoids, rutin, hesperidin, etc.) compliment the formula. Add some high-fiber rice bran and almond meal, essential fatty acids (vitamin F), some iodine from a sea source (kelp), throw in the amino acids (glycine, tyrosine, etc.), and you have a superior recipe for ideal nutritional support. When is a Multiple Vitamin helpful? Preventative measures, fatigue, overall good health, good starting point to address possible deficiencies.
Contraindications: Use caution in pregnancy (prenatal vitamins are available). High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease. Hyperparathyroidism or sarcoidosis patients should avoid vitamin D supplementation. Do not use in PKU (contains phenylalanine).
Ingredients: Vitamin A (as palmitate) 300 mcg, Vitamin C (as sago palm) 350 mg, Vitamin D3 (as cholecalciferol) 3.5 mcg, Vitamin E (as succinate) 38 mg, Thiamine (as hydrochloride) 5 mg, Riboflavin 4 mg, Niacin 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 8 mg, Folate (as L-5 methyltetrahydrofolate) 70 mcg, Vitamin B-12 (as methylcobalamin) 10 mcg, Biotin 130 mcg, Pantothenic Acid (as calcium pantothenate) 10 mg, Choline (as bitartrate) 15 mg, Calcium (as aspartate) 30 mg, Iodine (as kelp) 16 mcg, Magnesium (as aspartate) 16 mg, Zinc (as aspartate) 1 mg, Selenium (as chelate) 10 mcg, Manganese (as aspartate) 0.500 mg, Chromium (as chelate) 10 mcg, Molybdenum (as chelate) 15 mcg. Proprietary blend 281 mg* of: Almond (meal), Rice Bran, Inositol, Lemon Bioflavonoid, Eleuthero (root), Garlic (root), Hesperidin, Para Amino Benzoic Acid (PABA), Irish Moss (red algae)(plant), Rutin, L-Leucine, L-Valine, L-Phenylalanine, LIsoleucine, L-Lysine, L-Glycine, Chlorophyll, DL-Methionine, L-Threonine, L-Tyrosine, Black Currant Seed Oil, L-Histidine, L-Glutamic Acid.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Core Level Health Reserve (60) (1621)

Supportive Function: Packed with a powerhouse of essential vitamins and minerals, this formula provides a true, "core level" answer to full nutritional support. This formula provides high amounts of the antioxidant nutrients, i.e. vitamin C, vitamin E, selenium, zinc, and the bioflavonoids. In addition to the long list of vital nutrients, Core Level Health Reserve also contains well-known herbs such as eleuthero, goldenseal, garlic and tillandsia. Plant constituents such as the balancing chlorophyll, and phytochemicals (lemon bioflavonoids, rutin, hesperidin, etc.) complement the formula. Add some high-fiber rice bran and almond meal, essential fatty acids (vitamin F), some iodine from a sea source (kelp), throw in the amino acids (glycine, tyrosine, etc.), and you have a superior recipe for ideal nutritional support. The high concentration of nutrients in Core Level Health Reserve makes it an ideal choice for anyone looking for a complete balanced multi vitamin.
Contraindications: Use caution in pregnancy (prenatal vitamins are available). High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease. Hyperparathyroidism or sarcoidosis patients should avoid vitamin D supplementation. Do not use in PKU (contains phenylalanine).
Ingredients: Vitamin A (as palmitate) 300 mcg, Vitamin C (as sago palm) 350 mg, Vitamin D3 (as cholecalciferol) 3.5 mcg, Vitamin E (as succinate) 38 mg, Thiamine (as hydrochloride) 5 mg, Riboflavin 4 mg, Niacin 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 8 mg, Folate (as L-5 methyltetrahydrofolate) 70 mcg, Vitamin B-12 (as methylcobalamin) 10 mcg, Biotin 130 mcg, Pantothenic Acid (as calcium pantothenate) 10 mg, Choline (as bitartrate) 15 mg, Calcium (as aspartate) 30 mg, Iodine (as kelp) 16 mcg, Magnesium (as aspartate) 16 mg, Zinc (as aspartate) 1 mg, Selenium (as chelate) 10 mcg, Manganese (as aspartate) 0.500 mg, Chromium (as chelate) 10 mcg, Molybdenum (as chelate) 15 mcg. Proprietary blend 281 mg* of: Almond (meal), Rice Bran, Inositol, Lemon Bioflavonoid, Eleuthero (root), Garlic (root), Hesperidin, Para Amino Benzoic Acid (PABA), Irish Moss (red algae)(plant), Rutin, L-Leucine, L-Valine, L-Phenylalanine, LIsoleucine, L-Lysine, L-Glycine, Chlorophyll, DL-Methionine, L-Threonine, L-Tyrosine, Black Currant Seed Oil, L-Histidine, L-Glutamic Acid.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Core Level Liver (120) (1605A)

Supportive Function: Nutritional liver support.
Contraindications: Some glandulars are contraindicated in cancers of the reproductive organs. High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Vitamin A (as acetate) 500 IU, Vitamin C (as ascorbic acid) 150 mg, Niacin 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 15 mg, Folate (as folic acid) 40 mcg, Vitamin B-12 (as cyanocobalamin) 10 mcg, Phosphorus (as chelate) 30 mg, Copper (as chelate) 1 mg. Proprietary blend 574 mg* of: Liver (bovine), Beet (leaf), Choline (as bitartrate), Inositol, Kidney (bovine), Prostate (bovine), Uterus (bovine), Lymph (bovine), Aorta (bovine), Pancreatin (porcine), Rice Bran, L-Threonine, DL-Methionine, L-Cystine, Pancreas (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Core Level Liver (60) (1605)

Supportive Function: Nutritional liver support
Contraindications: Slome glandulars are contraindicated in cancers of the reproductive organs. High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Vitamin A (as acetate) 500 IU, Vitamin C (as ascorbic acid) 150 mg, Niacin 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 15 mg, Folate (as folic acid) 40 mcg, Vitamin B-12 (as cyanocobalamin) 10 mcg, Phosphorus (as chelate) 30 mg, Copper (as chelate) 1 mg. Proprietary blend 574 mg* of: Liver (bovine), Beet (leaf), Choline (as bitartrate), Inositol, Kidney (bovine), Prostate (bovine), Uterus (bovine), Lymph (bovine), Aorta (bovine), Pancreatin (porcine), Rice Bran, L-Threonine, DL-Methionine, L-Cystine, Pancreas (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Core Level Lung (1606)

Supportive Function: Core Level Lung is a nutritional supplement that has been developed for support of the respiratory, bronchial and lung systems. The lungs are the main organs of the respiratory system. Air entering the nose is warmed and humidified by the sinuses after which it passes to the trachea, to the bronchi, the bronchioles and finally the alveoli. The alveoli are one cell thick and lay in direct contact with the capillary blood. This allows oxygen to pass freely into the blood and the carbon dioxide to pass into the lungs for elimination. The blood then delivers oxygen to the body. When is Lung Support helpful? Asthma, Respiratory, Bronchial and Lung Support.
Clinical Applications Research: Vitamin A (as beta carotene) is considered to be an essential immune vitamin. It is necessary to cellular growth, repair, and regeneration. Its role in regenerating epithelial tissue is vital to immune organs. It has been known for a long time that a lack of vitamin A in the diet will result in reduced resistance to infection. Calcium (as chelate): Calcium functions in many biochemical reactions, and is especially important for the contraction-relaxation phase of muscles. Magnesium acts synergistically with calcium in this phase. Vitamin B-6 (as pyridoxine hydrochloride) helps in the absorption of B-12, antibody production, and immune system function. It is necessary for the production of hydrochloric acid and the absorption of protein and fat. Manganese (as chelate) is an important mineral for activating enzymes in the many processes of infection fighting. It helps to maintain cellular integrity, and is essential for utilization of vitamin C. Thymus (bovine): Glandular nutrients such as thymus are believed to help repair damaged, deteriorated, or autoimmune system attacks on aging and malfunctioning glands and help restore them to normal activity (Balch JF and PA Balch, Prescription for Nutritional Healing, 2nd Edition, New York: Avery, 1997; 555-556).
Contraindications: Do not take in pregnancy. Pituitary glandular is contraindicated in cancer. Female/male glandulars are contraindicated in cancers of the reproductive organs. Korean ginseng should not be taken in high quantities, however; only small amounts are included in this synergistic formula.
Ingredients: Each 2 Tablets Contains: Vitamin A (as beta carotene) 2500 IU 1500 mcg, Vitamin B-6 (as pyridoxine hydrochloride) 20 mg, Calcium (as chelate) 20 mg 30 mg, Iodine (as kelp) 40 mcg, Magnesium (as chelate) 8 mg, Manganese (as chelate) 3.5 mg. Proprietary blend 955 mg* of: Lung (bovine), Thymus (bovine), Pancreas (bovine), Duodenum (porcine), Spleen (bovine), Kidney (bovine), Stomach (porcine), Rutin, L-Tyrosine, Asian Ginseng (root), Pleurisy (root), L-Cysteine (as hydrochloride), Black Currant Seed Oil, Uterus (bovine), Prostate (bovine), Whole Pituitary (bovine), L-Glycine, Yellow Dock (root), Uva Ursi (leaf), Blue Cohosh (root).
Vegetarian: No
Suggested Dosage: 2 tablets daily or as directed
Pack: 120 Tablets
Product:

Core Level Thyro (1618)

Supportive Function: Nutritional support of the thyroid, this compound contains iodine.
Ingredients: Vitamin E (as succinate) 60 IU, Ribofl avin 7 mg, Niacin 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 40 mg, Folate (as folic acid) 400 mcg, Pantothenic Acid (as calcium pantothenate) 15 mg, Iodine (as kelp) 100 mcg, Magnesium (as chelate) 10 mg, Manganese (as chelate), 300 mg. Proprietary blend 615.5 mg* of: Horsetail (herb), Burdock (root), Dong Quai (root), Skullcap (herb), Almond (meal), DL-Methionine, L-Glutamine, Black Currant Seed Oil, L-Ornithine (as hydrochloride), Choline (as bitartrate).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Digest Plus (T-50)

Supportive Function: A herbal tincture to support the upper G.I. and pancreas.
Contraindications: Medicinal amounts of any herb should only be taken under the supervision of a licensed professional. Some herbs in large amounts are contraindicated in certain conditions or with certain drugs, for instance: hawthorn berries and ACE inhibitors/digitalis-like drugs, Eleuthero and hypertension, and ginger/pau d\'arco and anticoagulant drugs such as coumadin.
Ingredients: Pure tincture extract of: Ginger (root), Blessed Thistle (herb), Fenugreek (seed), Red Beet (root), Dandelion (leaf), Dandelion (root), Slippery Elm (bark), Pau D’Arco (bark), Red Clover (fl ower), Marshmallow (root), Hawthorne (fruit), Star Anise (seed), Cayenne (fruit), Eleuthero (root), Gotu Kola (herb), Wood Betony (herb).
Vegetarian: Yes
Suggested Dosage: 5-20 drops in water or as directed
Pack: 1 oz Herbal Tincture
Product:

DIM Renew (2810)

Supportive Function: To promote the balance of male and female organs (particularly breast, uterine and prostate) and hormonal health, while supporting the immune system, cell regulation and liver function. When is DIM Support helpful? Hormonal Health, Sleep, Brain Function, Immune Activity, Gene Regulation.
Clinical Applications Research: DIM is a strong product that was formulated to promote the balance of male and female organs (particularly breast, uterine and prostate ) and hormonal health, while supporting the immune system, cell regulation and liver function. Metabolized estrogen by-products can have oxidative effects in the body. DIM (Di-Indole Methane) , one of the best antioxidant ingredients in cruciferous vegetables, detoxifies estrogen by-products properly, and encourages a healthy balance of the right estrogens and their metabolites. Synergistic factors in DIM RENEW boost the effect of DIM and contribute to the energetic influence in many areas, including sleep, brain function, immune activity, gene regulation etc. Each Tablet Contains: Proprietary blend 390 mg* of: DIM (diindolylmethane), Olive Leaf Extract (20% oleuropein), Green Tea Extract (decaffeinated), Calcium D-Glucarate, Lecithin (sunflower), Broccoli Sprouts (4% sulforaphane), Grape Seed Extract (95% proanthones), Mangosteen (90% xanthones), Apigenin. Estrogen needs to be in balance for optimal health. Excess estrogen has a place for beneficial effects in the body, but it can get out of balance with other hormones easily and the estrogen metabolites can get out of balance very easily as well. This can be responsible for sluggish metabolism, fatigue, weight gain, mood swings, bloating, occasional sleeplessness, decreased sex drive, etc. Without trying to oversimplify, there are “good” estrogens and “not so good” estrogens (considering side effects), and while you do not want total estrogen to be out of balance with other hormones, particularly progesterone and testosterone, the ratios of these estrogens and their by- products is critically important. Inflammation and Oxidation pathways have a detrimental effect on these ratios, so it is important to keep optimal ratios of estrogen and its metabolites. Estrogen methylation is an important step involved in beneficial estrogen mechanisms, and also in successful detoxification of oxidative estrogen metabolites. The Lowdown on Estrogens: E1 (Estrone); E2 (Estradiol); and E3 (Estriol) Estrone (E1) is not considered a “good” estrogen. It is derived from the hormones that are stored in body fat and is found in increased amounts in postmenopausal women. Estrone is similar to estradiol but is much weaker in its effects. Estrone is rarely used in estrogen replacement therapy. Estradiol (E2) is the strongest estrogen believed to be responsible for most of the side effects/risk factors, and a lot of the benefits (mostly for bones, the cardiovascular system, relief of menopausal symptoms) that are attributed to estrogen. Estradiol is made in the ovaries and is the principal estrogen found in a woman's body during the reproductive years Because of the down side of estradiol, it is considered not the best estrogen; functional health focuses on achieving balance of estradiol (and estrone) with the “good” estrogen, E3 (Estriol). Estriol (E3) is considered the “good” estrogen; estriol is much weaker than estradiol and in fact is the weakest of the three major estrogens. It is 1,000 times weaker in its effect on breast tissue. Estriol is the estrogen that is made in large quantities during pregnancy and has potential health properties. Estriol derives a lot of its benefit from blocking estrone (for instance occupying the estrogen receptor sites on the breast cells), and for helping to achieve good ratios of the three estrogens, and also good ratios of the metabolites of the estrogens. Vegetarians and Asian women are known to have high levels of estriol. Estriol is the estrogen that may be most beneficial to the vagina, cervix and vulva. Many people believe that relatively higher levels of estriol should be sought after, and that the higher levels are beneficial for achieving an optimal health profile (especially concerning hormone balance) while providing some of the symptomatic benefits as well. Bioidentical estrogen therapy involves a higher ratio of estriol to estradiol for this reason (usually 80:20). Bottom Line for Type of Estrogen: You want a healthy balance of estriol without an overload of either estradiol or estrone. The Estrogen By-Products or Metabolites: The other critical factor needing to be in balance is the metabolites of the different estrogens. The hydroxyestrones or methoxyestrones are metabolites of these estrogens, (which for simplicity will just be referred to by their numbers, 2, 4 and 16), determine a health profile, backed by a lot of research. Again, without trying to oversimplify, 2 is referred to as a good metabolite, 16 is not so good, and the 4 depends on whether it’s methoxy (good) or hydroxy (fairly innocuous). High levels of 4 hydroxy can cause issues, so low levels of 4 hydroxy are best. The ratio of one metabolite over the other represents the relative dominance of one pathway over the other and is believed to be modifiable by diet. The main ratio is represented as the 2/16 ratio. It has been hypothesized that women who have a higher estrogen metabolite ratios (high 2/16) tend to be healthier. Bottom Line for Type of Metabolite: You want a higher number for 2 and a lower number of 16, and a higher ratio overall of 2:16 to be considered in the healthiest profile group. Aromatase , or “estrogen synthase”, is an enzyme that catalyzes the last steps of estrogen biosynthesis from androgens (specifically it transforms androstenedione to estrone (bad) and testosterone to estradiol (bad, especially for men). So aromatase is bad, and aromatase homeostasis is good. Some natural ingredients have the power to affect this enzyme, and that is a good thing. When the following ingredients are described as affecting aromatase, the description means that they help to maintain a favorable balance of estrogens and their metabolites. Low Testosterone: High aromatase activity converts too many androgens to estrogens, and can be responsible for throwing off the homeostasis of testosterone balance. This is important for both males and females. SUPPORT CATEGORIES: DIM Renew is great support for: estrogen and estrogen metabolite balance, testosterone balance; breast health; uterine health; prostate health; healthy female and male function; premenopausal symptoms; menopausal symptoms. DIM , or di-indole methane, is one of the biggest reasons we get encouraged to eat our cruciferous vegetables. This nutritional ingredient is well known for its health properties and its ability to facilitate liver clearance of oxidizing substances (including estrogenic metabolites); these metabolites can be epigenetic influences. DIM provides powerful natural support for healthy, balanced estrogen/estrogen metabolite ratios. Olive Leaf Extract (20% oleuropein) is one of the most powerful antioxidants available. Olive leaf is extremely effective against oxidation. It is a putative secretagogue of Glucagon-like peptide-1 (GLP-1), which means that it mimicks the action of an intestinal peptide involved in glucose regulation. It also has a stimulatory effect on the thyroid. Green Tea Extract (decaffeinated) is another powerful antioxidant. The research supports the theory that green tea extract (GTE) is a key ingredient for healthy cell cycle regulation (Hu G. et al. 2014). GTE has been studied for many years, and found to be excellent support for cell cyclye regulation in a wide variety of tissues, including breast, prostate, uterine, genito-urinary, etc.; green tea affect cell cycle signaling pathways. Z. Wang et al. 2013 point out that a number of nutraceuticals serve as candidates for development of agents “because of promising epidemiological, preclinical and pilot clinical findings,” adding that their mechanisms of action may involve an ability to target multiple molecular pathways without eliciting toxic side effects. Green tea extracts have been discovered to decrease the expression of genes (epigenetic influence) that promote dysregulated cell cycles (Mineva ND. et al. 2013) . Calcium D-Glucarate is the calcium salt of D-glucaric acid, found in high concentrations in cruciferous vegetables. Supplementation of calcium D-glucarate has been shown to inhibit beta-glucuronidase. Beta glucaronidase is an enzyme responsible for releasing estrogen into the system after it has already been conjugated (not a good thing). High levels of this enzyme are associated with unbalanced estrogen levels. Calcium D-glucarate helps to maintain a good balance of this enzyme, and contributes to estrogen metabolism regulation. Lecithin is an emulsifier that is beneficial for increasing the absorption and bioavailability of many nutrients. Lecithin has been researched for its favorable effect in supporting prostate health. Broccoli Sprouts (4% sulforaphane) have been noted by Gerhauser (2013) as being a strong epigenetic influence for induction and translational areas, and that the influence on oxidative pathways (among others) makes broccoli sprouts an interesting candidate for future research. Sulforaphane (contained in broccoli sprouts) may exert its effect in part via epigenetic modifications of the Nrf2 gene (a key regulator of cellular antioxidant defense systems), with subsequent induction of its downstream anti-oxidative stress pathway. Grape Seed Extract (95% proanthones) has a high concentration of proanthocyanidins and is believed to keep aromatase expression in homeostasis. Its high antioxidant activity makes it a helpful addition for regulating everything involved with oxidative pathways. Ting, H. et al (2014) suggest that grape seed extract is one of the promising botanical extracts to support prostate health. A meta-analysis by Carlson, S. et al (2008) listed grape seed extract and its high phenol content to have several beneficial effects on metabolic homeostasis. Mangosteen (90% xanthones), favorably affects aromatase homeostasis. Shen Q. (2014) note the favorable affect on Nrf2 (antioxidant power) that mangosteen brings about, to support healthy cell environments. Apigenin is one of the citrus bioflavonoids; it has high antioxidant activity, and it can be very helpful in creating a healthy cellular environment. Apigenin also helps maintain healthy uric acid levels. It is also believed to have a favorable effect on central noradrenergic, dopaminergic and serotonergic activities. Apigenin is another nutrient believed to contribute to normal cell cycle regulation and an optimal health risk profile.
Contraindications: None known
Ingredients: Propriety blend 390 mg* of: Dim (diindolylmethane), Olive Leaf Extract (20% oleuropein), Green Tea Extract (decaffeinated), Calcium D-Glucarate, Lecithin (sunfl ower), Broccoli Sprout (4% sulforaphane), Grape Seed Extract (95% proanthones), Mangosteen (90% xanthones), Apigenin.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Disc-Zym (1475)

Supportive Function: Disc-zym is an exciting two-phase proteolytic enzyme and mineral formula that technologically addresses two separate phases of digestion (stomach and small intestine), in order to optimize absorption and assimilation of nutrients necessary for support of healthy spinal discs and optimization of flexibility and movement. When is Disc Support helpful? Back, neck and shoulder pain, laxity of ligaments, disc injury, ligament support; difficulty holding adjustments, TMJ problems.
Clinical Applications Research: Calcium (as ascorbate) and Magnesium (as aspartate): Calcium and magnesium act synergistically in hundreds of reactions in the body, and they must both be respected and taken in balance. As important as calcium is in muscle function, the contraction-relaxation phase cannot operate without magnesium. Bones also need healthy balances of both calcium and magnesium. Manganese (as aspartate): Principle uses include: trauma and injury (sprains and strains), inflammation, ligament support, osteoporosis, epilepsy and diabetes. Manganese is an important component of Manganese Superoxide Dismutase (MnSOD), which is an enzyme that battles the damaging free radicals that cause swelling. Immediately after trauma, the body starts coding for more MnSOD to be produced (J Biol Chem. 1992; 267:10625-30) . Repletion of manganese after inflammatory trauma is necessary to keep up the free radical defense system. Recent research has shown MnSOD to be an efficient anti-inflammatory agent in models of acute and chronic inflammation; administration has decreased swelling up to 50-70% (Free Rad Res Comm. 1991: 15:297-301) . In another study, “MnSOD at 5 micrograms produced a significant suppression (44% p<0.05) in knee joint swelling at 24 hours... “These findings support a therapeutic potential of MnSOD in inflammatory disorders...” (Free Rad Res Comm. 1993; 18:291-8) . Low levels have been found in epileptics/diabetics. Enzymes: Enzymes have been shown to be helpful for inflammation and injury when taken away from meals, and for digestive problems when taken with meals.
Contraindications: Avoid at least one week prior to, and one week after, surgery.
Ingredients: Each Tablet Contains: Phase One: Calcium (as ascorbate) 30 mg, Magnesium (as aspartate) 8 mg, Manganese (as sulfate) 35 mg. Phase Two: Proprietary blend 107 mg* of: Bromelain, Papain, Trypsin, Chymotrypsin (as trypsin).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Diu-Plus (1530)

Supportive Function: Natural Diuretic With Potassium Vitamin-rich herbs, along with vitamin B-6 and kidney concentrate. DIU-Plus replenishes the valuable mineral potassium.
Contraindications: Alfalfa contains L-canavanine, suspected in some allergic reactions.  Avoid if pregnant.
Ingredients: Each Tablet Contains: Potassium (as sulfate) 70 mg, Vitamin B-6 (as pyridoxine hydrochloride) 15 mg. Proprietary blend 650 mg* of: Dandelion (root), Alfalfa (leaf, stem), Fennel (seed), Horsetail (herb), Celery (seed), Uva Ursi (leaf), Kidney (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Drainage D-Tox Lymph (Homeopathic) (0157)

Supportive Function: Water-Based Tri-Potent Sublingual Spray Facilitates drainage and removal of toxins, impurities by way of lymphatic system.
Contraindications: None known.  WARNING: STOP USE AND CALL A DOCTOR IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN.
Ingredients: Active Ingredients: Contains equal volumes of each ingredient in 10X, 30X, and 100X potencies. Belladonna, Calcarea Iodata, Conium Maculatum, Echinacea Purpurea, Hepar Sulphuris Calcareum, Kali Iodatum, Kali Muriaticum, Mercurius Vivus, Phytolacca Decandra, Pulsatilla, Ricinus Communis, Scrophularia Nodosa, Solidago Virgaurea, Sulphur Iodatum. Inactive Ingredients: Citric Acid, Potassium Sorbate, Purified Water.
Vegetarian: Yes
Suggested Dosage: 1 or 2 sprays under the tongue, or as directed
Pack: 1 oz Sublingual Spray
Product:

DSF Herbal (2728)

Supportive Function: The perfect supplement to be chosen in stressful times! Vitamins, minerals, antioxidants and phytochemicals synergistically work together to support the various energy-producing systems of the body.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 30 mg, Ribofl avin 5 mg, Niacin (as niacinamide) 15 mg, Vitamin B-6 (as pyridoxine hydrochloride) 5 mg, Folate (as folic acid) 50 mcg, Vitamin B-12 (as cyanocobalamin) 50 mcg, Pantothenic Acid (as calcium pantothenate) 15 mg, Zinc (as chelate) 0.500 mg, Chromium (as chelate) 50 mcg. Proprietary blend 306.4 mg* of: Lemon Biofl avonoids, L-Tyrosine, Deglycyrrhizinated Licorice (root), American Ginseng (root), 5-Hydroxy Tryptophan, Chlorella (plant), Astragalus (root), Slippery Elm (bark), L-Glutamine, Pyridoxal-5-Phosphate, L-Taurine, L-Histidine, L-Glycine, L-Cysteine, L-Arginine, L-Methionine, Grapeseed Extract (seed), Lactobacillus Acidopholis, Lactobacillus Bulgaricus.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

DTX-A (T-47)

Supportive Function: A comprehensive formula to support the body during detoxification and dealing with free radicals.
Clinical Applications Research: Red Clover (10%): Anti-bacterial; cleanses and detoxifies the lymph and blood Cleavers (10%): A potent diuretic and lymphatic cleanser; often described as a blood purifier. Burdock Root (10%): Helps kidney function; cleanses the blood and helps the skin Garlic (10%): Antifungal, antiviral and broad spectrum natural antibiotic Wild Indigo: A lymphatic cleanser with anti-microbial properties. Yellow Dock Root: Detoxifies and purifies the blood Cayenne: Calms down inflammation and improves circulation Butternut Bark: Mild, but effective laxative; increases bile secretion Cascara Sagrada: Laxative Milk Thistle: Liver protector and regenerator Dandelion: Supports the liver and kidneys; helps eliminate toxins from the blood Echinacea: Immune system stimulant Red Beet Root: Aids liver, gallbladder and lymphatic function Uva Ursi: Used as a tonic and diuretic Gotu Kola: Blood purifier, glandular tonic and diuretic Blessed Thistle: Helps liver congestion
Contraindications: Do not take in pregnancy. Cascara sagrada is purgative and may be too powerful in high amounts for children or long-term use. Echinacea contains sugars in its cell membrane which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (I.e. 8 weeks on, 1 week off). High doses of garlic should not be taken with anticoagulant drugs (small amounts are used in this synergistic formula).
Ingredients: Red Clover, Cleavers, Burdock Root, Garlic, Wild Indigo, Yellow Dock Root, Cayenne, Butternut Root Bark, Cascara Sagrada Bark, Milk Thistle, Dandelion, Echinacea Purpurea, Red Beet Root, Uva-Ursi, Gotu Kola, Blessed Thistle, in an alcohol base.
Vegetarian: No
Suggested Dosage: 5-20 drops in water 3 times per day or as directed
Pack: 1 oz Herbal Tincture
Product:

E-Tocotrienols (1542)

Supportive Function: Helps maintain healthy cholesterol; works as an antioxidant; helps maintain and stabilize capillary walls and cell membranes; prevents proteins, lipids, hormones (such as pituitary, thyroid and adrenal hormones as well as the sex hormones), and other substances from being oxidized. When is Vitamin E and Tocotrienol Support Useful? Vitamin E and the tocotrienols are helpful in supporting the skin and heart health, and conditions either caused by free radical damage or resulting in free radical damage (including blood sugar maintenance and eyesight).
Clinical Applications Research: Vitamin E is involved in maintaining the integrity, function, and flexibility of all cell membranes. It stabilizes the cell membrane, which is a necessary feature for ensuring cell health. The natural, d-alpha tocopherol portion of vitamin E serves an important antioxidant function in the body, which means that it prevents free radicals (harmful substances with unstable electron structure) from attacking and damaging the cell membrane. There are also synergistic, naturally occurring tocotrienols (alpha, beta, gamma, and delta) that are members of the natural vitamin E family, which all contribute to the health benefits of this essential vitamin. This formula is boosted by rice bran, which additionally contains fiber, gamma-oryzanol and tocotrienols. D-Alpha Tocopherol (Alpha tocopherol is used synonymously with vitamin E in the literature) is the natural form of this major lipid antioxidant, and there are many reports in the literature of health benefits. Vitamin E and the Immune System: Vitamin E “was capable of restoring mucosal and systemic humoral immune responses to mature adult levels” after vaccine-induced immune depression (Enioutina EY, et al. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Vaccine. 2000 May 8;18(22):2381-93). Vitamin E is described as having a positive influence on age-related immune and inflammatory changes , and also as having an ability to reduce the suppressive factor (PGE2), (which is a pro-inflammatory factor and an immune-activating factor), and in fact, the researchers were quoted as saying, “Vitamin E reverses an ageassociated defect in T cells, particularly naïve T cells” (Wu D. & Meydani SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol. 2008 Oct;84(4):900-14) . This effect of vitamin E was also reflected in support for the upper respiratory tract, especially in the elderly. Vitamin E and the Eye: Several studies have found that micronutrients (including vitamin E) support the homeostasis of eye health, and slow down the onset and progression of age-related disruption of that homeostasis; also that vitamin E has specific potential to support retina health (Kowluru RA, et al. Arch Ophthalmol. 2008 Sep;126(9):1266-72). Additionally, antioxidative agents (including vitamin E) may play a role in keeping the eye in good health free from obstructive film (Nourmohammadi I, et al. Ann Nutr Metab. 2008;52(4):296-8). Vitamin E and the Nervous System: Vitamin E levels are decreased in nerve dysfunction. “Increased oxidative stress contributes to neuronal dysfunction... We investigated whether the pathological changes in (these) brains may also be present in peripheral tissues… These results suggest increased oxidative damage and decreased antioxidant capacity in peripheral blood” (there was also a significant correlation between oxidation and severity of nerve dysfunction ) (Chen CM, et al. Increased oxidative damage in peripheral blood correlates with severity... Neurobiol Dis. 2009 Mar;33(3):429-35). The Tocotrienols: While d-alpha tocopherol gets most of the limelight for its antioxidant properties, the tocotrienols are being researched for their synergistic and stand-alone properties. It has been suggested that the vitamin E research done only with the alpha tocopherol portion of vitamin E does not do justice to the properties of the vitamin. Besides the fact that the tocotrienols balance the alpha tocopherol portion of the vitamin E molecule and work in synergy with it, the tocotrienols have emerged as vitamin E moieties with functions in health and disease that are clearly distinct from that of alpha tocopherol. Tocotrienols possess powerful neural, lipid and cell-regulating properties that are often not exhibited by tocopherols. Current developments in vitamin E research clearly indicate that members of the vitamin E family are not redundant with respect to their biological functions” (Sen CK. Et al. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 2006 Mar 27;78(18):2088-98. Another study reported that tocotrienols “possess potent antioxidant activities”, and they additionally reported that they possess activity to promote a healthy, non-inflammatory cellular environment, probably by inhibiting substances like nitric oxide, cox 2, and NF-kappaB expression (Wu SJ, et al. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators…. Mol Nutr Food Res. 2008 Aug;52(8):921-9). Tocotrienols have been found to function as efficacious support for nerves and the nervous system (Das S, et al. …Palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H970-8). Another study confirms the neural support qualities of the tocotrienols, and reports that oral tocotrienol maintains brain neural health , and that “taken orally, tocotrienols are bioavailable to all vital organs” (Sen CK, et al. Tocotrienols in health and disease. Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728). Tocotrienols are reported to be useful in maintaining healthy cholesterol levels (Ajuluchukwu JN, et al. Comparative study of the effect of tocotrienols and -tocopherol on fasting serum lipid profiles … a preliminary report. Niger Postgrad Med J. 2007 Mar;14(1):30- 3) ; in providing heart support (Das S, et al. Cardioprotection with palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H970-8) ; and in guarding against biochemical and molecular changes associated with glucose maintenance (Kuhad A, Chopra K. Life Sci. 2009 Feb 27;84(9-10):296-301) .
Contraindications: Large doses of vitamin E are contraindicated with blood thinners (>1200 IUs).
Ingredients: Each Tablet Contains: Vitamin E (as d-alpha tocopherol) 125 mg. Proprietary blend 130 mg* of: Tocotrienols (mixed-alpha, beta, gamma, delta), Rice Bran (with naturally occurring tocotrienols).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Enzyme Forte (1476)

Supportive Function: Highly Active Pancreatin Enzymes Potent formula of highly active pancreatic enzymes (includes proteolytic enzymes). Proteolytic enzymes are naturally produced by phagocytes (white blood cells) during times of non specifi c infl ammation response in the body.
Contraindications: Do not take enzymes directly before or directly after surgery (for at least one week). They may prevent scar tissue from forming. Gradual dosage increase is recommended.
Ingredients: Each Tablet Contains: Chromium (as chelate) 3 mcg. Proprietary blend 550 mg* of: Pancreatin (porcine) (which supplies the naturally occurring enzymes): Chymotrypsin (Trypsin) Protease, Lipase, Amylase.
Vegetarian: No
Suggested Dosage: 1-2 tablets daily between meals or as advised
Pack: 100 Tablets
Product:

F-Complex (1495F)

Supportive Function: F-complex provides a comprehensive formula of essential fatty acids in a favorable ratio. It includes sources of linoleic acid, omega 3 fish oils, and alpha-linolenic acids. Getting the right balance of essential fatty acids, although challenging in this day and age, is vital to the health of organs and tissues, especially skin. Fatty acids are building blocks for hormones and cell membranes and precursors for the highly active prostaglandins. When are Essential Fatty Acids helpful? Inflammation, skin conditions (psoriasis, eczema and dermatitis), allergies, heart disease, hypertension, premature aging, autoimmune disorders, ulcerative colitis, neonatal development, arthritis, immune impairment, PMS, reduced sex drive, menopause and fibrocystic breast disease.
Clinical Applications Research: Cardiovascular: Fish oil (omega-3/n-3) seems to have many beneficial effects on the cardiovascular system. In fact, "The mechanisms by which dietary n-3 fatty acids might modulate the morbidity and mortality from coronary heart disease have been related to their effects on plasma lipids and lipoproteins, eicosanoid metabolism, and platelet-endothelial cell interactions. In addition, more recent studies have shown positive effects on myocardial function and blood pressure" (AJCN 1993; 57:634) . Since fish oil does thin the blood, it may increase risk of stroke from hemorrhaging. Gastro-Intestinal Complaints: The effect of fish oil on ulcerative colitis was investigated in 87 patients. Treatment with fish oil resulted in, "measurable clinical benefit" - They suggested fish oil could also be working by a beneficial effect on cytokines, by scavenging free radicals, and by increasing intestinal mucosal surface area. Additionally, they noted that fish oil is used as a treatment for a variety of chronic inflammatory disorders (NEJM 1996; 334:1557-1560) . Brain/Visual Development: Artificial formulas, unlike human milk, do not contain any long-chain polyunsaturated fatty acids (PUFA’s). The PUFA’s found in fish oil, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are an example of very long chain PUFA’s. Their high degree of unsaturation is needed for membrane fluidity. Arachidonic acid, along with DHA, is an essential requirement for proper brain function, especially in the fetus and neonatal subject. Immune System: Fish oil may very well have an important role to play in reducing the incidence of autoimmune diseases, because it can inhibit the inappropriate expression of certain molecules on the cell surface (MHC class II) that are involved with initiating autoimmune disease.
Contraindications: Since fish oil does thin the blood, large doses may increase risk of stroke from hemorrhaging. Fish oil has been used in combination with anticoagulant therapy; however, caution should be employed when larger doses are used. Hyperparathyroidism or sarcoidosis patients should avoid vitamin D supplementation. Hypercalciuria and hypercalcemia are usually not seen unless the daily dose exceeds 2400 IU. Medicinal amounts of any vitamin, mineral or specialty nutrient should only be taken with the advice of a trained licensed healthcare professional. If digestive upset is present, check gallbladder function and check for potential blockage of the bile duct.
Ingredients: Each Capsule Contains: Vitamin A (from cod liver oil) 1250 IU, Vitamin D (as cholecalciferol) 125 IU. Proprietary blend 785 mg* of: Cod Liver Oil, Flaxseed Oil, Safflower Oil.
Vegetarian: No
Suggested Dosage: 1 capsule daily or as directed
Pack: 90 Gelatin Capsules
Product:

Fem Plus (Tincture) (T-41)

Supportive Function: A formula to support the female reproductive system. When is Female Herbal Support helpful? Female problems including PMS, menopause, irregular menstruation, ovarian or uterine problems, infertility problems, sexual desire
Clinical Applications Research: Chaste-Tree (plant): Stimulates the pituitary and increases progesterone production; helpful in PMS and menopausal symptoms. Wild Yam Root (root): Contains hormonal precursors, especially progesterone and other cortical steroids; balances entire endocrine system. Dong Quai (root): Helpful in PMS and menstrual irregularities; Herbalists refer to dong quai as the female ginseng for its ability to bring a proper balance to the female hormones. Its hormone balancing properties make it a valuable therapy for women coming off oral contraceptives and for many other female conditions. Black Cohosh (root): Black cohosh is most widely used in combinations for female conditions because of its natural estrogen properties. When combined with other relaxing herbs (i.e. scullcap, valerian, passionflower, and wood betony), black cohosh has a mild tranquilizing effect. Traditionally, black cohosh has been used for inducing the menstrual cycle, relieving cramping during menstruation and facilitating labor and delivery. Blue Cohosh (root): Blue Cohosh was used by the Indians to help dilate the cervix and promote rapid delivery during childbirth. Blue cohosh is effective in stopping false labor pains and although used to induce real labor, it isn’t effective unless the body is ready to go into labor. It is also effective in regulating the menstrual cycle and bringing on delayed or suppressed menstruation. Damiana (leaf): Enhances sexual activity; provides kidney support. Eleuthero (root): Supports the adrenals; natural aphrodisiac. Passion Flower (flower): Antispasmodic; helpful in anxiety. Raspberry (leaf): Uterine relaxant and helps with menstrual irregularities; helps prevent miscarriage. Cayenne (fruit): Enhances circulation and calms down inflammation. Dandelion (leaf): Liver and kidney support; eliminates toxins from the blood. Blessed Thistle (seed): Helps liver congestion commonly found with abnormal periods; Blessed thistle is a beneficial herb for amenorrhea (the absence of menstruation after the onset of menstruation), female hormone balance and improving the quality and quantity of milk in nursing mothers. Blessed thistle is often combined with other herbs (ginger, cramp bark, blue cohosh root, and false unicorn root) for menstrual problems. Other conditions relieved by the medicinal properties of blessed thistle include liver congestion, weak heart and lungs, circulation (takes oxygen to the brain and strengthens memory) and fevers. Suggested
Contraindications: Contraindicated in pregnancy. Eleuthero should not be taken in high quantities, however; only small amounts are included in this synergistic formula.
Ingredients: Ingredients: Pure Tincture Extract of: Chaste Tree (plant), Wild Yam (root), Dong Quai (root), Black Cohosh (root), Blue Cohosh (root), Damiana (leaf), Eleuthero (root), Passion Flower (flower), Raspberry (leaf), Cayenne (fruit), Dandelion (leaf), Blessed Thistle (seed).
Vegetarian: Yes
Suggested Dosage: 5-20 drops in water daily or as directed
Pack: 1 oz Herbal Tincture
Product:

GB-LIV (#3) (DH3)

Supportive Function: A whole host of nutrient-packed herbs are formulated together to support healthy liver and gallbladder function. When is Gallbladder Support helpful? Liver cleansing/support, gallbladder support/conditions, i.e. stones etc., bile flow enhancement, flatulence, and digestion, and chronic skin conditions.
Clinical Applications Research: Bayberry (bark): Bayberry bark alleviates liver and kidney problems, and can reduce fevers and intestinal parasites. It has medicinal properties similar to barberry; it relieves and prevents varicose veins, which are often caused by a sluggish liver (Heinerman, Heinerman's Encyclopedia of Fruits, Vegetables and Herbs, Parker Publishing Company, W. Nyack, NY, 1988, p. 22). Beet (root): Beets have been used since ancient times for medicinal purposes. Beets aid in gallbladder function, lymphatic function, and digestion (Balch JF and Balch PA, Prescription for Nutritional Healing, 1990 Avery Publishing, Garden City Park, NY, p. 39) . Red beet root has a powerful ability to present wastes to the liver (Dr. Ferenczi, Australian International Clinical Nutrition Review July 1986) . Additionally, the betaine in beets helps to convert cholesterol into bile acids and is important in fat metabolism (Heinerman, John. Heinerman's Encyclopedia of Fruits, Vegetables and Herbs, Parker Publishing Company, West Nyack, NY, 1988, p. 29-31). Betaine is listed in the Merck index as a hepatoprotectant (p. 1202). Yellow Dock (root): Yellow dock works on three of the major detox pathways: liver, blood and colon. It is an astringent (causing contraction of tissue). It is also a blood purifier, cooling and detoxifying the blood. It detoxifies the liver, and so is used frequently for jaundice. It stimulates bile and has a laxative action, relieving constipation without pain (Tierra L. The Herbs of Life. The Crossing Press, Freedon, Ca. 1992 pp. 82-83) . Yellow dock contains high amounts of natural iron and has been used to treat chronic skin complaints. Dandelion (root): Dandelion is an excellent liver remedy and has a high carotenoid content. "The plant was noted to have an almost specific affinity for the liver, modifying and increasing its secretion" (Weiner, M. Herbs that Heal p. 139) . Dandelion and fennel seeds are good, natural herbal cleansers, and a good source of calcium, phosphorus, and potassium. According to A. Leung, who reviewed several studies on dandelion, it, "...enhances the flow of bile, alleviating liver congestion, bile duct inflammation, hepatitis, gallstones, and jaundice. Dandelion ... has been clinically used to treat gallstones" (as cited in, Marti, J. & Hine, A. Alternative Health Medicine Encyclopedia 1995. Visible Ink Press, Washington, D.C. p. 84) . Dandelion is also a powerful diuretic. It is one of the best natural sources of potassium and replenishes this mineral, whereas other diuretics can deplete potassium. Fennel (seed): Fennel has a reputation for relieving gas and colic (Wild, R., ed.) The Complete Book of Natural and Medicinal Cures. 1994. Rodale Press, Emmaus, Pa. p. 277) . Fennel seed is a natural herbal cleanser, and a good source of calcium, phosphorus, and potassium. Peppermint (leaf): Peppermint leaf has reported value as being an anti-inflammatory, antimicrobial, and antiulcer agent. Its therapeutic properties include aiding with circulation, digestion, constipation, diarrhea, mental fatigue, and viral infections. Peppermint has a reputation for absorbing intestinal gas, calming an upset stomach, and preventing colic. Peppermint stimulates the contractions of the gallbladder to encourage bile secretion, and normalizes gastrointestinal activity (David B. Mowry, Ph.D. The Scientific Validation of Herbal Medicine. 1986. Keats Publishing, New Canaan, Conn, pp. 75, 192) . Ginger (root): In herbal literature, ginger has been touted as a digestive stimulant and has been used to improve weak digestion (Wild, R., ed). The Complete Book of Natural and Medicinal Cures. 1994. Rodale Press, Emmaus, Pa. p. 298) . Ginger tea taken 30 minutes before meals has been known to be helpful as a digestive aid. Ginger has been used for colitis, diverticulosis, gas, indigestion, vomiting, colon cleansing, and morning sickness. (David B. Mowry, Ph.D. The Scientific Validation of Herbal Medicine. 1986. Keats Publishing, New Canaan, Conn.). Ginger is an excellent carminative (a substance that promotes elimination of intestinal gas) and an intestinal spasmolytic (relaxes and soothes the intestinal tract). Ginger contains some of the most powerful anti-candida substances available (Duke, JA. Handbook of Medicinal Herbs. 1985. CRC Press, Boca Raton, FL) . Wild Yam (root): Wild yam root preparations have been long used to treat bilious colic (abdominal/colon discomfort associated with bile). It has been noted in some cases that the wild yam root rapidly and effectively reduced the pain of biliary colic caused by gallstones, and eased the passage of small stones (Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy. Eclectic Med Publ. Portland, OR. 1983) . Blessed Thistle (herb): Among the thistle's reported characteristics are that of appetite stimulant, indigestion and flatulence reliever, and antibacterial/anti-yeast/anti-tumor agent (Weiner, M.A. Herbs that Heal. 1994. Quantum Books, Mill Valley, Ca. p. 87) . Garlic (bulb): Garlic has had a reputation for centuries for being antibacterial, antiviral, and anti-inflammatory. There are many clinical trials that demonstrate its ability to lower cholesterol, triglycerides, and blood pressure, and its ability to favorably influence liver enzymes (Indian J Exp Biol 1992; 30(6): p. 523) . Garlic contains high amounts of sulfur and also contains bioflavonoids.
Contraindications: Do not take in pregnancy. Garlic in large amounts can have an interaction with anticoagulants (coumadin, salicylates, antiplatelet drugs, etc.) (The smaller amounts used in this formula should not pose a problem for contraindications). Similarly, ginger in large amounts is contraindicated with anticoagulants, however the smaller amounts in this formula should not be a problem.
Ingredients: Each Tablet Contains: Vitamin E (as succinate) 0.770 mg. Proprietary blend 465 mg* of: Bayberry (bark), Beet (root), Yellow Dock (root), Dandelion (root), Fennel (seed), Peppermint (leaf), Ginger (root), Wild Yam (root), Blessed Thistle (herb), Garlic (bulb).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 100 Tablets
Product:

GB-Plus (1545)

Supportive Function: GB-Plus is formulated to optimize the digestive process in the small intestine. Ox bile is combined with cleansing herbs that support liver/gallbladder detoxification and maintenance of the GI tract. When is Gallbladder Support helpful? Liver support, gallbladder support, bile flow enhancement, flatulence, and digestion, varicose veins, hemorrhoids and skin health.
Clinical Applications Research: Ox Bile: Bile is needed for the proper emulsification of fat. It breaks the fat into droplets so that pancreatic enzymes can digest it. Bile salts are usually needed to prime the biliary system for proper bile production in any gallbladder problem, and ox bile salts are an excellent source. Purified bile salts act as an excellent liver detoxifier in certain toxic states. “The bile acids in bile help keep cholesterol from becoming too concentrated and forming gallstones. A bile acid given in tablet form increases the bile acid concentration within the gallbladder, helping to balance cholesterol in solution (Larson, D, M.D., Mayo Clinic Family Health book. William Morrow and Company, Inc., N.Y., 1990, p. 662). Stone Root (root): stimulates, tones and cleanses the mucous membranes of the gastrointestinal tract. It is referred to in herbal literature as a “vascular astringent." In most patients with hemorrhoids or varicose vein problems, the patient has a congested liver. Bile salts are often combined with collinsonia for a synergistic and ameliorating effect. Radish (root): Radish is a detoxifying herb for the lymphatics and the bowel. It is especially helpful for the ileocecal valve, allowing efficient closing and opening of the valves. It is beneficial for constipation problems. Radish root is reported to support the gallbladder and the gastrointestinal (GI) tract valves. Red Beet (root): Beets aid in gallbladder function, lymphatic function, and digestion (Balch JF, Prescription for Nutritional Healing, p. 39) . Red beet root has been utilized for treating abnormal cell cycle regulation; this property may be due to betaine, the natural red coloring of the beet (Australian International Clinical Nutrition review July 1986, Dr. Ferenczi, as cited in: Heinerman, John. Heinerman’s Encyclopedia of Fruits, Vegetables and Herbs. Parker Publishing, West Nyack, NY pp. 29-31) . The powerful ability of red beetroot to present wastes to the liver when breaking up toxic assaults stresses the need to detoxify the liver and colon at the same time (ibid, p. 31) .
Contraindications: Biliary colic.
Ingredients: Each Tablet Contains: Thiamine (as hydrochloride) 2 mg, Riboflavin 2 mg, Niacin (as niacinamide) 5 mg. Proprietary blend 625 mg* of: Stone Root (root), Ox Bile, L-Glycine, Pepsin, Liver (bovine), Red Beet (root), Pancreas (bovine), Radish (root), Duodenum (porcine).
Vegetarian: No
Suggested Dosage: 1-2 tablets daily with meals or as directed
Pack: 90 Tablets
Product:

Ges-Cid (1460)

Supportive Function: HCL, important for digestion and bacterial protection, is combined with added plant digestive enzymes.
Contraindications: Do not take if ulcer is present.
Ingredients: Each Tablet Contains: Proprietary blend 200 mg* of: Choline (as bitartrate).
Vegetarian: No
Suggested Dosage: 1 tablet daily with meals, or as directed
Pack: 90 Tablets
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Glycan Renew (2816)

Supportive Function: Immune System, Multiple Organ Systems, Healthy Cell Proliferation and General Well- Being and Homeostasis (they are adaptogenic). When is Mushroom Glycan Support Helpful? Immune conditions, aging process, joint/structural issues, energy, and much more.
Clinical Applications Research: Coriolus Versicolor (high in PSK): Chu, K. et al. report that the a wide array of coriolus versicolor biological activities has been extensively demonstrated, including stimulatory effects on different immune cells (Chu KK, et al. Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values. J Clin Pharmacol. 2002 Sep;42(9):976-84). PSK (polysaccharide K) , one of the substances that can be extracted from Coriolus Versicolor has several properties that support immune cell activity and normal cell turnover. PSK is believed to be a strong antioxidant, a compound that blocks the action of free radicals (activated oxygen molecules that can damage cells). More than 2 dozen human studies of PSK have been reviewed by experts at the University of Texas, who concluded that PSK is excellent immune support. Researchers hoping to provide clear evidence of augmentation of immune responses demonstrated that PSK was “surprisingly active” (Ragupathi G, et al. Evaluation of widely consumed botanicals as immunological adjuvants. Vaccine. 2008 Sep 2;26(37):4860-5.) A systematic review and meta-analysis (a meta-analysis drawing from several randomized, placebo-controlled, double-blind trials is considered the strongest evidence to support a theory) assessed the efficacy of coriolus versicolor. After reviewing 13 of these clinical trials, findings showed that coriolus was a strong herbal support factor (Eliza WL, et al. Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87). Reishi Mushroom: has a multitude of benefits; it is known in ancient Eastern medicine as the "mushroom of immortality" and the "medicine of kings." Health issues mean that the body is out of balance, which is why an equilibrium-enhancing formula with an adaptogenic herb such as reishi in it can help in so many ways. Reishi’s high content of substances like sterols, ganoderic acids, coumarin, mannitol and polysaccharides support heart health and rhythms, including healthy cholesterol and triglyceride levels, and normal blood pressure. Reishi is good support for the liver, and is reported in the International Journal of Medicinal Mushrooms as a “wellknown traditional medicinal mushroom” that has been shown to have obvious beneficial effects on the liver (Wu X, et al. Int J Med Mushrooms. 2013;15(4):383-91). The International Journal of Medicinal Mushrooms also reports that “bioactive components found in the G. lucidum mushroom have numerous health properties” and is used to support liver health (Batra P, et al. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43). Reishi affects survival and proliferative signaling pathways that act on translation, and this method of action enhances its support effects (Suarez-Arroyo IJ, et al. PLoS One. 2013;8(2):e57431). Maitake Mushroom , described as immunomodulatory, is noted to have an effect on maintaining the homeostasis of normal blood sugar levels, which might be related to the fact that it decreases levels of factors that destroy pancreatic β-cells, such as oxidative stress” (Lei H, et al. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-81). Maitake was on a list from the Clinical Practice Committee of The Society of Integrative Oncology, of leading supplements that have “the best suggestions of benefit” when it came to recommending complementary therapies (Frenkel M, et al. Integr Canc Ther. 2013 Feb 25). One research group reported on the antioxidant and immunomodulatory effects of two of the polysaccharides in maitake, saying that the activity to support normal cell proliferation may result from the improved immune response (Bi Y, et al. Biological and physicochemical properties of two polysaccharides from the mycelia of Grifola umbellate. Carbohydr Polym. 2013 Jun 20;95(2):740-5). Scientists refer to maitake as a “high value medicinal mushroom”, and describe it as being popularly consumed, especially for supporting immune functions (Wu SJ, et al. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. Am J Chin Med. 2013;41(1):131-44). In one study, the bioactive compound ergosterol peroxide (EPO), found in maitake, was discovered to offer full protection against induced cell toxicity. Researchers concluded that EPO may play an important role in the immunomodulatory activity of maitake, by inhibiting both the production of pro-inflammatory mediators and activation of the NF-κB signaling pathway (Ibid, Wu) . Shiitake Mushroom: Researchers demonstrated that a novel polysaccharide from shiitake mushroom stimulates the differentiation of myeloid-derived suppressor cells (MDSCs) and supports homeostasis, shedding new light on developing strategies related to those cells (Wu H, et al. PLoS One. 2012;7(12):e51751). Shiitake is purported to have potent properties due to the presence of many bioactive compounds such as ergothioneine, and it has demonstrated an antioxidant activity “through the regulation of nitric oxide concentration and thiol redox status” (Zembron-Lacny A, et al. Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. J Physiol Pharmacol. 2013 Apr;64(2):249-54). In a clinical trial of 45 subjects, shiitake beta glucans increased the number of circulating B cells (Gaullier JM, et al. Supplementation with a soluble β-glucan exported rom Shiitake medicinal mushroom: a crossover, placebo-controlled study in healthy elderly. Int J Med Mushrooms. 2011;13(4):319-26). Activated hexose correlated compound (AHCC), derived from shiitake mushrooms has positive effects on dendritic cells, natural killer cell function and interleukin 12 production. It may also be affecting a systemic response by regulating the secretion of cortisol and norepinephrine (NE)  (Love KM, et al. A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis. J Trauma Acute Care Surg. 2013 Jun;74(6):1411-8). The researchers theorized that the immune function could be due, in part, to the effect on the stress hormones. Another potent ingredient in shiitake is lentinan. Lentinan , the backbone of β-(1, 3)-glucan with β-(1, 6) branches, is one of the active ingredients purified from shiitake mushrooms and “has been approved as a biological response modifier” in Japan. Lentinan supports the repair of DNA damage and lessens cell death that resides, at least in part, on “its ability to modulate the cellular antioxidant levels” (Attia SM. Et al. J Biochem Mol Toxicol. 2013 Jul;27(7):370-7). One publication noted that “These results suggest that lentinan exhibits intestinal support for gut inflammation activity through inhibition of IL-8 mRNA expression associated with the inhibition of NF-κB. (Nishitani Y, et al. Intestinal anti-inflammatory activity of lentinan: PLoS One. 2013 Apr 22;8(4):e62441). Cordyceps: WebMD describes cordyceps as a tonic and an adaptogen used to strengthen the immune system, increase energy, and support liver function (WebMD.com cordyceps overview). Modern applications for cordyceps include increased production of ATP, support for brain, heart, lung and mitochondria, heavy metal detoxification, and improving the integrity of the HPA (Hypothalamus/pituitary) axis, thus affecting the nervous system and supporting restful sleep (“this experiment can provide basic evidence that cordycepin may be helpful for sleep-disturbed subjects”) – (Hu Z, et al. Evid Based Complement Alternat Med. 2013;2013:840134). It possesses antioxidant properties, and is known for its ability to support kidney function (Yuan M, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 May;38(5):448-57). A study from Int Immunopharmacol states that many studies have shown that cordyceps sinensis has immunoregulatory activity in many models” (Shi B, et al. Int Immunopharmacol. 2009 May;9(5):582- 6). A study which noted that cordyceps has benefits in immunoregulation attempted to clarify some of the mechanisms by looking at the influence of cordyceps on gene expression in immature dendritic cells. They looked specifically at genes that participate in the adjustment of immune response and the regulation of cell proliferation and death. They discovered that cordyceps specifically regulates the gene expression of genes involved in the regulation of the focal adhesion pathway, ECM-receptor interaction pathway, and hematopoietic cell lineage pathway. When studied in combination with lipopolysaccharide, cordyceps affected genes that were significantly involved in the regulation of oxidative phosphorylation pathway (Kreb’s cycle) (Li CY, et al. Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment. PLoS One. 2012;7(7):e40824).  Lion’s Mane Mushroom is one of the mushrooms that are considered nutritionally functional foods and a source of physiologically beneficial effects. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is reported to be rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for immune support, lipid support, antioxidant support and nerve support. Lion’s mane has also been reported to have many other therapeutic potentials (Khan MA, et al. Hericium erinaceus: an edible mushroom with medicinal values. J Complement Integr Med. 2013 May 24;10).
Contraindications: High doses of mushrooms might increase the risk of bleeding in some people with thrombocytopenia. This product may lower blood pressure and/or thin the blood, which is ordinarily a good thing, however it means that caution should be exercised when on drugs that lower blood pressure or thin the blood, or if one has thrombocytopenia (clotting disorder).
Ingredients: Proprietary blend 725 mg* of: Coriolus Versicolor, Reishi Mushroom, Maitake Mushroom, Shiitake Mushroom, Cordyceps Sinensis, Lions Mane Mushroom, 1,3 Beta Glucans, Lentinan.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Hemo-Lyph (1550)

Supportive Function: Iron with Synergistic Factors Iron combines with protein and copper to make hemo- globin, the protein in the blood that is responsible for its oxygen carrying capacity. Iron is also necessary for the formation of myoglobin, which is the protein found in muscle tissue that is responsible for its red color, and its ability to store oxygen. Iron is a necessary co- factor in many reactions, including collagen synthesis. Supplementation may be useful to ensure an adequate supply of this important nutrient.
Contraindications: WARNING: ACCIDENTAL OVERDOSE OF IRON CONTAINING PRODUCTS IS A LEADING CAUSE OF FATAL POISONING IN CHILDREN UNDER 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. IN CASE OF ACCIDENTAL OVERDOSE CALL A DOCTOR OR POISON CONTROL CENTER IMMEDIATELY.    
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 300 mg, Iron (as peptonate) 20 mg, Thiamin (as hydrochloride) 10 mg, Riboflavin 10 mg, Niacin (as niacinamide) 10 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Folate (as folic acid) 400 mcg, Vitamin B-12 (as cyanocobalamin) 300 mcg, Biotin 10 mcg, Manganese (as chelate) 5 mg. Proprietary blend 226 mg* of: Liver (bovine), Spleen (bovine), Duodenum (porcine), Stomach (porcine), Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet per day or as directed
Product:

Homocysteine Redux (2707A)

Supportive Function: Homocysteine is a toxic substance, and is slowly reaching the ranks with cholesterol as a household word associated with risk for heart disease. Faulty pathways are suspect, and Homocysteine Redux was formulated to totally support every aspect of the biochemical reactions in the pathway. When the homocysteine pathway is facilitated and functioning correctly, SAM (S-adenosyl methionine) is produced to methylate brain neurotransmitters. Natural sulfur is also produced at the end of the pathway, providing a building block for joint/connective tissue. When are Homocysteine Nutrients helpful? Clinical applications include decreasing risk for heart disease; atherosclerosis (hardening of the arteries), thrombosis (clots), etc., vascular, ocular, and skeletal complications, osteoporosis, depression, Fibromyalgia, alcoholism, depression, diabetic complications, Parkinson’s, Alzheimer’s, multiple sclerosis, rheumatoid arthritis, schizophrenia, spontaneous abortion, and all complications of impaired sulfation pathways, i.e. sluggish liver detoxification, adrenal problems, joint cartilage degeneration.
Clinical Applications Research: B vitamins: Many studies have now shown that supplementation of particular B vitamins, most notably folate, B-6, B-12, and niacinamide, can protect the heart by lowering homocysteine levels. These B vitamins have major roles in the pathway of homocysteine metabolism, and supplementation seems to facilitate the clearance of this potentially harmful substance. Many studies have shown decreased homocysteine levels and decreased risk for heart disease with the consumption of these B vitamins (Science News 1998; 153:105; Rosenberg IH. Colloquium on Homocysteine, Vitamins, and Arterial Occlusive Diseases. Experimental Biology Conference, Atlanta, Ga. 1995). Vitamin E (as succinate): Vitamin E is associated with lower risk for heart disease. It is a powerful free radical scavenger that prevents oxidative damage, such as that caused by homocysteine damage. Trimethylglycine and Dimethylglycine: Trimethylglycine (betaine) can help facilitate the pathway so that homocysteine is metabolized correctly. It serves as a methyl donor, which means that it gives up some of its functioning groups to help another substance needing the methyl group for biological function, such as phosphatidylserine. Dimethylglycine also works to facilitate the pathway in the same manner. Cysteine: Cysteine is one of the by-products that should naturally be produced by homocysteine. It is an important amino acid, which needs to be in balance, and faulty pathways can compromise levels of this important amino acid. Beet (root): Red beetroot contains high amounts of betaine, which has proven to be successful in lowering homocysteine levels. Betaine stimulates one of the key enzymes in the pathway that makes homocysteine nontoxic. Red beets are liver cleansing and are high in proanthocyanidins. Molybdenum (as chelate): Molybdenum is an essential trace element that plays a role in three human enzymes. A decrease in the first two enzymes has no known clinical consequences, however the third enzyme is involved in sulfur reactions such as those in the homocysteine pathway, and consequences of a decrease in enzyme concentration can be very harmful. When MSM is supplemented long-term, it depletes the body of necessary molybdenum. Magnesium (as citrate): Magnesium is needed for many various enzyme reactions (it’s a cofactor in > 80% of the enzyme reactions in the body), including those of the homocysteine pathway. On its own, magnesium has been shown to lower blood pressure, relax smooth muscle, and improve heart/muscle function.
Contraindications: None known
Ingredients: Vitamin E (as succinate) 10 IU, Niacin (as niacinamide) 20 mg, Vitamin B-6 (as pyridoxine hydrochloride) 15 mg, Folate (as L-5 methyltetrahydrofolate) 275 mcg, Vitamin B-12 (as methylcobalamin) 200 mcg, Magnesium (as citrate) 16 mg, Zinc (as chelate) 1 mg, Selenium (as chelate) 15 mcg, Molybdenum (as chelate) 30 mcg. Proprietary blend 215 mg* of: Trimethylglycine, Beet (root), N-Acetyl Cysteine, Dimethylglycine, Choline (as bitartrate), Pyridoxal-5-Phosphate.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 180 Tablets
Product:

Hydroxo B-12 Lozenge (2834)

Supportive Function: Together with folic acid, cobalamins are essential cofactors required for DNA synthesis in cells, for maintaining the methylation cycle, for producing glutathione in detoxification, and for producing precursors for the citric acid cycle and energy production. When is Hydroxocobalamin Support helpful? The blood, digestive system, vision, and the nervous system.
Clinical Applications Research: Vitamin B-12 is a member of a group of vitamins called cobalamins. B-12 is a cofactor for many reactions in the body. It helps support the health of the blood, digestive system, vision, and the nervous system. Together with folic acid, cobalamins are essential cofactors required for DNA synthesis in cells, for maintaining the methylation cycle, for producing glutathione in detoxification, and for producing precursors for the citric acid cycle and energy production. The main dietary sources of vitamin B-12 are meat (especially liver), eggs, and dairy products. Given these food sources, vegetarians are at risk of inadequate B-12 levels. Only bacteria and archaea (single-celled microorganisms) have the enzymes required for the synthesis of B-12. Shortages commonly occur in adults as they age due to changes in absorption. In addition, genetic variations (or SNiPs) can lead to inadequate levels of this vital nutrient. The prevalence of these variations was determined by the American Journal of Epidemiology to affect an average of 46.9% of people in the United States. (Man-huei Chang, et. al, Am J Epidemiol. Jan 1, 2009; 169(1): 54–66.) With the presence of the genetic variations in the methylation cycle, the absorption of B-12 can be significantly reduced. (Watkins, David, and Rosenblatt, David S(Feb 2010) Vitamin B12: Disorders of Absorption and Metabolism. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0002267.pub2]). While there are many types of vitamin B-12 or “cobalamins,” only the following four are generally used as dietary ingredients.  Hydroxocobalamin  Cyanocobalamin  Methylcobalamin  Adenosylcobalamin All four are considered “Vitamin B-12”; however, choosing the correct one for a patient can be a critical decision as each one functions in different ways. Cyanocobalamin is probably most commonly used in supplementation. However, it may not be the best choice for some people. Cyanocobalamin is a cheaper form, but it requires a higher dosage for the same effectiveness as the active hydroxycobalamin. Cyanocobalamin must be converted in the liver to methylcobalamin or adenosylcobalamin before it can be utilized. Methylcobalamin is considered by many practitioners to be a good choice. It helps protect the nervous system by promoting nerve cell regeneration. People who get jittery from caffeine, coke, or tea may react better to Hydroxo B-12 than to Methyl B-12. Adenosylcobalamin (dibencozide), another highly-active form of vitamin B-12, is essential for energy metabolism and is required for myelin sheath formation and RNA/DNA synthesis which has been associated with maintenance of nerve and spinal cord health. Hydroxocobalamin is mainly produced by bacteria and can be converted in the body to useable coenzyme forms of B-12. Hydroxocobalamin is a unique form of B-12 that participates in detoxification and is a scavenger of nitric oxide. Hydroxocobalamin may be a preferred choice of B-12 for some because it is more highly protein-bound and therefore remains longer in the circulation. (Hall, Charles A., James A. Begley, and Pamela D. Green-Colligan. "The availability of therapeutic hydroxocobalamin to cells." Blood 63.2 (1984): 335-341). Methylation Methylation is a critical function in the body and one of the main ways the body detoxifies itself. One of the most important cofactors in the methylation process is cobalamin. Our exposure to environmental pollutants, excess consumption of sugars and caffeine, and stress in our lives will cause us to deplete our stores of this nutrient. The “methyl” group needed for this important process is supplied by methylcobalamin. However, for some people the hydroxo form of B-12 works better for them; the hydroxyl form of B-12, hydroxocobalamin, is able to slow the process down by incorporating an additional step in its conversion to methylcobalamin. Understanding the differing needs of individuals and their genetic patterns will go a long way toward determining the optimal form of B-12 supplementation to choose for your patient.
Contraindications: Vitamin B-12 is non-toxic. Being water soluble, excesses are excreted in the urine.
Ingredients: Vitamin B-12 (as hydroxocobalamin) 1000 mcg
Vegetarian: Yes
Suggested Dosage: 1 lozenge daily or as directed
Pack: 120 Lozenges
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Hypo-D (1470)

Supportive Function: The individual with insufficient acid secretion who is looking for additional HCL and digestive enzyme support might choose Hypo-D. When is Hydrochloride and Enzyme Support helpful? Digestive upset, burping and belching directly after meals, food allergies, osteoporosis, eczema, skin conditions caused by allergies.
Clinical Applications Research: Betaine (as hydrochloride): Hydrochloric acid (HCL) aids in phase one digestion in the stomach. HCL is necessary for protein digestion. It plays a key role in activating inactive precursor proenzymes (chymotrypsinogen and trypsinogen) to their active form (chymotrypsin and trypsin), which then start to uncurl protein in the stomach. It also maintains the acid environment of the stomach, which is necessary to prevent bacterial growth. Pepsin: Pepsin is a protein-digesting enzyme that is most active in a 1-2 pH environment. Pepsin is most helpful in the stomach as a digestive aid. Papain: Extracted from papayas, papain soothes the stomach and aids in protein digestion. Papain has been shown "to be effective in celiac disease patients by digesting the wheat gluten and rendering it harmless" (Murray and Pizzorno, Encyclopedia of Natural Medicine, Prima Publishing, Rocklin, CA, 1991, p. 54) . Pancreatin (porcine): Pancreatin is utilized in phase II digestion in the duodenum. Pancreatin refers to preparations of enzymes secreted by the pancreas. Pancreatic enzyme deficiency is said to be at the root of many degenerative diseases. Pancreatin is often used in treatment of indigestion, malabsorption and inflammatory conditions. "It converts not less than 25 times its weight of starch into soluble carbohydrates and not less than 25 times its weight of casein into proteoses (hydrolyzed protein) within 5 minutes" (Merck Index, Merck and Co., Rahway, NJ, 1989, p. 1581) . Pancrelipase (porcine): Pancrelipase is a pancreatic enzyme preparation with a high lipase concentration to improve fat digestion. Amylase: Amylase is a highly effective, carbohydrate-digesting enzyme. Bromelain: Bromelain is a highly effective, proteolytic (protein-digesting) anti-inflammatory enzyme extracted from pineapple. It is most active in the 5-8 pH range, which starts digestive activity in the duodenum. Ox Bile (bovine): Ox bile contains bile salts that act as excellent liver detoxifiers in certain toxic states. The bile acids in bile keep cholesterol from becoming too concentrated and thus forming gallstones. Studies show that bile extract supplementation stimulates bicarbonate secretion by the pancreas and duodenum (Gastroenterol. Clin Biol 1991; 15 (8-9): 574-9) .
Contraindications: Do not take in the presence of an ulcer. DO NOT CHEW
Ingredients: Each Tablet Contains: Phase One: Proprietary blend 410 mg* of: Betaine (as hydrochloride), Pepsin, LGlutamic Acid (as hydrochloride), Papain. Phase Two: Proprietary blend 277 mg* of: Pancreatin (porcine), Ox Bile (bovine), Pancrelipase (porcine), Amylase, Bromelain, Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily with meals or as directed
Pack: 90 Tablets
Product:

Immuno Plus (Tincture) (T-48)

Supportive Function: Immuno Plus provides complete immune system herbal support. When are Immune Herbs helpful? Immune conditions, colds, flu, fever, infection, and malaise due to lowered immune defenses.
Clinical Applications Research: Echinacea Purpurea (root): Acts as an immune system stimulant; antibacterial and anti-viral properties. Pau D’Arco (bark): Contains quinones, known to have anti-bacterial and anti-viral properties Cat’s Claw (root): Powerful immune stimulant. Garlic (bulb): Acts as broad spectrum antibiotic, antifungal and antiviral Cayenne (fruit): Calms inflammation and improves circulation; increases effectiveness of other herbs. Astragalus (root): The Chinese herbal (huang qi), or astragalus, has been used traditionally in Chinese medicine for viral infections. It is valued as a tonic for building resistance to disease. Parts commonly used include the root (which may be made into a tincture, fluidextract or powder). Astragalus is very high in trace minerals and micronutrients. Black Walnut (bark): Potent vermifuge. Suma (root): Energy tonic and adaptogen. Red Clover (flower): Assists in liver detoxification; potent blood purifier. Elderberry (fruit): Rich in vitamin C; immune support and blood purifier. Dandelion (root) and Dandelion (leaf): Supports the liver and kidneys; helps eliminate toxins from the blood.
Contraindications: Contraindicated in pregnancy. Echinacea contains sugars in its cell membrane, which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (i.e. 8 weeks on, 1 week off). Garlic and pau d'arco should not be taken in large doses with anticoagulant drugs (only small amounts are included in this formula).
Ingredients: Ingredients: Pure Tincture Extract of: Echinacea Purpurea (root), Pau D’Arco (bark), Cats Claw (root), Garlic (bulb), Cayenne (fruit), Astragalus (root), Black Walnut (bark), Dandelion (root), Dandelion (leaf), Suma (root), Red Clover (flower), Elderberry (fruit).
Vegetarian: Yes
Suggested Dosage: 5 - 20 drops in water per day or as directed
Pack: 1 oz Herbal Tincture
Product:

Iodine Rescue (1133)

Supportive Function: Iodine is one of the 14 essential minerals that are crucial to the growth and production of bones, teeth, hair, blood, nerves, skin, enzymes, hormones, etc. Iodine is also important for the healthy functioning of a multitude of biochemical processes, including hormonal balance but especially thyroid pathways; Iodine is incorporated into the thyroid hormones. Sufficient Iodine is essential to good health. Although the primary function of Iodine is in the production to thyroid hormones by the thyroid gland, many other organs require Iodine for optimal function. Iodine deficiency is associated with reduced mental performance, fibrocystic breast disease and breast cancer. Iodine is known as a potent antioxidant (References can be provided on request). It is estimated that 15% of American women are below the World Health Organization’s classification for Iodine sufficiency and this is a conservative estimate and almost one third of the world’s population lives in areas of iodine deficiency. The most recent trend in the US is a 50% reduction in urinary iodine excretion between 1970 and 1990. The RDA for iodine is 150 mcg/day, which pales in comparison with the daily average intake of 13.8 mg/day for the mainland Japanese population. The mainland Japanese consume on the average 92 times the US RDA and have reduced rates of many chronic diseases. In fact, the optimal iodine consumption level has never been determined; yet, the incidence of breast cancer is much lower in the Japan. In 1829 Jean Lugol, a French physician, discovered a method to dissolve iodine in an aqueous solution. This is known as Lugol’s solution and has been used for a myriad of maladies for more than 150 years. The collective experience of clinicians over this period led to a recommended daily amount of Lugol’s equivalent to be 12.5- 37.5 mgs, which so happens to be the recommended dosage to maintain whole body sufficiency using the recently developed iodine/iodide loading test.
Clinical Applications Research: FAQ About Iodine: Should I Take Iodide Or Iodine and In What Form, Liquid Or Tablets? Iodine and iodide are the same element and they are used interchangeably here, the only difference in the two is one electron. Dietary iodine is changed to iodide in the GI tract, and back to iodine in the cell. Potassium iodide (KI) is extremely bio available and has proven to be an efficacious supplement for iodine repletion. Liquid forms of Iodine/Iodide (Lugol’s) and of potassium iodide (SSKI) have similar efficacy, however, they may have a metallic taste, can stain clothing, may cause gastric irritation and can vary in accurate delivery. However, a tablet form consisting of potassium iodide (KI) (providing 76.45% iodine) is more precise and pleasant to ingest. Nutri-West’s Iodine Rescue has the advantage of being coated to pass by the taste buds without ill effect and will not stain clothing or cause gastric upset. Tablets travel more easily and do not cause problems with airport security. The RDA for Iodine Is 150 mcg: Don’t I Get Enough in My Diet? No, the iodine in salt is just enough to prevent goiter and severe mental retardation. Therapeutic doses are much higher. The mainland Japanese diet provides a daily average of 13,800 mcg: which is 92 times the RDA. In fact, in Europe, the RDA for iodine in cats is 150 mcg. Since bromine knocks iodine off receptors and it is prevalent in our environment (bakery items, hot tubs, i phones, etc.), it increases iodine deficiency. How Can I Determine a Clinical Deficiency in Iodine? A conservative estimate is that 30% of the general population is iodine insufficient. Some physicians report up to 90% of their patients showing insufficiency. Signs and symptoms of iodine deficiency include thyroid problems (both hypo- and hyper-), goiter, impaired immune system, etc. Iodine deficiency is associated with many conditions, including fibroids, fibrocystic breast disease, cardiac arrhythmias, adult onset diabetes, arthritis, weight imbalances, and many more. Can’t I Just Use the Iodine Skin Test Instead of the Iodine Load/Urine Test for Determining a Deficiency in Iodine? No, the skin test does not accurately assess body tissue stores; it reflects local absorption at that site. 88% of iodine applied to the skin will evaporate; only 12% is absorbed. “The iodine patch test is not a reliable method to assess whole body insufficiency for iodine. Many factors play a role in the disappearance of the yellow color of iodine from the surface of the skin… the iodine/iodide loading test is much more accurate” (Guy Abrahams MD) (10). Utilizing an Iodine Load/Urine Test provides documentation for patient records, for insurance, for protocol rationale, and for liability support (you must have a health practice to order the Iodine test). I’ve Heard That the Thyroid Prefers Iodide and the Breast Prefers Iodine. Multiple studies and clinical observations show that the efficacy of Iodide vs. Iodine is statistically the same regardless of the tissue involved. Can Iodine Deficiency Cause Estrogen Dominance? Yes. It is believed that estrogen receptors are more sensitive to estrogen when a person is iodine deficient. In fact, Stadel found that a diet low in iodine can lead to a hyperestrogen state with high estrone and estradiol and a low estriol to estrone ratio that can increase the risk for cancer. Other researchers report: “This paper reviews evidence showing iodine as an antioxidant and antiproliferative agent contributing to the integrity of a normal mammary gland. Seaweed is an important dietary component in Asian communities and a rich source of iodine. The high consumption of this element has been associated with the low incidence of benign and cancer breast disease in Japanese women. In animal and human studies, iodine supplementation exerts a suppressive effect on the development and size of both benign and cancer neoplasias. This effect is accompanied by a significant reduction in cellular lipoperoxidation. Iodine, in addition to its incorporation into thyroid hormones, is bound into antiproliferative iodolipids in the thyroid called iodolactones, which may also play a role in the proliferative control of mammary gland. We propose that an iodine supplement should be considered as an adjuvant in breast cancer therapy” (Aceves C, Anguiano B, Delgado G. Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):189-96). Some People Still Believe We Get Enough Iodine From Salt and Our Diet; How Do I Justify Using Larger Doses? The proof is in the pudding. A lab test conducted by an MD verifying iodine deficiency and clinical results/improved lab reports after supplementation speaks volumes. What About Allergies to Iodine? The American Academy of Allergy, Asthma and Immunology has issued a position statement on the rarity of a true iodine allergic reaction. They state that people who react to iodine-containing intravenous contrast material, skin preparations and shell fish are reacting allergically to a component other than the iodine (position statement, Feb. 24, 2004). What Are the Possible Side Effects? Dr. Guy Abraham clearly describes the known risk to iodine supplementation and reports that adverse effects are extremely uncommon if not non-existent in the doses in the ranges suggested here (14). Potential adverse effects related to iodide include: Thyrotoxicosis; iodine-induced goiter; brassy taste; increased salivation; coryza (symptoms of a head cold); sneezing; headache; mild acneiform lesions in the seborrheic areas. Since bromine toxicity is common (bromine replaced iodine in breads and other bakery items in the 70’s and most people are exposed to high levels), there may be symptoms of bromine detox. Detoxification consists of mobilization, binding and removal. Detoxes should always be monitored; if toxins are being bound and removed it should alleviate detox symptoms. If symptoms occur, reducing the dosage (reduces mobilization) and increasing nutritional support helps (Nutri-West’s Total Systemic D-Tox, Complete Glutathione, Complete Omega 3 Essentials 2:1 or Complete Hi-Potency Omega 3 Liquid are all good detox products). As with any protocol, if any ill effects are suspected, stop taking the product and check with your practitioner. Some Claim That the Relatively High Doses of Iodine Used In Orthoiodosupplementation May Lead to Hypothyroidism, Goiter or Other Thyroid Problems. “This just is not the case. A review of the literature revealed that the organic forms of iodine were involved in most of these complications (editor’s note: even though “organic” is usually a good thing, it is not when it comes to the form of iodine supplementation you want). Iodine intake has fallen over 50% in the U.S. over the last 30 years. During this same time, major increases in diabetes, hypertension, obesity, breast and thyroid cancer, and other thyroid disorders, have been reported. It appears to us that iodine deficiency, not iodine excess may be responsible for the increase of these conditions” (Dr. Guy Abraham, MD). Again, utilizing a Iodine Load/Urine Test can be helpful, and monitoring lab tests can help to document clinical improvement. Dr. Alan Gaby points out that absence of iodine side effects is most likely correlated to utilizing a comprehensive nutritional program. Suggestions have included nutrients such as vitamin C and magnesium (Nutri-West has C-1000 TR and Aspartic-Mag). See above question for diminishing effects due to bromine detox. What Are the Drug Interactions? Because of the high iodine content of the drug amiodarone, the thyroid gland is effectively saturated, thus preventing further uptake of isotopes of iodine. Supplementing with additional iodine is generally not warranted. Diuretics (like amiloride, spironolactone or triamterene) can raise potassium levels, and additional potassium may not be warranted. Are Some People Especially Sensitive to the Adverse Effects of Iodine? Technically it is correct to say that some will be especially sensitive, just as some people are more sensitive to vitamin C therapy. If someone is immune-compromised or toxic from excess bromine exposure for instance, they may be more susceptible to adverse effects. If there is any question, careful monitoring, individualized doses, proper follow-up visits and lab testing can help minimize adverse effects. What about Pregnancy/Breast-Feeding? There is a good review suggesting iodine supplementation in pregnancy (18), however, since there are limited studies, we suggest erring on the side of caution and avoiding in pregnancy and breast-feeding. What About Supplementing in Children? Most studies have not been conducted in children. As with those who are especially sensitive to the adverse effects of iodine, careful monitoring, individualized doses, proper follow-up visits and lab testing can help minimize adverse effects. What If I’m On Thyroid Meds? Once the body iodine stores are replete, a lower dose or complete cessation of the medication is possible (consult your physician). Lab tests are suggested for monitoring. What If TSH Levels Go Up? Please keep in mind that the need for more iodine symporters (to bring iodine into the cell) during iodine repletion can temporarily raise TSH levels (because TSH functions to increase the symporters). This can occur for up to six months after iodine supplementation, especially when the deficiency was more pronounced and should not be a concern when other lab parameters are normal.
Contraindications: See the relevant references in FAQs.
Ingredients: Each Tablet Contains: Iodine (as potassium iodide) 12,500 mcg. Proprietary blend 40 mg* of: Colloidal Silica.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed.
Pack: 90 Tablets
Product:

ISB Formula (1524)

Supportive Function: ISB has a collection of nutrients, which are all known for their reputed roles in supporting the immune system. Echinacea, Goldenseal, garlic, and suma all have phytochemically active constituents. The list of ingredients is expanded to include antioxidants, synergistic vitamins, and thymus glandular support. When is Immune Support helpful? Immune conditions, colds, flu, fever, infection, and malaise due to lowered immune defenses.
Clinical Applications Research: Vitamin A (as palmitate): Supports the mucous lining. It also appears to improve antibody response and white blood cell functions. Supplementary treatment of vitamin A is reported by some investigators to enhance antibody and cell-mediated immune response (Levis WR & Emden RG. Proc. Am Assoc. Cancer Res. (1976); 17:112; Cohen BE & Cohen IK. J. Immunol. (1976); 111:1376) . Vitamin C (as sago palm): Extra addition of vitamin C seems to boost the immune system by increasing cellular immune functions and stimulating neutrophils. Patients receiving 1 gram of vitamin C daily had improved neutrophil activity, resulting in a dramatic reduction of infectious attacks (Anderson, R. Int J Vitam Nutr Res. Suppl. 23:23-34, 1982; Patrone, R, Dallegri, F, Bonvivi, E, et al. Acta Vitaminol Enzymol. 4:163-68, 1982) . Vitamin E (as succinate): Vitamin E protects cells, including the cells of the immune system. Additionally, it seems to boost immune activity. "Vitamins E, A, C and carotenoids are able to protect cells and enhance humoral and cellular immune responses in disease" (Nockels, C.F. The role of vitamins in modulating disease resistance. 1988. Vet Clin North Am Food Anim Pract 4(3): 531-42) . B-Complex: The B vitamins help give us the energy to function. They are known as the "catalytic spark plugs" of the body; they catalyze many biochemical reactions because of their role as Co-enzymes. Zinc (as chelate): Zinc is necessary for the proper function of white blood cells (WBC’s) and the thymic hormones. Zinc helps prevent the age-related shrinking of the thymus (involution), and is especially effective in restoring depressed cell-mediated immunity in the elderly. Echinacea Purpurea (root): Echinacea is a natural herb that has been used for centuries as a medicinal agent, and in many scientific studies for its ability to enhance the immune system. It is known to stimulate macrophages and antibodies.
Contraindications: Do not take in pregnancy. Echinacea contains sugars in its cell membrane, which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (i.e. 8 weeks on, 1 week off). Goldenseal is contraindicated in pregnancy.
Ingredients: Each Tablet Contains: Vitamin A (as palmitate) 300 IU, Vitamin C (as sago palm) 150 mg, Vitamin E (as succinate) 70 IU, Niacin 10 mg, Vitamin B-6 (as pyridoxine hydrochloride) 15 mg, Folate (as folic acid) 165 mcg, Vitamin B-12 (as cyanocobalamin) 20 mcg, Pantothenic Acid (as calcium pantothenate) 55 mg, Zinc (as chelate) 0.300 mg. Proprietary blend 150 mg* of: Thymus (bovine), Superoxide Dismutase, Echinacea Purpurea (root), Garlic (bulb), Suma (root), L-Aspartic Acid, L-Cysteine (as hydrochloride), L-Ornithine (as hydrochloride).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 42 Tablets
Product:

K-B Plus (Tincture) (T-43)

Supportive Function: Kidney, bladder and urinary system support.
Contraindications: Caution in pregnancy. Echinacea contains sugars in its cell membrane which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (I.e. 8 weeks on, 1 week off).
Ingredients: Ingredients: Pure tincture extract of: Uva Ursi (leaf), Trailing Arbutus (root), Dandelion (leaf), Dandelion (root), Burdock (root), Marshmallow (root), Juniper (berries), Fo-Ti (root), Stone (root), Echinacea Purpurea (root), Barberry (root), Cayenne (fruit), Red Clover (flower).
Vegetarian: Yes
Suggested Dosage: 5-20 drops in water daily or as directed
Pack: 1 oz Herbal Tincture
Product:

L-Cysteine-S (1912F)

Supportive Function: Cysteine is an amino acid which uses its sulphur groups to conjugate certain toxins in the body and aid in their removal.
Contraindications: No known contraindications.
Ingredients: Each Tablet Supplies: L-Cysteine HCL 500mg
Vegetarian: Yes
Suggested Dosage: 1-2 tablets daily
Pack: 60 Tablets
Product:

L-Glutamine Plus (2100AF)

Supportive Function: Glutamine is the major fuel of the intestines and contributes to the metabolic processes that are necessary for restorative tissue repair. A healthy intestinal lining maximizes nutrient absorption, while acting as a barrier to foreign invaders. Glutamine is boosted with Lactobacillus and bifidus flora to support immune function, along with the antioxidant vitamin E and chlorophyll, which has a gentle, non-irritating action that is important in digestive well being. When is Glutamine helpful? Intestinal permeability (leaky gut), food allergies, acid reflux, Crohn’s Disease, ulcers, nausea, anorexia, muscle growth (weight lifters), athletic activities (buffers lactic acid), achlorhydria, surgery, trauma, cancer and other immune-challenged conditions, chemotherapy; General indications for repairing intestinal NSAIDS/drug damage, and/or any condition of the bowel, especially small bowel, requiring synthesis and healing of intestinal cells.
Clinical Applications Research: Glutamine: L-glutamine is the main fuel of the intestinal cells. It aids in tissue healing, maintains a healthy digestive tract, and effectively treats small intestine absorption problems. It is an integral amino acid needed for the synthesis of the mucoproteins present in the intestinal mucous secretions (Texas J Med 1957; 53:840-3) . Probiotics: Supports the gastrointestinal tract by replenishing the good bacteria.
Contraindications: High doses of glutamine are contraindicated in kidney disease.
Ingredients: Each Tablet Contains: Vitamin E (as succinate) 5 IU. Proprietary blend 573 mg* of: L-Glutamine, N-Acetyl Glucosamine, Chlorophyll, Alpha Lipoic Acid, Lactobacillus Acidophilus, Lactobacillus Bulgaricus, Bifidobacterium Bifidum.
Vegetarian: No
Suggested Dosage: 1 tablet daily taken on an empty stomach, or as directed
Pack: 90 Tablets
Product:

L-Tyrosine-S (1944F)

Supportive Function: Tyrosine is an integral precursor for important compounds, specifi cally thyroid hormones, and neurotransmitters such as dopamine, epinephrine and norepinephrine.
Contraindications: Should not be taken with MAO inhibitors.
Ingredients: Each Tablet Contains: L-Tyrosine 500mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

LB-CLN (#14) (Herbal) (DH14)

Supportive Function: A special blend of cleansing herbs chosen for optimal bowel function.
Contraindications: Contraindicated in pregnancy. Cascara sagrada is purgative, and may be too harsh for children. Ginger should not be taken in large doses with anticoagulant drugs (small amounts are included in this formula).
Ingredients: Each Tablet Contains: Proprietary blend 440 mg* of: Cascara Sagrada (bark), Bayberry (bark), Raspberry (leaf), Fennel (seed), Slippery Elm (bark), Cayenne (fruit), Ginger (root).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 100 Herbal Tablets
Product:

Liga-PN (1382)

Supportive Function: Amazing nutritional support for tissues damaged by injury and overuse, Liga-PN is a complex of soothing, calming herbs and nutrients. Liga-PN is a popular supplement often chosen by those affected by overworked muscles/ligaments. Great support for menstrual symptoms. When is Ligament Support and Calming Herbs Helpful? Tired/overworked muscles and ligaments, muscle spasms, headache, muscle/ligament discomfort, laxity of ligaments (helps hold an adjustment), menstrual symptoms.
Clinical Applications Research: Valerian (root): Valerian contains valepotriates, which seem to be active ingredients in calming the nervous system. White Willow (bark): White willow bark, or salicin, is the forerunner of acetylsalicylic acid. In ancient times, chewing on pieces of this bark were known to alleviate symptoms of discomfort without side effects. Skullcap (herb): Scullcap is a calming relaxing herb used for muscle and joint health Passionflower (herb): Passionflower is known for its calming effects. Bromelain: Extracted from pineapple, bromelain is an enzyme which "has therapeutic effects” in maintaining a calm cellular environment (Med. Sci. Sports Ex. 1992; 24:20-5) . Bromelain has been shown in many studies to aid the body's normal response to inflammation. Magnesium (as citrate): Magnesium has many roles in the body; one of the major roles is involved in muscle relaxation. Feverfew (herb): Feverfew is an herb that contains compounds called parthenolides, which support the expansion and contraction of blood vessels in the brain (Wild R, ed. The Complete Book of Natural and Medicinal Cures. 1994. Rodale Press, Emmaus. PA p. 295) . Calcium (as lactate): Calcium functions in many biochemical reactions, and is especially important for the contraction-relaxation phase of muscles. Magnesium acts synergistically with calcium in this phase.
Contraindications: Feverfew and ginger should not be taken in large doses with anticoagulant drugs (small amounts are included in this formula). Do not take during pregnancy.
Ingredients: Each Tablet Contains: Calcium (as lactate) 21 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Magnesium (as citrate) 30 mg, Manganese (as chelate) 1.5 mg. Proprietary blend 515 mg* of: Fever Few (herb), White Willow (bark), Shark Cartilage, Valerian (root), Passionflower (herb), Skullcap (herb), Turmeric (rhizome), Oregano (leaf), Thyme (leaf), Basil (herb), Ginger (root), Suma (leaf), N-Acetyl Glucosamine, Bromelain.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

LIV-GB Plus (T-42)

Supportive Function: Liver and gall bladder support.
Contraindications: Do not take during pregnancy. Garlic should not be taken in large doses with anticoagulant drugs (small amounts are included in this formula). Eleuthero should not be taken in high quantities, however, only small amounts are included in this synergistic formula.
Ingredients: Ingredients: Pure tincture extract of: Milk Thistle (seed), Dandelion (leaf), Dandelion (root), Red Clover (fl ower), Red Beet (root), Blessed Thistle (herb), Barberry (root), Garlic (bulb), Eleuthero (root), Burdock (root), Worm Wood (herb).
Vegetarian: Yes
Suggested Dosage: 5-20 drops in water daily or as directed
Pack: 1 oz Herbal Tincture
Product:

LNG-RESP (T-36)

Supportive Function: Supports lungs and respiratory system.
Contraindications: Caution during pregnancy. Eleuthero and hawthorn berries (in large amounts) are contraindicated in hypertension. Hawthorn berries (in large amounts) must be regulated when on ACE inhibitors or cardiac glycosides (eg. Digitalis), but are often given in combination with those drugs. Small amounts of these herbs are included in these formulas.
Ingredients: Ingredients: Pure tincture extract of: Pleurisy (root), Mullein (leaf), Lungwort (herb), Wild Cherry (bark), Slippery Elm (bark), Milk Thistle (seed), Chickweed (herb), Eleuthero (root), Hawthorne (fruit), Cayenne (fruit), Uva Ursi (root), Suma (root), Star Anise (seed), Marshmallow (root).
Vegetarian: Yes
Suggested Dosage: 5-20 drops in water daily or as directed
Pack: 1 oz Herbal Tincture
Product:

LV-Renew (2812F)

Supportive Function: LV Renew boasts a powerful combination of Milk Thistle (80% silymarin) with synergistic nutrients known for their ability to support liver function. N-Acetyl Cysteine raises glutathione, the body’s strongest antioxidant, the majority of which functions in the liver. Other ingredients, such as cordyceps sinensis, dandelion, burdock and green tea also contribute to the strength of the formula.
Clinical Applications Research: Milk Thistle Extract (80% silymarin) is a flowering herb native to the Mediterranean region. It has been used for thousands of years for many things, but historically it is utilized mostly for the support of liver function. Silymarin is a flavonolignan complex isolated from milk thistle (which also contains “silybin”) that has been called “cytoprotective” (cell-protective),” immunostimulatory”, “antioxidant”, and “hepatoprotective” (liver protective) by researchers (Gharagozloo M, et al. Immunomodulatory effects of silymarin in patients with β-thalassemia major. Int Immunopharmacol. 2013 Apr 26;16(2):243-247.) It is believed that silymarin exerts some of its effects through inhibition of free radicals and influence on inflammation. Scientists set out to assess liver function tests of 77 gas refinery workers chronically exposed to hydrogen sulfide gas before and after administration of silymarin (140 mg, three times per day for 1 month). A significant reduction of liver enzymes (blood AST, ALT and ALP) was observed after 30 days of consumption of silymarin. (Mandegary A, et al. Hepatoprotective effect of silyamarin in individuals chronically exposed to hydrogen sulfide; modulating influence of TNF-α cytokine genetic polymorphism. Daru. 2013 Apr 8;21(1):28.) Silibinin has been described as the most active component of the silymarin complex of flavonoids contained in milk thistle. According to Kostek et al. (2012), its mechanism of action is complex and highly beneficial for liver cells, blocking the penetration of various toxins into the hepatocytes. It decreases oxidative free radicals by increasing the activity of the enzymes superoxide dismutase and glutathione peroxidase, as well as by increasing the concentration of glutathione (the body’s well known and powerful antioxidant found mostly in liver). Silibinin strengthens and stabilizes the cell membranes, inhibits the synthesis of prostaglandins associated with the lipid peroxidation and “promotes regeneration of liver” through the stimulation of protein synthesis and effect on the production of new hepatocytes. “Clinical trials conducted in this respect are very encouraging. The other beneficial application of silibinin is in therapy of the alcoholic liver cirrhosis. The evidence shows that the use of silymarin leads to a significant reduction in liver-related mortality and even reduction in the number of patients with encephalopathy in the course of the disease. Application of silibinin goes beyond liver disease. What is interesting is the fact that this substance of herbal origin occurring in the environment is so strong, favorable, beneficial and multidirectional” (Kostek H, et al. Silibinin and its hepatoprotective action from the perspective of a toxicologist. Przegl Lek. 2012;69(8):541-3.) Blood Sugar : Milk thistle was one of the nutraceuticals determined to “be the most beneficial” when it comes to supporting glucose control (Lee T & Dugoua JJ. Nutritional supplements and their effect on glucose control. Adv Exp Med Biol. 2012;771:381-95.) Nerve Health : Researchers claimed that “Our data demonstrate that milk thistle extract can promote neuronal differentiation and survival, suggesting potential benefits of chemicals in this plant on the nervous system” (Kittur S, et al.Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture. J Mol Neurosci. 2002 Jun;18(3):265-9.) Cordyceps Sinensis has been used widely in traditional Chinese medicine (TCM) for centuries. WebMD describes cordyceps as a tonic and an adaptogen used to strengthen the immune system, increase energy, and improve liver function (WebMD.com cordyceps overview). Modern applications for cordyceps include muscle/athletic performance (increases production of ATP), brain, heart, lung and mitochondria support, heavy metal detoxification, and improving the integrity of the HPA (Hypothalamus/pituitary) axis, thus calming the nervous system and supporting restful sleep (“this experiment can provide basic evidence that cordycepin may be helpful for sleep-disturbed subjects” - Hu Z, et al. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evid Based Complement Alternat Med. 2013;2013:840134). It possesses antioxidant properties, and is known for its ability to help kidney function (“Cordyceps sinensis may protect against chronic hypoxia injury in diabetic nephropathy” - Yuan M, et al. Effect of Cordyceps sinensis on expressions of HIF-1α and VEGF in the kidney of rats with diabetic nephropathy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 May;38(5):448-57.) In a comprehensive two part review series that covered preclinical in vitro and in vivo studies, and open-label and double-blinded clinical trials on the respiratory, renal, hepatic, cardiovascular, immunologic, and nervous systems, and its effects on the immune system, glucose metabolism, and inflammatory conditions (Part I, which appeared in the Fall 1998 issue (4(3):289-303) , discussed effects on antisenescence, endocrine and sexual functions, atherosclerosis, hyperlipidemia, and free radicals) the reports were amazingly favorable in all categories (Jia-Shi Ahu et al. The Scientific Rediscovery of a Precious Ancient Chinese Herbal Regimen: Cordyceps sinensis Part II The J Alt Comp Med 1998;4(4):429-457.) A study from Int Immunopharmacol states that “many studies have shown that cordyceps sinensis has immunoregulatory activity in many disease models, but the underlying mechanism remains elusive.” Researchers tried to hypothesize about the underlying mechanisms with an experiment that altered T cell subsets in diabetes-prone mice. They discovered that the onset of diabetes was associated with an imbalance of regulatory T cells (cells that regulate and prevent overreactivity of the immune system) and aggressive T cells known as TH17 cells. When they administered cordyceps sinensis, it “resulted in reduction in the overall incidence of diabetes, and this was due to an increase in the ratio of Treg cells to Th17 in the spleen and pancreatic lymph nodes. Taken together, these data imply that cordyceps sinensis is able to modulate Treg to Th17 cell ratio in vivo...” (Shi B, et al. Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice. Int Immunopharmacol. 2009 May;9(5):582-6.) The major know effect of cordyceps is on the liver. In a rat study, researchers found that Cordyceps sinensis could “inhibit liver fibrogenesis derived from chronic liver injury, retard the development of cirrhosis, and notably ameliorate the liver function”; the possible mechanism involved inhibiting TGFbeta(1) expression, thereby preventing the deposition of procollagen I and III (Liu YK, Shen W. Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. World J Gastroenterol. 2003 Mar;9(3):529-33.) Nerve Health : Cordyceps was able to help when there was some impairment of the central nervous system; it reduced autonomic movements, and was able to increase the effects of sedatives (Jia-Shi Ahu et al. The Scientific Rediscovery of a Precious Ancient Chinese Herbal Regimen: Cordyceps sinensis Part II The J Alt Comp Med 1998;4(4):429-457.) N-Acetyl Cysteine is the main building block of the antioxidant glutathione. Since gastrointestinal absorption of the glutathione molecule is limited, administration of N-acetyl cysteine, as the rate limiting building block, is actually more effective at raising glutathione levels than administering glutathione because the N-acetyl cysteine is carried to the cells where glutathione is made internally. In fact, when someone suffers from acetaminophen (Tylenol) overdose, their symptoms are due to depletion of glutathione. However, the hospital standard of care is not to administer glutathione (due to poor absorption), the protocol is to administer N-acetyl cysteine, in order that the N-acetyl cysteine can be carried to the cells to make glutathione (Amathieu R, et al. Severe toxic acute liver failure: Etiology and treatment. Ann Fr Anesth Reanim. 2013 May 14.) In a model of rats prone to liver injury, those given N-acetyl cysteine showed a decrease in congestion, polymorphonuclear leukocytes, mononuclear leukocytes, vacuolar degeneration of hepatocytes, and hepatocellular necrosis. Researchers hypothesized that the antioxidant properties of N-acetyl cysteine were responsible for the favorable effect on liver health (Sahin S, Alatas O. The protective effects of n-acetylcysteine against acute hepatotoxicity. Indian J Gastroenterol. 2013 Mar 10.) N-Acetyl-Cysteine and Nerve Health/Inflammation : N-acetyl-cysteine demonstrated an effect on axonal sprouting in rats, leading scientists to speculate that there might be a therapeutic potential in the early treatment of traumatic spinal cord injury (Karalija A et al. Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. PLoS One. 2012;7(7):e41086.) Other researchers encourage “the use of N-actyl-cysteinefor the experimental treatment of inflammatory pain in humans.” (Bernabucci M, et al. N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors. Mol Pain. 2012 Oct 23;8:77.) Green Tea Extract (leaf) consists of several catechins, which include the well-known epigallocatechin gallate (EGCG). These catechins are rich in polyphenols and act as scavengers of reactive oxygen species (free radicals); their antioxidant activity is believed to function, in part, through modulation of transcriptional factors and enzyme activities. In PubMed, 168 studies pulled up under “green tea extract and liver” alone, attesting to the fact that green tea is a widely researched nutrient (especially in the animal model) for its “antioxidant and anti-inflammatory effects” (Cai Y, et al.Pathog Dis. 2013 Feb;67(1):76-83; Hodgson AB et al. Adv Nutr. 2013 Mar 1;4(2):129-40.) In animal studies, green tea catechins were found to stimulate liver regeneration and attenuate liver dysfunction (Saito Y, et al. Beneficial effects of green tea catechin on massive hepatectomy model in rats. J Gastroenterol. 2013 Mar 30). Green tea reduces lipid peroxidation and increases the activities of antioxidant enzymes, such as catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver. Reducing oxidative stress and increasing antioxidant enzymes may be mechanisms by which green tea is able to affect the deposition of collagen and fibrotic activity in the liver (Tsai CF, et al. The in vivo antioxidant and antifibrotic properties of green tea (Camellia sinensis, Theaceae). Food Chem. 2013 Feb 15;136(3-4):1337-44.) Green Tea and Nerve Health : Exogenously administered nerve growth factor (NGF) repairs injured axons, but it does not cross the blood-brain barrier. Therefore, scientists believe that agents with the ability to affect endogenous NGF would be of great utility for neurological injuries. An interesting study reporting that green tea polyphenols potentiated NGF demonstrated that the polyphenols, not one in particular, all “synergistically promoted this action”. This report suggested that the polyphenols of green tea extract in its entirety (not fractionated into a specific catechin) was more effective than fractionated polyphenols (separated into specific catechins such as EGCG) (J Neurosci Res. 2010 Dec;88(16):3644-55. Gundimeda U, et al. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species.) Dandelion (root) has a reputation for liver support and action as a mild diuretic. Mechanisms may include the effect of dandelion root on fibrotic activity, possibly mediated by “the inactivation of hepatic stellate cells and the enhancement of hepatic regenerative capabilities”, leading scientists to believe that there is enough scientific evidence to substantiate the traditional use of dandelion root in hepatic health (Domitrović R, et al. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. J Ethnopharmacol. 2010 Aug 9;130(3):569-77.) It’s believed that excessive oxidative stress contributes to the development of atherosclerosis-linked metabolic syndrome. According to one study, dandelion root can “protect against oxidative stress linked atherosclerosis and decrease the atherogenic index” (Ung-Kyu Choi et al. Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. Int J Mol Sci. 2010 January; 11(1): 67–78.) Dandelion has shown an effect on immune parameters, including cytokines and interleukins, being cited as improving “fatigue-related indicators and immunological parameters” (Lee BR, et al. Effects of Taraxacum officinale on fatigue and immunological parameters in mice. Molecules. 2012 Nov 7;17(11):13253-65.) Dandelion and Nerve Health : In a study reporting beneficial effects of a diet with added dandelion on lead toxicity (on rats) showed that the antioxidant property of dandelion was thought to be responsible for preventing absorption of lead into the brain and related damages (Food Chem Toxicol. 2012 Jul;50(7):2303-10. doi: 10.1016/j.fct.2012.04.003. Gargouri M, et al. Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn rats.) Burdock (root) , a perennial herb, has been cultivated for a long time as a popular vegetable. Burdock root improved activity of superoxide dismutase (antioxidant enzyme), lowered MDA (sign of lipid peroxidation) and dramatically reduced lipofuscin (a wear and tear pigment associated with aging) in rats (Liu S, et al. An experimental research into the anti-aging effects of Radix Arctii Lappae. To delve into the anti-aging effects and mechanism of Niubanggen (Radix Arctii Lappae). J Tradit Chin Med. 2005 Dec;25(4):296-9.) Burdock also suppressed the SGOT and SGPT elevations (liver enzymes) induced by toxic assault and alleviated the severity of liver damage based on histopathological observations in a similar study. Mechanisms of action included reversing the decrease in glutathione and P-450 normally induced by the toxic assault. The antioxidative effect was believed responsible for the beneficial effects on liver cells (Lin CC, et al. Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am J Chin Med. 2000;28(2):163-73; Lin CC, et al. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med. 1996;24(2):127-37.)
Contraindications: Some of the herbs in this formula may lower blood sugar levels. This is normally a good thing, but use caution with diabetes, hypoglycemia or drugs affecting blood sugar. This product contains natural blood thinners and should not be combined with blood thinning drugs. Not recommended in pregnancy/lactation.
Ingredients: Each Tablet Contains: Proprietary blend 700 mg of: Milk Thistle Extract (80% silymarin), Cordyceps Sinensis, Green Tea Extract (leaf), N-Acetyl Cysteine, Dandelion (root), Burdock (root)
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Lyso-Lyph-Forte (120) (1486F)

Supportive Function: A highly potent formula of specially prepared enzymes to support processes that clear cellular debris from the body to help maintain homeostasis and a non-inflammatory environment; supports arterial circulation. When are Proteolytic Enzymes helpful? Any site of trauma, joint support, the healing process, and wherever cellular debris needs to be cleared.
Clinical Applications Research: Proteolytic Enzymes (An overview of enzymes and support of clearing processes): In the normal inflammatory response, proteolytic enzymes are released from the neutrophils to clear toxic debris. During this time, toxic protein-containing material is released which can foster dysfunction unless it is removed. Neutrophils release proteolytic enzymes when they arrive at the scene, to break apart this toxic material and improve the cellular environment. This, “clean up process” helps rid the tissue of substances that prolong the normal response. Zinc (as gluconate) supplementation has been demonstrated to support immune function and lymphocyte activity in particular (Duchateau J et al, “Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects,” Am J Clin Nutr 1981; 34: 88-93; Fraker PJ et al, “Interrelationships between zinc and immune function,” Fed Pro 1986; 45:1474-9) . Zinc is an antioxidant and plays a role in the synthesis of the antioxidant enzyme superoxide dismutase (SOD). Zinc is necessary to maintain vitamin E levels and assists in the absorption of vitamin A. Zinc also participates in the promotion of glandular, reproductive, and immune system health (Balch & Balch, ibid: 45-46) . Zinc lozenges are reported to reduce the severity of symptoms in the common cold and to reduce the duration of the infection (Lininger S, Wright J, Austin S, Brown D, Gaby A, The Natural Pharmacy, Rocklin, CA: Prima Health, 1998: “Enzymes, Proteolytic”: 73) . Zinc is one of four minerals known to support the release of human growth hormone. Zinc is essential for the body’s protein synthesis, regulates the contraction of muscle, and is important in the formation of insulin. Zinc has been reported to support the healing process, growth parameters and mental alertness (Mindell E, Earl Mindell’s Vitamin Bible, New York: Warner Books, 1991:112, 94) . Pancreatin (porcine) and Chymotrypsin (as trypsin) are animal-based proteolytic enzymes that help the body digest proteins from food and other sources. When taken with food, proteolytic enzymes aid digestion in the intestines and lessen the demands of the body to supply enzymes to convert food into energy. Proteolytic enzymes can also be absorbed into the body when they are taken between meals. After absorption, proteolytic enzymes can assist and support the immune system’s defense mechanisms (Morley JE et al, Nutritional Modulation of Neural Function, UCLA Forum in Medical Sciences 28.San Diego, CA: Academica Press, 1988) . Partially digested protein molecules can enter the immune system where they can be treated as foreign antigens by the immune system. Antibodies combine with these antigens that pass through the gut barrier and form Circulating Immune Complexes (CICs) where they can trigger allergic reactions. CICs begin to accumulate in soft tissues where they cause problems and stress to tissues and organs. Pancreatic enzymes help break down CICs for elimination by the kidneys. Enzymes ingested for this purpose are taken between meals so they will not be used for digesting food. Proteolytic enzymes help digest other foreign proteins. After sports injuries, pancreatic enzymes are taken to support the healing process. Enzymes are also taken before sporting events as prophylaxis to support faster healing in case of injury (Deitrick RE, “Oral proteolytic enzymes in the treatment of athletic injuries: A double-blind study,” Pennsylvania Med J Oct 1965:35-7) . Pancreatic enzymes are used to digest the protein coat of foreign invaders and to help remove CICs produced as a byproduct of foreign invasion (Jaeger CB et al, “Polymer encapsulated dopaminergic cell lines as ‘alternative neural grafts,’ Progress in Brain Research 1990; 82: 41-6; Wolf & Ransberger, 1972) . Pancreatic enzymes have been shown to expose antigens on the surface of foreign cells so that the aberrant cells can be more easily recognized by the immune system as antigens for immune system destruction. Pancreatic enzymes help remove CICs byproducts produced by abberrant cells that are shed into the circulation. Pancreatic enzymes also have been shown to support the immune system’s T-cells, killer cells, and TNF alpha. Pancreatic enzymes may enter cancer cells in their reproductive phase and help digest them. In German studies, pancreatic enzymes have been directly injected into dysfunctional tissue masses (Wolf & Ransberger, 1972; Cichoke AJ, “The effect of systemic enzyme therapy on … the immune system,” Townsend LfDP Nov 1995: 30-2) . Proteolytic enzymes have been shown to be natural blood thinners and to support both blood and lipid circulation (Heinicke R et al, “Effect of bromelain (Ananase) on human platelet aggregation,” Experiencia 1972; 28: 844-5) . Note: We recommend avoiding enzymes in high doses right before surgery because of a blood thinning effect, and we also recommend waiting a week after surgery because some scar tissue formation after surgery is desirable to a degree. Bromelain: Known as a natural blood thinner, bromelain is a proteolytic enzyme from pineapples that is very effective in supporting blood platelets and circulation. It has also been shown to support the urinary tract, kidney, bladder, and urethra. It has been shown to support recovery from injury, relaxing smooth muscle and reducing cramps during PMS, and is particularly helpful reducing bruising following tooth extraction. The journal Medicine and Science in Sports and Exercise (1992; 24(l): 20-25) reports a study on bromelain for being helpful support in soft tissue injuries. Following injury, bromelain significantly optimized the maximum muscle force in the treated group, indicating that bromelain can be helpful support after injury. The Merck index lists it as an excellent enzyme for maintaining a normal, non-inflammatory environment (Merck Index, 11th ed. 1989. Merck & Co. Inc., Rahway, NJ, p. 1382) . Bromelain therapy has become quite popular for use in rheumatoid arthritis and joint inflammation. The smooth muscle supportive properties of bromelain contribute to the documentation for attenuating menstrual cramps. Papain: Papain is a proteolytic enzyme derived from papaya. Obstructions in the gastrointestinal tract can cause symptoms of discomfort, nausea and vomiting; however, they can be ameliorated by the proteolytic enzyme papain (Kinderarztl Prax 1990 58(10): 531-4) . Papain is soothing to the stomach; helps digest protein-based substances, and can be effective in digesting wheat gluten (celiac patients are advised to avoid wheat regardless of enzyme support). Lipase helps split fats into essential fatty acids and glycerol. Supplemental enzymes spare stress on the body, help improve digestion, increase uptake of nutrients from food, and prevent partially digested fats from entering the bloodstream, which can cause obstruction, dysfunction, and allergies. Amylase is a carbohydrate-digesting enzyme found in the saliva, pancreatic, and intestinal juices. People with allergies are frequently deficient in this enzyme. Rutin is a powerful noncitrus bioflavonoid that works with vitamin C to support capillaries, circulation, the eye, and the immune system. Bioflavonoids are used frequently for relieving discomfort and bruising. Rutin deficiency, as well as deficiencies in other bioflavonoids and vitamin C, can weaken the collagen structure of veins, which can lead to varicose veins. Rutin was shown to be the most powerful of superoxide scavengers out of seven bioflavonoids tested. It has strengthening and supportive effects on blood vessels and many other tissues (Chen et al, "Flavonoids as superoxide scavengers and antioxidants," Free-Radic Biol Med 1990; 9(1): 19-21) . Thymus (bovine): The thymus produces T- cells. The thymus continues to grow into puberty, when it begins to shrink. In early life, it is the main manager of the immune response. In later life, it is the learning center where lymphocytes acquire roles for identifying antibodies, as messengers for the immune system, as killer cells, and as helper cells. Killer cells recognize and target foreign toxins and cells (Merck Manual, 1992:279-87) . Glandular nutrients such as thymus are believed to support and help repair damaged, deteriorated, or aberrant immune system attacks on aging and malfunctioning glands and help restore them to homeostasis (Balch JF and PA Balch, Prescription for Nutritional Healing, 2nd Edition, New York: Avery, 1997; 555-556) . Parotid (bovine): The parotid is one of 3 sets of salivary glands. Saliva is part of the body’s first line of defense for antigenic materials entering the mouth and alimentary tract. The parotid produces a number of supportive polypeptides, defensins, and lactoferrin (an iron binding glycoprotein, which blocks unfriendly bacteria from obtaining a source of iron. Lactoferrin is also found in the products of all exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, in saliva, tears, nasal secretions, and seminal plasma. In blood, lactoferrin is derived from a special group of white blood cells, the neutrophils. Lactoferrin also supports the immune system, promotes flora in the gut, helps regulate iron metabolism, and helps prevent harmful oxidation. Saliva also contains digestive enzymes, which begin the digestion of starches, and bathe the teeth in healthful alkaline mineral nutrients (Levay & Viljoen, 1995:252-67; Reiter, 1985: 281-336) .
Contraindications: Do not use 7 days before or after major surgery, or in pregnancy.
Ingredients: Each Tablet Contains: Zinc (as gluconate) 0.500 mg. Proprietary blend 553 mg* of: Pancreatin (porcine), Papain, Rutin, Bromelain, Thymus (bovine), Trypsin, Amylase, Lipase, Chymotrypsin (as trypsin), Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Magna-B-6 Plus (1273)

Supportive Function: Magnesium-Potassium with B-Complex An ample dose of vitamin B-6 helps maintain many functions. Supports joint health including the wrists.
Contraindications: Doses above 250 mg/day of B-6 are generally not recommended, as they may cause neuropathy symptoms.
Ingredients: Each Tablet Contains: Vitamin E (as succinate) 30 IU, Thiamine (as hydrochloride) 1 mg, Riboflavin 1.7 mg, Niacin 10 mg, Vitamin B-6 (as pyridoxine hydrochloride) 100 mg, Pantothenic Acid (as calcium pantothenate) 5 mg, Magnesium (as oxide) 50 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed.
Pack: 90 Tablets
Product:

Methyl Renew (2800F)

Supportive Function: One of the most important reactions in the body for producing bioactive compounds is methylation. At least half of the population carries a gene polymorphism that impairs the ability to methylate. Methyl Renew contains active folate (5 MTHF) and other synergistic nutrients that optimize the methylation process. When is Methyl Renew helpful? Methylation is important for maintaining and accelerating many pathways, especially brain neurotransmitters, hormones, detoxification, DNA synthesis, immune system activity and joint health. Also promotes healthy cells and is necessary for gene expression, gene repair, chromosome stability and embryonic development.
Clinical Applications Research: Methylation is one of the most important biochemical reactions in the entire body. Methyl groups (one-carbon molecules) can be added to inactive compounds and thereby biologically activate them. This process, called methylation, is extremely important for maintaining and accelerating many pathways, especially brain neurotransmitters, hormones, detoxification, DNA synthesis, immune system activity and joint health. Methylation promotes healthy cells and regulates the expression of genes. An alarming fact is that the majority of people are lacking in optimal methylation, and this could be putting them at a disadvantage for coping with daily insults to the body. At least 50% of people carry what’s called a gene polymorphism (variant) that predisposes them to insufficient methylation. This gene polymorphism is a mutation of MTHFR and if present (and activated), it will result in the decreased ability to methylate and an “increased risk for the development of cardiovascular disease, Alzheimers, depression in adults, and of neural tube defects in the fetus [and more]” (Trimmer EE. Methylenetetrahydrofolate Reductase: Biochemical Characterization and Medical Significance, Curr Pharm Des 2012 Oct 31). This polymorphism is associated with elevated homocysteine (linked to over 100 medical conditions). DNA Methylation is necessary for many essential functions, including gene expression, gene repair, chromosome stability and embryonic development. Inability to methylate DNA will create a host of problems. DNA methylation research has exposed the fascinating potential we possess for potential modification to the sequence of DNA we inherited. “Specifically, there is new evidence to suggest that the balance between growth promoting (oncogenes) and growth suppressor (tumor suppressor) genes is altered by inappropriate methylation (www.methylation.net Jan 2013) . Epigenetic regulation, which includes changes in DNA methylation and alteration in microRNA expression without any change in the DNA sequence, “constitutes an important mechanism by which dietary components can selectively activate or inactivate gene expression ” (Simone Reuter et al. Epigenetic changes induced by curcumin and other natural compounds Genes Nutr. 2011 May; 6(2): 93–108). The Astounding Field of Epigenetics and how Methylation is Key Epigenetics refers to functionally relevant environmental modifications to DNA that do not involve a change in the sequence. Epi- comes from the Greek, meaning over or above, so epigenetics is above genetics. In other words, epigenetics describes a way to look at potential changes to our genomic function. There are changes to DNA that happen differently to each individual. Therefore, knowing what is unique about each person is crucial for any protocol. This is known as “bio-individual medicine”. Most disease results from interplay between genetic and environmental factors; some conditions are due more in part to genetics, and some more in part to environmental, while for the vast majority, it is unclear where one comes in the other does not. It is likely that epigenetic factors, i.e., heritable, but often reversible changes to genomic function that are independent of DNA sequence, are also important. It is known that epigenetic processes can be induced following exposure to a range of external factors, and thus provide a mechanism by which the environment can lead to long-term alterations in phenotype. A genotype is the genetic material we inherit from our parents. The phenotype is what we express on a daily basis, and the two are not the same. “ Genotype " is an organism's full hereditary information. " Phenotype " comes from the Greek word “show”, and it refers to an organism's actual observed properties, such as structural features, development , or behavior . But even though genotype can determine phenotype, the relatively new and exciting field of Epigenetics is demonstrating that environmental factors can change genetic expression . The best example of an epigenetic relevant modification to DNA is DNA methylation . Synergy is crucial for optimal methylation; the right amounts and the right co-factors of certain nutrients (described below) are extremely important in the equation, especially in terms of facilitating methylation for those in the population suffering from the inability to methylate due to the common gene polymorphism. L 5-MTHF (methyl tetrahydrofolate) : This is the active form of MTHF and the most biologically active form of folate. As you can see from the diagram, MTHF is responsible for promoting DNA synthesis and for recycling toxic homocysteine back to methionine. This recycling of homocysteine alone facilitates a pathway responsible for: reduction of a toxic substance (homocysteine), provision of sulfur for joint health, production of detoxification enzymes, formation of pyruvate for energy, and the activation of neurotransmitters, some hormones, and gene expression (DNA methylation). MTHF-R, or MTHF reductase, is an enzyme that plays a key role in folate metabolism and in the homeostasis of the homocysteine pathway. As previously mentioned, MTHF keeps homocysteine cycled back to methionine, and the reaction by which MTHF-R creates MTHF is the only source for MTHF in the body. Mutations in the MTHF-R enzyme are common (at least 50% of the population) and lead to high levels of the toxic homocysteine. High levels of homocysteine are associated with multiple disorders. Many practitioners encourage all of their patients to test for the MTHFR polymorphisms to know if a greater risk for improper methylation exists, establishing the need for preventive therapeutics to include greater amounts of pre-methylated folate (L-5 MTHF) and other methylation co-factors included in Methyl Renew . It is a fairly simple test that can be done through many labs. It is important that the test include both forms of MTHFR alleles C677T and A1298C. Compared with other forms of folates, 5-methyl tetrahydrofolate is more highly recommended due to the exceptional bioavailability. For instance, researchers noted that it “may represent a preferable treatment option for Major Depressive Disorder (MDD) given its greater bioavailability in patients with the genetic polymorphism” (Papakostas GI. Folates and s-adenosylmethionine for major depressive disorder. Can J Psychiatry. 2012 Jul;57(7):406-13.) According to the report from the Shanghai Breast Cancer Study (n > 2700), since folate is involved in DNA synthesis, repair, and methylation, it is hypothesized that “high intake of folate may reduce the risk of human cancers, including cancer of the breast” (Shrubsole MJ. Et al. Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Res. 2001 Oct 1;61(19):7136-41.) Additionally, they reported that their study “adds additional support to the protective role of dietary folate in breast carcinogenesis and suggests further that the effect of folate may be modified by dietary intake of methionine, vitamin B(12), and vitamin B(6)”, which further supports the idea of synergy with methylating nutrients. The importance of potential environmental modification of the aberrant gene polymorphism to optimize methylation becomes very apparent in studies such as the one published in the Journal of Molecular Neuroscience. Researchers established that both genetic and inflammatory factors are suspected in the etiology of multiple sclerosis (MS), and they also established that of genetic factors, the MTHF-R polymorphism is associated with increased levels of plasma homocysteine, which is toxic to neurons. The researchers recruited 230 healthy and 194 MS patients to test the association between MS and the MTHF-R polymorphism (MS patients have elevated levels of homocysteine). Their conclusion was that the polymorphism was indeed most likely associated with higher levels of inflammatory markers and a vulnerability to an earlier age of onset (Alatab S. et al. Inflammatory profile, age of onset, and the MTHFR polymorphism in patients with multiple sclerosis. J Mol Neurosci. 2011 May;44(1):6- 11). P-5-P, Methyl B-12, Niacin, and Biotin are all synergistic B vitamins that contribute to methylation processes. P-5-P is the activated form of vitamin B-6. B-6 is necessary to bring homocysteine down the pathway to produce glutathione, taurine for bile acids, pyruvate for energy, and sulfur for joint health. It is also necessary in the folate pathway responsible for DNA synthesis and also for recycling homocysteine back to methionine. Methyl B-12 recycles homocysteine to methionine. The power of B-12 to methylate in many areas, including DNA synthesis and immune activity, has been confirmed (Paula Dominguez-Salas Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc. 2012 February). All of these B vitamins work together in different stages of the methylation processes to optimize the results, which include methylation of neurotransmitters, lipids, DNA, and some hormones. Methylation is needed for many biochemical reactions, including activating DNA for gene expression and repair. N-Acetyl Cysteine (NAC) : NAC is the main precursor to glutathione, the major antioxidant of the body. Administration of N-acetyl cysteine is utilized to raise glutathione levels. As shown in the diagram, B-12 and MTHF methylate homocysteine and recycle it back to methionine; it has been proposed that glutathione is necessary for the synthesis of methyl B-12 and that glutathione is also necessary for the enzyme activity involved in the recycling process. When researchers studied alcohol-induced decreases in that methylation cycle, they discovered that the deleterious effect of the alcohol was secondary to the effects on methylation from decreased glutathione levels and a decreased ability to synthesize glutathione. This greatly emphasizes the importance of glutathione to optimize methylation processes. When glutathione was added, the enzyme (methionine synthase) and thereby the methylation process, was restored to control levels (Waly MI et al. Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner. Alcohol Clin Exp Res. 2011 Feb;35(2):277-83.) NAC, Glutathione and Autism/ADHD : Diagnostic criteria for these conditions have traditionally relied solely on behavioral criteria without consideration for a potential biomedical foundation, however, “newer evidence reveals that autism spectrum disorders (ASDs) are associated with: oxidative stress, decreased methylation capacity, limited production of glutathione , and mitochondrial dysfunction” (Bradstreet JJ. et al. Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Altern Med Rev. 2010 Apr;15(1):15-32.) Bradstreet et al. also note that glutathione is a biomarker that provides “useful guides for selection, efficacy, and sufficiency of biomedical interventions. The use of these biomarkers is of great importance in young children with ADHD or individuals of any age with ASD, because typically they cannot adequately communicate regarding their symptoms”. It is interesting that intestinal dysbiosis, increased toxic metal burden, immune dysregulation (characterized by a unique inflammatory bowel disease and immune activation of neuroglial cells), and ongoing brain hypoperfusion were other suggested biomarkers. Phosphatidylcholine is an important bioactive lipid. Besides being a bioactive lipid with health benefits in its own right, phosphatidylcholine additionally helps to preserve the status of the main methyl donor, namely SAM-e. Green Tea Catechins exert their effects on major metabolic pathways that explain some of their health benefits, and those pathways include methylation, glucuronidation, and sulfation (Sang S, et al. The chemistry and biotransformation of tea constituents. Pharmacol Res. 2011 Aug;64(2):87-99). “Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression and growth factor-mediated pathways” (Chen D, et al. EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment. Adv Clin Chem. 2011;53:155-77). Accumulating data, such as that published in the journal Carcinogenesis , “suggest that dietary phytochemicals may alter cancer risk by modifications of epigenetic processes in the cells”. They investigated whether tea catechins would modify epigenetic events to regulate DNA methylation, and they found that administration of the catechins “resulted in re-expression of the mRNA and proteins of silenced tumor suppressor genes”. In other words they were able to re-activate the suppressor genes. “Together, our study provides new insight into the epigenetic mechanism of action of EGCG (tea catechin) that may contribute to the chemoprevention of skin cancer and may have important implications for epigenetic therapy 4 (Nandakumar V, et al. EGCG reactivates silenced tumor suppressor genes. Carcinogenesis. 2011 Apr;32(4):537-44.) SAM-e supplementation benefits are widespread; methylation affects so many pathways it is not surprising that the research holds so many diverse reports of favorable effects. More than 40 metabolic reactions involve the methyl transfer from SAM-e, a natural substance, to various substrates, such as nucleic acids , proteins , lipids and secondary metabolites . SAM-e supplementation is recommended in addition to 5 MTHF especially for those exhibiting the gene polymorphism that impedes methylation processes. Please see the fact sheet on SAMe for more detailed info on this powerful nutrient. Curcumin (diferuloylmethane) is a component of the spice turmeric and has recently been determined to induce epigenetic changes (epigenetic changes include DNA methylation changes without any change in DNA sequence). Scientists claim that this can be an important mechanism “by which dietary components can selectively activate or inactivate gene expression” and furthermore, “The development of curcumin for clinical use as a regulator of epigenetic changes, however, needs further investigation to determine novel and effective chemopreventive strategies, either alone or in combination with other anticancer agents, for improving cancer treatment” (Simone Reuter et al. Epigenetic changes induced by curcumin and other natural compounds Genes Nutr. 2011 May; 6(2): 93–108.) Intrinsic Factor is manufactured in the parietal cells of the stomach and forms a complex with B-12 that allows the B-12 to be absorbed in the small intestine. Vitamin B-12 is not easily absorbed in people with gastrointestinal problems. People with GI problems are at higher risk for B-12 insufficiency and deficiency. There are many types of anemia, but pernicious anemia is an autoimmune condition resulting in a lack of intrinsic factor. That in turn causes a deficiency of B-12 (needed for the DNA synthesis of new red blood cells), and without enough red blood cells to carry oxygen to the body, weakness and fatigue can result. Supplying intrinsic factor can increase the probability of forming the B-12 – intrinsic factor complex so that the B-12 gets absorbed. Many people have intrinsic factor antibodies which make it less likely for B-12 to be absorbed. It may also take decades for B-12 deficiencies to show up as pernicious anemia, making it that much more difficult to detect early and avoid neurological problems. Furthermore, as one ages intrinsic factor production slows, perhaps explaining why many elderly people show signs of B-12 deficiency. Sulforaphane (SFN) , an isothiocyanate derived from cruciferous vegetables, “induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effects of SFN is the modulation of epigenetic marks, … the effects of SFN on other common epigenetic marks such as DNA methylation are understudied”. In this study appearing in Clinical Epigenetics, scientists investigated the effects of SFN on DNA methylation status because of the role SFN plays in impacting epigenetic pathways. Their results demonstrated the ability of SFN to epigenetically modulate important gene expression, “and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent” (Hsu A, et al. Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics. 2011;3:3).
Contraindications: Side effects are uncommon for SAM-e, but occasionally gastrointestinal upset and anxiety can occur (Can Fam Physician. 2011 June; 57(6): 659–663). There are no confirmed drug interactions with SAM-e, but caution is advised with the use of antidepressants, including serotonin re-uptake inhibitors and MAO inhibitors due to potentially enhanced serotonin. Some recommend avoiding SAM-e for individuals with bipolar disorder or manic depression (this is controversial and at least one trial studied those with MDD (manic depressive disorder) (Levkovitz Y, et al. J Affect Disord. 2012 Feb;136(3):1174-8).
Ingredients: Niacin (as niacinamide) 20 mg, Folate (as L-5-Methyltetrahydrofolate) 500 mcg, Vitamin B-12 (as methylcobalamin) 500 mcg, Biotin 2000 mcg. Proprietary blend 415 mg* of: Sulforaphane (as broccoli sprout ext.), N-Acetyl Cysteine, Phosphatidyl Choline, Green Tea Catechin (leaf) (decaffeinated), S-Adenosyl Methionine (SAMe), Curcumin, Intrinsic Factor, Pyridoxal-5-Phosphate.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Multibalance for Men (2321F)

Supportive Function: A special formulated balanced multiple to support the needs of the male.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (as palmitate)(65% as beta carotene) 3450 mcg, Vitamin C (as ascorbic acid) 62.5 mg,  Vitamin D3 (as cholecalciferol) 2.5 mcg, Vitamin E (as succinate) 32 mg, Thiamine (as hydrochloride) 17.5 mg, Riboflavin 15 mg, Niacin (as niacinamide) 100 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Folate (as folic acid) 225 mcg, Vitamin B-12 (as cyanocobalamin) 50 mcg, Biotin 75 mcg, Pantothenic Acid (as calcium pantothenate) 25 mg, Calcium (as citrate) 30 mg, Iron (as glycinate) 0.750 mg, Iodine (as potassium iodide) 25 mcg, Magnesium (as aspartate) 12.5 mg, Zinc (as aspartate) 0.625 mg, Manganese (as aspartate) 0.500 mg, Chromium (as picolinate) 12 mcg. Proprietary blend 224.4875 mg* of: Betaine (as hydrochloride), Rice Bran, Lemon Bioflavonoid, Almond Meal, Para Amino Benzoic Acid (PABA), Hawthorn (berry), Eleuthero (root), Saw Palmetto (berry), Dandelion (root), Pepsin, Pumpkin (seed), Stinging Nettle (leaf), Lecithin (phosphytidal choline), Deglycyrrhizinated Licorice (root), Papain, Rosemary (herb), Gotu Kola (herb), Pygeum Africanum (bark), Bromelain, Flax (seed), Vanadyl Sulfate, Boron (as chelate).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Multibalance for Women (2322F)

Supportive Function: A special formulated balanced multiple to support the needs of the female.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (as palmitate)(65% beta carotene) 3,450 mcg, Vitamin C (as ascorbic acid) 62.5 mg,  Vitamin D3 (as cholecalciferol) 2.5 mcg, Vitamin E (as succinate) 32 mg, Thiamine (as hydrochloride) 17.5 mg, Riboflavin 15 mg, Niacin (as niacinamide) 100 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Folate (as folic acid) 225 mcg, Vitamin B-12 (as cyanocobalamin) 50 mcg, Biotin 75 mcg, Pantothenic Acid (as calcium pantothenate) 25 mg, Calcium (as citrate) 30 mg, Iron (as glycinate) 0.750 mg, Iodine (as potassium iodide) 25 mcg, Magnesium (as aspartate) 12.5 mg, Zinc (as aspartate) 0.625 mg, Manganese (as aspartate) 0.500 mg, Chromium (as picolinate) 12 mcg. Proprietary blend 213.7375 mg* of: Betaine (as Hydrochloride), Rice Bran, Lemon Bioflavonoid, Almond Meal, Para Amino Benzoic Acid (PABA), Eleuthero (root), Dandelion (root), Damiana (leaf), Dulse (leaf), Wild Yam (root), Pepsin, Dong Quai (root), Lecithin (phosphatidyl choline), Deglycyrrhizinated Licorice (root), Papain, Rosemary (herb), Gotu Kola (herb), Bromelain, Flax (seed), Vanadyl Sulfate, Boron (as chelate).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Niacin B-6 (1280)

Supportive Function: Niacin and B-6 Formula Provides support for the circulation and for vascular tone.
Contraindications: Doses above 250 mg/day of B-6 are generally not recommended, as they may cause neuropathy symptoms. The naturally occurring Niacin flush can cause the upper extremities, face, neck and ears to become red and itch.This is a natural reaction, as Niacin is a vasodilator. Taken with cold milk or a banana can lessen the flush.
Ingredients: Each Tablet Contains: Niacin 100 mg, Vitamin B-6 (as pyridoxine hydrochloride) 50 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Nitric Oxide Formula (2840F)

Supportive Function: Nitric Oxide (NO) Formula balances NO whether high or low, contributing to circulation support and the optimal functioning of many pathways, especially when genetic mutations impede the process. Nitric Oxide (NO) plays a very important role in relationship to cardiovascular health. It also participates in virtually every cellular function in the body. Since NO is a vasodilator, its benefits are also noted for contributing to sexual health in males. Low levels are associated with health imbalances, so for optimal functioning, we should be sure to maintain sufficient levels in the bloodstream. Genetics can greatly influence NO metabolism, and since the importance of nitric oxide production and management in the human body can appear complicated, a clarified overview will help. Increasing levels of NO must be done safely, because NO can form dangerous peroxynitrites (potent free radicals) in the absence of nutritional support (antioxidants). Peroxynitrite is a very damaging molecule that is produced when the body tries to fight infections. It damages the cells of bacteria, viruses and other foreign invaders however if this molecule is not broken down well, it can attack our own tissues through the production of free radicals. This may lead to chronic inflammation, imbalances, and cell membrane damage. In addition to environmental and dietary imbalances contributing to low levels, genetic variants can also affect circulating NO levels. Genetic variants in the SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase) and NOS (nitric oxide synthase) genes can have a profound effect on nitic oxide levels in the body. These enzymes may affect NO levels by using up nitric oxide to quench free radicals or by decreasing production of nitric oxide.
Clinical Applications Research: Nutritional interventions can be a tremendous help to balancing out these critical metabolites. By adding antioxidants to quench free radical production and adding in potent precursors to NO, we can optimize levels in the body and reduce risks of imbalances that can lead to many health risks. There are three types of NO in the body; neuronal, endothelial, and inducible. These three types of NO have very different roles in the body. The neuronal form (nNOS) is involved in cell to cell communication; the endothelial form (eNOS) is involved in arterial health, vascular tone and blood flow; and the inducible form (iNOS) is involved in immune system response. Genetic variants in the nNOS, eNOS and iNOS genes can cause low levels to be produced. In the past, arginine was used to raise NO levels without tremendous success due to the fact that variants in one or more of these genes it can block the conversion of arginine to NO. Evidence suggests that the conversion of arginine to NO occurs in the arterial system but the arginine molecule can have difficulty passing into the circulation system from the digestive system. Citrulline, on the other hand, can pass through into the circulation much more easily. This makes converting citrulline to arginine in the system the best way to raise NO more successfully. This is especially true when the genetic variants are slowing that conversion down (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.00 37439 http://www.biochemj.org/content/281/1/45). NO production requires several cofactors, including tetrahydrobiopterin (BH4). This molecule is produced when the methylation cycle is functioning correctly. FAD (flavin adenine dinucleotide) is another important cofactor (a product of the Krebs cycle) as is FMN (flavin mononucleotide) a riboflavin derivative. Lastly, the heme molecule in red blood cells is also a cofactor. Nitric Oxide can be reduced to the superoxide molecule (another damaging free radical) in the case of a deficiency of arginine or BH4. This so called “uncoupling” has been known to occur in sugar, pressure and fat imbalances. Optimal levels of NO can lead to tremendous changes in cardiovascular profiles. It has been shown to help health imbalances by dilating blood vessels. In addition, it supports an anti-inflammatory environment by clearing up free radical damage. It also supports the immune system response by cleaning up chronic immune attacks that can lead to inflammation. It has even been shown to support the elimination of parasitic infections (Norris, et al, Infect. and Immun. July 1995 vol. 63 no. 7 2793-2796) . L-Citrulline (comes from watermelon) has been shown to be a major precursor to NO production in the body. High levels have been shown to support vasodilation and arterial pressure. L-Citrulline supplementation restores NO formation, while also reducing free radicals in the body (Clinical & Experimental Allergy Volume 47, Issue 2, pages 190–199, February 2017). Citrulline has recently received a great deal of attention for its potent antioxidant effect (Akashi et al. 2001) . Additional studies demonstrate many effects, including an important role in the cardiovascular system (Romero et al. 2006) , as a regulator of immunity (Norris et al. 1995) , and in the regulation of nitrogen balance (Osowska et al. 2004, 2006) . Citrulline seems to work in a different way than arginine and increases levels of NO in the bloodstream more effectively than arginine. Several studies support the idea that citrulline has a more potent therapeutic effect than arginine in increasing NO production (http://www.sciencedirect.com/science/article/pii/S1096719212000200). Citrulline could be helpful in pregnancy related imbalances (Lassala et al. 2009) , in cardiovascular imbalances (Romero et al. 2006; Wu and Meininger 2000) , in weight issues and/or sugar imbalances (Jobgen et al. 2006; Wu et al. 2007) , in intestinal imbalances, (Elwafi et al. 2012; Osowska et al. 2004; Wijnands et al. 2012) and in critically ill patients (Hao et al. 2004) . L-citrulline supplementation may help reduce ammonia levels through assistance in the urea cycle. It has also been shown to reduce lactic acid levels and levels of fatigue during workouts as well. Citrulline can be recycled to arginine in macrophages. “The citrulline-arginine cycle may contribute to the regulation of intracellular availability of arginine and thus the prolonged production of NO by macrophages” (http://www.biochemj.org/content/281/1/45). Cranberry Powder (fruit) is another natural source of nitric oxide precursors. In addition to its high levels of antioxidants and polyphenols, cranberries have been shown to have numerous health benefits, including their antioxidant properties (Yan et al. 2002; Bagchi et al. 2004; Ferguson et al. 2004; Seeram et al. 2004; Neto 2007; Zafra-Stone et al. 2007) . Cranberry extract has been shown to significantly reduce levels of TNFα, CAT, and SOD1 mRNA. This action secondarily reduces free radical activation and increases NO production (http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A249). Quercetin is a potent antioxidant that reduces free radicals and preserves the NO produced, helping to maintain its cardiovascular and other health effects (1998 British Journal of Surgery Society Ltd). Vitamin C (as ascorbic acid) is another source of free radical quenching antioxidant that helps keep NO in the beneficial form. Vitamin C has been shown to enhance NO bioactivity by increasing intracellular BH4 (tetrahydrobiopterin) levels (http://www.jbc.org/content/275/23/17399.short). Resveratrol is a polyphenol that is found in red wine; “it increases the activity of nitric oxide synthase, this increases the production of NO especially in cultured pulmonary artery endothelial cells” (Cancer Research 59, 2596 – 2601, June 1, 1999). In addition, resveratrol helps prevent eNOS uncoupling and production of peroxynitrites. It has been shown to reduce levels of superoxide molecules as well both mechanisms preserve the NO molecule needed for cardiovascular health. (http://www.sciencedirect.com/science/article/pii/S0014299911005942). Huperzine A reduces the overexpression of proinflammatory enzymes such as NF Kappa-B, and decreases the overproduction of NO, thereby reducing cell damage. (http://www.sciencedirect.com/science/article/pii/S0047637412001820 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2008.05504.x/full). Beet Powder (root) - contains high levels of nitrites, which are converted into nitric oxide through the action of bacteria in the mouth and gastrointestinal system. Inorganic nitrate and beetroot juice supplementation was associated with a significant benefit is arterial pressure support (http://jn.nutrition.org/content/143/6/818.short). Fruits and vegetables rich in nitrate/nitrite added to the diet help balance blood sugar and vascular endothelial imbalances by increasing the NO levels. It may also help prevent other lifestyle-related problems, including bone density imbalances, respiratory imbalances and free radical pathologies (Nutrients 2015, 7(6), 4911-4937; doi:10.3390/nu7064911). In summary, in order to balance nitric oxide levels in the body, it is important to first make sure to clean up or prepare for extra free radical production. The new Nitric Oxide Formula does both, by providing antioxidant support and also supplying precursors to nitric oxide production itself. Adding the NO product in a regimen with SOD lozenges can increase the benefits of this product.
Contraindications: When there is a shortage of the enzyme required to catalyze the citrulline-arginine urea cycle (not common), ammonia can accumulate in the blood. Research indicates, however, that supplementation with zinc can improve the conversion of citrulline-arginine in the liver and at the same time keep the levels of NH3 (ammonia) in the blood low. Some people avoid large doses of arginine when they have the herpes virus.
Ingredients: Each tablet contains: Vitamin C (as ascorbic acid) 50 mg. Proprietary blend 817.025 mg* of: L-Citrulline, Beet Powder (root), Cranberry Powder (fruit), Quercetin, Resveratrol, Huperzine A
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Pan-Lyph Chelate (1110)

Supportive Function: Pancreatic glandular support. Helps maintain a healthy blood sugar level.
Contraindications: None known
Ingredients: Each Tablet Contains: Zinc (as chelate) 15 mg, Chromium (as chelate) 200 mcg. Proprietary blend 151 mg* of: Pancreas (bovine), Pancreatin (porcine), Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily with meals or as directed
Pack: 90 Tablets
Product:

Pantothenic Acid (1295)

Supportive Function: A whole host of biochemical reactions depend on coenzyme A, which has pantothenic acid as part of its structure, especially the conversion of food into energy.
Contraindications: None known
Ingredients: Each Tablet Contains: Pantothenic Acid (as calcium pantothenate) 250 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Parazym-A (2352)

Supportive Function: Supports a healthy intestinal environment.
Contraindications: Contraindicated in pregnancy. Garlic should not be taken in large doses with anticoagulant drugs (small amounts are included in this formula).
Ingredients: Each Tablet Contains: Vitamin A (as palmitate) 1200 IU. Proprietary blend 385 mg* of: Almond Meal, Fig (fruit), Artemisia Annua (seed), Black Walnut (hull), Burdock (root), Garlic (bulb), Papain, Bromelain, Pancrelipase (porcine), Cellulase, Amylase (diastase).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Parotid-Lyph (1121)

Supportive Function: The parotid is one of the salivary glands, responsible for supporting a crucial first step in digestion. When is Parotid Support helpful? Chemical and heavy metal toxicity; biological tagging.
Clinical Applications Research: No known research exists regarding parotid glandular. However, clinically, many practitioners agree that parotid glandular will cause the body to begin detoxifying heavy metals and chemicals from the body.
Contraindications: None known
Ingredients: Calcium (as lactate) 20 mg, Parotid (bovine) 200 mg.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Pedia-C (1304)

Supportive Function: A pleasant-tasting chewable to appeal to the younger crowd! Added biofl avonoids and immune-supporting nutrients and glandulars complete a well-rounded product.
Contraindications: None known. High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Chewable Tablet Contains: Vitamin A (as palmitate) 1500 IU, Vitamin C (as sago palm) 125 mg, Folate (as folic acid) 10 mcg, Biotin 20 mcg. Proprietary blend 29 mg* of: Lemon Bioflavonoids, Hesperidin Complex, Rutin, Lymph (bovine), Propolis, Spleen (bovine), Thymus (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Capsules
Product:

Penta-Cal-Plus (250) (1362)

Supportive Function: Six forms of phosphorus-free calcium: Calcium (as chelate/caseinate/carbonate/gluconate/lactate/sulfate), are supplemented with other nutrients to maximize absorption and utilization.
Contraindications: Hyperparathyroidism or sarcoidosis patients should avoid vitamin D supplementation. Hypercalciuria and hypercalcemia are usually not seen unless the daily dose exceeds 2400 IU.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 20 mg, Calcium (as chelate, caseinate, gluconate, sulfate, lactate, carbonate) 250 mg, Vitamin D3 (as cholecalciferol) 135 IU, Magnesium (as oxide) 10 mg. Proprietary blend 15 mg* of: Betaine (as hydrochloride), L-Glutamic Acid (as hydrochloride), L-Lysine (as hydrochloride).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 250 Tablets
Product:

Penta-Cal-Plus (90) (1361)

Supportive Function: Six forms of phosphorus-free calcium: Calcium (as chelate/caseinate/carbonate/gluconate/lactate/sulfate), are supplemented with other nutrients to maximize absorption and utilization.
Contraindications: Hyperparathyroidism or sarcoidosis patients should avoid vitamin D supplementation. Hypercalciuria and hypercalcemia are usually not seen unless the daily dose exceeds 2400 IU.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 20 mg, Calcium (as chelate, caseinate, gluconate, sulfate, lactate, carbonate) 250 mg, Vitamin D3 (as cholecalciferol) 135 IU, Magnesium (as oxide) 10 mg. Proprietary blend 15 mg* of: Betaine (as hydrochloride), L-Glutamic Acid (as hydrochloride), L-Lysine (as hydrochloride).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Phos-Drops (1384)

Supportive Function: Phosphorus is critical to healthy cell growth in many tissues of the body. Ortho phosphoric acid provides acidic support for an alkaline environment. When is Acidic Phosphorus helpful? Kidney stone formers, tendonitis, bursitis, gallstones, gout, arthritis, high blood pressure, excess calcium deposits, excess tarter on the teeth, complaints of nausea, bone spurs.
Clinical Applications Research: Acidifying phosphorus: Acidifying phosphorus will provide acidic support when the environment is too alkaline. For example, a kidney stone former is too alkaline and as a result calcium is making deposits in the body. To break up calcium and cause it to go back into solution, an acidifying agent is necessary. Phosphorus is a calcium mobilizer. Our diet contains plenty of inorganic phosphorus in the form of soda pop or red meat, but we ingest very little organic phosphorus. Choline and Inositol: To be an effective calcium mobilizer, orthophosphoric acid needs to be in partnership with its co-factors, choline and inositol.
Contraindications: Do not apply undiluted. Caution in pregnancy and with children. Phos Drops is contraindicated in cases of hyperthyroidism as the ortho-phosphoric acid may increase the metabolic rate. Do not give if pulse rate is greater than 90.
Ingredients: Each 30 Drops Contains: Phosphorus (as ortho phosphoric acid) 390 mg. Proprietary blend 21 mg* of: Inositol, Choline (as bitartrate).
Vegetarian: No
Suggested Dosage: 10 drops daily in water or as directed. Use much smaller doses in children.
Pack: 60cc Liquid
Product:

Phyto Renew Chewable (2818F)

Supportive Function: Oxidative damage (free radicals), energy, detoxification, brain/memory support, nervous system, bones, aging, inflammation, muscle damage, reflux, gallstones, normal regulation of the cell cycle, heart, immune system, circulation, collagen and also helpful for achieving compliance with children. When is Antioxidant Support helpful? anytime powerful nutrients and antixodants are missing from the diet
Clinical Applications Research: Phyto Renew (chewable) is a long list of heavy hitting plant nutrients to charge up the body instantly in a pleasant-tasting chewable. It has never been easier to add the healthful benefits of fruits and nutrients to the diet; it’s powerful, portable and palate-pleasing! It is chock-full of antioxidants and ingredients that pack a punch, condensed into a tasty chewable. The health benefit of a diet rich in fruits and vegetables is attributed to the presence of a large diversity of bio-active phytochemicals, and Phyto-Renew has a wide variety of phytochemical-rich nutrients. Pomegranate, blueberry, cherry, acai, raspberry, blackberry and resveratrol are just some of the amazing powerhouse ingredients in Phyto-Renew. The unique formula utilizes a comprehensive collection of flavones, anthocyanins, proanthocyanidins, polyphenols etc. to deliver an amazing ”Phyto” combo. Phyto Renew provides supportive function for: oxidative damage (free radicals), energy, detoxification, brain/memory support, nerves, bones, aging, inflammation, muscle damage, reflux, gallstones, normal regulation of the cell cycle and wherever powerful nutrients and antioxidants are missing from the diet. Pomegranate (fruit) is an excellent antioxidant, and it is well-known for raising levels of glutathione, considered one of, if not the most powerful, antioxidant we have in the body. Recent research shows that the antioxidant power of pomegranate contributes to many things, including bone health and a normal inflammatory response (Spilmont et al. 2013) , neuronal and aging support (Braidy et al. 2012) ; memory support (Ropacki et al. 2013) , heart support (Aviram & Rosenblat 2013) , healthy resistance to a bacterial environment (Bakkiyaraj et al.) , and recovery from exerciseinduced muscle damage (Sousa et al. 2013). Scientists have reviewed the nutritional and pharmaceutical benefits of pomegranate and concluded that pomegranate has “raised a growing scientific interest”; because of the effects that pomegranate is endowed with, “we hypothesized that it may have beneficial effects” (Spilmont et al. 2013) . Because of the ability to reduce oxidative stress and toxic assault, pomegranate is a good choice for detoxification support. The health benefits attributed to pomegranate have been associated with its high content in various polyphenols, particularly polyphenols called “ellagitannins”, amongst others. It has been noted by Viladomiu M, et al. (2013) that “the synergistic action of the pomegranate constituents appears to be superior when compared to individual constituents”. Blueberry (fruit), Raspberry (fruit) and Blackberry (fruit) : Small berries have long been considered as one of the richest sources of natural antioxidants, the pharmaceutical value of which is reviewed in “Berry antioxidants: small fruits providing large benefits” by Manganaris GA, et al. 2013. Blueberries have been found to support a normal inflammatory response and recovery from exercise-induced muscle damage (Sousa M, et al. 2013) . Cherry (fruit) can increase antioxidant levels in the body, and has even been referred to by Garrido et al. (2013) as a “neuraceutical tool”. Cherry has a favorable effect on melatonin, and can help contribute to normal sleep patterns. Lemon Bioflavonoids are best known for supporting capillaries and circulation; they consist of many varieties of phytochemicals, including rutin, hesperidin and hydroxycinnamic acids. Amongst many various health benefits, hesperidin increases carotenoid absorption in the gut (Claudie DM et al. 2013) . Citrus flavonoids were found by Park, HY et al. (2013) to prevent excessive lipid formation, protect the antioxidant system and support the normal inflammatory response in the liver. D-Limonene is a major constituent of several citrus oils. It has a gastric acid neutralizing effect, supports normal peristalsis and gallstones, and increases Co Q 10 absorption. D-limonene is especially known for its powerful support for cell cycle regulation. D-limonene is an adenosine agonist, meaning that it binds to some receptor of a cell and triggers a response by that cell; agonists often mimic the action of a naturally occurring substance. Adenosine is a purine nucleotide that plays an important role in biochemical processes such as energy transfer ( adenosine triphosphate is ATP) and signal transduction . Acai (fruit) is full of strong antioxidants. Acai has been described by researchers as exhibiting “quite potent biological activity” (Kinghorn et al. 2011) . An evidence-based systematic review of acai was conducted by the Natural Standard Research Collaboration, and they found statistically significant evidence of benefit as an antioxidant from properly randomized trials (Ulbricht, C. 2012) . Most research on acai fruit has centered on its potential antioxidant properties (Singh, & Barrett, 2011; Mertens-Talcott et al., 2008; Rodrigues et al., 2006; Schauss et al., 2006; Udani, Singh) , however, there is a lot of research focused on other areas, which may or may not be related to the antioxidant potential (Pozo-Insfran, Percival, & Talcott, 2006; Stoner et al., 2010; Schauss et al., 2006) . One of the biggest areas acai offers the most support for is the lungs. Acai can “modulate various biochemical aspects” of lung processes and can enhance lung antioxidant levels with beneficial effects (Biswas et al. 2013) . Glutathione (reduced) : Glutathione (GSH) has been called the body’s most powerful protector by people like Dr. Jimmy Guttman, who realize that this super antioxidant, found mostly in the liver, plays a huge role is maintaining a positive antioxidant status for the best defense. Most glutathione is made directly in the cells from three amino acids, however some ingested glutathione is able to get to the liver by way of the enterohepatic circulation (intestines to liver). Glutathione is active in its reduced form. Grape Seed Extract has a very high concentration of proanthocyanidins. A study focusing on lifestyle intervention factors determined that several downstream proteins are produced when the body is out of homeostasis, and that grape seed extract reduced the occurrence of those proteins (Derry, MM et al. 2013) . Grape seed extract strongly supports delicate thin layers of actively metabolic cells such as capillaries in the lungs (that handle our oxygen/waste exchange) and the endothelium that lines the blood vessels and the heart. The endothelium of the blood vessels regulates vascular homeostasis through the release of numerous vasoactive factors that control vascular tone and vascular smooth cell proliferation. Grape seed extract has been shown to beneficially support the maintenance of homeostasis in the endothelium. Quercetin is a potent flavonoid that is actually present in many herbs and foods, however it is isolated as a single supplement because of its vast properties. Quercetin is mostly known for supporting the heart, blood vessels, lungs, normal blood sugar levels, energy, athletic performance and the immune system (Web MD) . Elderberry (fruit) is an antioxidant that highly supports cell viability and a healthy bacterial environment. One study on elderberry revealed an extensive range of phenolic metabolites of anthocyanin, including 11 previously undiscovered novel metabolites, which were identified at much higher concentrations and bioavailability than even the parent compounds (de Ferrars RM, et al. 2013) . Resveratrol is a unique botanical antioxidant with diverse biologic effects; its ability for molecular signaling and its effect on cellular mechanisms has been documented in scientific research (Farris, P. et al. 2013) . It is present in many substances, but is best known for being a constituent of red wine. Resveratrol provides some of the best support for mitochondrial and telomerase activity associated with healthy aging processes. Resveratrol also offers excellent support for nerves, the brain and other organ systems.
Contraindications: None known
Ingredients: Proprietary blend 745 mg* of: Pomegranate (fruit), Blueberry (fruit), Cherry (fruit), Elderberry (fruit), Blackberry (fruit), Acai (fruit), Raspberry (fruit), Arabinogalactan (larch tree gum), Lemon Bioflavonoid, Resveratrol, Glutathione (reduced), Luo Han Guo (fruit), Grapeseed Extract, Olive Leaf Extract (20% oleuropein), Quercetin, D-Limonene.
Vegetarian: Yes
Suggested Dosage: 1 tablet chewed with or away from meals one time daily or as directed.
Pack: 60 Tablets
Product:

Pre/Post Natal Minerals (1262F)

Supportive Function: Pre/Post Natal Minerals provide comprehensive mineral support for the pregnant mother before, during and after pregnancy. When are the Pre-natal Formulas helpful? Before pregnancy to prepare the body for implantation, during pregnancy and after for rebuilding. Pre/Post Natal Minerals should be taken in combination with Pre/Post Natal Vitamins.
Contraindications: Iron is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Calcium (as carbonate, citrate, hydroxyapatite, chelate) 100 mg, Iron (as peptonate) 10 mg, Magnesium (as citrate, chelate) 50 mg, Zinc (as chelate) 5 mg, Selenium (as chelate) 8 mcg, Manganese (as chelate) 0.800 mg, Chromium (as chelate) 10 mcg, Molybdenum (as chelate) 3 mcg. Proprietary blend 2 mg* of: Betaine (as hydrochloride).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed.
Pack: 180 Tablets
Product:

Pro-En-zyme (3500)

Supportive Function: For clearing cellular debris that can cause inflammation when present in the body.
Clinical Applications Research: Proteolytic Enzymes: Proteolytic enzymes are released from the neutrophils to clear toxic debris. During inflammation, toxic protein-containing material is released which can foster dysfunction unless it is removed. Neutrophils release proteolytic enzymes when they arrive at the scene, to break apart this material and prevent infection. This “clean-up process” helps rid the tissue of substances that prolong inflammation. Protease: Protease plays a powerful role in the clean-up cascade. Proteases do not inhibit the immune system, they support it. Proteases also support blood circulation and supply, therefore facilitating cleansing of the tissue. They will also support wound healing to minimize scar formation. Bromelain: The journal Medicine and Science in Sports and Exercise (1992; 24(l): 20-25) reports a study on bromelain, one of the proteolytic enzymes that has therapeutic effects for support of soft tissue injuries. Following injury, bromelain significantly increased the maximum muscle force in the treated group, indicating that bromelain can be helpful for a quick recovery from injury. The Merck index lists it as an excellent antiinflammatory enzyme (Merck Index, 11th ed. 1989. Merck & Co. Inc., Rahway, NJ, p. 1382) . Bromelain therapy has become quite popular for use in rheumatoid arthritis to decrease joint inflammation. The smooth muscle relaxant properties of bromelain contribute to the documentation for relieving cramps. Vitamin C (as ascorbic acid) and Bioflavonoids: Beneficial nutrients to aid in the normal inflammatory response. Proteolytic Enzymes: Proteolytic enzymes are released from the neutrophilsto clear toxic debris. During inflammation, toxic protein-containing material is released which can fosterdysfunction unless it is removed. Neutrophils release proteolytic enzymes when they arrive at the scene, tobreak apart this material and prevent infection. This “clean-up process” helps rid the tissue of substances thatprolong inflammation.Protease: Protease plays a powerful role in the clean-up cascade. Proteases do not inhibit the immune system,they support it. Proteases also support blood circulation and supply, therefore facilitating cleansing of thetissue. They will also support wound healing to minimize scar formation.Bromelain: The journal Medicine and Science in Sports and Exercise (1992; 24(l): 20-25) reports a study onbromelain, one of the proteolytic enzymes that has therapeutic effects for support of soft tissue injuries.Following injury, bromelain significantly increased the maximum muscle force in the treated group, indicatingthat bromelain can be helpful for a quick recovery from injury. The Merck index lists it as an excellent antiinflammatoryenzyme (Merck Index, 11th ed. 1989. Merck & Co. Inc., Rahway, NJ, p. 1382). Bromelain therapy has becomequite popular for use in rheumatoid arthritis to decrease joint inflammation. The smooth muscle relaxantproperties of bromelain contribute to the documentation for relieving cramps.Vitamin C (as ascorbic acid) and Bioflavonoids: Beneficial nutrients to aid in the normal inflammatoryresponse.Turmeric (rhizome), Astragalus (root) & Horsetail (herb): Powerful herbs used historically to promote andsupport and anti-inflammatory environment.Powerful herbs used historically to promote and support and anti-inflammatory environment.
Contraindications: Do not take in pregnancy.
Ingredients: Each Capsule Contains: Vitamin C (as ascorbic acid) 65 mg. Proprietary blend 395 mg* of: Protease 50,000 HUT, Bromelain 384,000 FCCPU, Protease 6.42 SAPU, Cellulase 100 CU, Turmeric (rhizome), Astragalus (root), Horsetail (herb), Lemon Bioflavonoid, Rosemary (leaf) Extract.
Vegetarian: Yes
Suggested Dosage: 1 capsule daily or as directed. Take supplements between meals.
Pack: 60 Capsules
Product:

Prostate-Support (2018)

Supportive Function: The well-referenced herbals, saw palmetto and pygeum Africanus, associated with male prostate support, are mixed with other synergistic nutrients to comprise a great support product for this gland. When is Prostate Support helpful? Benign prostatic hyperplasia (BPH) (improvements with nutritional support have been noted in prostate volume, urinary frequency and peak urinary flow rates), prostate disorders, cystitis, epididymitis, stimulates bladder, prostate, testicles, ovaries and uterus, stimulates mucous membranes (respiratory and genitourinary), male infertility, impotence, prostatitis, aphrodisiac, diuretic, sedative, dysentery, androgen excess in women, and polycystic ovarian disease.
Clinical Applications Research: Vitamin C, Vitamin E, Vitamin B-6, and Zinc are accessory nutrients, which help support and build healthy prostate tissue and protect cells from oxidative damage. Zinc has long been associated with support of the male sexual organs. Pumpkin (seed): They are high in unsaturated fatty acids, vitamins and minerals (especially zinc), and have been used traditionally for urinary problems, nephritis, as a diuretic, an anti-inflammatory, and have proven useful in the early stages of prostate problems (Chevallier A. The Encyclopedia of Medicinal Plants. Dorling Kindersley Ltd, London 1996) . Saw Palmetto (berry): Saw palmetto is a small palm tree native to the West Indies and the North American Atlantic coast. The most common therapeutic use for saw palmetto is for benign prostatic hyperplasia (BPH), or enlargement of the prostate. Saw palmetto inhibits an enzyme that prevents testosterone from being converted to a more potent hormone, dihydrotestosterone, implicated in the cause of BPH. Stinging Nettle (leaf): Stinging nettle is used as a cleansing, nourishing spring tonic and has a high vitamin C content. It is a diuretic, astringent, and circulatory stimulant. The aerial parts of the plant clear uric acid to relieve gout and arthritis. It contains histamine and formic acid, which can cause an allergic response in sensitive people. Echinacea Purpurea (root): Echinacea has demonstrated superb ability to fight foreign invaders and boost the immune system. It provides excellent protection from bacterial, viral, and microbial attack, to which the genitourinary system is particularly susceptible. Ginkgo Biloba (leaf): Ginkgo Biloba is well known for its ability to increase microcirculation, or the circulation of blood near the small vessels and one-celled capillaries of tissue nutrient exchange. This makes it especially helpful for the blood circulation of the sexual organs. Pygeum Extract (bark): Pygeum targets mostly the prostate, having beneficial effects on benign prostatic hyperplasia (BPH) specifically, and has been shown to enhance prostate and bulbourethral gland secretions, in quantity and quality. Components of pygeum africanum also have anti-inflammatory activity. The fatty acid components are similar to that of saw palmetto, and may explain why it also has a beneficial effect on BPH. 187 Pygeum extract shows clinical significance of improvement in the symptoms of BPH (such as nocturnal frequency, difficulty in micturition, and incomplete bladder emptying) (Ann Urol 1984; 18:193-195) . Large doses of pygeum can result in gastrointestinal irritation in sensitive individuals. Wild Yam (root): Wild yam contains phytosterols (plant steroids including precursors to progesterone and estrogen). These phytosterols are important in keeping the right hormonal balance for optimal health. Uva Ursi (leaf): Uva ursi's purported properties include that of anesthetic, anticarcinogenic, antibiotic, antiseptic, diuretic, and urinary disinfectant, and it is used in cases involving weakened liver, kidneys, and other glands (Mowry D. Scientific Validation of Herbal Medicine Keats Publ. New Canaan, Conn. 1986).
Contraindications: Do not take during pregnancy. Echinacea contains sugars in its cell membrane, which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (i.e. 8 weeks on, 1 week off). Ginkgo in large quantities is contraindicated with anticoagulant drugs (only a small amount is used in this synergistic formula). Monitor PSA levels regularly.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 10 mg, Vitamin E (as succinate) 3 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Zinc (as chelate) 1 mg. Proprietary blend 846 mg* of: Pumpkin (seed), LGlycine, L-Alanine, L-Glutamic Acid, Saw Palmetto (berry), Stinging Nettle (leaf), Echinacea Purpurea (root), Pygeum (bark), Ginkgo Biloba (leaf), Wild Yam (root), Pygeum Extract (bark), Uva-Ursi (leaf).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Pyridoxal-5-Phosphate (1289)

Supportive Function: The biologically active form of vitamin B-6 ready to act with no conversions!
Ingredients: Pyridoxal-5-Phosphate 25 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
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Quercetin-S (1937)

Supportive Function: Quercetin is a powerful antioxidant; its popularity is reflected by the fact that it has even been named, "the most important flavonoid" (Nutr. Cancer 1993, 20:21-9) . When is Quercetin helpful? Allergies (both environmental and food), cold/flu, immune system, varicose veins, bone spurs, gum support, bruising, nosebleeds and eye support.
Clinical Applications Research: Quercetin: Quercetin, called, "the most important flavonoid" by some researchers, is a powerful antioxidant which has demonstrated cell-cycle homeostatic properties (Nutr. Can. 1993, 20:21-9) . Being a potent bioflavonoid, quercetin is used for cellular homeostasis. It is effective because it stabilizes cell membranes, decreases the release of toxic mediators, and supports normal smooth muscle contraction (Murray M. Enc of Nat Med. Prima Publ., Rocklin, CA. 1991. p.298) . Bioflavonoids also support capillary integrity (Merck Index, 11th ed. 1989. Merck and Co. Inc. Rahway, N.J. p. 1243) , and stabilize the collagen matrix by preventing free radical damage. Quercetin has also demonstrated a positive, supportive effect on the immune system (J. Med. Virol. 15:71-79) . It has been hypothesized that flavonoids, especially quercetin, provide such strong support for the immune system and mental well-being that it is important to introduce them early in life (Clin Ther. 2015 May 1;37(5):984-95. Gut-Microbiota-Brain Axis and Its Effect … Immune Dysregulation. Petra AI, et al).
Contraindications: None known
Ingredients: Proprietary blend 200 mg* of: Quercetin
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
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Re-Cal-B (1397)

Supportive Function: A special hydroxyapatite formula provides super bone support with calcium, magnesium, and other important nutrients (including the herb horsetail, traditionally used to maintain bone health); organically complexed with boron. When is Bone Support helpful? Osteoporosis (or prevention) bone trauma, and daily calcium requirements.
Clinical Applications Research: Vitamin C (as ascorbic acid) and Betaine (as hydrochloride): Vitamin C and hydrochloric acid (as hydrochloride) increase absorption of calcium from the intestines. An acid environment solubilizes and ionizes the insoluble calcium salts in the body (calcium has to be ionized in the intestines in order to be absorbed). Calcium (as chelate, aspartate, gluconate, hydroxyapatite, citrate): Calcium is critical to normal bone function, and supplementation has been beneficial in preventing bone loss. “The current RDA of calcium for older adults (800 mg) is controversial, and it has been suggested that 1500 mg/day is required for adequate calcium balance” (Gastroenterology Clinics of North America 1990; 19(2): p.484) . A National Institutes of Health panel reported that ½ of all Americans consume too little calcium (NIH Committee, Nutrition Week 22:7, June 10, 1994) . Hydroxyapatite, veal bone, and red bone marrow are all excellent natural sources of both calcium and magnesium with other trace minerals. Vitamin D3 (as cholecalciferol): Vitamin D increases the absorption of calcium from the intestines, and regulates the blood level of calcium. Parathyroid hormone works to regulate blood levels of calcium, mostly by its effect on vitamin D. Vitamin D occurs naturally in cod liver oil, but not in many dietary sources. Trace amounts are found in eggs. Some conversion to vitamin D takes place with exposure to sunlight. Magnesium (as chelate): Magnesium increases the solubility and retention of calcium. Many people feel that magnesium has not gotten enough attention in light of the focus on calcium for prevention of bone loss, however magnesium is just as important, if not more important, than calcium. Magnesium slows bone loss and strengthens muscles (Wright, Jonathan V. M.D. Healing with Nutrition. 1990. Keats Publishing, Inc. New Canaan, Conn. p. 205) . Clinical trials showing supplementation of at least as much magnesium with calcium has proven dramatic results in reduction for risk of osteoporosis. Horsetail (herb): Horsetail rush (shave grass) is highly absorbable and is utilized to promote bone growth and collagen formation. Horsetail’s silica content makes it useful in sitz baths, which aid in treating peripheral vascular disorders and post-thrombotic swelling, as well as treating ligaments and tendons after ankle sprains and fractures (Weiner, M.A. Herbs that heal. 1994. Quantum Books, Mill Valley, Ca. p. 197) . Boron (as chelate): Boron is a, “dynamic ultra trace element that affects major mineral metabolism in higher animals. Boron naturally elevates estradiol levels, and decreases urinary excretion of calcium and magnesium, both of which decrease risk for osteoporosis. Osteoarthritis patients have shown improvement when supplemented with boron (Giller, R., M.D., and Matthews, K., Natural Prescriptions, Ballantine Books, NY, p. 245) . A possible mechanism is via the parathyroid gland, which contains more boron than any other tissue. Boron enhances parathyroid hormone activity, and the parathyroid gland is the primary organ controlling mineralization of bone (Burton Goldberg Group, Alternative Medicine: The Definitive Guide, Future Medicine Publishing, Inc. WA, 533) .
Contraindications: Not recommended for children. Boron may raise estrogen levels which can be irritating in pre-menopausal females, which is not normally a problem. If that is the case, switch to Cal/Mag 1:1.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 12.5 mg, Calcium (as chelate, aspartate, gluconate, hydroxyapatite, citrate) 120 mg, Vitamin D3 (as cholecalciferol) 25 IU, Magnesium (as chelate) 40 mg. Proprietary blend 49 mg* of: Horsetail (herb), L-Glutamic Acid (as hydrochloride), Safflower (herb), Ammonium Chloride, Betaine (as hydrochloride), Parathyroid (bovine), Boron (as chelate).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Rutin Plus (1254)

Supportive Function: Rutin Plus is an amazing combination of bioflavonoids, providing the best that nature offers in phytochemically active plant constituents. Bioflavonoids were first discovered in the white rind of citrus fruits. Also known as “vitamin P” (for permeability factors), bioflavonoids have a beneficial effect on building capillary strength. Bioflavonoids are water-soluble plant pigments that give the bright color to fruits and vegetables. Bioflavonoids include such things as flavones, flavonones, flavonols, anthocyanidins and proanthocyanidins. When is Rutin helpful? Increases capillary integrity, especially for easy bruising, bleeding gums, bleeding ulcers, hemorrhoids, varicose veins and nosebleeds, high blood pressure, spontaneous abortions, repeated miscarriages, heavy menstrual flow, colds and flu’s
Clinical Applications Research: Vitamin C (as ascorbic acid): Works synergistically with bioflavonoids. Lemon Bioflavonoids, Rutin and Hesperidin: Bioflavonoids have been shown to have anti-inflammatory, anti-allergic, antiviral and anticarcinogenic properties. They are also powerful antioxidants. Bioflavonoids include rutin from buckwheat, Hesperidin from citrus fruits and quercetin from garlic and onions. Rutin and Hesperidin also have beneficial effects on capillary permeability and blood flow. Quercetin has been shown to have anti-tumor activity. Alfalfa (herb, stem): Alfalfa is an infection fighter; the high chlorophyll content in alfalfa was used by doctors in the 1940's for treating infections from surgical incisions, bedsores and inner ear problems (Heinerman, J. Heinerman’s Encyclopedia of Fruits, Vegetables and Herbs. 1988; Parker Publishing, West Nyack, NY. p. 2) . Carrot (root): Carrots have also been used to “benefit the lungs, strengthen the spleen and pancreas, improve liver function, stimulate the elimination of wastes, act as diuretic, dissolve accumulations such as stones and tumors, treat indigestion including excess stomach acid and heartburn, eliminate putrefactive bacteria in the intestines that cause poor assimilation and provide relief in diarrhea and chronic dysentery.” (Pitchford, P., Healing with Whole Foods, North Atlantic books, Berkeley, CA, 1993, pg. 498). Carrots are powerful antioxidants that are important in many illnesses, including cancer. The carotenoids found in carrots have been linked to lung cancer prevention. Rose Hips (fruit): Natural source of vitamin C.  Witch Hazel (leaf): Witch hazel has been known for centuries to be helpful in hemorrhoids.
Contraindications: High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease. Alfalfa contains L-canavanine, which is suspected of causing some allergic reactions in susceptible people.
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 100 mg, Calcium (as TriCalcium Phosphate) 100 mg, Phosphorus (as TriCalcium Phosphate) 50 mg. Proprietary blend 210 mg* of: Lemon Bioflavonoids, Rutin, Alfalfa (herb, stem), Acerola (fruit), Carrot (root), Rose Hips (fruit), Witch Hazel (leaf), Hesperidin.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

S.O.D. Lozenge (1490)

Supportive Function: Superoxide dismutase, catalase, and glutathione peroxidase are the dominant free-radical-scavenging enzymes in the body that build our antioxidant defenses against the harmful radicals.
Ingredients: Zinc (as chelate) 0.300 mg. Superoxide Dismutase 156* mg*, which contains Catalase and Glutathione Peroxidase. Natural Peppermint Flavor.
Vegetarian: No
Suggested Dosage: Lozenge dissolved slowly in mouth or as directed.
Pack: 60 Chewable Lozenges
Product:

Sago-C-500 (1562)

Supportive Function: Sago-C-500 is a powerful mixture featuring corn-free, Sago Palm Vitamin C teaming up with rich bioflavonoids and glandular support to help maintain solid immune support. When is Vitamin C helpful? Cold/flu, respiratory and immune support, antioxidant function, adrenal and thyroid support, trauma, arterial and venous support, heavy metal toxicities, blood sugar, eye health (antioxidant effect), heart health, and fatigue.
Clinical Applications Research: Immune System: Given the many varied functions of vitamin C in the body, it is no surprise that it is essential to the immune system function. Vitamin C is utilized to help clear toxic metals and substances from the body in order to detoxify and achieve optimal health. The American Journal of Clinical Nutrition reports that consumption of vitamin C has been inversely related to incidences dysfunction in several epidemiological studies (Kromhout D. Essential micronutrients... Am J Clin Nutr 1987; 45:1361-7) . According to a report in Allergy and Imm. (Feb. 1993), vitamin C has a "special influence” on supporting the immune response and warding off foreign invaders. Several studies of groups taking vitamin C show that it reduces the longevity and severity of colds (Brit. J. Nutr. 67:3-16) . One group, taking 600 mg supplements, experienced upper respiratory tract support during supplementation (Amer. J. Clin. Nutr. 57:170-74) . Extra addition of vitamin C seems to support the immune system by increasing cellular immune functions and stimulating neutrophils (immune-fighting cells). Patients receiving 1 gram of vitamin C daily had improved neutrophil activity, resulting in a dramatic reduction of foreign attacks on the immune system, allowing the system to function in homeostasis (Anderson, R. Int J Vitam Nutr Res. Suppl. 23:23-34, 1982; Patrone, R, Dallegri, F, Bonvivi, E, et al. Acta Vitaminol Enzymol. 4:163-68, 1982) . Vitamin C treated groups did not report feeling as bad while under attack as those who were not supplemented. Many people believe that vitamin C contributes to a feeling of well-being. Healthy Aging: Vitamin C is a potent antioxidant which guards against the oxidant stress involved in lung dysfunction (Hatch GE Am J of Clin Nutr 1995; 61(suppl): p. 628S) . A UCLA researcher, James Enstrom, says that 300-mg of vitamin C a day (half from supplements) will support healthy aging moreso than those getting only 25 mg. (Fort Collins Coloradoan USA Weekend, Sept 30, 1994 p. 10) . Heart Health: The presence of imbalances in lipid levels, vascular integrity, and heart homeostasis is more frequent in humans with a low intake of vitamin C. Optimum intake of vitamin C suggested by some researchers ... “probably exceeds tenfold the doses officially recommended and is in the range of some hundred milligrams of vitamin C per day" (Miquel & Quintanilha The CRC Handbook of Free Radicals and Antioxidants in Biomedicine 1989; CRC Press, Boca Raton, Fla. p. 194) . Studies show that administration of gram doses of vitamin C provide support for circulating triglyceride levels (Sokoloff, B, Hori, M, Saelhof, CC et al. J Am Geriatr Soc. 14:1239-60, 1966; Ginter, E, N Engl J Med. 294:559-60, 1976. Gooly, KL, Diamond, LH. Ann Intern Med. 93:511, 1980) . Vitamin C's antioxidant function guards against the oxidation of LDL-cholesterol (the bad cholesterol), which can be unhealthy when oxidized levels are raised. One puff on a cigarette can deplete the plasma vitamin C content by as much as 50%. This is why the RDA for vitamin C intake for smokers is six times that for non-smokers (Efstratopoulos AD & Voyaki SM J of Hypertension 1993 11(suppl 5): S112-113) .
Contraindications: High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Vitamin C (as Sago Palm) 500 mg. Proprietary blend 53 mg* of: Lemon Bioflavonoids, Rutin, Hesperidin, Thymus (bovine), Lymph (bovine), Spleen (bovine), Propolis.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Selenium Chelate (1400)

Supportive Function: In addition to being a co-factor for numerous enzymes, Selenium is an antioxidant which has received a lot of attention for its reported role in contributing to a healthy immune defense. Selenium is one of the minerals that is increasingly harder to fi nd in foods as our soils get depleted of natural nutrients.
Ingredients: Selenium (as chelate) 50 mcg. Proprietary blend 54 mg* of: Spleen (bovine), Liver (bovine), Stomach (porcine), Heart (bovine), Duodenum (porcine), Kidney (bovine), Thymus (bovine), Adrenal (bovine), Pituitary (bovine), Pancreas (bovine), Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Serene Renew (2806F)

Supportive Function: Supportive Function: Sleep, relaxation, calmness, mood support and focus. When is Calming Support helpful? Stressful or anxious times, busy schedules, sleepless nights.
Clinical Applications Research: Kava Kava (root) (70% kavalactones) is an herb used for relaxation and sleep support. Many studies (including a meta-analysis) confirm that kava is safe (Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 2013; Pittler, MH et al. 2003, Kava. Cochrane Database Syst Rev.) . The various mechanisms of action for kava contribute to its effect on neurotransmitter homeostasis (and adrenal insufficiency) and its ability to support energy levels and stress reactions (Blumenthal, Mark. The ABC Clinical Guide to Herbs. American Botanical Council. 2003) . Valerian (root)(0.8% valerenic acid) has been used for centuries an herbal support for stress homeostasis. Its effects are suspected to be mediated through the GABA receptor. The amino acid valine is named after this plant. The valerenic acids and sesquiterpenoids in valerian are considered to be the highly active components. Valerian supports neuronal and heart health in addition to the effects normally attributed to this anti-stress herb. Passion Flower (4% flavonoid) : Numerous pharmacological effects of Passiflora incarnata are mediated via modulation of the GABA system (Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011). The same two-year multicenter, prospective observational study on St. John's Wort, valerian root, and Passion Flower mentioned above (involving 115 children between 6 and 12 years) was well tolerated and found to be beneficial (Herbal triplet in treatment of nervous agitation in children. Wien Med Wochenschr. 2013 Feb). Inositol is used to stabilize cell structures thereby enhancing cell signaling and cell communication. It helps the second messenger system and aids in the production of ATP. L-Theanine : Web MD describes theanine as an amino acid found in green tea that has a chemical structure similar to a naturally occurring amino acid in the body that helps to transmit nerve impulses in the brain. It is a powerful amino acid with amazing properties. It raises glutathione, which is the body’s main antioxidant and cell stabilizer. L-Theanine has a homeostatic effect on the calming neurotransmitters, as well as balancing the homeostasis of excitatory neurotransmitters. It is through this neurotransmitter pathway that L-theanine may be exerting its effects of counteracting the results of too much caffeine. Phenibut (beta-phenyl-gamma-aminobutyric acid) is also a powerful antioxidant, and unlike GABA (gammaaminobutyric acid), it is able to cross the blood barrier to promote its effects. GABA is a natural neurotransmitter produced in the body. The proposed mechanisms of phenibut are aimed at neuronal responses, learning centers, and normal dopamine production. St. John’s Wort (herb)(0.3% hypericin) has historically been utilized as support for mood homeostasis. St. John’s Wort, valerian and passion flower were investigated in a multicenter, prospective observational study (2008) with 115 children between 6 and 12 years, and found to be safe, well tolerated, and good support. 191 St. John’s Wort was studied with kava kava in a systematic review that was conducted using the electronic databases MEDLINE, CINAHL, and The Cochrane Library during late 2008 and those results also supported the historical use of St. John’s Wort. (Kava and St. John's Wort: current evidence for use in mood and anxiety disorders. J Altern Complement Med. 2009). Lecithin (sunflower) is an emulsifier that is beneficial for increasing the absorption and bioavailability of many nutrients. Lecithin is also known for fostering a normal non-inflammatory state, and has been researched for its favorable effects in supporting health. Lecithin has lowered C-reactive protein in some studies (CRP is an inflammatory marker).
Contraindications: The ingredients in this formula have a good safety profile. Use caution when used concomitantly with other drugs, especially benzodiazepines, and CNS depressants as they sometimes affect similar biochemical pathways, and statins/acetaminophen which lower liver function. Possible interaction with goldenseal supplements. St. John’s Wort can interact (usually slow the metabolism of) some drugs. Consult with your practitioner if in doubt.
Ingredients: Proprietary blend 590 mg* of: Kava Kava (root)(70% kavalactones), Valerian (root)(0.8% valerenic acid), Passionflower (4% flavonoid), Inositol, L-Theanine, Phenibut, St. Johns Wort (herb)(0.3% hypericin), Lecithin (sunflower).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Sino-Lung Formula (2011A)

Supportive Function: Sino-Lung-Formula is a revolutionary mixture of ingredients that optimizes natural defenses by including glandular immune support, strong-acting propolis, healthful herbs, N-acetyl cysteine to maintain cell protection, along with synergistic nutrients and antioxidants to facilitate the maintenance of a healthy respiratory tract. When is Sinus Support helpful? Sinus infection, nasal congestion, asthma, and respiratory conditions.
Clinical Applications Research: Vitamin A (beta-carotene): Beta-carotene is a potent antioxidant, which works in areas of low oxygen tension, making it especially important at the cellular level of the lungs, where deoxygenated blood reaches the lungs and accepts fresh oxygen. Vitamin C (as ascorbic acid): Vitamin C is the most abundant antioxidant in the extra cellular fluid lining of the lungs. Low vitamin C intake has been correlated with pulmonary dysfunction (National Health and Nutrition Examination Survey) , asthmatics have lower than normal serum levels of vitamin C (Aderele WR et al., Afr J Med Sci 1985; 14:115-20) , and supplementation with vitamin C seems to help. It has been noted that symptoms of ongoing asthma in adults appear to be increased by exposure to environmental oxidants and decreased by vitamin C supplementation. Seven clinical trials showed an improvement in respiratory measurements as a result of supplementation with 1-2 grams of vitamin C. Lemon Bioflavonoids: Bioflavonoids are found in nature with vitamin C, and they boost the therapeutic effect of vitamin C, helping to build strong connective tissue, and create a protective barrier to infection. N-Acetyl-Cysteine: N-acetyl-cysteine (NAC) has a unique cell-protecting ability, potent antioxidant activity, is a precursor for extra cellular connective tissue, and is a precursor for glutathione, another important antioxidant found in the extra cellular fluid lining of the lungs. Propolis: Propolis is a substance made by bees, which is sometimes called, “bee glue," which is highly antibacterial and anti-inflammatory. It is very effective in counteracting lung inflammations. Cranberry (fruit) and Elderberry (flower): Cranberry and elderberry have phytochemicals called proanthocyanidins, which are potent phytochemicals that prevent the release and synthesis of compounds that promote inflammation, such as histamine, serine proteases, prostaglandins and leukotrienes (Trends Pharm Sci.1984; 5:335-8) . Additionally, cranberry has the ability to reduce adhesion of bacteria and microbes to mucous linings, such as those in the respiratory system. Elderberry reduces phlegm, acts as an anti-inflammatory and expectorant, and is useful for upper respiratory tract mucous, especially associated with colds and hay fever (Ody, P. The Complete Medicinal Herbal. 1993. Dorling Kindersley Ltd, London) . Glandulars: Glandulars are thought to provide precursor substances that the body can use to support and enhance the function of a specific gland. They may provide the potential “life force” the body needs to enhance function of a specific organ or gland. Glandulars are tissue concentrates, usually of a bovine source, which stimulate the glands they respond to, such as the lungs and thymus gland. They provide integral amino acid sequencing and signaling substances to enhance their respective organs. Glandular therapy began in the late 19th century when doctors suggested to their patients that eating the glandular parts from a cow that correspond to the weaknesses in their own bodies may help them to heal. The Egyptians and Greeks used glandular therapy many years ago because they believed in the concept that “like heals like” (Haas, E. MD. Staying Healthy with Nutrition. 1992; Celestial Arts, Berkeley, Ca. p. 283) . In the late 1800s, desiccated thyroid glandular was used for patients with hypothyroidism or goiter, but was replaced once the thyroid hormone thyroxin (T4) was isolated. Many doctors felt that the whole glandular was superior, due to better utilization, absorption, and synergistic action. Dr. A. Kemet investigated whether or not oral glandulars were organ specific. Using radioactive isotope tracings, he found that glandular tissues were absorbed in the blood and deposited in the corresponding organs. He documented his findings in German medical publications of 1958 and 1972 (Balch, J.F., M.D. and Balch, P.A., C.N.C. Prescription for Nutritional Healing. 1990. Avery Publishing, Garden City Park, NY. p. 326) .
Contraindications: Contraindicated in pregnancy. Echinacea contains sugars in its cell membrane, which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (i.e. 8 weeks on, 1 week off).
Ingredients: Each Tablet Contains: Vitamin A (beta-carotene) 750 mcg, Vitamin C (as ascorbic acid) 75 mg. Proprietary blend 525 mg* of: Lemon Bioflavonoid, Hesperidin Complex, Echinacea Purpurea (root), Skullcap (plant), Lung (bovine), Thymus (bovine), Spleen (bovine), N-Acetyl Cysteine, Cranberry (fruit), Rutin, Propolis, Elderberry (flower).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Spleeno-Lyph (1165)

Supportive Function: Lymph is one of the main ways in which the body detoxes poisons that can pose a threat to the immune system. The spleen is the major lymph organ, and Spleeno-lyph offers glandular support for this important tissue. When is Spleen Support helpful? Lowered immune function, infections, fatigue, hypocalcaemia, hypoparathyroidism
Clinical Applications Research: Spleen Glandular: The spleen has many functions in the body. It disposes of red blood cells, manufactures leukocytes, increases immune factors, and provides resistance to infection assists in iron metabolism and monitors intestinal peristalsis to some extent.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 2 mg, Proprietary blend 251 mg* of: Spleen (bovine), Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

St. John's-DEP (1717)

Supportive Function: Mood support When is St. John’s Wort helpful? Disruption of the feeling of well-being, low serotonin levels.
Clinical Applications Research: St. John’s Wort (herb): St. John’s wort has been used extensively for mood support for ages. Many clinical trials have been conducted to confirm the efficacy of the herb in this area. One study, which listed some of the active ingredients in the herb, such as mucilage, anthraquinones, oils, catechins, etc... was carried out “to study the elemental, nutritional, phytochemical and biological evaluation” of this herb (Pak J Pharm Sci. 2016 Mar;29(2):547-55. Elemental, nutritional, phytochemical and biological evaluation of Hypericum perforatum Linn. Dastagir G et al). The efficacy of St. John’s wort may be attributed to properties that prevent oxidation, glycation, and cell toxicity (Pak J Pharm Sci. 2016 Mar;29(2):397-405. Pharmacological screening of Hypericum androsaemum extracts for antioxidant, anti-lipid peroxidation, antiglycation and cytotoxicity activity. Saddiqe Z. et al). B Vitamins: B vitamins are essential to our energy making processes, and some B vitamins are especially critical to those processes. Folate (as folic acid) and Vitamin B-12 (as cyanocobalamine) , for instance, are very important. They are necessary to stimulate tetrahydrobiopterin (BH4). BH4 is a vitamin- like compound which functions as an essential co-enzyme in the synthesis of several neurotransmitters. Low levels of tetrahydrobiopterin (BH4) in the brain can elicit many symptoms associated with mood imbalance. Folic acid deficiency is the most common nutrient deficiency in the world. Supplemen-0tation has proven useful for feelings of well-being (J Neurosci Rural Pract. 2016 Jul-Sep;7(3):362-7. Effect of Vitamin B12 and folic acid supplementation…Adhikari PM et al). Thiamine (as hydrochloride) (B-1): A thiamine deficiency may result in metabolic acidosis, changes in the peripheral nervous system, gastric upset and altered brain chemistry. Low thiamine levels can contribute to the symptoms of mood imbalance. Efficacy of supplementation is evidenced by clinical trials, and results were reported in six weeks time in one study. (Eur Arch Psychiatry Clin Neurosci. 2016 Mar 16. Adjuvant thiamine:… results from a randomized, double-blind, and placebo-controlled clinical trial. Ghaleiha A et al). Niacin (as niacinamide): Niacinamide is the form of niacin that does not cause vasodilatory flushing: Deficiencies can cause insomnia, irritability, strain, tension, and affect mood. Niacinamide is very important for brain metabolism. Nicotinamide may act in part by preventing NADH hyperoxidation (Neurobiol Dis. 2014 Feb;62:469-78. Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation … Shetty PK et al). Calcium (as citrate) and Magnesium (as citrate): Calcium and magnesium are two minerals that are essential for normal metabolic functioning. They both affect multiple organ systems, like the muscular system and the neuronal system. They work synergistically to provide the needed support for optimal well-being. They both act as co-enzymes in many metabolic functions, and both are extremely integral nutrients for mental well-being  (BMC Psychiatry. 2016 Jun 8;16:192. … rationale and design of the MooDFOOD prevention trial. Roca M et al). Ginkgo (leaf) and Gingko Extract (leaf): Ginkgo biloba is a well known herb, studied for its support of circulation, brain plasticity and mood support. The various phenols in ginkgo may be responsible for its efficacy. (Oxid Med Cell Longev. 2015;2015:248529. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy? Trebatická J, Ďuračková Z. et al). Damiana (leaf): Damiana has been used traditionally for years as a tonic for the nervous system. The plant contains thymol, flavonoids (such as 5 hydroxy-7,3",4-trimeathoxyflavone) and the hydroquinone arbutin, that may be responsible for its efficacy. Blue Vervain (herb): The uses of vervain are varied, including as a tonic for the nervous system. Vervain contains iridoids, verbenin, verbenalin and bastatoside with numerous essential oils, which may be responsible for its effects. Eleuthero (root): The eleutherosides contained in Eleuthero (called Siberian ginseng) have been shown to be responsible for the adaptogenic properties of this plant. Eleutherosides are a range of glycosides with aromatic alcohol aglycones. The glycosides appear to act on the adrenal glands, helping to prevent adrenal hyper-trophy and excess response to stress. The eleutherosides additionally help reduce the exhaustion phase of the stress response and support adrenal homeostasis (Roca M et al. ibid) . Pyridoxal-5-Phosphate (P-5-P): P-5-P is the active form of vitamin B-6. Vitamin B-6 (and thus P-5-P) helps to metabolize brain neurotransmitters, especially the monoamines, like dopamine, epinephrine, norepinephrine and serotonin. A reduction in the availability of the active form of this vitamin is known to affect tryptophan hydroxylase, the enzyme leading to serotonin synthesis  (J Physiol Parmacol. 2016 Feb;67 (1):3-19. Overview of the role vitamins and minerals on the kynurenine pathway in health and disease. Majewski M. et al).
Contraindications: Do not take while taking any mood-altering drugs, or drugs that raise neurotransmitters, unless monitored by a physician. Do not take with drugs metabolized by cytochrome P450, as decreased drug effectiveness may occur. Cautions to avoid tyramine-containing foods because St. John’s wort is a possible MAO inhibitor, etc., have not been substantiated. Hypericin, the concentrated extract, can cause sun sensitivity, however there is not as much concern with the whole herb. Use caution in pregnancy. None of the herbs in this formula are directly contraindicated in pregnancy; however, it is a good idea to check with a licensed professional when contemplating the use of herbs during pregnancy.
Ingredients: Each Tablet Contains: Calcium (as citrate) 20 mg, Thiamine (as hydrochloride) 10 mg, Niacin (as niacinamide) 50 mg, Folate (as folic acid) 100 mcg, Vitamin B-12 (as cyanocobalamine) 250 mcg, Magnesium (as citrate) 16 mg. Proprietary blend 520 mg* of: St. Johns Wort (herb), Ginkgo (leaf), Damiana (leaf), Blue Vervain (herb), Hyssop (leaf), Eleuthero (root), Pyridoxal-5-Phosphate, Riboflavin-5-Phosphate, Gingko Extract (leaf).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Super-Ox (2403)

Supportive Function: Proanthocyanidins have become a buzz word because of their strong reputation for being the most potent of the recently discovered highly-active phytochemicals available in plants. These powerful plant constituents are presented in a nutrient-rich formula with other free-radical fighting substance, contributing to maximal antioxidant defense.
Ingredients: Vitamin C (as ascorbic acid) 100 mg, Vitamin E (as succinate) 31 mg, Zinc (as chelate) 2 mg, Selenium (as chelate) 50 mcg, Manganese (as chelate) 0.100 mg, Chromium (as chelate) 50 mcg. Proprietary blend 182 mg* of: Milk Thistle (seed), Grape Seed Extract, N-Acetyl Cysteine, Milk Thistle (extract) (seed), L-Glutathione.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Surgery/Trauma (0904)

Supportive Function: Support for Inflammation due to Surgery or Trauma Indications: Swelling, inflammation and pain due to trauma or surgery
Clinical Applications Research: HYPERICUM 30X: Trauma of the nerve, post surgery pain, lacerated wounds and burns ARNICA MONTANA 200X: Pre-post surgery, blows, contusions, bruising, comatose, cerebral congestion, tendency to hemorrhage, thrombosis SYMPHYTUM 6X: Wounds penetrating to perineum and bones, non-union fractures, tramatic injuries of the eye BELLIS PERENNIS 12X: Trauma, venous congestion and injuries to deeper tissues after major surgical work, ingures to nerves STAPHYSAGRIA 12X: Lacerated tissues, colic after abnormal operations and severe pain after abdominal surgery
Contraindications: WARNING: STOP USE AND CALL A DOCTOR IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN. CONTAINS ALCOHOL: IN CASE OF ACCIDENTAL OVERDOSE, CONSULT A POISON CONTROL CENTER IMMEDIATELY.
Ingredients: Active Ingredients: Arnica 200X, Bellis 12X, Hypericum 30X, Staphysag 12X, Symphytum 6X. Contains equal volumes of each ingredient. Inactive Ingredients: Alcohol (20% v/v), Purified water.
Vegetarian: Yes
Suggested Dosage: 4-6 drops , 4x per day Acute situations: 4-6 drops every 15-30 minutes until symptoms subside
Product:

THY (#8) (Tincture) (T-8)

Supportive Function: A thyroid-supporting tincture.
Ingredients: Ingredients: Pure tincture extract of: Skullcap (herb), Parsley (leaf), Uva Ursi (leaf).
Vegetarian: Yes
Suggested Dosage: 10 drops daily in water or as directed
Pack: 1 oz Herbal Tincture
Product:

Thymo-Lyph (1170)

Supportive Function: High-quality, concentrated thymus glandular supports the organ responsible for production of many of our immune cells.
Ingredients: Each Tablet Contains: Thymus (bovine) 150 mg, Parotid (bovine) 1 mg.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Thyro Plus (T-40)

Supportive Function: Supports the thyroid gland.
Contraindications: Use caution during pregnancy
Ingredients: Ingredients: Pure tincture extract of: Bladderwrack (leaf), Gotu Kola (herb), Hawthorn (fruit), Saw Palmetto (berries), Cayenne (fruit), Skullcap (herb), Ginkgo Biloba (leaf), Dandelion (root), Dandelion (leaf), Eleuthero (root), Wood Betony (herb), Chaste Tree (plant), Wild Yam (root).
Vegetarian: Yes
Suggested Dosage: 5-20 drops in water daily or as directed
Pack: 1 oz Herbal Tincture
Product:

Thyroid (0952)

Supportive Function: Mental menses, skin and immune system conditions associated with hypothyroidism
Clinical Applications Research: IODIUM 12X: Thyroid enlarged, sluggish vital reaction PULSATILLA 12X: Chilliness, acne, amenorrhea, leucorrhea BARYTA CARBONICA 12X: Mental weakness, loss of memory, confusion and immune system suppressed CALCAREA CARBONICA 12X: Weight gain, shortness of breath, apprehensive, goiter, swelling of glands, rheumatoid pains, constipation THYROIDINUM 12X: Tachycardia, rheumatic pains, cold extremities, edema of the legs ARSENICUM IODATUM 12X: Verigo, skin eruptions, suppressed immune system FUCUS VESICULOSUS 3X: Goiter, constipation BADIAGA 12X: Rheumatic pains, swollen glands, overweight in children
Contraindications: WARNING: STOP USE AND CALL A DOCTOR IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN. CONTAINS ALCOHOL: IN CASE OF ACCIDENTAL OVERDOSE, CONSULT A POISON CONTROL CENTER IMMEDIATELY.
Ingredients: Active Ingredients: Arsenicum iod 12X, Badiaga 12X, Baryta carb 12X, Cal carb 12X, Fucus 3X, Iodium 12X, Pulsatilla 12X, Thyroidinum 12X. Contains equal volumes of each ingredient. Inactive Ingredients: Alcohol (20% v/v), Purified water.
Vegetarian: Yes
Suggested Dosage: 4-6 drops, 4x per day Acute situations: 4-6 drops every 15-30 minutes until symptoms subside
Product:

Total Alpha Lipoic Acid (2725)

Supportive Function: This formula provides comprehensive nutritional support for antioxidant protection, glucose balance/insulin sensitivity. When is Lipoic Acid Support helpful? Support of diabetes, liver, pancreas, kidneys, eyes, capillaries, skin, infection, glucose tolerance, and insulin sensitivity.
Clinical Applications Research: Thiamine (as hydrochloride) (B-1) works with B-2 and B-3 to release energy from glucose. Thiamine Pyrophosphate, the enzymatic form of B-1, is included because some people have difficulty-converting B-1 into its active enzymatic form. Riboflavin (B-2) is needed to convert amino acids, fats, and carbohydrates into energy. Restricted diabetic diets frequently result in B-2 deficiencies. Riboflavin 5 Phosphate, the enzymatic form of B-2, is included because some people have difficulty-converting B-2 into its active enzymatic form. Niacin , a form of vitamin B-3, has been shown to help people with diabetes in small milligram amounts; massive gram amounts of B-3 have been found to work against diabetics. B-3 is necessary to release energy from carbohydrates and is synergistic with B-1 and B-2. Vitamin B-6 (as pyridoxine hydrochloride) levels are low in diabetics. B-6 helps prevent diabetes caused by pregnancy and birth control pills. B-6 helps produce normal blood sugar levels. Pyridoxal forms of B-6, such as Pyridoxal 5 Phosphate, has been found to improve glucose tolerance dramatically. Pantothenic Acid (as d-calcium pantothenate) (B-5) works with vitamins B-1, B-2, and B-3 to produce ATP, the energy molecule the body needs to run on. B-5 deficiency can lead to hypoglycemia, blood, and skin disorders. B-5 helps maintain the central nervous system and is necessary for the conversion of sugar and fat into energy. Magnesium deficiencies create greater glucose intolerance and contribute to damaging nerves and organs. Magnesium supplements improve arterial health by reducing plasma lipids and improving vasodilation. Magnesium improves production of insulin in the elderly and helps prevent retinopathy. Zinc “may have immunomodulatory activity. It may also have antioxidant activity. Zinc has putative antiviral, fertility-enhancing and retinoprotective activities” (PDR Health) . Zinc deficiency is common in diabetes (Ho E, Quan N, Tsai YH, Lai W, Bray TM Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med (Maywood). 2001 Feb;226(2):103-11) . Zinc is essential for the production of insulin and the digestion of proteins (Burton Goldberg Group. Alternative Medicine: The Definitive Guide. Future Medicine Publishing, Inc., Puyallup, Wa. 1994:652) . Zinc supplements have been shown to lower blood sugar levels in mice (Simon SF, Taylor CG. Dietary zinc supplementation attenuates hyperglycemia in db/db mice. Exp Biol Med (Maywood). 2001 Jan;226(1):43-51) . Selenium deficiency has been associated with pancreatic insufficiency. Selenium is needed to maintain a healthy pancreas, a healthy liver, and heart as well as protect against harmful oxidation of fats, protect the immune system, and protect against damage to arteries and eyes (Balch, J.F., M.D. and Balch, P.A., C.N.C. Prescription for Nutritional Healing. Avery Publishing, Garden City Park, NY. 1990:11,22,33). Diabetes is also known to predispose diabetics to infection. Selenium is a necessary co-factor for the enzyme glutathione peroxidase (GPx), which has well-documented activity against HIV activation (Diamond AM, Hu YJ, Mansur DB. Glutathione peroxidase and viral replication: implications for viral evolution and chemoprevention. Biofactors. 2001;14(1-4):205-10) . Selenium is believed to have an antiviral effect on the immune system (Lukác N, Massányi P. Effects of trace elements on the immune system. Epidemiol Mikrobiol Imunol. 2007 Feb;56(1):3-9). Selenium can “alter mutagenesis rates in both viral genomes and the DNA of mammalian cells exposed to carcinogens” (Diamond, AM et al., Ibid.) . Recent studies suggest that a viral cause may be implicated in some cases of diabetes (Berg AK, Olsson A, Korsgren O, Frisk G. Antiviral treatment of Coxsackie B virus infection in human pancreatic islets. Antiviral Res. 2007 Apr;74(1):65-71). Manganese deficiency is common in people with diabetes. Deficiency is associated with glucose intolerance, among other complications of diabetes. Manganese is necessary to maintain and repair the pancreas, and it is a co-factor in the enzymes that regulate glucose metabolism (Balch & Balch, 1997: 27-8; 228-32; Manganese and glucose tolerance. Nutr Rev. 1968 Jul;26(7):207-9) . Molybdenum has been shown in animal studies to function as an insulin mimic that reduces hyperglycemia in genetically obese, insulin-resistant mice to blood sugar levels of normal lean mice. Molybdenum also improved glucose tolerance (Reul BA, et al., “Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate,” J Endocrinol 1997 Oct; 155 (1): 55-64; Ozcelikay AT, et al, “Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate,” Am J Physiol 1996 Feb; 270 (2 Pt 1): E344-E352) . Molybdenum is essential for the metabolism of sugar into energy. Alpha Lipoic Acid enhances glucose conversion for cell protection, maintenance, and rebuilding. In diabetes, cells starve from unconverted glucose, resulting in diabetic complications to tissues and organs. Lipoic Acid protects against capillary damage and cataract formation. Lipoic Acid helps regenerate and recycle other antioxidants, especially C, E, and glutathione. It protects against arterial plaque and oxidative damage to LDL cholesterol. It helps neutralize toxins in alcohol and tobacco smoke, mobilize and detoxify heavy metals. Lipoic Acid protects liver from alcohol damage, enhances glucose disposal in adult onset, Type II diabetes, improves insulin sensitivity; and protects against diabetic complications of nerve damage. It has been shown to improve nerve blood flow, reduce oxidative stress, improve distal nerve conduction, and improve reduced levels of deficient glutathione and deficient E in the nerves of diabetics. Lipoic Acid prevents cataracts in animals by increasing levels of C, E, and glutathione in the lens. It binds with the DNA of some viruses and prevents replication. Viral causes are implicated in some cases of diabetes. Supplements have been shown to improve neuropathy and reduce nerve pain. Betaine (as hydrochloride) helps the digestion and absorption of nutrients, especially important in diabetes where the pancreas does not function well enough to produce adequate digestive, pancreatic enzymes.
Contraindications: In HIV infected individuals, doses up to 600 mg have proven helpful in interrupting viral activation, but doses over 600 mg may result in thrombocytopenia (this formula contains only 100 mg.)
Ingredients: Each Tablet Contains: Thiamine (as hydrochloride) 5 mg, Riboflavin 5 mg, Niacin 5 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Pantothenic Acid (as d-calcium pantothenate) 5 mg, Magnesium (as citrate) 10 mg, Zinc (as chelate) 3 mg, Selenium (as chelate) 5 mcg, Manganese (as chelate) 1 mg, Molybdenum (as chelate) 25 mcg. Proprietary blend 132 mg* of: Alpha Lipoic Acid, Betaine (as hydrochloride), Riboflavin-5- Phosphate, Pyridoxal-5-Phosphate, Thiamin Pyrophosphate.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Andro-Bal (0970)

Supportive Function: Water Based Sublingual Spray. Male and Female Hormone Support When is Total Andro-Bal helpful? For the temporary relief of both male and female conditions including fatigue, loss of libido, impotence, premature ejaculation, supports the balance of the male hormonal system including the production and release of sperm, prostate afflictions and exhaustion after coition.
Clinical Applications Research: Damiana is an antioxidant, anti-inflammatory herb (Nascimento MA, et al.Turnera ulmifolia L. (Turneraceae): preliminary study of its antioxidant activity. Bioresour Technol. 2006 Aug;97(12):1387-91) that improves blood flow; it is used for various conditions, including sexual neurasthenia (nervous exhaustion), erectile dysfunction, chronic prostatic discharge, renal and cystic catarrh (inflammation), libido, stamina and vitality, migraines, incontinence, sterility, and many others. Damiana has been studied “in relation to effects that are considered as part of an adaptogen effect (anti-stress, memory enhancement, increased physical and/or sexual performance)” (Mendes FR, Carlini EA. Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in Brazil. : J Ethnopharmacol. 2007 Feb 12;109(3):493-500). Adaptogens are well-known for balancing the system, whether high or low to start. Lecithinum homeopathic is traditionally used for a forgetful, dull, confused mind, ovarian insufficiency, weak sexual power, low libido, aching, lack of energy, and scanty urine with phosphates, sugar or albumin (a percentage of testosterone and estrogens circulate in the blood while bound to albumin) (Boericke's Materia Medica) . Lecithin is important in the vital processes of life; it is an integral component of cell membranes. Lecithin has a favorable influence upon the nutritive conditions and especially upon the blood; it increases the red corpuscle count and hemoglobin in the blood. Phosphoricum Acidum is indicated for conditions such as impaired memory, listlessness, thinning hair, headache after coition, frequent urination, especially at night, possibly preceded by anxiety and followed by burning, scanty milk from nursing, early menses, profuse bleeding, swollen reproductive glands, nighttime emissions, seminal vesiculitis, profuse sweat, and acne (Boericke's Materia Medica) . It is also indicated for erectile dysfunction, testicular pain, low libido, and exhaustion after sex (A Classic Homeopathic Guide, by John Henry Clarke, MD) . Sabal Serrulata (Saw palmetto) is used in homeopathy to address glandular swelling, ovarian and prostate irritation, urinary symptoms, sleep problems, stress headaches, among other uses. Cholesterinum: The precursor of all steroid hormones, cholesterol is a necessary building block for all the sex hormones. Consequently, hormonal balance depends on the production of the sex hormones from this precursor. Cholesterinum addresses imbalances in cholesterol metabolism. Hypothalamus: The hypothalamus is an organ that regulates much of our hormonal control. The hypothalamus synthesizes GnRH, which acts to release FSH and LH, causing release of androgens and secretion of androgen-binding protein. As a homeopathic, it is used for psychological or physical stress, inflammation of the epididymis, and promotion of spermatogenesis. DNA binds to a complex of testosterone (which has bound to an intracellular receptor), and is used in homeopathy to address imbalances such as low libido and hypertrophy of the prostate (Julian Winston, Wellington College of Homeopathy) .
Contraindications: WARNING: STOP USE AND CALL A DOCTOR, IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN.
Ingredients: Active Ingredients: Cholesterinum, Damiana, DNA, (18X, 36X and LM2), Hypothalamus, Lecithin, Phosphoricum ac, Sabal. Equal volumes of each ingredient in 12X, 30X, and LM1 potencies, unless otherwise noted. Inactive Ingredients: Citric acid, potassium sorbate, purified water.
Vegetarian: No
Suggested Dosage: 2 pump sprays 3 times daily or as directed. For ages 12 to adult.
Pack: 1 oz. Homeopathic Spray
Product:

Total Boron (2713)

Supportive Function: Boron is a trace mineral essential for healthy bone and joint function; it helps to build strong bone tissue. Boron also facilitates the detoxification process. When is Total Boron helpful? Osteoporosis, bone injury, metal or other detoxification
Clinical Applications Research: Vitamin B-6 (as pyridoxine hydrochloride) has been reported to help remove lead from the brain (Balch & Balch, 1997:364) . The B vitamins, especially B6, has been reported to be important in helping rid the intestinal tract of excess metals, removing them from the body, and protecting the cells and the brain: identified heavy metals include aluminum and mercury (Balch & Balch, 1997: 123, 386, The Burton Goldberg Group, 1995:928) . B6 is essential for antibody formation, important in detoxification functions of the body (Mindell, 1991:33) . B6 is essential for synthesizing and breaking down most amino acids. The amino acids Lmethionine, L-Cysteine, and L-glutathione play important roles in helping detoxify the body of heavy metals and other toxins (Chaitow, 1988) . Apple Pectin has been reported to bind with heavy metals in the colon and help excrete them from the body. Apple pectin has been reported especially to help protect against arsenic, lead, mercury, and nickel (Balch & Balch, 1997:123, 135, 363, 386, 404) . Asparagus (root) is a member of the allium, lily family, which includes asparagus, garlic, and onions. The allium family contains sulfur compounds that have been reported to help eliminate arsenic, cadmium, excess copper, lead, mercury, nickel, radiation products, from the body (Balch & Balch, 1997:135, 176, 215, 364, 387, 404, 456) . In addition, asparagus has been traditionally used as a diuretic. Aluminum is excreted principally through the urine, and Eck and Wilson (1989) reported that enhancing eliminative organ activity helps in heavy metal detoxification. Asparagus has been reported to enhance female hormone levels and was used for that purpose in India to relieve menstrual pains (sometimes linked to copper overload, Schmitt, 1991), and generally strengthen the female reproductive system. By enhancing female hormone levels, calcium, magnesium, and phosphorous levels may increase and antagonize heavy metals. In China, asparagus therapy has been traditionally prescribed for “kidney deficiency” and severe “adrenal deficiency,” syndromes associated with chronic exhaustion and fatigue. By strengthening the kidney, elimination of heavy metals through the urine may be enhanced. Asparagus contains steroidal and bitter glycosides and asparagine, an amino acid, which functions to help detoxify the brain of excess ammonia. It has been traditionally used as a diuretic, nutritive tonic, and to strengthen the lungs (Tierra, 1990:110-111) . Boron (as aspartate) has been reported to enhance the uptake and spare the loss of calcium, magnesium, and phosphorous from the body (Lininger, 1998:142) . Both calcium and magnesium are reported to bind with aluminum, cadmium, excess copper, and help eliminate it from the body (Balch & Balch, 1997:123, 176, 214) . Adequate calcium is reported to prevent lead from being deposited in body tissues (Balch & Balch, 1997:363) . Calcium and magnesium have been reported to protect against radiation, especially radioactive strontium (Balch & Balch, 1997: 455) . In studies with postmenopausal women, 3 mg of boron per day significantly reduced calcium lost in the urine (Hunt, CD, et al, Am J Clin Nutr March 1997; 65(3): 803-13) . Boron supplementation in both animals and humans results in higher estradiol, (natural human estrogen level), higher testosterone levels, and higher vitamin D levels (Samman, S, et al, Biol Trace Elem Res Winter 1998; 66(1-3): 227-35) . Low levels of boron in tissues have also been linked to lower hormonal levels. Boron is now suspected of being a mineral regulator of many minerals, in addition to calcium, magnesium, and phosphorous, but its exact mechanisms, its possible antagonisms and protective functions are still unclarified (Naghii, MR, Samman, S, Prog Food Nutr Sci Oct Dec 1993; 7(4): 331-49) . However, boron is combined with steel in nuclear utility plants to trap radiation (Boron, National Academy Press, 1980: 71-83) . It is also used in experimental drugs for trapping neutrons in radiation therapy and it may--we believe--play a protective role against uranium, radium, and radon’s damaging effects (Chou, FI, et al, “Preparation and in vitro evaluation of B-lipiodol as a boron delivery agent for neutron capture therapy of hepatoma,” Anticancer Res May-June 1999; 19(3A): 1759-64) . Adequate calcium and vitamin D intake can help prevent or reverse osteomalacia caused by cadmium poisoning (Eck & Wilson, 1989:11) . Boron increases calcium and vitamin D levels. Higher levels of calcium, magnesium, and phosphorous have been found to protect against lead toxicity. Calcium and phosphorous either compete with lead for absorption, or help replace lead in storage sites (Eck & Wilson, 1989:39; 40; 41) . Boron increases levels of calcium, magnesium, and phosphorous. Pyridoxal-5-Phosphate is one of the essential components of vitamin B6 (Mindell, 1991:33) . B6 has been reported to be a copper antagonist. B6 deficiency can enhance iron absorption, which may lead to iron toxicity. (Eck & Wilson, 1989:22; 28) . Recommendations: The use of TOTAL BORON while using the Total Homeopathic Metals detoxification program can make the detoxification much easier on the patient.
Contraindications: Since one of the mechanisms of bone protection is increasing estradiol levels, boron may not work for some sensitive pre-menopausal women.
Ingredients: Each Tablet Contains: Vitamin B-6 (as pyridoxine hydrochloride) 15 mg. Proprietary blend 205 mg* of: Apple Pectin, Asparagus (root), Boron (as aspartate), Pyridoxal-5-Phosphate.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Chelate (2736)

Supportive Function: Supportive Function: Nutritional support for strong, elastic arteries and healthy circulation to the heart, kidneys and brain. When is Chelation Support helpful? Poor circulation, blocked arteries, high cholesterol, etc.
Clinical Applications Research: Niacin (as niacinamide) or Vitamin B-3, and Niacinamide, a form of niacin, increase the activity of two crucial enzymes needed to facilitate conversion of homocysteine into non-toxic substances and provide the sulfur groups necessary for liver detoxification. In a placebo-controlled study of 8000 men who had suffered one heart attack, niacin was shown to be beneficial in lowering the death rate and increasing longevity (Canner et al, J of the Am College of Cardiology Dec 1986 8 (6): 1245-55) . Vitamin B-6: (as pyridoxine hydrochloride) McCulley found that heart patients had 80% less of vitamin B-6 than healthy people (Atherosclerosis Reviews 1983; (11): 157-246) . Supplementation with vitamin B-6 can inhibit platelet aggregation that characterizes atherosclerosis (Lancet June 1981; (1) 8233:12-99-1300) . B-6 is essential to break down potentially toxic homocysteine into harmless and beneficial forms that do not cause oxidation, clotting, or injury to blood vessel walls. Biotin is essential in the metabolism of carbohydrates, fatty acids, and protein. Biotin aids in cell growth, lowers blood glucose, and stimulates the production of insulin. Choline (as bitartrate) , a B vitamin, is reported to intensify vitamin B12’s effect of reducing homocysteine levels (Olszewski et al, Ibid.) Magnesium (as chelate): People who die suddenly from heart attacks have been found to have lower levels of magnesium and potassium than controls (Wood et al, Lancet Jul 1984; 2 (8395): 117-21) . Magnesium helps dilate arteries and ease the heart’s pumping of blood, which may help prevent irregular heartbeats. It can help raise good HDL cholesterol, lower total cholesterol, inhibit platelet aggregation, and help prevent calcium deposits in blood vessels (Seelig & Heggtveit, Am J of Clin Nutri Jan 1974; 27 (1): 59-79) . Zinc, Selenium, and Magnesium are all essential mineral co-factors in enzymatic reactions in the methionine/homocysteine metabolic pathways. All are co-factors for anti-oxidant enzymes that fight free radicals that damage cells that can lead to atherosclerosis, arteriosclerosis, and heart disease. Zinc (as chelate) has been shown to shorten the duration of colds by inhibiting viral replication (Landis, Herbal Defense, NY: Warner Books, 1997) . Zinc, magnesium, and selenium are antagonistic to heavy metals and help remove them from the body. Selenium (as chelate) is a co-factor in the antioxidant enzymes, glutathione peroxidase and Sn-superoxide dismutase, and is reported to strengthen the immune system. Low serum selenium has been associated with higher incidence of cardiovascular disease (Salonen et al, Brit Med J Mar 1991; 302 (6779):756-760). Supplementation of selenium has been shown to reduce platelet aggregation (Stead et al, Am J of the Med Sci Dec 1985; 290 (6): 228-233) . Cocksaxie virus has been implicated in heart disease under nutritionally deficient circumstances, where it has been described as attacking heart muscle and causing heart failure (Beck & Levander, Nature Medicine May 1995; (1) 433-6) . In a doctor’s practice it has been found many of his patients with heart problems also have viral infections. Taylor and Ramanathan have built theoretically compelling cases for the viruses, Ebola, HIV, and coxsackie, mutating into aggressively virulent strains triggered by selenium deficiency (J of Med Chemistry, Aug. 19, 1994; (37): 26-37-54) . It has been theorized that the heart is a likely target since it is one of the largest selenium depots in the body. Taylor believes that adequate selenium acts as an inhibiting factor, shutting down rapid viral replication. EDTA (edetate calcium disodium) has been safely used since the 1950’s for successful reduction of atherosclerotic plaque in cardiovascular disease, treatment of lead poisoning, and as a beneficial food preservative preventing oxidation. EDTA Chelation therapy helps remove calcium deposits and other harmful minerals that promote blood clotting and arteriosclerosis. In combination with other synergistic nutrients including B-6 and garlic, EDTA has an anti-clotting effect and helps reduce blood platelet stickiness. EDTA promotes improved cellular respiration, enhanced mitochondrial action, increased exercise tolerance and walking distance, lessened pain from angina and claudication, improved elasticity of arterial walls, improved function in senility, enhanced bone growth, and improved blood flow. Patients who gain little improvement in blood flow do sometimes show marked improvement of function and relief of symptoms. EDTA helps dissolve metastatic calcium that has been deposited where it is not wanted in the joints, the kidneys, arteries, and the bones of the inner ear. EDTA enhances absorption of beneficial nutrients including B-12 and minerals, although chronic long-term use may lead to nutrient deficiencies. It helps decrease absorption of iron and copper, protects against free-radical damage stemming from iron-copper overload, and prevents coppercatalyzed oxidation of vitamin C. EDTA protects against many toxic metals including nickel, cadmium, vanadium, lead, cobalt, and lowers the body’s burden of fission products. EDTA helps lower total cholesterol and improves the deposition of calcium and phosphorus in bone. Patients with lead poisoning experience reduced blood pressure and improved kidney function after EDTA treatment. In a study of 27 patients scheduled for limb amputation due to poor circulation, EDTA resulted in saving 24 limbs. EDTA enhances nitric oxide production, which kills bacteria, protects the heart, stimulates the brain, enhances oxygen delivery to tissues, helps prevent blood clots, and helps regulate blood flow and blood pressure (Cranton EM, “Current Status of EDTA Chelation Therapy in Occlusive Arterial Disease,” in Textbook of EDTA Chelation Therapy 2nd Ed, Charlottesville,VA: Hampton Roads, 2001; Loren K & Gordon GF, “Oral EDTA, Lead & More,” http://www.oralchelation.net/data14k.htm) . Contraindications: May not be appropriate for patients with severe renal disease. Precaution: effects on fetal development have not been established and may be contraindicated in pregnancy. Caution: Doses exceeding 4,000mg daily may have toxic effects. Irish Moss (carrageenan) acts synergistically with EDTA to help remove heavy metal concentrations. Iron is a mineral that can encourage bacterial growth. Chronic infections of many kinds have been implicated in arteriosclerosis, blood clotting, and heart disease. Sulfated polysaccharides in Red Algae’s carrageenan show broad-spectrum anti-viral activity. Carrageenan is incorporated into infected cells and inhibits viral replication (http://www.bryantlabs.com/redmarinealgae-abstracts.htm; “Protocol for Chronic Infections,” at http://www.gordonresearch.com/Protocols/protocol_cronic_infections.html) Garlic (bulb) has been shown to lower LDL oxidation by 34% (Lipids 1993; (28): 475-77) . One of garlic's components, methyl allyl trisulfide, lowers blood pressure by dilating blood vessel walls. Garlic helps thin blood by inhibiting platelet aggregation, reducing the risk of blood clotting, and aiding in the prevention of heart attacks. Garlic has antibiotic properties useful for reducing chronic levels of infections implicated in heart disease. Garlic also lowers total serum cholesterol levels and helps in digestion (Balch & Balch, 1997:54) . Apple Pectin contains both soluble and insoluble fiber, which lowers fat absorption and cholesterol, and reduces the risk of heart disease. By slowing the absorption of food, pectin has proven helpful to diabetics. The insoluble fiber of pectin binds to cholesterol, heavy metals, and other toxins, and helps remove them from the body (Balch & Balch, 1997: 53) . Beta Sitosterol boosts the effects of isoflavones (J of Urology 1995; (154): 391; Cancer Res 1991; (51): 3445) . Isoflavones are special bioflavonoids that block the sorbitol pathway that is linked with oxidative damage in diabetes. They are also known as natural blood thinners that protect blood vessels and reduce platelet aggregation. As antioxidants, bioflavonoids protect cholesterol from oxidative damage. High cholesterol levels in themselves may not be the problem they were first thought to be, but oxidized LDL cholesterol may be the greater issue (Kostner et al, “The interaction of human plasma low density lipoproteins with glucosaminoglycans: influence of the chemical composition,” Lipids Jan. 1985; 20 (1): 24-28, Lininger et al, 1998:140-1; Potter, SM, "Overview of the proposed mechanisms for the hypo-cholesterolemic effect of soy," J Nutri 1995; 606S-611S) . Lipase (vegetable) helps split fats into essential fatty acids and glycerol. Supplemental enzymes spare stress on the body’s own production of enzymes, helping improve digestion and uptake of nutrients from food (The Burton Goldberg Group, 1995:215-6) . DL Methionine helps remove heavy metal toxins from the body and neutralize free radicals. It also helps the digestive process. Inositol is most prevalent in the heart and brain. It is necessary for cell membrane formation and aids in the transport of fatty acids. Betaine (as hydrochloride): Betaine has been credited with lowering homocysteine levels even when patients were not responsive to other treatments (NEJM 1983; (309): 448-453) . Betaine has been shown to stimulate an enzyme in the metabolic pathway that renders homocysteine non-toxic (Neth J Med 1994; 45 (1): 34-41) . Betaine HCL helps breakdown and digest proteins, fats, and carbohydrates in the stomach, reduce bacterial and viral colonization of the stomach, and enhance the absorption of minerals and other nutrients.
Contraindications: May not be appropriate for patients with severe renal disease. Contraindicated in pregnancy. Doses of EDTA (Edetate Calcium Disodium) exceeding 4,000 mg daily may have toxic effects
Ingredients: Each Tablet Contains: Each Tablet Contains: Niacin (as niacinamide) 10 mg, Vitamin B-6 (as pyridoxine hydrochloride) 10 mg, Biotin 100 mcg, Choline (as bitartrate) 24 mg, Magnesium (as chelate) 25 mg, Zinc (as chelate) 5 mg, Selenium (as chelate) 40 mcg. Proprietary blend 735 mg* of: EDTA (edetate calcium disodium), Irish Moss (carrageenan), Garlic (bulb), Apple Pectin, Beta Sitosterol, Lipase (vegetable), DL-Methionine, Inositol, Betaine (as hydrochloride).
Vegetarian: Yes
Suggested Dosage: One tablet daily or as directed.
Pack: 90 Tablets
Product:

Total Cort (2739F)

Supportive Function: Weight balance; stress management; restful sleep; memory; mental function; depression. When is Cortisol Support helpful? Periods of stress; weight loss; depression, anxiety, insomnia.
Clinical Applications Research: Thiamine (as hydrochloride) (B-1) works with B-2 and B-3 to release energy from our food. B Vitamins are necessary for the mitochondria to produce energy from carbohydrates in the Kreb's citric acid cycle. Riboflavin (B-2) is needed to convert carbohydrates, amino acids, and fats into energy. Restricted diabetic diets frequently result in B-2 deficiencies. Niacin (as niacinimide) , a form of vitamin B-3, helps people with diabetes in small milligram amounts. Massive gram amounts of B-3 have been found to work against diabetics. B-3 is necessary to release energy from carbohydrates and is synergistic with B-1 and B-2. It increases the activity of two crucial enzymes needed to convert homocysteine into non-toxic substances and provide the nutrients necessary for liver detoxification. In a placebo-controlled study of 8000 men who had suffered one heart attack, niacin was shown to be beneficial in lowering the death rate and increasing longevity (Canner et al, J of the Am College of Cardiology 1986 Dec; 8 (6): 1245- 55) . Vitamin B-6 (as pyridoxine hydrochloride) is known to trigger the nighttime release of growth hormone (GH) during sleep. GH helps enhance the building and toning of muscle and enhances the immune response. It can facilitate weight loss, reduction of body fat, and increase muscle mass. It helps in the formation of anti-aging nucleic acids (Mindell, 1991:33) . It helps convert tryptophan into niacin (B-3), alleviate nervousness, and reduce muscle spasms at night. B-6 is necessary for tryptophan metabolism, and together with vitamin C, enhances tryptophan uptake by the brain. B-6 helps shorten the time it takes for sleep onset, improve the quality of sleep, and induce a more relaxed waking state. Supplementation with vitamin B-6, by itself, can help change blood stickiness that characterizes atherosclerosis (Lancet June 1981; (1) 8233:12-99-1300) . Folate (as folic acid) helps alleviate depression and anxiety (Balch & Balch, 1997: 17) . Folic acid is required for enzymatic reactions reducing homocysteine. Excess homocysteine can lead to muscular degeneration, ocular and neurological problems, cardiovascular disease, brittle hair, and thin skin (Stanbury et al, Metabolic Basis of Inherited Diseases, New York: McGraw Hill, 1983; N England Med J 1983; 309(8): 448-453) . Folic acid is essential to the growth and repair of cells. Folic Acid helps prevent folic acid anemia, is essential in the formation of red and white blood cells, and can protect against parasite infections and food poisoning. Deficiencies are common and come from not eating fresh fruits and vegetables. Cooking and microwaving destroy folic acid. Some studies state that 80% of the population is deficient in folic acid. Tobacco smoking, drinking alcohol, and using oral contraceptives promote folic acid deficiency. Vitamin B-12 (as cyanocobalamin) and folic acid are involved in different steps of the body’s use of carbohydrates and sugar. Supplementation has been reported to improve muscle strength and alleviate sensory impairment (Nagaishi et al 2003) . B-12 helps reduce stress, prevent anemia, and is necessary for all bodily functions. It is necessary for proper digestion and absorption of nutrients. It helps prevent nervousness, irritability, depression, headaches, memory loss, nerve and spinal cord degeneration. Vitamin B-12 is needed for healthy digestion, absorption of nutrients, and synthesis of protein. It helps prevent anemia and works with folic acid to form red blood cells. Pantothenic Acid (as calcium panothenate) , vitamin B-5, works with other B vitamins to produce ATP from sugar and fat, the energy molecule the body needs to run on. Pantothenic Acid is known as an anti-stress nutrient. Deficiency can lead to low blood sugar levels and other blood and skin disorders. Phosphatidyl Serine is found in high concentrations in the brain. Phosphatidylserine is believed to allow individuals to sustain an adaptive response and minimize some of the systemic effects of stress (Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev. 1999 Aug;4(4):249-65). The effects of phosphatidylserine supplementation on the neuroendocrine responses to physical stress was examined in a placebo-controlled study in 9 healthy men. Phosphatidylserine blunted the cortisol responses, leading researches to report that, “oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man” (Monteleone et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992;42(4):385-8) . Supplementation helps improve mental functioning in individuals diagnosed with Alzheimer’s disease (Crook et al 1992) . After 45 days of supplementation, depression has been reported to be 60% less with phosphatidylserine supplementation than placebo controls in older women (Maggioni et al 1990) . Banaba (leaf) Extract has been reported to significantly reduce weight and reduce body fat in animal studies (Suzuki et al 1999) . Banaba has been traditionally used as a folk medicine for diabetes in the Philippines. Banaba contains a potent alpha-amylase inhibitor (Hosoyama et al 2003) . Banaba extract has demonstrated blood sugar lowering and total-cholesterol lowering capabilities (Kakuda et al 1996) . Beta Sitosterol boosts the effects of isoflavones (J of Urology 1995; (154): 391; Cancer Res 1991; (51): 3445) . Isoflavones are special bioflavonoids that block the sorbitol pathway that is linked with free-radical damage in diabetes. They are also known as natural blood thinners that protect blood vessels and reduce blood stickiness. Bioflavonoids protect cholesterol from free-radical damage  (Kostner et al, “The interaction of human plasma low density lipoproteins with glucosaminoglycans: influence of the chemical composition,” Lipids Jan. 1985; 20 (1): 24-28; Lininger et al, 1998:140-1; Potter, SM, "Overview of the proposed mechanisms for the hypo-cholesterolemic effect of soy," J Nutri 1995; 606S- 611S) . Sterols and sterolins, also known as phytosterols, have been shown to exert significant unique biochemical effects. Beta-sitosterol is the major phytosterol in higher plants along with its glycoside, betasitosterolin. Studies have reported that beta sitosterol and its glycoside, beta-sitosterolin possess antiinflammatory, antipyretic, antineoplastic, and immune-modulating properties, showing promise in normalizing T-cell function, dampening overactive antibody responses, and normalizing DHEA:cortisol ratios (Bouic PJ et al. Monograph. Plant sterols and sterolins. Altern Med Rev. 2001 Apr;6(2):203-6) . Additionally, researchers believe that restoring balance (with these phytosterols) to the immune system may be of therapeutic benefit in disease processes such as chronic viral infections, stress-induced immune suppression, tuberculosis, allergies, cancer, and rheumatoid arthritis and other autoimmune conditions" (Bouic, ibid). Runners participating in an ultra-marathon who were supplemented with beta sitosterol showed significant increases in their total white blood cell numbers as well as in their neutrophils and significantly decreased the cortisol:DHEA ratio, suggesting that these volunteers had less of an inflammatory response and were less immune suppressed during the post-marathon recovery period. It is believed that the findings of this study demonstrate that phytosterols may prevent the subtle immunosuppression associated with excessive physical stress (Bouic PJ et al. The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation Int J Sports Med. 1999 May;20(4):258-62). L-Theanine has been shown to work antagonistically against the effects of caffeine, helping to lower stress, promote relaxation, reduce anxiety, lower blood pressure, and increase mental alertness (Lekh R J et al, “L-theanine--a unique amino acid of green tea and its relaxation effect in humans,” Trends in Food Sci & Tech June 1999, Vol 10 (6-7): 199-204) .
Contraindications: Probably should be avoided during pregnancy or lactation.
Ingredients: Each Tablet Contains: Thiamine (as hydrochloride) 1.5 mg, Riboflavin 1.5 mg, Niacin (as niacinamide) 5 mg, Vitamin B-6 (as pyridoxine hydrochloride) 1.5 mg, Folate (as folic acid) 50 mcg, Vitamin B-12 (as cyanocobalamin) 25 mcg, Pantothenic Acid (as calcium pantothenate) 2 mg. Proprietary blend 127.5 mg* of: Phosphatidyl Serine, Banaba (leaf) Extract, Beta Sitosterol, L-Theanine.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Enzymes (2404A)

Supportive Function: Gentle, fast-acting plant enzymes assist in the normal breakdown of food that is necessary to extract vital nutrients from our diet. Often a pancreatic insufficiency limits the optimal utilization of essential vitamins, minerals, and other nutrients. Ideally, food should be completely broken down to assure that macromolecules do not pass into the system. Plant enzymes work in various pH environments, increasing their effectiveness along the gastrointestinal tract. When are Plant Enzymes helpful? High-potency, plant-digestive enzymes are highly suggested to enhance digestion. They are extremely well tolerated, work in a wide range of pH environments (for the entire intestinal tract), and optimize the breakdown of food. Complete breakdown of food eliminates multiple allergen sources, and provides support for allergy-related conditions such as eczema.
Clinical Applications Research: Amylase : Amylase breaks down large carbohydrates (starches and other polysaccharides) to disaccharides including sucrose, lactose and maltose. (Shils and Young, Modern Nutrition in Health and Disease, Lea & Febiger, Philadelphia, PA, 1988) Protease : Protease breaks down long protein chains (polypeptides) into single amino acids (Shils and Young, Modern Nutrition in Health and Disease, Lea & Febiger, Philadelphia, PA, 1988) Lipase : Lipase digests fats (triglycerides) into free fatty acids and glycerol. (Shils and Young, Modern Nutrition in Health and Disease, Lea & Febiger, Philadelphia, PA, 1988) Invertase : Invertase is a concentrated source of disaccharidase enzymes. Invertase breaks down the disaccharide sucrose (refined table sugar) into glucose and fructose. The American diet contains high amounts of refined sugar. The inability to break the sugar down may contribute to digestive distress and may be a contributing factor in food allergies. Supplemental invertase will increase the assimilation and utilization of this sugar. Malt Diastase : Malt diastase assures the breakdown of starch into maltose and then into glucose molecules, allowing greater absorption of this energy-giving sugar. Lactase : Lactase deficiency is a common and well-known form of carbohydrate intolerance. Lactase digests lactose (milk sugar) into glucose and galactose. Lactase activity declines as we age, which causes maldigestion of milk and other lactose-containing foods. Approximately 70% of the world's population are deficient in lactase and are therefore unable to digest dairy products. Cellulase : Cellulase is not found in humans, but it aids in breaking the bonds found in the fiber matrices which envelope most of the nutrients in plants. Cellulase increases the nutritional value of fruits and vegetables. Beet (root) : Beets aid in gallbladder function, lymphatic function and digestion. Red beet root is excellent for liver and biliary detoxification.
Contraindications: None known
Ingredients: Chromium (as chelate) 3 mcg. Proprietary blend 360 mg* of: Amylase 4,500 DU*, Protease 15,000 HUT*, Lipase 65 LU*, Invertase 25 INVU*, Malt Diastase 150 DP*, Lactase 200 LacU*, Cellulase 60 CU*, Beet (root).
Vegetarian: Yes
Suggested Dosage: 1 capsule daily or as directed
Pack: 120 Capsules
Product:

Total Eyebright-C (2714)

Supportive Function: Total Eyebright C is an eye care formula consisting of the eyebright herb, along with vitamins, minerals, enzymes and potent antioxidants intended to optimize homeostasis for the eyes. The eye is highly susceptible to free radical damage and is in need of optimal antioxidant protection. Total Eyebright C is a support product for general eye conditions or people prone to cataracts. When is Eye Support helpful? Eye infections, any eye diseases (glaucoma, macular degeneration, cataracts), dry eyes, floaters.
Clinical Applications Research: Antioxidants: Antioxidants include vitamin C, vitamin E, beta carotene, selenium, zinc, quercetin, ginkgo biloba, bilberry, bioflavonoids and turmeric. All of these substances are potent antioxidant radical scavengers; beta carotene specifically scavenges radicals caused by UV light, vitamin E protects the high concentration of lipid membranes, ginkgo biloba works in the micro capillaries of the eye, and bilberry seems to be an eye-specific radical scavenger. Vitamins: Vitamin D3 aids in calcium absorption for healthy tissue maintenance. Sometimes eye conditions dictate avoidance from UV light, which is one of the main sources of vitamin D production by the body. Riboflavin is very easily destroyed by UV light, and is essential for cellular repair. Folic acid is also necessary, playing an important role in DNA/RNA synthesis. Zinc (as chelate): Zinc has antioxidant activity, stabilizes cell membranes, and provides the cofactor for many enzymes involved in visual function. Research demonstrates that high levels of a zinc antioxidant enzyme, “protect mitochondria from oxidative damage that probably occurs with aging in the retinal pigment epithelium" (Invest. Ophthalmol. Vis. Sci. 1992, 33:1909-18) . Zinc is also the important nutrient in the “zinc fingers” which is an integral part of gene expression. The Proceedings of the National Academy of Sciences reported that an eye-specific enzyme (containing these zinc fingers) is necessary to prevent rod degeneration (the eye is made up of rods and cones) (Proc. Nat. Acad. Sci. 1993, 90:11157-61) . Eyebright (leaf): Eyebright is a medicinal herb containing vitamins A, B3 (Niacin), B5 (Pantothenic acid), B12, C, D, and E; its properties lend to the recommendation that it is, “good for all eye disorders” (Presc for Nutr Healing, 1990, Avery Publ., NY, p.52) . Bilberry (fruit): Bilberry contains potent proanthocyanidins to prevent capillary fragility and inhibit platelet aggregation, and is an excellent anti-inflammatory herb. “Many clinical tests have shown that bilberry anthocyanosides given orally to humans improve vision in healthy people and also help treat people with eye diseases such as pigmentary retinitis” (Weiner, M.A. Herbs that Heal. 1994. Quantum Books, Mill Valley, Ca. p. 84) . Ginkgo Biloba (leaf): Ginkgo biloba was reported in Drugs Exp Clin Res (1991, 17:571-4) , to have antioxidant properties that can protect the retina against oxidation. In a randomized, open clinical trial involving 42 patients, a significant increase in microcirculation and elasticity of blood vessels was noted (Fortschr Med. 1993, 111:170-2) . Bromelaine: Bromelaine is a proteolytic enzyme with strong anti-inflammatory properties. Pancreatin, papain, trypsin, chymotrypsin, pancreolipase and amylase are all enzymes, which decrease inflammation when taken away from meals, and increase digestion when taken with meals. They clear toxic debris from the inflammatory response and help tissue return to normal. Ox bile and HCL (hydrochloric acid) enhance the activity of the enzymes. Other Plant Nutrients: Gymnema sylvestre is an herb that significantly reduces blood glucose and glycosylated proteins, an important factor in determining diabetic retinopathy damage (see diabetic retinopathy). Turmeric may increase detoxification systems in addition to its antioxidant properties. Turmeric is believed to counteract the effects of several dietary carcinogens (Plant Foods Hum. Nutr 1993, 44:87-92) . Quercetin is a very powerful free radical scavenger. Lemon bioflavonoids and rutin are potent phytochemicals that prevent capillary fragility and reduce inflammation. They are particularly helpful in collagen formation of the microcirculation of the eye.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (100% Beta Carotene) 1000 IU, Vitamin C (as ascorbic acid) 25 mg, Vitamin D3 (as cholecalciferol) 75 IU, Vitamin E (as succinate) 10 IU, Thiamine (as hydrochloride) 1.5 mg, Riboflavin 1.7 mg, Vitamin B-6 (as pyridoxine hydrochloride) 2 mg, Folate (as folic acid) 100 mcg, Selenium (as chelate) 25 mcg, Zinc (as chelate) 15 mg, Chromium (as chelate) 1000 mcg. Proprietary blend 535 mg* of: Eyebright (leaf), Gymnema (leaf), Lemon Bioflavonoids, Bilberry (fruit), Bitter Melon (fruit), Pancreatin, Super Oxide Dismutase (as SOD), Oxbile, Rutin, Trypsin, Amylase-Diastase, Bromelain, Pancrelipase, Papain, Lactase, L-Taurine, L-Glycine, L-Glutamic Acid (as hydrochloride), L-Methionine, Betaine (as hydrochloride), Turmeric (rhizome), Ginkgo Biloba (leaf), Quercetin, N-Acetyl Cysteine, Alpha Lipoic Acid, L-Histidine, LPhenylalanine, Eleuthero (root), Chymotrypsin (as trypsin), Bilberry Extract (25% anthocyanosides) (fruit), Lutein (with Zeaxanthin), Lycopene.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Eyebright-M (2715)

Supportive Function: Total Eyebright M is an eye care formula consisting of the eyebright herb, along with vitamins, minerals, enzymes and potent antioxidants intended to optimize homeostasis for the eyes. The eye is highly susceptible to free radical damage and is in need of optimal antioxidant protection. Total Eyebright-M is general eye support for macular degeneration. When is Eye Support helpful? Eye infections, any eye diseases (glaucoma, macular degeneration, and cataracts) dry eyes and floaters.
Clinical Applications Research: Macular degeneration was one of five retinal disorders studied in the massive Eye Disease Case-Control Study, which obtained data from 421 patients with macular degeneration and 615 controls. Serum levels of carotenoids, vitamins C and E, and selenium were evaluated, and subjects were classified by level of the micronutrient (low, medium, and high). Persons in the medium and high carotenoid groups had, “markedly reduced risks” of macular degeneration. Risk in the “high” group was reduced to one half, and risk in the “medium” group was reduced to one third, demonstrating a dose-dependent result. “An antioxidant index which combined all four micronutrient measurements showed statistically significant reductions of risk with increasing levels of the index... these results suggest that higher blood levels of micronutrients with antioxidant potential, in particular, carotenoids, may be associated with a decreased risk of the most visually disabling form of age-related macular degeneration” (Arch. Ophthalmol. 1993, 111:104-9) . Authors of “Antioxidant protection of the ageing macula” report epidemiological evidence that suggests patients with macular degeneration have a lower intake of carotonoids, and, “moreover, a preliminary therapeutic trial in patients with AMD (Age-related macular degeneration) or diabetic retinopathy showed that supplementation with beta-carotene, vitamin C, vitamin E and selenium halted the progression of degenerative changes and in some cases even brought improvement” (Age and ageing 1991, 20:60-69) . The authors note that even though the retina contains higher concentrations of carotenoids, vitamin E and vitamin C than many other tissues, “the fact that the development of AMD still occurs indicates that in these cases the balance between lifelong exposure to light and antioxidant protection has been disturbed in favor of light damage. A higher intake of these antioxidant nutrients may thus be required to counteract the influence of light” (p. 66) . Antioxidants: Antioxidants include vitamin C, vitamin E, beta-carotene, selenium, zinc, quercetin, ginkgo biloba, bilberry, and bioflavonoids. All of these substances are potent antioxidant radical scavengers; beta carotene specifically scavenges radicals caused by UV light, vitamin E protects the high concentration of lipid membranes, ginkgo biloba works in the micro capillaries of the eye, and bilberry seems to be an eye-specific radical scavenger. Zinc (as chelate): Zinc has antioxidant activity, stabilizes cell membranes, and provides the cofactor for many enzymes involved in visual function. Research demonstrates that high levels of a zinc antioxidant enzyme, “protect mitochondria from oxidative damage that probably occurs with aging in the retinal pigment epithelium" (Invest. Ophthalmol. Vis. Sci. 1992, 33:1909-18) . Zinc is also the important nutrient in the “zinc fingers” which is an integral part of gene expression. The Proceedings of the National Academy of Sciences reported that an eye-specific enzyme (containing these zinc fingers) is necessary to prevent rod degeneration (the eye is made up of rods and cones) (Proc. Nat. Acad. Sci. 1993, 90:11157-61) . Eyebright (herb): Eyebright is a medicinal herb containing vitamins A, B3 (Niacin), B5 (Pantothenic acid), B12, C, D, and E; its properties lend to the recommendation that it is, “good for all eye disorders” (Presc for Nutr Healing, 1990, Avery Publ., NY, p.52) . Bilberry (fruit) Extract: Bilberry contains potent proanthocyanidins to prevent capillary fragility and inhibit platelet aggregation, and is an excellent anti-inflammatory herb. “Many clinical tests have shown that bilberry anthocyanosides given orally to humans improve vision in healthy people and also help treat people with eye diseases such as pigmentary retinitis” (Weiner, M.A. Herbs that Heal. 1994. Quantum Books, Mill Valley, Ca. p. 84). Ginkgo Biloba (leaf) Extract: Test results published in Drugs Exp Clin Res (1991, 17:571-4) , “confirm that the antioxidant properties of Ginkgo biloba can protect the retina against lipoperoxidation”. In a randomized, open clinical trial involving 42 patients with pathophysiological visco-elasticity values (the elasticity of their blood vessels had already been compromised), the effect of a single intravenous injection of 50, 100, 150, or 200 mg of Ginkgo biloba extract was investigated. A significant increase in microcirculation and visco-elasticity was noted. The response was dose dependent, with effects increasing as the dose increased. “The present study thus confirms the positive effect of Ginkgo biloba extract on the microcirculation and whole-blood visco-elasticity values, already found in earlier studies, and shows it to be dependent on the dose employed” (Fortschr Med. 1993, 111:170-2) . A German study was conducted on 24 patients with retinal insufficiency. Utilizing a randomized, double blind study, Ginkgo biloba was used as a treatment, with a significant increase in retinal sensitivity seen within four weeks. Results in the lower dose group (80 mg/day) were not seen until the dose was increased to 160 mg/day. “The results presented here show that damage to the visual field by chronic lack of blood flow are significantly reversible” (Klin Monatsbl Augenheilkd. 1991, 199:432-8) . Free radicals are responsible for much of the damage induced by ischemia (lack of adequate blood flow) and reperfusion (dilation of blood vessels and return of oxygen). This leads to damaging ion shifts in the eye, which were prevented by administration of 100 mg/kg/day Ginkgo biloba for 10 days in a rat model. It is interesting to note that the drug allopurinol, which was also tested, failed to correct the retinal shifts. Other Plant Nutrients: Quercetin is a very powerful free radical scavenger. Lemon bioflavonoids and rutin are potent phytochemicals that prevent capillary fragility and reduce inflammation. They are particularly helpful in collagen formation of the vessels of the eye, which makes up the microcirculation. Lycopene, a carotenoid found in tomatoes has potent antioxidant properties and has also been shown to be helpful in eye problems. Lutein, a carotene found in dark green leafy vegetables (such as spinach and collard greens), is thought to protect the macula from light-induced damage. Vitamins: Vitamin D aids in calcium absorption for healthy tissue maintenance. Sometimes eye conditions dictate avoidance from UV light, which is one of the main sources of vitamin D production by the body. Riboflavin is very easily destroyed by UV light, and is essential for cellular repair. Folic acid is also necessary, playing an important role in DNA/RNA synthesis.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (as cod liver oil) (66% as beta carotene) 3000 IU, Vitamin C (as ascorbic acid) 20 mg, Vitamin E (as succinate) 15 IU, Riboflavin 10 mg, Zinc (as chelate) 15 mg, Selenium (as chelate) 33 mcg. Proprietary blend 471 mg* of: Spinach (leaf), Eyebright (herb), Milk Thistle (herb, leaf), L-Taurine, Pea Powder, Bioflavonoids, Blueberry (leaf), Rutin, Trypsin, N-Acetyl Cysteine, Betaine (as hydrochloride), Amylase-Diastase, Lipoic Acid, Ginkgo (leaf) Extract, Chymotrypsin, Lutein, Bilberry (fruit) Extract, Lycopene, Grapeseed Extract, Quercetin, L-Glutathione.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Fiber (2746F)

Supportive Function: Slowing gastric emptying, bulking up stools, detoxifying, increasing probiotic growth and balance in the intestinal tract. When is Fiber Support helpful? Blood sugar regulation, healthy cholesterol/triglyceride levels, satiety, weight balance, removal of toxins/excess estrogen (many female complaints are due to high estrogen), hormonal balance, constipation/diarrhea, colon health.
Clinical Applications Research: Inulin is a form of soluble fiber and is categorized as a prebiotic , which means that it promotes the growth of good bacteria in the gut (probiotics). There is evidence that inulin may increase calcium and magnesium absorption (1,2). Glucomannan (konjac root) is a water-soluble dietary fiber derived from konjac root and has the highest molecular weight and strongest viscosity among any dietary fiber known to science. Glucomannan can absorb up to 200 times its weight in water, which is one of the ways it increases bulk and slows insulin response. It promoted bowel movement and improved colonic ecology in constipated adults in a placebo-controlled, dietcontrolled trial (15). Banana Flakes – bananas are high in fiber, potassium and phosphorus, and contain other vitamins and minerals as well. Banana is also a good source of healthful flavonoids and pre-biotics (16). Freeze Dried Apple: Both apple fiber and gum arabic lowered total and low-density lipoprotein cholesterol (LDL-C) in men with moderately high cholesterol levels (12). Rice Bran contains a high level of dietary fibers such as beta-glucan, pectin and gum. Constituents of these fibers include tocotrienols (a natural fraction of vitamin E), gamma-oryzanol and beta-sitosterol; all these ingredients have been noted to have a positive correlation to the lipid profile (cholesterol) (3). Flax (seed) is used to provide bulk and counteract constipation because of its dietary fiber content (5). A 2009 study in the American Journal of Clinical Nutrition reported that flax seeds may lower cholesterol levels, especially in women (6). Other studies suggest that flax seeds may be beneficial in other conditions as well, including stabilization of blood-sugar levels (7). Apple Pectin is a soluble fiber that acts as a digestive aid and intestinal regulator. It slows gastric emptying, which is good for blood sugar and healthy cholesterol levels, and helps remove unwanted toxins from the colon. A research article published in Carcinogenesis, Apr 2010, describes a fraction of apple pectin as “highly effective against intestinal toxicities”, and “active against inflammation”, and reported that it “may be useful for treatment of colitis” (8). Yet another 2010 study, in Anaerobe, pointed out that apple pectin is one of the effective apple components improving the large intestine environment (9). Apple pectin is believed to increase the absorption capacity of the small intestine, increases levels of quercetin, (10). Chia (seed) is rich in omega-3 fatty acids and amino acids, and contains significant levels of antioxidants and dietary fiber (mostly soluble). The antioxidants include caffeic acids, myricetin, quercetin, and kaempferol flavonols. A systematic review showed that “the available human and non-human studies show possible effectiveness for allergies, angina, athletic performance enhancement, coronary heart disease (CHD), heart attack, hormonal/endocrine disorders, hyperlipidemia, hypertension, stroke, and vasodilatation” (13). Some evidence also suggests possible anticoagulant and antiviral effects of chia (14). Coconut Fiber is full of lignans and cellulose, with many health properties; indeed, some varieties of coconut have even been demonstrated to have “antinociceptive (analgesic) and anti-inflammatory activities which confirm the popular use of this plant” (4). Spirulina is green, full of fiber, vitamins and minerals, has high anti-oxidant capacity and has been extensively researched. 2010 studies show that spirulina is helpful for inflammation, cholesterol, and toxic assault, amongst other health benefits (17). Spirulina has been proven to be, “effective to treat certain allergies, anemia, hepatotoxicity, viral and cardiovascular diseases, hyperglycemia, hyperlipidemia, immunodeficiency, and inflammatory processes, among others” (18). These activities are attributed to some of the components in spirulina, including an isolated complex called Ca-Spirulan. Agave Nectar is a raw natural sweetener. Beta Glucans are not only high in fiber and well-known for being soluble fiber supplements, they lower bad cholesterol and raise good cholesterol (19). Beta glucans increase the phagocytosis of antigens (20) which is one of the ways in which it modulates the immune system. In fact, beta glucans have “been shown to enhance the envelopment and digestion (phagocytosis) of pathogenic microorganisms that cause infectious disease” (21), and positively affect the immune cascade, especially T cells, B cells and dendritic cells (22). It is important to drink plenty of filtered water with fiber supplements. References available on request
Contraindications: It is important to note that even though fiber is important for colon health, if the colon is actively inflamed, such as with Inflammatory Bowel Syndrome, it is best to rest the gut with protein powders during those active bouts. High fiber may slow absorption of some drugs; take the supplement away from the drug by several hours.
Ingredients: Each Tablet Contains: Fiber 500 mg. Proprietary blend 857.5 mg* of: Inulin, Glucomannan (konjac root), Banana Flakes, Freeze Dried Apple, Gum Arabic, Rice Bran, Flax (seed), Apple Pectin, Chia (seed), Coconut Fiber, Spirulina, Agave Nectar, Beta Glucans.
Vegetarian: Yes
Suggested Dosage: One tablet daily or as directed
Pack: 90 Tablets
Product:

Total FLM (2712)

Supportive Function: Natural substances that have reported anti-inflammatory effects, with decades of anecdotal history. For joint and ligament support we recommend you add TOTAL CMO. When are Inflammatory herbs helpful? Any site of inflammation, trauma, surgery, swelling, redness, acute arthritis pain, ovarian cysts, sinus infections, etc.
Clinical Applications Research: Boswellia Serrata (Gum) is reported to have strong analgesic (painrelieving) effects (Kar, A. & Menon, M.K. Life Sci. 1969; 8:1023) , along with anti-inflammatory and antiarthritic activity. Clinical trials in India report beneficial results on arthritic patients, and boswellic acids are marketed as antiarthritic drugs in India (Handa, S.S. et al. Fitoterapia. 1992; 63(1): 3) . Milk Thistle (seed), Milk Thistle Extract has always had a strong reputation for supporting liver function and pathways of detoxification. Removal of wastes and toxins is crucial in decreasing inflammation. Silymarin, which is one of the main ingredients in milk thistle, has an anti-inflammatory effect on blood platelets (Altorjay I et al. Acta Physiol Hung 1992; 80:375-80) , and the ability to inhibit free radical production and leukotrienes synthesis means that it prevents the powerful, inflammatory leukotrienes from wreaking havoc in the body (Alarcon de la Lastra, C. et al. Planta Medica 1995; 61:116-119; Fiebrich F and Kock H. Experientia 1979; 35:148-150) . Turmeric (rhizome) is a root belonging to the ginger family, in which the rhizome part is used in many flavorings but most noticeably in curry powder. Research has demonstrated excellent anti-inflammatory and antioxidant properties of turmeric, and especially of curcumin, which is the active component of turmeric that is responsible for the yellow pigment (Reddy AP & Lokesh, BR. Mol Cell Biochem. 1992; 111-117) . The anti-inflammatory properties are due to the ability of curcumin to reduce histamine levels and possibly increase natural cortisone production by the adrenal glands (Aora RB, Basu N, Kapoor V, Jain AP. Anti-inflammatory studies on Curcuma longa (turmeric). Ind.J.Med Res. 1971:59:1289-95) . Ginger (root) is a herb known mostly for its therapeutic effect in nausea. Ginger also has powerful abilities to combat inflammation, and these anti-inflammatory effects are well backed by scientific studies. Ginger contains phenolic compounds that inhibit the enzymes responsible for generating important mediators of pain and inflammation in more than one pathway (Kiuchi et. al. Inhibition of prostaglandin and leukotrienes biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull. 1992; 40:387-91). Lemon Bioflavonoids are plant nutrients with healthful properties. Bioflavonoids in general operate to stabilize cell membranes, decrease the release of inflammation mediators, inhibit the inflammatory process, decrease the contraction of smooth muscle (Amella et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica 1985; 51:16-20) , as well as improve capillary integrity (decrease permeability) and stabilize the collagen matrix by preventing free radical damage (Merck Index, 11th ed. 1989, Merck & Co. Rahway, New Jersey, p.1243) . Quercetin is a potent bioflavonoid - in fact, it has been named, "the most important flavonoid" by a leading peer-reviewed journal (Nutr. Cancer 1993, 20:21-9) . It is a powerful antioxidant, and Michael Murray suggests that, "quercetin appears indicated in virtually all inflammatory and allergic conditions" (Murray, M. Encyclopedia of Nutritional Supplements, 1996, Prima Publ., Rocklin, Ca. p. 327) . Lipoic Acid is an excellent antioxidant that also binds heavy metals and toxins, thereby removing many of the substances that can cause and/or aggravate inflammation.
Contraindications: None known
Ingredients: Each Tablet Contains: Proprietary blend 184 mg* of: Boswella Serrata (Gum), Milk Thistle (seed), Turmeric (rhizome), Ginger (root), Lemon Bioflavonoids, Milk Thistle Extract, Quercetin, Glutathione, Cayenne (fruit), Lipoic Acid.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Flu-Cld #1 Nasal Spray (Homeopathic) (0968)

Supportive Function: Nasal Spray for support of flu-like symptoms.  When is Total Flu-Cld Nasal Spray helpful? For temporary relief of a broad spectrum of flu-like symptoms including fever, chills, night sweats, nausea, vomiting, headache, runny nose, congestion, sore throat, cough, diarrhea and tired achy feeling.
Clinical Applications Research: Arsenicum Album is a homeopathic remedy used for treatment of flu and upset stomach. It has a strong effect on mucous membranes of the respiratory and digestive systems. It helps severe colds or hay fever accompanied by sneezing, coughing and watery, burning secretions, and headaches with weakness. Arsenicum Alb-treated mice showed revival and restoration in organs damaged from arsenic, including the liver, and “Efficacy of the homeopathic drug Arsenicum Alb-30 in reducing arsenic-induced damage to protein and nucleic acids is substantiated and the mechanism of action of the homeopathic drug through expression of regulatory genes inferred” (Kundu SN, et al. Efficacy of a potentized homeopathic drug (Arsenicum- Aalbum-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles, and content of DNA and RNA. Complement Ther Med. 2000 Sep;8(3):157-65). In fact, another study showed that the effect was so powerful that, “Arsenicum album can be considered as an antidote to arsenic poisoning” (Mitra K, et al. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations in body weight, tissue weight and total protein. Complement Ther Med. 1999 Mar;7(1):24-34). Baptisia is commonly used for flu and cold symptoms. One scientific review of common cold and influenza viruses, highlights select botanicals, including Baptisia, “that may help in the prevention and treatment of these conditions” (Roxas M, Jurenka J. Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Altern Med Rev. 2007 Mar;12(1):25-48). Bryonia and Phytolacca are helpful for many symptoms associated with colds and the flu. Breastfeeding mothers who think they have the flu may have mastitis; when a homeopathic formula containing byronia and phyolacca were administered for mastitis (in cows), it was not only more effective than antibiotics, it was less expensive as a treatment (Varshney JP, Naresh R Comparative efficacy of homeopathic and allopathic systems of medicine in the management of clinical mastitis of Indian dairy cows. Homeopathy. 2005 Apr;94(2):81-5). Bryonia “showed significant analgesic and antipyretic activity” in a scientific study (Sivakumar T, et al. Evaluation of analgesic, antipyretic activity and toxicity study of Bryonia laciniosa in mice and rats. Am J Chin Med. 2004;32(4):531-9). Bryonia was also found to exhibit significant anti-inflammatory activity, significant inhibition on edema caused by histamine, decreased formation of granuloma tissue, and inhibition of leukocyte migration (Gupta M, et al. Evaluation of anti-inflammatory activity of chloroform extract of Bryonia... Biol Pharm Bull. 2003 Sep;26(9):1342-4). Bryonia is widely used as an adaptogenic and restorative substance “with immunomodulatory and stressprotective properties that increase the non-specific resistance of an organism toward harmful stimuli” (Nersesyan AK, Collins AR. Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells. Neoplasma. 2002;49(2):114-6). Bryonia has shown inhibitory activity against EBV (Epstein Barr virus) (Ukiya M, et al. Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J Nat Prod. 2002 Feb;65(2):179-83.) Causticum is typically used to relieve ailments of a burning, raw, or sore character, hoarse cough, ringing in the ears, and pain in the extremities. Causticum has been evaluated using acute and chronic inflammatory models, and was found to show significant inhibition of the inflammation (Prado Neto Jde A, et al. Action of Causticum in inflammatory models. Homeopathy. 2004 Jan;93(1):12-6.) Causticum is also excellent for bladder symptoms and urinary retention (Dr Tom Whitmarsh, Homoeopathy and multiple sclerosis. Open Door; Autumn 2001:4-5 - Glasgow Homoeopathic Hospital) . Cinchona, Rhus Tox, and Sulfur are all recommended as excellent cold and flu remedies by Dan Ullman, MPH (Dana Ullman MPH, Essential Homeopathy. New World Library, 2002) . Cinchona has exerted specific antioxidative, antiproliferative and biochemical effects on liver cells “which all point to a potential hepatoprotective and tumoristatic action” (Gebhardt R. Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Arzneimittelforschung. 2003;53(12):823-30). Rhus tox “in homeopathic dilution appears to interfere with inflammatory processes involving histamine, prostaglandins and other inflammatory mediators” (Dos Santos AL, et al. In vivo study of the anti-inflammatory effect of Rhus toxicodendron. Homeopathy. 2007 Apr;96(2):95-101) . Rhus tox has cox-2 inhibiting abilities and is also effective against cox 1 and the powerful leukotrienes (Jaggi R, et al. Dual inhibition of 5-LOX/COX by a reconst. homeopathic remedy; possible explanation for clinical efficacy and favorable gastrointestinal tolerability. Inflamm Res. 2004 Apr;53(4):150-7) . Dulcamara is anti-inflammatory, and has exhibited inhibitory activity against prostaglandins in scientific studies (Tunon H, et al. Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. J Ethnopharmacol. 1995 Oct;48(2):61-76). In fact, it has been named as a specific cox-2 inhibitor (Jaggi R, et al. ibid). Dulcamara traditionally helps ailments worsened by cold weather, such as congestive headaches, rattling cough, icy cold feet, and stiff neck and shoulders. Eupatorium Perfoliatum is a well-known homeopathic remedy for flu-like symptoms (Jaric S, et al. An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia). J Ethnopharmacol. 2007 Apr 20;111(1):160-175.) It is especially good for relief of headache, violent chills, and bone-pains. Echinacea Purpurea homeopathic has been found to “modulate peritoneal inflammatory reaction and have a cytoprotective action on leukocytes” (Pedalino CM, Effect of Atropa belladonna and Echinacea angustifolia in homeopathic dilution on experimental peritonitis. Homeopathy. 2004 Oct;93(4):193-8.) It is particularly helpful in controlling fever and lymphatic inflammation. Eucalyptus is a powerful antiseptic, useful in conditions of the mucous surfaces of the air passages and GI tract. Gelsemium Sempervirens is particularly helpful for relief of sneezing, runny nose, dull headache, diarrhea and fever. Influenzium “06” Lachesis is a nosode, developed from the most current flu virus strain, and is particularly helpful for alleviating inflammation of the mucous membranes, particularly respiratory, as well as general relief of flu-like symptoms. Sarcolacticum Ac eliminates the tired, “sore-all-over” feeling, restless sleep, and nausea/vomiting symptoms of the flu. Wyethia is extremely helpful in relieving sore throats, hoarseness, and clearing up dry, hacking coughs. Anas Barbaraie: Anas Barb specifically addresses fevers, chills, and body aches and pains. Avaire acts most prominently on the lungs, especially in flu and bronchitis.
Contraindications: WARNING: STOP USE AND CALL A DOCTOR, IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN.
Ingredients: Active Ingredients: Contains equal volumes of each ingredient in 10X, 30X, 100X potencies: Arsenicum Album, Baptisia, Byronia Alba, Causticum, Cinchona Officinalis, Dulcamara, Eupatorium Perfoliatum, Echinacea Purpurea, Eucalyptus Globulus, Gelsemium Sempervirens, Influenzinum, Lachesis, Phytolacca Decandra, Rhus Toxicodendron, Sarcolacticum Acidum, Sulphur, Wyethia Helenoides. Anas Barbaraie in 35C, 50C 100C potencies. Inactive Ingredients: Saline solution: {Ascorbic acid (0.075% v/v), disodium EDTA (0.0025% v/v), grapefruit seed extract (0.25% v/v), potassium phosphate dibasic (0.0025%), sodium chloride (0.65% v/v), sodium hydroxide (0.078%), xylitol (2.985% v/v)}, purified water.
Vegetarian: No
Suggested Dosage: One spray up each nostril 3 times a day or as directed. For ages 2 to adult.
Pack: 1 oz Liquid Spray
Product:

Total Green (Protein Powder) (2743PF)

Supportive Function: For general health, supports the body, provides vitamins, minerals, accessory nutrients, antioxidants, phytochemicals, etc. for a healthy profile and optimal function of all processes. When is Total Green Protein helpful? Any condition that can be improved with comprehensive nutritional support. Supports energy, protein balance, detox, inflammation, weight, cholesterol levels, a strong immune system, intestinal homeostasis/bowel function, cell repair, and overall good health!
Clinical Applications Research: is an excellent source of protein to provide all the precursors for enzymes, cell receptors, hormones, and other biologically active compounds. Whey protein is believed to increase glycogen content in liver and skeletal muscle, which has implications for energy production and fitness capacity (Morifuji M. et al. 2005) . Whey protein has even demonstrated antibacterial and antiviral effects (Sitohy M. et al. 2005) . Whey contains one of the most bioavailable sources of calcium, and its beneficial effect on bone metabolism has been shown in adult humans, and is also believed to affect bone metabolism in earlier life (Kelly O. et al. 2003) . Whey protein also has high anti-inflammatory potential and has been utilized to help reduce the inflammation in critically ill trauma patients receiving enteral nutritional support; C-reactive protein concentrations (marker of inflammation) and total inflammatory index dramatically fell in one study (Vehe KL et al. 1991) . The whey protein source used for Total Green Protein has an 18% glycomacropeptide content (GMP). The biological activity of GMP “has received much attention in recent years. Research has focused on the ability of GMP to bind cholera and Escherichia coli enterotoxins, inhibit bacterial and viral adhesion, promote bifidobacterial growth and modulate immune system responses ” (Brody E.P. 2000) . In describing GMP, the Journal of Nutrition reports that the “magnitude of the anti-inflammatory effect was comparable to that of sulfasalazine , an established drug used in the treatment of Inflammatory Bowel disease”, and that GMP “acts as an anti-infectious factor, promoting the growth of bifidobacteria while inhibiting the proliferation of pathogens. In addition, GMP may combat infection by binding to lectins, viruses, and mycoplasma ” (J Nutr 2005) . Rice Bran is high in fiber, has antioxidant properties, and lowers post-prandial glucose concentrations, making it an excellent candidate for cholesterol and weight support (Seki T et al. 2005) . Gamma oryzanol is derived from rice bran. Apple Pectin contains soluble fiber that releases hormones signaling satiety (fullness), which can reduce hunger. Apple pectin slows absorption of glucose/food from the intestines, binds toxins, supports healthy cholesterol levels and normalizes bowel function. Pectin protects the stomach lining by strengthening the mucus layer and significantly inhibits ulcer formation (Nippon Shokakibyo Gakkai Zasshi 1991) . The high fiber content supports normal appetite and weight balance. Parsley (leaf) & Carrot (root): These healthful plants are both high in phytochemicals and enzymes. Parsley is an excellent cleanser and assists in digestion. It is well known for being a tonic for the blood vessels and a good blood purifier. Carrot fiber increases and softens stool bulk, improves regularity, and helps keep the colon healthy. Carrot consumption is also connected with lower cholesterol levels. High beta-carotene foods, especially carrots, help promote the health of many organ systems (Colditz GA et al, 1987) . Spirulina, Chlorella and Kelp (plant) are beneficial, healthful green algae nutrients. Spirulina is a particularly rich source of proteins, vitamins, amino acids, minerals, and other nutrients. Spirulina has been proven to be, “effective to treat certain allergies, anemia, cancer, hepatotoxicity, viral and cardiovascular diseases, hyperglycemia, hyperlipidemia, immunodeficiency, and inflammatory processes, among others” (Chamorro G. et al. 2002 Sep;52(3):232-40) . These activities are attributed to some of the components in spirulina, including a recently isolated complex called Ca-Spirulan. Spirulina and chlorella have both been found to have antioxidant and antiproliferative qualities in rigorous scientific testing (Wu, L.C. et al. 2005) . Kelp helps to regulate function of the thyroid and pituitary glands, and assists many other organs, such as pancreas, adrenals, and male and female organs. It also has antibiotic properties and is reported to help in weight regulation (Heinerman, John. 1988) . Certified Organic Sprouts: All sprouts in Total Green Protein are certified organic and free of toxic residues. Sprouts are one of the richest source of food enzymes, vitamins, mineral and phytochemicals available to us. As powerful and as protective as the cruciferous vegetables are, the sprouts are even more potent - researchers at Johns Hopkins University reported that sprouts from cruciferous vegetables can exhibit 10-100 times higher levels of the protective ingredients than the corresponding mature plants (Fahey J. et al. 1997) . “ Small quantities of cruciferous sprouts may protect against the risk of cancer as effectively as much larger quantities of mature vegetables of the same variety ”…. (Fahey 1997) . The healthful phytochemicals in sprouts include carotenoids, flavonoids, chlorophyll, indoles (indole-3-carbinol; DIM), glucosinolates, dithiolthiones, isothiocyanates, isoflavones, glycosides, phenols, glucoraphanin and sulphoraphane). Cauliflower Sprouts is a cruciferous vegetable high on the list of recommended foods compiled by the American Cancer society that contain the protective sulforaphane. Cauliflower Sprouts contain high amounts of sulforaphane, unlike the mature plant that is relatively low in sulforaphane. Total Green Protein contains organic cauliflower sprouts, even though, as researcher Jeff Fahey comments: “Cauliflower sprouts are exceedingly expensive to produce (Jeff W. Fahey, Ibid, p. 2) . The indoles in cauliflower sprouts are believed to be responsible for strengthening the immune system, enhancing detoxification, and protecting the GI tract. Broccoli Sprouts contain many of the beneficial phytochemicals, but are particularly high in sulforaphane, one of the key phytochemicals that induces key protective enzymes in tissues, especially the liver, that “ enhance an already present capacity to detoxify carcinogens ” (Fahey, J. 2003) . Researcher Jeff Fahey also points out that the broccoli seed, and therefore the sprout, is the most concentrated source of the phytochemical sulforaphane, because the compound becomes diluted as the plant matures. Research has found the sulforaphane in broccoli sprouts to be a potent anti-bacterial agent effective in inhibiting the highly resistant stomach bug, Helicobacter pylori, and is also effective in “ blocking gastric (stomach) tumor formation ” (Fahey JW, et al. 2002) Yellow Dock (root) and Milk Thistle (herb, leaf) are detoxifying and tonifying herbs. Milk thistle contains silymarin and silybin, powerful antioxidants and cell protectors, especially in the liver (Shalan MG et al. 2005) Silymarin increases glutathione levels (a major detoxifying and conjugating nutrient). Yellow Dock cleanses the skin and the blood, two of the major detox routes in the body. Yellow dock is antifungal, and has also exhibited antioxidant capabilities (Kim, JC et al2004; Yildirim A et al 2001).  Papaya (fruit) is rich in phytochemicals, antioxidants, and contains papain, a helpful digestive enzyme. Papaya and rose hips, also rich in phytochemicals, are two of the few plant substances containing high amounts of the potent antioxidant lycopene (Mourvaki E, et al. 2005) . Beta Sitosterol is a plant sterol possessing “anti-inflammatory, antipyretic (fever-reducing), antineoplastic, and immune-modulating properties, showing promise in normalizing T-cell function, dampening overactive antibody responses (uncontrolled autoimmune response), and normalizing DHEA:cortisol ratios (abnormal ratios can lead to disease) (Bouic PJ et al. 2001) . Beta-sitosterol also decreases the inflammatory PGE2 prostaglandin, with the mechanism believed to be alteration of the cox-2 enzyme (Awad AB et al. 2004) . It is one of the ingredients in grape skin extract that gives it its anti-inflammatory properties (Zhang Y. et al. 2004) . Rosemary (herb) reduces pathogenic substances such as bacteria, raises detoxification enzymes in the liver, and decreases inflammation and liver cell injury (Ahn J. et al. 2004; Sotelo-Felix JI, et al. 2002). Carnosol, rosmanol, and epirosmanol, are all components of the rosemary herb and all demonstrate high antioxidant activity (Zeng HH, et al. 2001) . Carnasol is a potent inhibitor of cox 2 (Subbaramaiah K. et al. 2002) . Protease (vegetable) is a type of digestive enzyme that helps to break down protein so that we can extract an optimal amount from our food. Protease enzymes also optimize digestive processes and reduce allergic reactions (antibodies do not form against individual amino acids) and other problems of incomplete digestion. Chia (Salvia columbariae)(seed) , high in omega 3’s, has many antioxidant and health benefits (Yen WJ et al. 2005) . On diets with chia seed included, weight reductions up to 6.2% have been recorded (Averza R. et al 2002) . Luo Han Guo , or Lo Han Kuo (from the Momordicia grosvenori fruit) is a novel, natural sweetener that has many beneficial, health-promoting properties. The sweet elements, called triterpene glycosides, actually suppress the rise in blood glucose after a meal! (Suzuki YA t. al.. 2005) . Researchers have found the natural sweetener to exhibit significant anti-tumor activity by decreasing both initiation and promotion (Ukiya M. et al. 2002) . Additionally, it prevents the oxidation of LDL (bad cholesterol) and may reduce the risk of heart disease by reducing the atherogenicity of the LDL (Takeo E. et al. 2002) . Researchers have determined that it possesses many advantages, such as having high sweetness capability with low adherence (good news for the teeth!) (Mu, J. 1998; Lee, C. 1975) . Cloves possess many medicinal properties, including antibacterial and antimicrobial activity (Bagamboula CF et al. 2001; Lai PK & Roy J). Cloves also have “antioxidative, antimutagenic and anticarcinogenic properties” (Sengupta A. et al. 2004) Lactobacillus Acidophilus and Lactobacillus Bulgaricus (enteric-coated) are probiotics that are helpful in maintaining a healthy balance of good gut flora in the intestines, supporting the immune system. Probiotic administration during remission of inflammatory bowel disease reduces the severity of recurrent colitis by inducing an immunoregulatory response (DiGiacinto C. et al2005) . Medium Chain Triglycerides (MCT) are known to have a favorable effect on lipid levels, insulin, and body weight, and gut inflammation. Subjects on a MCT diet demonstrated significant decreases in body fat weight (Nosaka N. 2003) . MCT are believed to decrease fat pads, down regulate key fat genes, improve insulin sensitivity/glucose tolerance, reduce enzymes affecting cholesterol and lipid levels (Han J. et al. 2003) . Anti-Inflammatory, Natural Cox-2 Inhibitors: Cox 2 is the enzyme that causes inflammatory substances to be produced in the body and is also the enzyme targeted by the cox-2 inhibitor drugs (some of these drugs were pulled from the market). The following nutrients inhibit cox-2 naturally: Spirulina, Rosemary and Beta Sitosterol. Xylitol is a natural sugar alcohol; we produce up to 15 grams of xylitol from food sources; some of the best sources are fruits and berries. Xylitol can also stimulate saliva, the natural tooth protector. A number of studies have demonstrated that xylitol is antibacterial and anticariogenic (fights cavities) (Sahni PS et al. 2002).
Contraindications: Total Green is high in vitamin K, so caution is indicated with blood-thinning drugs. Should not be used by whey-sensitive people. The components of whey include lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, bovine serum albumin and immunoglobulins. Those sensitive to dairy may be sensitive to the whey portion, however, that does not mean that all of those sensitive to dairy will necessarily be sensitive to the whey portion.
Ingredients: Each Tablespoon/Scoop* Contains: Calories: 35; Protein: 6 gms; Calcium (as citrate) 30 mg, Magnesium (as citrate) 13 mg. Proprietary blend 7.9 grams* of: Whey Powder, Rice Bran, Rose Hips (fruit), Apple Pectin, Lecithin, Spirulina, Parsley (leaf), Cauliflower Sprouts, Broccoli Sprouts, Asparagus Shoots, Yellow Dock (root), Milk Thistle (herb,leaf), Carrot (root), Caprylic Acid, Papaya (fruit), Beta Sitosterol, Rosemary (herb), Protease (vegetable), Chlorella, Kelp (plant), Chia (salvia columbariae)(seed), Luo Han Guo, Cloves (bud, stem), Lactobacillus Acidophilus, Lactobacillus Bulgaricus.
Vegetarian: No
Suggested Dosage: 1 Tbsp/Scoop daily or as directed. *53 servings per container Can be blended with fruit or water. Also good sprinkled on salad.
Pack: 16 oz Powder
Product:

Total Heart II (2718F)

Supportive Function: Synergistic heart support is boosted with other ingredients, including the electron-carrier nutrient Co-enzyme Q-10, a vitamin-like molecule best known for its supporting actions on energy, circulation, and the heart. Supports heart health, and the health of the vessels. When is Total Heart II helpful? Support for heart health and all cardiovascular functions; such as blood pressure, workload capacity, etc.
Clinical Applications Research: Vitamin C (as acorbic acid) has been shown to reverse arteriosclerosis in humans (Rath & Pauling, Proceed of N Academy of Sci of the USA, Aug 1990; 87 (16): 125-134). Vitamin C is essential to maintain and repair the integrity of arteries, may help prevent the oxidation of cholesterol by protecting against free radicals, and has been shown to boost the immune system (Cameron & Pauling, 1982; Cordoba, 1982; Leibovitz & Steigal, 1978; Pauling, 1970) . Vitamin E (as succinate) : In European population studies, those with low serum levels of vitamin E were shown to be at greater risk from heart disease than those with high cholesterol levels and high blood pressure (Gey et al, “Inverse Correlation between Plasma Vitamin E and Mortality from Ischemic Heart Disease in cross-cultural Epidemiology,” Am J of Clin Nutri Jan 1991; 53 (1): 326S-334S) . Vitamin E supplements may inhibit platelet formation, prevent blood clots, and help repair the lining of blood vessel cells (Hennig et al, “Protective Effects of Vitamin E in Age-Related Epithelial Cell Injury,” International J of Vitamin & Nutri Research 1989; (59): 273-279) . In one Harvard Medical School Study of 87,245 female nurses, those who took 100 i.u. of vitamin E for more than 2 years had a 46% lower risk of developing heart disease (Stampfer et al, “Vitamin E and Heart Disease Incidence in the Nurses Study,” Am Heart Assoc Annual Meeting, Nov 18, 1992) . Another Harvard study of 39,910 male health professionals, who took 100 i.u. of vitamin E for an undisclosed period of time, had a 37% lower risk of heart disease (Rimm et al, “Vitamin E and Heart Disease Incidence in the Health Professionals Study,” Am Heart Assoc Annual Meeting, Ibid.) . As a natural antioxidant, supplementation may also protect against the cardiotoxic effects of alcohol and cardiomyopathy caused by magnesium deficiency. Heart (bovine) : heart tissue supplies whole nutritional support to strengthen the heart, including co-enzyme Q- 10. Co-enzyme Q-10 concentration in heart and heart tissue is 10 greater than in brain or colon tissue. Spleen (bovine) tissue supplies nutritional support factors to help enhance the spleen’s role in immune functions. NN-Dimethyl Glycine (betaine in red beets) and Folate (as folic acid) reduce homocysteine, which can be toxic to the cardiovascular system. Dimethylglycine is a methylator for important biological functions, including synthesis of brain neurotransmitters. Co-Enzyme Q-10 has been shown to have antioxidant properties protecting against oxidized cholesterol. It has been demonstrated to scavenge free-radicals produced by lipid peroxidation, stabilize cellular membranes, and prevent depletion of metabolites necessary for resynthesis of ATP in mitochondria (Beyer, 1985) . It helps strengthen the heart muscle and the cardiovascular system in many heart patients  (Dolkers et al, 1985). Co-enzyme Q-10 may protect against atherosclerosis (Hanaki et al, New Eng J of Med Sept 1991; 325 (11): 814-5).
Contraindications: None known
Ingredients: Vitamin C (as ascorbic acid) 100 mg, Vitamin E (as succinate) 100 IU, Folate (as folic acid) 50 mcg. Proprietary blend 187 mg* of: Heart (bovine), Spleen (bovine), NN-Dimethyl Glycine, LCarnitine (as hydrochloride), Co-Enzyme Q-10.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total JT Plus (120) (2402A)

Supportive Function: Total JT Plus is a superb formula tested against individual nutrients for its synergistic action in supporting healthy bone and connective tissue. In the body, some glucosamine sulfate is converted to N-acetyl glucosamine (NAG), which is listed by the Merck Index in its own antiarthritic category. Liver detox, gastrointestinal and antioxidant nutrients all lend support that can be helpful when arthritis affects bone and connective tissue. Mucopolysaccharides are also important building blocks, which are furnished in this formula by green-lipped mussel. When is Glucosamine Support helpful? Osteoarthritis, tissue and joint pain, and injury.
Clinical Applications Research: Vitamin C (as ascorbic acid) is a very potent antioxidant that protects the cells of the body as well as protecting other antioxidants such as Vitamin E. Vitamin C detoxifies many other harmful substances that threaten to damage the tissues of the body (Balch & Balch, 1997:45) . People who have high levels of antioxidants in their diet show a much slower rate of joint deterioration (McAlindon TE, et al, "Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?" Arthrit Rheum 1996; 39:648-56) . Vitamin E (as succinate) is depleted when joints are inflamed with Rheumatoid Arthritis (Lininger et al, 1998:116) . Vitamin E supplementation alleviates many symptoms of RA (Sherak O and G Kolarz, "Vitamin E and rheumatoid arthritis,"Arthrit Rheum 1991; 34:1205-6) . Vitamin E has also reduced many symptoms of osteoarthritis (Macktey I, and Ouaknine L, "Tocopherol in osteoarthritis: a controlled pilot study," J of Am Geriatr Soc 1978; 25(7): 328-30) . Vitamin E is a powerful antioxidant that prevents damage to lipids and the lipid portion of cell membranes. It improves oxygen utilization and enhances immune responses ( Balch & Balch, 1997:45) . Pantothenic Acid (as calcium pantothenate) , also called vitamin B5, may be deficient in people subject to Rheumatoid Arthritis (Lininger et al, 1998:116) . Pantothenic acid supplementation alone has been reported to alleviate morning stiffness, disability, and pain (General Practitioner Research Group,"Calcium pantothenate in arthritic conditions," Practitioner 1980; 224:208-11) . Glucosamine (as sulfate) provides the essential building block needed for the construction and repair of joint cartilage, bone, tendons, and ligaments. Glucosamine further transforms into polyglycans that provide the foundation of synovial fluid and the lining of joints. Supplementation with glucosamine sulfate reduces pain and swelling and helps repair joints. Benefits become evident within 8 weeks. Continued supplementation is needed to maintain benefits (Drovanti A, et al, "Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebocontrolled double blind investigation,"Clin Ther 1980: 3(4): 260-72) . Milk Thistle (seed) has been used for 2000 years to support liver function and liver detoxification. It helps protect liver cells by blocking the entrance of toxins and removing toxins from the liver. N-Acetyl Glucosamine (NAG) has been shown to reduce joint pain, swelling, and restricted motion in clinical trials. NAG is also important in maintaining the protective layer of digestive organs. Dr. Braly found that RA is frequently caused by leaky gut, or abnormal permeability of the intestinal wall, allowing undigested food particles to deposit in tissues resulting in inflammatory responses and autoimmune attacks on many tissues (The Burton Goldberg Group, 1995: 531; Freed D, Brit Med J April 1999: 318:1023-25; J Cell Biochem 1994; 56: 225-35) . L-Cysteine (as hydrochloride) cannot be metabolized from the basic amino acid methionine in many chronic diseases, so supplementation has proved useful in many conditions. It helps remove many heavy metal deposits, which suppress immune responses, and protects against environmental pollutants. It also protects the brain, liver, and other organs from the damaging effects of smoking and alcohol. Cysteine boosts the levels of protective enzymes that slow cellular damage (Chaitow, 1988: 95; Balch & Balch, 1997:43) . L-Glutamic Acid serves as a source of fuel for cells lining the intestines, which support uptake of nutrients, and helps prevent bowel permeability noted in arthritis. It has been reported to aid in peptic ulcer healing. It is a component of folic acid and glucose tolerance factor. It is also used to alleviate depression (Lininger, 1998:166, Chaitow, 1998:95, 99) . L-Glycine supplementation has been reported to increase the secretion of gastric acid, which enhances digestion, converts into betaine, important in protein digestion, is a component of bile acids, and is major component of glutathione, which plays a detoxification role in the body (Chaitow, 1988: 83-84) . Glutathione has been reported to counteract the cross-linking effects and cellular damage of free-radical activity (Functions of Glutathione, New York: Springer-Verlag, 1978) . L-Taurine is a component of bile acids, which are essential in absorbing fats and fat-soluble vitamins such as vitamin A. It is also an important component that helps maintain cell membrane stability (Lininger, 1998:206) . Trachea (bovine): Food sources of chondroitin sulfate only come from animal cartilage such as soluble trachea (Lininger et al, 1998:149) . Chondroitin sulfate is a major constituent of bone and cartilage. Cartilage holds water and allows nutrients to pass through its matrix. Animal studies show that chondroitin sulfate may promote the healing of bone (Moss M et al, "The effect of chondroitin sulfate on bone healing," Oral Surg Oral Med Oral Path 1965; 20: 795- 801) . Chondroitin sulfate also helps restore joint function in some forms of arthritis (Kerzberg FM et al, "Combination of glycosamino-glycans and acetylsalicylic acid in knee osteoarthritis," Scand J Rheum 1987; 16:377) . Green Lipped Mussel (Natural source of Mucopolysaccharides and Superoxide Dismutase): Mucopolysaccharides are building blocks for chondroitin sulfate, the major constituent of bone and cartilage (Lininger et al, 1998:149) . Superoxide Dismutase (SOD) is a powerful free radical scavenger that helps protect against the superoxide free radical responsible for cartilage damage and pain. SOD is known to repair cells and reduce the rate of cell destruction (Toohey L, "Natural alternatives to drugs," Nutri-Notes 1999; 6(3): 3; Balch & Balch, 1997:45) . N-Acetyl Cysteine has been reported to help prevent degenerative changes in the liver, has strong antioxidant activity, and is generally cell-protective (Gaby, AR, Wright, JV, J of Advancement in Med Spring 1993; 6 (1): 27-39) . People with Inflammatory Bowel Disease and other conditions have an impaired metabolism that will not allow them to convert L-Cysteine into its NAG bioactive form. As a liver nutrient, it helps remove toxins that accelerate degeneration and interfere with healing. N-acetyl cysteine is an important building block for Lglutathionine (Chaitow, 1988: 79-81) . Milk Thistle Extract (silymarin) a bioflavonoid complex in Milk Thistle, has anti-inflammatory effects on blood platelets and helps prevent inflammatory free-radical production. Silybin, the most active ingredient of Silymarin, has the ability to help regenerate liver cells (Lininger et al, 1992:290-1; Alarcon de la Lastra C et al, Planta Medica 1995(61): 116-9; Sonnenbichler J et al, Proceed of the Internat Bioflav Symp (Munich, Frg) 1981) . L-Glutathione helps bind with toxins in the liver for removal and helps prevent free-radical damage associated with collagen cross-linking, poor cellular circulation, and stiffness (Chaitow, 1988:88-9) . L-Glutathione has been reported to counteract the cross-linking effects and cellular damage of free-radical activity. This tripeptide composed of glutamic acid, Glycine, and cysteine helps deactivate lipid peroxidation, enhance immune system function, and detoxify the heavy metals lead, cadmium, mercury, and aluminum. The primary use of this nutrient has been reported helpful in the prevention and treatment of degenerative conditions. Through the action of glutathione-S transferases, glutathione enables the liver to detoxify undesirable compounds for excretion through the bile (Functions of Glutathione, New York: Springer-Verlag, 1978) . Tidbit: Some people, (especially Inflammatory Bowel Disease people) with compromised health and conversion capabilities, cannot acetylate their glucosamine into N-acetyl glucosamine (NAG). These people miss out on getting one of the most important building blocks of connective tissue. When they take 1500 mg of glucosamine, they are assuming that some will be converted to NAG, however that doesn’t happen due to their inability to convert glucosamine to N-acetyl glucosamine. Total JT Plus includes a synergistic combination of several building blocks necessary for building healthy cartilage tissue.
Contraindications: High doses of glucosamine sulfate can cause high blood sugar levels and/or GI distress (smaller synergistic amounts are used in this formula and there are no reported problems).
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 50 mg, Vitamin E (as succinate) 30 IU, Pantothenic Acid (as calcium pantothenate) 50 mg. Proprietary blend 487 mg* of: Glucosamine (as sulfate), Milk Thistle (seed), N-Acetyl Glucosamine, L-Cysteine (as hydrochloride), L-Glutamic Acid, L-Glycine, L-Taurine, Trachea (bovine), Green Lipped Mussel, N-Acetyl Cysteine, Milk Thistle Extract (silymarin), L-Glutathione.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Total JT Plus (60) (2402)

Supportive Function: Total JT Plus is a superb formula tested against individual nutrients for its synergistic action in supporting healthy bone and connective tissue. In the body, some glucosamine sulfate is converted to N-acetyl glucosamine (NAG), which is listed by the Merck Index in its own antiarthritic category. Liver detox, gastrointestinal and antioxidant nutrients all lend support that can be helpful when arthritis affects bone and connective tissue. Mucopolysaccharides are also important building blocks, which are furnished in this formula by green-lipped mussel. When is Glucosamine Support helpful? Osteoarthritis, tissue and joint pain, and injury.
Clinical Applications Research: Vitamin C (as ascorbic acid) is a very potent antioxidant that protects the cells of the body as well as protecting other antioxidants such as Vitamin E. Vitamin C detoxifies many other harmful substances that threaten to damage the tissues of the body (Balch & Balch, 1997:45) . People who have high levels of antioxidants in their diet show a much slower rate of joint deterioration (McAlindon TE, et al, "Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?" Arthrit Rheum 1996; 39:648-56) . Vitamin E (as succinate) is depleted when joints are inflamed with Rheumatoid Arthritis (Lininger et al, 1998:116) . Vitamin E supplementation alleviates many symptoms of RA (Sherak O and G Kolarz, "Vitamin E and rheumatoid arthritis,"Arthrit Rheum 1991; 34:1205-6) . Vitamin E has also reduced many symptoms of osteoarthritis (Macktey I, and Ouaknine L, "Tocopherol in osteoarthritis: a controlled pilot study," J of Am Geriatr Soc 1978; 25(7): 328-30) . Vitamin E is a powerful antioxidant that prevents damage to lipids and the lipid portion of cell membranes. It improves oxygen utilization and enhances immune responses ( Balch & Balch, 1997:45) . Pantothenic Acid (as calcium pantothenate) , also called vitamin B5, may be deficient in people subject to Rheumatoid Arthritis (Lininger et al, 1998:116) . Pantothenic acid supplementation alone has been reported to alleviate morning stiffness, disability, and pain (General Practitioner Research Group,"Calcium pantothenate in arthritic conditions," Practitioner 1980; 224:208-11) . Glucosamine (as sulfate) provides the essential building block needed for the construction and repair of joint cartilage, bone, tendons, and ligaments. Glucosamine further transforms into polyglycans that provide the foundation of synovial fluid and the lining of joints. Supplementation with glucosamine sulfate reduces pain and swelling and helps repair joints. Benefits become evident within 8 weeks. Continued supplementation is needed to maintain benefits (Drovanti A, et al, "Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebocontrolled double blind investigation,"Clin Ther 1980: 3(4): 260-72) . Milk Thistle (seed) has been used for 2000 years to support liver function and liver detoxification. It helps protect liver cells by blocking the entrance of toxins and removing toxins from the liver. N-Acetyl Glucosamine (NAG) has been shown to reduce joint pain, swelling, and restricted motion in clinical trials. NAG is also important in maintaining the protective layer of digestive organs. Dr. Braly found that RA is frequently caused by leaky gut, or abnormal permeability of the intestinal wall, allowing undigested food particles to deposit in tissues resulting in inflammatory responses and autoimmune attacks on many tissues (The Burton Goldberg Group, 1995: 531; Freed D, Brit Med J April 1999: 318:1023-25; J Cell Biochem 1994; 56: 225-35) . L-Cysteine (as hydrochloride) cannot be metabolized from the basic amino acid methionine in many chronic diseases, so supplementation has proved useful in many conditions. It helps remove many heavy metal deposits, which suppress immune responses, and protects against environmental pollutants. It also protects the brain, liver, and other organs from the damaging effects of smoking and alcohol. Cysteine boosts the levels of protective enzymes that slow cellular damage (Chaitow, 1988: 95; Balch & Balch, 1997:43) . L-Glutamic Acid serves as a source of fuel for cells lining the intestines, which support uptake of nutrients, and helps prevent bowel permeability noted in arthritis. It has been reported to aid in peptic ulcer healing. It is a component of folic acid and glucose tolerance factor. It is also used to alleviate depression (Lininger, 1998:166, Chaitow, 1998:95, 99) . L-Glycine supplementation has been reported to increase the secretion of gastric acid, which enhances digestion, converts into betaine, important in protein digestion, is a component of bile acids, and is major component of glutathione, which plays a detoxification role in the body (Chaitow, 1988: 83-84) . Glutathione has been reported to counteract the cross-linking effects and cellular damage of free-radical activity (Functions of Glutathione, New York: Springer-Verlag, 1978) . L-Taurine is a component of bile acids, which are essential in absorbing fats and fat-soluble vitamins such as vitamin A. It is also an important component that helps maintain cell membrane stability (Lininger, 1998:206) . Trachea (bovine): Food sources of chondroitin sulfate only come from animal cartilage such as soluble trachea (Lininger et al, 1998:149) . Chondroitin sulfate is a major constituent of bone and cartilage. Cartilage holds water and allows nutrients to pass through its matrix. Animal studies show that chondroitin sulfate may promote the healing of bone (Moss M et al, "The effect of chondroitin sulfate on bone healing," Oral Surg Oral Med Oral Path 1965; 20: 795- 801) . Chondroitin sulfate also helps restore joint function in some forms of arthritis (Kerzberg FM et al, "Combination of glycosamino-glycans and acetylsalicylic acid in knee osteoarthritis," Scand J Rheum 1987; 16:377) . Green Lipped Mussel (Natural source of Mucopolysaccharides and Superoxide Dismutase): Mucopolysaccharides are building blocks for chondroitin sulfate, the major constituent of bone and cartilage (Lininger et al, 1998:149) . Superoxide Dismutase (SOD) is a powerful free radical scavenger that helps protect against the superoxide free radical responsible for cartilage damage and pain. SOD is known to repair cells and reduce the rate of cell destruction (Toohey L, "Natural alternatives to drugs," Nutri-Notes 1999; 6(3): 3; Balch & Balch, 1997:45) . N-Acetyl Cysteine has been reported to help prevent degenerative changes in the liver, has strong antioxidant activity, and is generally cell-protective (Gaby, AR, Wright, JV, J of Advancement in Med Spring 1993; 6 (1): 27-39) . People with Inflammatory Bowel Disease and other conditions have an impaired metabolism that will not allow them to convert L-Cysteine into its NAG bioactive form. As a liver nutrient, it helps remove toxins that accelerate degeneration and interfere with healing. N-acetyl cysteine is an important building block for Lglutathionine (Chaitow, 1988: 79-81) . Milk Thistle Extract (silymarin) a bioflavonoid complex in Milk Thistle, has anti-inflammatory effects on blood platelets and helps prevent inflammatory free-radical production. Silybin, the most active ingredient of Silymarin, has the ability to help regenerate liver cells (Lininger et al, 1992:290-1; Alarcon de la Lastra C et al, Planta Medica 1995(61): 116-9; Sonnenbichler J et al, Proceed of the Internat Bioflav Symp (Munich, Frg) 1981) . L-Glutathione helps bind with toxins in the liver for removal and helps prevent free-radical damage associated with collagen cross-linking, poor cellular circulation, and stiffness (Chaitow, 1988:88-9) . L-Glutathione has been reported to counteract the cross-linking effects and cellular damage of free-radical activity. This tripeptide composed of glutamic acid, Glycine, and cysteine helps deactivate lipid peroxidation, enhance immune system function, and detoxify the heavy metals lead, cadmium, mercury, and aluminum. The primary use of this nutrient has been reported helpful in the prevention and treatment of degenerative conditions. Through the action of glutathione-S transferases, glutathione enables the liver to detoxify undesirable compounds for excretion through the bile (Functions of Glutathione, New York: Springer-Verlag, 1978) . Tidbit: Some people, (especially Inflammatory Bowel Disease people) with compromised health and conversion capabilities, cannot acetylate their glucosamine into N-acetyl glucosamine (NAG). These people miss out on getting one of the most important building blocks of connective tissue. When they take 1500 mg of glucosamine, they are assuming that some will be converted to NAG, however that doesn’t happen due to their inability to convert glucosamine to N-acetyl glucosamine. Total JT Plus includes a synergistic combination of several building blocks necessary for building healthy cartilage tissue.
Contraindications: High doses of glucosamine sulfate can cause high blood sugar levels and/or GI distress (smaller synergistic amounts are used in this formula and there are no reported problems).
Ingredients: Each Tablet Contains: Vitamin C (as ascorbic acid) 50 mg, Vitamin E (as succinate) 30 IU, Pantothenic Acid (as calcium pantothenate) 50 mg. Proprietary blend 487 mg* of: Glucosamine (as sulfate), Milk Thistle (seed), N-Acetyl Glucosamine, L-Cysteine (as hydrochloride), L-Glutamic Acid, L-Glycine, L-Taurine, Trachea (bovine), Green Lipped Mussel, N-Acetyl Cysteine, Milk Thistle Extract (silymarin), L-Glutathione.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Total L-Carnitine (2744F)

Supportive Function: Carnitine is dubbed the “energy nutrient;” it brings fatty acids across the mitochondrial membrane to be burned for energy. Combined with co-factors, carnitine works biochemically to help maintain weight homeostasis.
Ingredients: Each Tablet Contains: Thiamine (as hydrochloride) 2 mg, Ribofl avin 2 mg, Vitamin B-6 (as pyridoxine hydrochloride) 2 mg, Zinc (as chelate) 0.500 mg, Selenium (as chelate) 2 mcg. Proprietary blend 260 mg* of: L-Carnitine (as hydrochloride), Gamma Oryzanol.
Vegetarian: Yes
Suggested Dosage: 1 tablet dail or as directed
Pack: 60 Tablets
Product:

Total Leaky Gut (2703A)

Supportive Function: Total Leaky Gut provides a comprehensive array of nutrients to support the integrity of the intestinal lining, one of the most crucial assets to health we have. When are Leaky Gut Nutrients helpful? Healing the gut lining is applicable in: asthma, arthritis, food allergies, ulcers, Crohn’s, ulcerative colitis, celiac disease, autoimmune diseases, alcoholism, chronic fatigue, joint pain, migraines, diarrhea, parasitic infections, dysbiosis, candidiasis, multiple sclerosis, diabetes, T-cell lymphomas, and generally as a preventative measure, since we all have permeability to some degree. People who smoke, drink, take aspirin/ibuprofen/antibiotics/drugs, get exposed to environmental toxins, have poor digestion, sluggish liver detoxification, or stored toxins, or who have bacterial/microbial infections or inflammation are all at high risk for intestinal permeability.
Clinical Applications Research: Antioxidants: Vitamins C and E, lipoic acid, zinc and ginkgo biloba are all antioxidants, which protect the lining from free radical damage. Additionally, vitamin C and lipoic acid bind heavy metals, which can cause disease, when deposited in the tissues instead of being detoxified in the liver. Vitamin E maintains the integrity of all lipid cell membranes. Ginkgo biloba also increases circulation in the smaller vessels and capillaries, which increases nutrient delivery and tissue healing. Zinc is essential for proper immune system functioning. It is believed to play a role in regenerating epithelial tissue and protecting it from damage, making it an excellent nutrient to support gut healing. L-Glutamine is the main fuel that the intestinal cells need for maintenance and repair (they slough off every three days). Glutamine reinforces the immune system, and there is considerable evidence that glutamine can enhance the barrier function of the gut against viral, bacterial, and food antigen invaders (Hall JC et al. Br J Surg 1996 Mar; 83(3): 305-312) . Glutamine has been proven to stimulate intestinal cell growth while reducing cell injury and infection. It also stimulates mucosal cells, which are highly protective against the damage seen in ulcers. Slippery Elm (bark) is a soothing, protective demulcent renowned for its beneficial effects on the gastrointestinal lining. Slippery elm calms the inflamed mucous membranes of the stomach (Balch JF Presc for Nutr Healing 1990, Garden City, NY) . In addition to a soothing texture that coats the stomach lining, slippery elm contains the fiber-rich ingredient mucilage, which stimulates mucous secretion (especially protective against ulcers). N-Acetyl Glucosamine (NAG) , aside from being able to heal the extra cellular tissue surrounding intestinal epithelial cells, has the unique ability to decrease the binding of some lectins to the intestinal lining. Lectins are antinutrients found in many grains and legumes that increase intestinal permeability and can cause immune responses. Recent research shows that in susceptible people, food proteins can have "molecular mimicry" with self-proteins in the body, and lectins allow them to enter through the lining. This means that the wheat protein causes antibodies to be formed, which then attack collagen tissues because they have similar protein structures. Recent research also shows that NAG is one of the few nutrients with the power to bind to some of these lectins and prevent their damage to the intestinal lining. Deglycyrrhizinated Licorice (root) (DGL) increases the integrity of the mucusal cells - it increases the life span of the intestinal cells, improves the quality of protective substances, and improves the blood supply of nutrients (Glick L. Lancet ii: 817, 1982). Additionally, it has a high healing rate and significantly low relapse rate for ulcers (Kassir ZA Irish Med J 78:153-56, 1985) . Cat’s Claw (bark) is a novel herb that has been researched lately for its, "remarkable ability to cleanse the entire intestinal tract and help those suffering from different stomach and bowel disorders," including Crohn's disease, gastritis, ulcers, parasites, candidiasis, diverticulitis, hemorrhoids, leaky gut, and intestinal flora imbalance (Dr. Brent Davis, DC Wellness Advocate Feb 1995; 5(1): 1-4) . Lactobacillus Acidophilus are friendly bacteria that offset populations of bad bacteria and boost the immune system. Overpopulation of bad bacteria can beat away at the intestinal lining. Friendly bacteria especially counteract candida, which can spread long mycelial arms right through the intestinal lining and perforate it, permitting wide-open entry to microorganisms and toxins. Candida can also release over 60 known candidal toxins which activate the immune system, and which can further increase the “leakiness” of the gut. Jerusalem artichoke is a dietary source of FOS (fructooligosaccharides), which attracts beneficial bacteria to inhabit the gut.
Contraindications: Ginkgo in large quantities is contraindicated with anticoagulant drugs (only a small amount is used in this synergistic formula). Use caution in pregnancy (a small amount of cat's claw is included).
Ingredients: Each Tablet Contains: Vitamin C (as sago palm) 25 mg, Zinc (as chelate) 0.500 mg. Proprietary blend 469.20 mg* of: L-Glutamine, Slippery Elm (bark), N-Acetyl Glucosamine, Ginkgo Biloba (leaf), Deglycyrrhizinated Licorice (root), Jerusalem Artichoke (head), Cats Claw (bark), Alpha Lipoic Acid, Ginkgo Biloba Extract (leaf), Lactobacillus Acidophilus, Bifidobacterium Bifidum.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Total Lipotrophic (2720AF)

Supportive Function: Supports the ability of the body to regulate lipid/cholesterol balance. When is Lipid/Cholesterol Support helpful? High blood cholesterol levels increase the risk for heart disease. Maintaining low levels of lipids/cholesterol is a good idea for preventive maintenance of a healthy heart.
Clinical Applications Research: High cholesterol levels are known to be a risk factor for heart disease. Lowdensity lipoprotein cholesterol, or LDL as we call it, is known as the “bad cholesterol”. Maintaining good ratios between the “bad cholesterol” and the “good cholesterol”, or high-density lipoprotein cholesterol (HDL) is necessary for a healthy balance. Heart disease is the number one cause of death in the United States and in Europe. Americans suffer more than 1.5 million heart attacks each year and more than 1/3 die on their first attack. Even though heart disease causes over 40% of all deaths in the USA, responsible for over 550,000 heart attack deaths and 500,000 strokes each year in the United States alone, heart disease is believed to be one of the most preventable of chronic conditions. When deposits of cholesterol, fat, and calcium form in the major arteries (atherosclerosis) supplying the heart, blood flow to the heart can become restricted and trigger heart attacks. Atherosclerosis in arteries supplying blood to legs causes a condition called intermittent claudication. People with elevated cholesterol levels are at much higher risk of developing atherosclerosis, hardening of the arteries, than people with low cholesterol levels (Lininger et al, 1998: 11) . Most doctors believe that total cholesterol levels should stay under 200 mg/dl. As levels fall below 200, heart disease risks decline. The balance of "bad" LDL cholesterol to "good" HDL cholesterol is thought to be more important than total cholesterol. Overweight conditions and diabetes are other risk factors increasing the likelihood of heart disease. Favorable dietary changes: Minimize high fat intake from dairy and meat. Avoid refined sugars and hydrogenated fats, especially margarine. Limit alcohol intake (no more than 1 to 2 drinks per day). Drink only paper-filtered coffee. Eat smaller, more frequent meals, consisting of more fish, more vegetables, and other high fiber foods such as whole grains (Lininger et al, 1998: 62-3) . Many nutrients have a favorable, natural effect in maintaining healthy and balanced cholesterol levels. Apple Pectin contains both soluble and insoluble fiber; it aids in candida elimination, decreases cholesterol and increases metal detoxification. In addition to apple pectin's ability to bind water and toxins, slow food absorption, and decrease fat absorption, it has the ability to, "protect gastric mucosa by strengthening the mucous-phospholipid layer" (Scand J Gastroenterol 1993; 28(10): 894-9) and inhibit ulcer formation (Nippon Shokakibyo Gakkai Zasshi 1991; 88(10): 2636-43). In other words, apple pectin is a great nutrient for working on leaky gut! By slowing the absorption of food, pectin has proven helpful to diabetics. In Russia, they have a drink called, “Anti-cholest” comprised solely of apple pectin. Garlic (bulb) has been shown to lower cholesterol (Pharmacotherapy. 1993; 1314:406-407) and help in digestion (Balch & Balch, Prescription for Nutritional Healing, 2nd Edition, New York: Avery, 1997:54) . Garlic contains an active ingredient which is a sulphur-containing amino acid allicin (5-ally-L-Cysteine sulfoxide). It also exhibits significant triglyceridereducing properties (Arzneim. 1993;43(9):978-81; J Postgrad Med 1991;37(3):132-5). More than 32 human studies demonstrating the lipid-lowering effects of garlic have been conducted since 1975 (Foster S: Herbal medicine: An introduction for pharmacists. NARD J 10:127-144, 1996. 3.Brown DJ, Foster S: Phytotherapy: Herbal medicine meets clinical science: Part II. America's Pharmacist 6:31-48, 1997). Two meta-analyses have examined the major clinical trials of garlic supplementation for high cholesterol, and they both reported favorable effects on cholesterol levels, both LDL and HDL (Foster and Brown, ibid.) It is thought that one of the mechanisms involved in lowering cholesterol is the ingredient nicotinic acid, which plays a major role in inhibiting HMG-CoA reductase activity (Lipids 1993; 28(7): 613-19). Recent evidence indicates that a person’s susceptibility to the oxidation of cholesterol and LDL may be more important than the total cholesterol level, and this is one reason antioxidants are so important in prevention of heart disease. Garlic, being an antioxidant, was shown to lower the LDL oxidation by 34% in a garlic-treated group compared to controls (Lipids 1993; 28:475-477). One of garlic's components, methyl allyl trisulfide, lowers blood pressure by dilating blood vessel walls. Garlic helps thin blood by inhibiting platelet aggregation, reducing the risk of blood clotting and aiding in the prevention of heart attacks. Beta Glucans consist of polysaccharides that make up part of the insoluble fiber of oat bran that help it to its claim of fame on cholesterol maintenance. The beta attachment is less likely to be broken down than an alpha attachment in the intestines; hence it is not as absorbable. Fiber binds to fat, cholesterol, and cholesterol containing substances and helps remove them from the body (Ripsin, CM, et al, "Oat products and lipid lowering--a metaanalysis," JAMA 1992; (267): 3317-25) . Beta Sitosterol boosts the effects of isoflavones (J of Urology 1995; (154): 391; Cancer Res 1991; (51): 3445) , which are known to have a favorable effect on cholesterol. Isoflavones are special bioflavonoids that block the sorbitol pathway that is linked with oxidative damage in diabetes. They are also known as natural blood thinners that protect blood vessels and reduce platelet aggregation. As antioxidants, bioflavonoids protect cholesterol from oxidative damage. High cholesterol levels in themselves may not be the problem they were first thought to be, but oxidized LDL cholesterol may be the greater issue (Kostner et al, “The interaction of human plasma low density lipoproteins with glucosaminoglycans: influence of the chemical composition,” Lipids Jan. 1985; 20 (1): 24-28, Lininger et al, The Natural Pharmacy, Rocklin, CA: Prima Health, 1998:140-1; Potter, SM, "Overview of the proposed mechanisms for the hypo-cholesterolemic effect of soy," J Nutri 1995; 606S- 611S) . Inositol Hexanicotinate appears to be a safer form of taking niacin without the side effects of the niacin form of vitamin B-3 (Lininger et al, ibid, 1998:64) . Large dosages of niacin-B-3 have been shown to lower cholesterol (Brown, NV, "Niacin for lipid disorders," Postgrad Med 1995; (98): 185-93) . The Inositol Hexanicotinate form of B-3 has the same effects as niacin in lowering serum cholesterol without side-effects (Head, KA, “Inositol hexaniacinate: a safer alternative to niacin,” Alt Med Rev 1996; (1): 176-84.; Murray, M. “Lipid lowering drugs vs. inositol hexaniacinate,” Am J Natural Med 1995; (2): 9-12) . Policosanol Extract is a purified mixture of primary alcohol’s isolated from sugar-cane wax or beeswax that helps prevent LDL oxidation. It helps lower total and LDL cholesterol by inhibiting cholesterol synthesis and helps reduce the cholesterol content of liver, heart, and fatty tissues. Policosanol helps reduce platelet aggregation by altering prostaglandin synthesis. Policosanol also helps prevent and reverse atherosclerotic lesions and thrombosis. In diabetic patients, policosanol favorably increased ratios of good HDL cholesterol to LDL cholesterol. In a study of patients with intermittent claudication, policosanol helped increase walking distance and reduce lower-limb symptoms of claudication. Policosanol also has anti-ischemic effects that may benefit patients with cerebral vascular disorders. Suggested cautions: high doses should be used cautiously by patients also taking propranolol, nifedipine, other antihypertensive agents, anticoagulant, or antiplatelet medications. Use cautiously in patients taking acetyl-cholinesterase inhibitors and cholinomimetic agents, since policosanol may increase the release of acetylcholine at the neuromuscular junction. Fiber can naturally bind to bile acids and help in the removal of these cholesterol-containing substances from the body. When cholesterol is removed from the body, the body makes more. However, there are also natural substances, such as garlic and policosanol, which can affect the natural regulation of the liver enzyme that regulates cholesterol production. There are many types of fiber, both soluble and insoluble. Both types of fiber are found in apple pectin. Soluble fiber can regulate blood sugar by decreasing gastric emptying and glucose uptake. This reduces insulin response and fat storage. The glycemic index studies of Jenkins et al. (among others) have proven that fiber has an important place in the diet of diabetics (Adv Nutr Res 1984; 6:169--202.) (Larson, D. Mayo Clinic Family Health Book, 1990. William Morrow & Co. Inc. NY, NY. p. 635.) By lowering fat absorption, soluble fiber also has a favorable effect on blood cholesterol. Insoluble fiber, such as the cellulose found in plant cell walls, has an effect mostly by binding to cholesterol, toxins, and carcinogenic secondary bile acids and drawing them out of the body. Both types of fibers can speed fecal transit time by adding bulk and holding water. Additionally, the delayed passage rate induced by fiber results in greater absorption of some of the amino acids (J Nutr 1994; 124(6): 833-41.) Apple pectin contains soluble and insoluble fiber, whereas beta glucan is a good insoluble fiber.
Contraindications: High doses should be used cautiously by patients also taking propranolol, nifedipine, other antihypertensive agents, anticoagulant/antiplatelet medications or cholesterol medications. Use cautiously in patients taking acetyl-cholinesterase inhibitors and cholinomimetic agents, since policosanol may increase the release of acetylcholine at the neuromuscular junction.
Ingredients: Each Tablet Contains: Proprietary blend 365 mg* of: Apple Pectin, Cordyceps, Garlic (bulb), Beta Glucans, Beta Sitosterol, Guggulipid, Inositol Hexanicotinate, Policosanol Extract.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Liver D-Tox (180) (2408A)

Supportive Function: This formula provides comprehensive nutritional support for liver detoxification. When is Total Liver D-Tox helpful? Detoxification, sluggish liver, toxic burden, environmental overload, any condition that can benefit from the clearing of waste and toxins, (especially Fibromyalgia, multiple chemical sensitivity, allergies, etc.), female disorders (clears excess estrogen), constipation, hemorrhoids, etc.
Clinical Applications Research: Vitamin A (from cod liver oil) has been reported by some investigators to enhance antibody and cell-mediated immune response. It is necessary for growth and repair of body tissues and is important in the healing process due to its important role in proper cellular reproduction. Deficiency can cause breakdown of the integrity of the GI barrier, resulting in leaky gut syndrome. Vitamin C (as ascorbic acid) is a potent antioxidant and immune enhancer. Vitamin C neutralizes toxic substances and contributes to cytochrome P450 activity in the liver, which is necessary for proper liver detoxification. Vitamin E (as succinate): Vitamin E is a powerful antioxidant that protects the liver from cellular damage by contributing to cytochrome P450 activity in the liver. Thiamine (as hydrochloride)(B-1) acts as a cofactor to thiamine pyrophosphate (TPP), which plays a key role in glucose metabolism and for metabolism of branched chain amino acids. Magnesium (as chelate) increases the solubility and retention of calcium. It is important in neuromuscular contractions/relaxations, it activates enzymes necessary for metabolism of carbohydrates and amino acids, and it is integral for any healing process. Magnesium is necessary for ATP (energy) production in the mitochondria. Zinc (as chelate): Zinc acts as an antioxidant and has shown major immune-boosting effects. It aids in the liver's role of detoxification and metabolism. Zinc activates a form of SOD, a potent detoxifying enzyme. Selenium (as chelate): Selenium is a powerful antioxidant and detoxifier of a number of environmental pollutants. Selenium activates glutathione peroxidase, a potent detoxifying enzyme. Manganese (as chelate) is an essential co-factor in the activity of the free radical detoxifying enzyme SOD. Manganese supplementation has been shown to increase SOD activity. High iron competes with manganese, thus high iron in the diet can deplete the body of manganese. Milk Thistle (seed) and Milk Thistle Extract (leaf) contains silymarin, which is a very potent liver-specific antioxidant. It works by inhibiting free radical damage and promoting synthesis of new protein to replace damaged liver cells. It protects the liver against poisoning by chemicals and is known as "one of the most potent liver medicines known." Cellulase is a plant wall-digesting enzyme, amylase is a starch-digesting enzyme, lipase is a fat-digesting enzyme, and protease is a protein-digesting enzyme. Garlic (root) has been used for centuries as an antimicrobial compound. It has been found to be effective against candida and parasites, it provides radiation protection, and it is used for cholesterol and triglyceride reduction. Beet (root) and Beet (leaf): Beets aid in gallbladder function, lymphatic function and digestion. Red beetroot is excellent for liver and biliary detoxification. Beets are high in iron and possibly possess "anti-tumor activity." Betaine accounts for the red color in beets, is listed in the Merck Index as a hepatoprotectant, and is also used as a digestive aid. A cancer clinic in Hungary did a study using red beet administration, and remarkable results were recorded (Heinerman, Heinerman's Encyclopedia of Fruits, Vegetables and Herbs, Parker Publishing Company, W. Nyack, NY, 1988) . Choline (as bitartrate) has potent lipotropic activity (fat-digesting properties). Without choline, fats become trapped in the liver, where they block metabolism. A study recently showed that humans fed a diet deficient in choline developed liver disorders. Calcium D-Glucarate: Calcium maintains healthy bones and tissues and acts as a co-factor in many enzyme reactions. Calcium plays a role in the intricate balance of ion transport, muscle contraction, heart maintenance, nerve impulses and muscle tone. Calcium is a natural chelating agent, which binds toxins in the body. Phosphatidyl Choline (from Lecithin): Sometimes called lecithin, phosphatidylcholine is a molecule composed of saturated, unsaturated and/or polyunsaturated fatty acids, as well as glycerin, phosphorus and choline. It is a main component of our cell membranes and protects against oxidant damage. It aids in synthesis of acetylcholine, a potent neurotransmitter. Liver (bovine): A glandular extract of liver provides the specific amino acid sequencing for support of the liver. Black Currant (Seed) Oil is a major source of gamma-linolenic acid (GLA), which is an essential fatty acid that has numerous functions in the body. DL-Methionine is an essential sulfur-containing amino acid in one of the most usable forms. It is considered to have therapeutic, lipotropic activity similar to choline. Cysteine and taurine biosynthesis are dependent upon methionine. These two amino acids are both required for phase II liver conjugation. It has been shown to be useful in detoxifying heavy metals, especially the sulfhydryl-reactive metals (mercury, cadmium, and lead), that are responsible for stealing sulfur from biologically active proteins. Alpha Lipoic Acid is also known as thioctic acid. It is a sulfur-containing, vitamin-like substance, and can efficiently address the sulfhydryl-reactive metals (mercury, lead, and cadmium) that bind to sulfur-containing proteins. Lipoic acid is also a good mobilizer for metal removal. It is an important co-factor in important energy-producing reactions in the body. Lipoic acid is effective as an antioxidant, both for water- and fatsoluble free radicals. Lipoic acid is found in high amounts in liver and yeast (Murray, M., Encyclopedia of Nutritional Supplements, Prima Publishing, Rocklin, CA, 1996, p.343).
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (from cod liver oil) 1000 IU, Vitamin C (as ascorbic acid) 25 mg, Vitamin E (as succinate) 10 IU, Thiamine (as hydrochloride) 5 mg, Magnesium (as chelate) 10 mg, Zinc (as chelate) 0.500 mg, Selenium (as chelate) 25 mcg, Manganese (as chelate) 0.100 mg. Proprietary blend 452.75 mg* of: Milk Thistle (seed), Cellulase, Amylase, Lipase, Protease, Garlic (root), Beet (root), Choline (as bitartrate), Calcium D-Glucarate, Phosphatidyl Choline (from Lecithin), Liver (bovine), Black Currant (Seed) Oil, DLMethionine, Milk Thistle Extract (leaf), Alpha Lipoic Acid.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 180 Tablets
Product:

Total Liver D-Tox (60) (2408)

Supportive Function: Supportive Function: This formula provides comprehensive nutritional support for liver detoxification. When is Total Liver D-Tox helpful? Detoxification, sluggish liver, toxic burden, environmental overload, any condition that can benefit from the clearing of waste and toxins, (especially Fibromyalgia, multiple chemical sensitivity, allergies, etc.), female disorders (clears excess estrogen), constipation, hemorrhoids, etc.
Clinical Applications Research: Vitamin A (from cod liver oil) has been reported by some investigators to enhance antibody and cell-mediated immune response. It is necessary for growth and repair of body tissues and is important in the healing process due to its important role in proper cellular reproduction. Deficiency can cause breakdown of the integrity of the GI barrier, resulting in leaky gut syndrome.  Vitamin C (as ascorbic acid) is a potent antioxidant and immune enhancer. Vitamin C neutralizes toxic substances and contributes to cytochrome P450 activity in the liver, which is necessary for proper liver detoxification.  Vitamin E (as succinate): Vitamin E is a powerful antioxidant that protects the liver from cellular damage by contributing to cytochrome P450 activity in the liver.  Thiamine (as hydrochloride)(B-1) acts as a cofactor to thiamine pyrophosphate (TPP), which plays a key role in glucose metabolism and for metabolism of branched chain amino acids.  Magnesium (as chelate) increases the solubility and retention of calcium. It is important in neuromuscular contractions/relaxations, it activates enzymes necessary for metabolism of carbohydrates and amino acids, and it is integral for any healing process. Magnesium is necessary for ATP (energy) production in the mitochondria.  Zinc (as chelate): Zinc acts as an antioxidant and has shown major immune-boosting effects. It aids in the liver's role of detoxification and metabolism. Zinc activates a form of SOD, a potent detoxifying enzyme.  Selenium (as chelate): Selenium is a powerful antioxidant and detoxifier of a number of environmental pollutants. Selenium activates glutathione peroxidase, a potent detoxifying enzyme.  Manganese (as chelate) is an essential co-factor in the activity of the free radical detoxifying enzyme SOD. Manganese supplementation has been shown to increase SOD activity. High iron competes with manganese, thus high iron in the diet can deplete the body of manganese.  Milk Thistle (seed) and Milk Thistle Extract (leaf) contains silymarin, which is a very potent liver-specific antioxidant. It works by inhibiting free radical damage and promoting synthesis of new protein to replace damaged liver cells. It protects the liver against poisoning by chemicals and is known as "one of the most potent liver medicines known."  Cellulase is a plant wall-digesting enzyme, amylase is a starch-digesting enzyme, lipase is a fat-digesting enzyme, and protease is a protein-digesting enzyme.  Garlic (root) has been used for centuries as an antimicrobial compound. It has been found to be effective against candida and parasites, it provides radiation protection, and it is used for cholesterol and triglyceride reduction.  Beet (root) and Beet (leaf): Beets aid in gallbladder function, lymphatic function and digestion. Red beetroot is excellent for liver and biliary detoxification. Beets are high in iron and possibly possess "anti-tumor activity." Betaine accounts for the red color in beets, is listed in the Merck Index as a hepatoprotectant, and is also used as a digestive aid. A cancer clinic in Hungary did a study using red beet administration, and remarkable results were recorded (Heinerman, Heinerman's Encyclopedia of Fruits, Vegetables and Herbs, Parker Publishing Company, W. Nyack, NY, 1988).  Choline (as bitartrate) has potent lipotropic activity (fat-digesting properties). Without choline, fats become trapped in the liver, where they block metabolism. A study recently showed that humans fed a diet deficient in choline developed liver disorders.  Calcium D-Glucarate: Calcium maintains healthy bones and tissues and acts as a co-factor in many enzyme reactions. Calcium plays a role in the intricate balance of ion transport, muscle contraction, heart maintenance, nerve impulses and muscle tone. Calcium is a natural chelating agent, which binds toxins in the body.  Phosphatidyl Choline (from Lecithin): Sometimes called lecithin, phosphatidylcholine is a molecule composed of saturated, unsaturated and/or polyunsaturated fatty acids, as well as glycerin, phosphorus and choline. It is a main component of our cell membranes and protects against oxidant damage. It aids in synthesis of acetylcholine, a potent neurotransmitter.  Liver (bovine): A glandular extract of liver provides the specific amino acid sequencing for support of the liver.  Black Currant (Seed) Oil is a major source of gamma-linolenic acid (GLA), which is an essential fatty acid that has numerous functions in the body.  DL-Methionine is an essential sulfur-containing amino acid in one of the most usable forms. It is considered to have therapeutic, lipotropic activity similar to choline. Cysteine and taurine biosynthesis are dependent upon methionine. These two amino acids are both required for phase II liver conjugation. It has been shown to be useful in detoxifying heavy metals, especially the sulfhydryl-reactive metals (mercury, cadmium, and lead), that are responsible for stealing sulfur from biologically active proteins.  Alpha Lipoic Acid is also known as thioctic acid. It is a sulfur-containing, vitamin-like substance, and can efficiently address the sulfhydryl-reactive metals (mercury, lead, and cadmium) that bind to sulfur-containing proteins. Lipoic acid is also a good mobilizer for metal removal. It is an important co-factor in important energy-producing reactions in the body. Lipoic acid is effective as an antioxidant, both for water- and fatsoluble free radicals. Lipoic acid is found in high amounts in liver and yeast (Murray, M., Encyclopedia of Nutritional Supplements, Prima Publishing, Rocklin, CA, 1996, p.343).
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (from cod liver oil) 1000 IU, Vitamin C (as ascorbic acid) 25 mg, VitaminE (as succinate) 10 IU, Thiamine (as hydrochloride) 5 mg, Magnesium (as chelate) 10 mg, Zinc (as chelate)0.500 mg, Selenium (as chelate) 25 mcg, Manganese (as chelate) 0.100 mg. Proprietary blend 452.75 mg* of:Milk Thistle (seed), Cellulase, Amylase, Lipase, Protease, Garlic (root), Beet (root), Choline (as bitartrate),Calcium D-Glucarate, Phosphatidyl Choline (from Lecithin), Liver (bovine), Black Currant (Seed) Oil, DLMethionine,Milk Thistle Extract (leaf), Alpha Lipoic Acid.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Total Male (2730)

Supportive Function: This formula provides comprehensive nutritional support for Male Health and vitality. When is Male Health Support helpful? Endocrine Balance, Male Potency & Libido, Prostate & Testes health, etc.
Clinical Applications Research: Vitamin A (as cod liver oil) is a powerful free radical scavenger; aids in maintaining a healthy immune system, healthy mucus membranes, and keeps the outer layers of glands and tissues healthy. Vitamin C (as ascorbic acid) , a major constituent of the prostate, the seminal vesicles, and prostatic fluid, is a powerful antioxidant that protects other antioxidants helping to promote arterial health and preserve blood flow to erectile tissues. Vitamin E (as succinate) helps increase circulation important in erectile function. Thiamine (as hydrochloride)(B-1) is necessary for hydrochloric acid formation, proper digestion, and enhances circulation, which is necessary for normal erectile function. Riboflavin (B-2) deficiency can present as poor digestion. B-2 maintains and improves the mucous membranes in the digestive tract. It is necessary for antibody production, cell respiration, and growth. Niacin is necessary for the synthesis of sex hormones, improves circulation, and helps prevent muscular weakness. Vitamin B-6 (as pyridoxine hydrochloride) aids in the prevention of arteriosclerosis, promotes the formation of DNA-RNA, is needed for formation of hydrochloric acid and proper absorption of proteins and fats. Folate (as folic acid) is necessary for energy production, the production of DNA-RNA, and may alleviate depression and anxiety. Vitamin B-12 (as cyanocobalamin) is needed for the proper digestion of food and absorption of nutrients. B- 12 helps maintain fertility, cell formation, and the metabolism of carbohydrates and fats. Magnesium (as malate) helps prevent the calcification of soft tissue, protect the arteries from stress damage, and prevent cardiovascular disease, which can restrict blood flow to the penis and heart. Malate helps promote aerobic glycolysis, the most efficient mode of energy production for maintenance and repair of organs. Zinc (as chelate) is needed for prostate gland function and reproductive organ growth. Zinc supports the concentration of vitamin E in the system, which promotes circulation. Deficiencies are associated with impotence, infertility, BPH, prostatitis, prostate cancer, and high cholesterol levels. Selenium (as chelate) helps provide relief from benign prostatic enlargement when combined with zinc and vitamin E. Selenium helps prevent the oxidation of fats implicated in fatty plaque obstruction of blood flow to the heart and genitals. Deficiency is associated with sterility. MACA (lepidum meyenii)(root) , called the Andean Ginseng for its invigorating properties, maca's lysine and arginine have been found to promote female and male fertility and sexual desire. Maca's sterols, brassycosterol, ergosterol, carnpesterol, delta 7.22 ergostadienol, and specially sitosterol and glucosinolates are associated with balancing reproductive hormones (Espinoza CL and Poma LP, Determinación de amino ácidos esenciales de la maca (Lepidum meyenii) y elaboración de una mezcla protéica a base de alimentos andinos, Thesis, Universidad Nacional Del Centro Del Perú, Huancayo, 1995 Fitomédica, "Maca, ginseng andino," in Fitomédica, Madrid, 1998; Johns TA, Ethnobotany and phytochemistry of Tropaeolum Tuberosum and Lepidium Meyenii from Andean South America Ph.D. Thesis, The University of British Columbia, Canada, 1980) . Panax Ginseng (root) helps strengthen male reproductive and adrenal glands, improves fertility, alleviates stress, and enhances immune function. It has long been prized as an aphrodisiac, helps stimulate and rebuild all body systems, and is considered the most effective of all tonic herbs. It contains measurable amounts of germanium, which helps oxygenate all cells. Eleuthero (root) helps increase blood flow, raise sexual potency, and rebuild energy and endurance. It helps stimulate and regenerate adrenal and immune function and lower blood pressure. It is considered superior by Traditional Chinese Medicine to treat impotence. Muira Puama (herb) is known as an aphrodisiac and sexual stimulant. It enhances male and female libido, helps alleviate impotence, and supports endocrine organ regeneration. Pumpkin (seed) is full of B vitamins, essential fatty acids, protein, and zinc that have proven useful in helping maintain a healthy prostate and successful in helping treat prostate disorders. Flax (seed) is high in omega-3 oils. Essential fatty acids (EFAs) are necessary in large amounts for the normal function of the prostate gland. Flaxseed oil has been successfully used to alleviate Benign Prostatic Hyperplasia with increases in libido. EFAs also reduce blood clotting associated with prostate cancer and help lower the potential for spreading of tumors. Chlorella (plant) , a micro-algae, is a vitamin-antioxidant-mineral rich nutritive tonic that accelerates tissue building and repair. It helps build blood and supports liver function. Oat (avena sative)(herb) have anxiety reducing and relaxing effects attributed to their alkaloids, gramine and avenine, and their saponins. They are also a rich source of iron, manganese, and zinc. Oats (rapidly dried green, aerial part of the oat plant) contain steroidal compounds, vitamins B-1, B-2, D, and E, alkaloids and flavonoids. Green oats help elevate mood, counteract anxiety, and nourish nerves. "Feeling one's oats" is an expression that has merit in male health: Dr. Robert Frankt, Budapest University, reported that green oats helped create great increases in sexual vitality and energy. Saw Palmetto (berry) helps maintain a healthy prostate and alleviates benign prostatic hypertrophy. The sterols and fatty acids, caproic, lauric, and palmitic acids, in saw palmetto inhibit dihydrotestosterone, a hormone, which contributes to enlargement of the prostate. The fatty acids in saw palmetto also discourage inflammation and infection. Quercetin is an important member of the flavonoids. It has been reported to protect cholesterol from oxidative damage that potentially leads to blocked arteries and capillaries, which can restrict blood flow to the penis and heart. Quercitin and other flavonoids protect and potentiate vitamin C’s roles in the body (Lininger, 1998:201-2) . Damiana (leaf) improves blood flow to the genitals. It helps balance hormones for both sexes and acts as a tonic for the hormone system. It helps enhance libido, elevate mood, and raise sexual potency by increasing oxygen to the genital area. Tribulus Terrestris (fruit) has been found to help enhance erectile function, sperm production and motility, cholesterol levels, promote better moods, and self-confidence, according to a 1981 study by the Chemical Pharmaceutical Institute in Sofia, Bulgaria, of more than 200 men suffering from impotence (Harrington C, "Puncture Vine, Tribulus Terrestris, Plant dubbed "Nature's Viagra," Canadian Press, www.GreenCanyon.com) . Pepsin is a proteolytic enzyme that enhances the digestion of proteins, acts as anti-inflammatory, and aids in the treatment of food allergies. Lipase (vegetable source) , enhances the digestion and extraction of nutrients from fats. Amylase (vegetable source) , enhances the digestion of carbohydrates. Pygeum Extract (bark) contains phytosterols, including beta-sitosterol that interferes with the formation of inflammatory chemicals that accumulate in benign prostatic hyperplasia. Pygeum's pentacyclic terpenes have a decongesting effect on the prostate. The ferulic esters of pygeum reduce prolactin in the prostate. Prolactin increases the uptake of dihydrotestosterone, which contributes to prostate enlargement. Boron (as chelate) supplementation in both animals and humans results in higher estradiol, natural human estrogen levels, higher testosterone levels, and higher vitamin D levels. Low levels of boron in tissues have also been linked to lower hormonal levels (Samman, S, et al, Biol Trace Elem Res Winter 1998; 66(1-3):227-35) .
Contraindications: Those with gluten sensitivity should not take green oats.
Ingredients: Vitamin A (as cod liver oil) 300 mcg, Vitamin C (as ascorbic acid) 50 mg, Vitamin E (as succinate) 16 mg, Thiamin (as hydrochloride) 1.5 mg, Riboflavin 1.8 mg, Niacin 5 mg, Vitamin B-6 (as pyridoxine hydrochloride) 3 mg, Folate (as folic acid) 150 mcg, Vitamin B-12 (as cyanocobalamin) 100 mcg, Magnesium (as malate) 20 mg, Zinc (as chelate) 5 mg, Selenium (as chelate) 20 mcg. Proprietary blend 373 mg* of: MACA (lepidium meyenii)(root), Panax Ginseng (root), Eleuthero (root), Muira Puama (herb), Pumpkin (seed), Flax (seed), Chlorella (plant), Barrenwort (root), Oat (avena sativa)(herb), Saw Palmetto (berry), Quercetin, Damiana (leaf), Passion (flower), Tribulus Terrestris (fruit), Pepsin, Lipase (vegetable source), Amylase (vegetable source), Pygeum Extract (bark), Boron (as chelate).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed.
Pack: 90 Tablets
Product:

Total Mitochondria (2722F)

Supportive Function: Nutritional support for the efficient production of energy. The mitochondria are called the “powerhouses of the cell” because it is in the mitochondria that our energy is made. The energy we need for everyday biochemical reactions and existence is derived from ATP, the currency for energy that is produced in the mitochondria of every living cell in the Kreb’s cycle. Protecting the mitochondria from damage is believed to help prevent the cell from aging. When is Mitochondrial Support helpful? Total Mitochondria is suggested in any instance where energy support is indicated, such as fatigue, chronic fatigue, Fibromyalgia, exercise training, etc., and also where support of the anti-aging process is indicated.
Clinical Applications Research: The mitochondria have the unique ability to make ATP, which is the energy that fuels virtually every biochemical function in the body, from protein synthesis and muscle contraction, to digestive enzyme production and nerve conduction. ATP is like an energy exchange, just like we use dollar bills for a money exchange. Without ATP, we would not have the energy to maintain normal function. The mitochondria accomplish this energy production by using electrons, derived from the carbohydrate, fat, and protein in our food, to produce ATP. When we lose energy from not being able to produce ATP, we see everything from muscle wasting, fatigue, energy loss, sleep disturbances, and impaired cognitive function. The aging of the mitochondria is one of the major theories of what causes the aging of our bodies. The mitochondria produce energy by being able to convert the electrons from our food into usable energy. The electron transport system, which utilizes Co-enzyme Q-10 as a major electron carrier, provides for the change in the energy of electrons to the energy of ATP production. Carnitine, which brings the fatty acids across the mitochondrial membrane for oxidation, facilitates energy production by providing the electrons from the fat to make ATP. It is also believed to play an integral role in branched chain amino acid metabolism (Shils M & Young V, eds. Modern Nutrition in Health and Disease. 7th ed. 1988. Lea & Febiger, Philadelphia, Pa. p.453) , which has been studied for its role in exercise performance. Vitamin C is needed for carnitine synthesis, and the symptoms such as fatigue that are seen in vitamin C-depleted human volunteers may actually be the result of poor energy production due to decreased carnitine biosynthesis" (Ibid, p. 422). This is one of the reasons that carnitine supplementation, along with Co-enzyme Q-10, vitamin E, and B-complex, are discussed for their therapeutic effects in Duchenne muscular dystrophy and conditions of mitochondrial defects (Scholte HR et al., "Carnitine deficiency, mitochondrial dysfunction and the heart. Identical defect of oxidative phosphorylation muscle mitochondria in cardiomyopathy due to carnitine loss and in Duchenne Muscular Dystrophy". Wiener Klinishe Wochenschrift. January 6, 1989; 101(1): 12-17). It is possible that chronic fatigued patients may have impairment of mitochondria and the oxidative metabolism that produces energy. (McCully, KK et al., Use of exercise for treatment of chronic fatigue syndrome. Sports Medicine, January 1996; 21 91): 35-48). Vitamin C (as ascorbic acid) is necessary for the body to synthesize carnitine. Deficiencies of vitamin C have been associated with extreme fatigue linked to poor energy because of decreased carnitine synthesis (Shils M and Young V, eds, Modern Nutrition in Health and Disease, 7th Ed., Philadelphia, PA: Lea & Fibiger, 1988:453). Vitamin E (as succinate) provides antioxidant protection against mitochondria damage and aging of cells. Positive to dramatic benefits have been achieved with E supplementation in FM (Lininger et al, 1998:54; 222; Mindell, 1985: 55; 60-1) . Vitamin E and B Vitamins; Thiamine (as hydrochloride) and Riboflavin have been successfully used in therapy for conditions of mitochondria defects and Duchenne muscular dystrophy (Scholte Ibid.) . B Vitamins are necessary for the mitochondria to produce energy from carbohydrates in the Kreb's citric acid cycle. FM patients have been found to have low B-1 status and reduced activity of B-1 dependent enzymes. Niacin (as niacinamide) (B3) can increase energy by properly utilizing food; necessary for healthy digestion, nervous system, and brain functions. Folate (as folic acid) is lost in food processing; folic acid alleviates pain; promotes antibody activity, cellular division, and is necessary for utilization of sugars and protein. Magnesium (as malate) : Magnesium combines with lactic acid, neutralizing the negative effect of excess lactic acid, normalizing breathing for asthma, emotional disturbances, and restoring the ill health of people in many disease conditions (Reich C, "Calcium and Vitamin D Deficiency," The Arthritis Trust, www.arthritistrust.org) . Magnesium is needed in the oxidation of fats into energy; essential for muscle contraction and relaxation, nerve health, normal blood pressure and heartbeat; helps build muscle. Szent-Gyorgyi found that malic acid (malate) stimulates cells into using oxygen to produce its energy, signaling the mitochondria to use oxygen to burn food as fuel, its most efficient mode of energy production. Malate has been used for CFS/CFIDS and FM to improve energy and reduce pain. ("Open Your Mind to the Possibilities," CFIDS Chronicle, Summer 1993; Lehninger A, Principles of Organic Chemistry (1982): 399, 400, 442;Lininger, et al, 1998:54) . Caution : Kidney disease patients should take magnesium only under supervision of their doctor. Zinc (as chelate) helps promote energy production, resistance to infections, regulation of blood sugar; protects against free-radical damage to cells and promotes tissue repair (Lininger et al, 1998: 14; 224) . Selenium (as chelate) is necessary to activate glutathione. Deficiency is linked with loss of stamina; synergistic with E in protecting cells from aging and hardening; necessary to activate thyroid hormones. Manganese (as chelate) is needed for the formation of thyroxin, the major hormone of the thyroid; essential for conversion of food into energy. Manganese helps eliminate fatigue; is an essential part of Mn SOD, which protects the mitochondria; aids muscle reflexes; improves memory; reduces nervous irritability (Mindell, 1985: 88-9; 83; Balch & Balch, 1997:45) . Catechin Extract (green tea) has been reported to enhance energy levels in chronic fatigue, has very powerful antioxidant protection, has antiviral and antibacterial inhibiting properties especially against H. pylori, and promotes ulcer healing (Lininger et al, 1998:104; 140; Konlee M, "Free radicals in HIV progression: pycnogenol reverses their effects," Townsend Letter for Doctors, Dec. 1994) . Alpha Lipoic Acid plays a key role in converting food into energy in the mitochondria. It enhances the antioxidant functions of Vitamins C, E, and glutathione (Balch & Balch, 1997:43) . N-Acetyl L-Carnitine (as hydrochloride) transports fatty acids across the membranes of the mitochondria where they can be used as sources of fuel to produce energy. Muscle weakness, extreme fatigue, and excess storage of fat in muscles have been reported to be common signs of L-Carnitine deficiency. Supplementation has reduced blood lipids by 50% and liver fat levels significantly. Carnitine supplementation has been reported to increase levels of ATP in heart muscle, to benefit heart strength, angina, and arrhythmia, and to lower blood lipids and triglycerides. Carnitine helps increase physical performance and appears to have an anti-fatigue effect in both animals and humans (Chaitow, 1988:75-7; Leibovitz, 1984: 109; 169; 171; 201; 207) . N-Acetyl Cysteine has antioxidant properties that protect mitochondrial cells against aging and cell death (Yamaguchi, et al, "Selenium concentration and glutathione peroxidase activity in plasma and erythrocytes from human blood," J of Clin and Biochem Nutri 1992; 12:41-50) . L-Tyrosine is a mood elevator and a precursor to active thyroid hormone. Deficiency symptoms include low body temperature and restless legs. Supplementation can be helpful against chronic fatigue. Caution : should not be taken with MAO inhibitor drugs (Balch & Balch, 1997:42) . L-Glycine in proper amounts produces more energy in the body, retards muscle degeneration, and is essential to the formation of DNA and RNA, bile, gastric acid, and glutathione (Balch & Balch, 1997: 39; Chaitow, 1988:83-4) . L-Glutamic Acid (as hydrochloride) helps metabolize sugars and fats, detoxifies ammonia from tissues, and converts into glutamine. Glutamine prevents muscle wasting, helps build and maintain muscle health; helps fuel the brain; enhances mental function; and enhances energy in treating chronic fatigue (Balch & Balch, 1997:38-9) . Co-Enzyme Q-10 is a necessary catalyst in the creation of all energy that cells need for life. It is a major electron carrier in the production of ATP energy. Low levels of Co-Q-10 are associated with aging and nearly all disease states. It has been used successfully to improve the health of people with hypertension and heart disease, those undergoing chemotherapy, in diabetes, infertility, and gum disease. It has been reported to have anti-aging effects and to significantly boost the immune system (Lininger, et al, 1998:152; Bliznakov, 1987; Balch & Balch, 1997: 43) . Co-enzyme Q-10 has been used therapeutically in conditions of mitochondria defects and Duchenne muscular dystrophy (Scholte HR, et al, "Carnitine deficiency, mitochondrial dysfunction and the heart. Identical defect of oxidative phosphorylation muscle mitochondria in cardiomyopathy due to carnitine loss and in Duchenne Muscular Dystrophy," Wiener Klinishe Wochenschrift Jan. 1989; 101(1): 12-7) . Phosphatidyl Serine and Lecithin (Phosphatidyl Choline) help transport lipids across cell membranes to reach the mitochondria and support the fluidity and integrity of cell membranes of the mitochondria. They help support both energy creation and brain function.
Contraindications: Tyrosine should not be taken with MAO inhibitor drugs. Liver disease patients should take magnesium only under the supervision of a doctor. One study reported reduced efficacy with the drug warfarin (trade name Coumadin) when taken with Co-Enzyme Q-10.
Ingredients: Vitamin C (as ascorbic acid) 45 mg, Vitamin E (as succinate) 45 IU, Thiamine (as hydrochloride) 15 mg, Riboflavin 15 mg, Niacin (as niacinamide) 15 mg, Folate (as folic acid) 250 mcg, Magnesium (as malate) 11 mg, Zinc (as chelate) 0.500 mg, Selenium (as chelate) 34 mcg, Manganese (as chelate) 0.083 mg. Proprietary blend 347.6 mg* of: Lecithin, Catechin Extract (green tea), Phosphatidyl Choline (as lecithin), Super Oxide Dismutase Type G, Alpha Lipoic Acid, N-Acetyl L-Carnitine (as hydrochloride), N-Acetyl Cysteine, L-Glutathione, L-Tyrosine, L-Glycine, L-Glutamic Acid (as hydrochloride), Co-Enzyme Q-10, Phosphatidyl Serine, Chlorophyll (as sodium chlorophillin).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed.
Pack: 90 Tablets
Product:

Total Multimune (2717)

Supportive Function: Provides support for the immune system with many well-known powerful nutritional ingredients. When is Immune Support helpful? When susceptibility to infection by bacteria, virus, and pathogens. Also, depressed immune system, cellular breakdown, and autoimmune disease.
Clinical Applications Research: Vitamin A (as cod liver oil) is necessary for the maintenance and repair of the skin and mucous membranes that make up the body’s first line of defense, vitamin A protects against colds, flu’s, and infections of mucous membranes. Without adequate levels of vitamin A, bacteria and viruses can penetrate the skin, lungs, intestinal lining, and other mucous tissues. Vitamin C (as ascorbic acid) has always been heralded as one of the best vitamins to boost the immune system; a deficiency of this vitamin has been highly correlated to a greater susceptibility to infection. Vitamin C elevates antiviral activity and supports the manufacturing of the immune cells necessary to fight infection. Vitamin C is carried to the site of infection by the white blood cells, and vitamin C helps the mobility and power of those white blood cells. Additionally, vitamin C indirectly helps fight cold and flu infection by addressing some of the other main causes for a depressed immune system: it promotes thymic hormone secretion, acts as an antioxidant to eliminate by-products of infection, stimulates adrenal function, aids in thyroid hormone production, detoxifies certain metals and drugs, recycles other antioxidants such as vitamin E, and aids in phagocytosis (digestion of damaged, dead or foreign cells) that can cause inflammation. In a study where dockworkers took 100 mg of vitamin C for 10 months, they caught influenza 28% less than controls that took no supplemental C. The average duration of illness in those who took the supplemental C was 10% less than controls (Deutsche Gesundheitswesen 1954; 9:702-06) . Other studies have shown rapid improvement in symptoms when vitamin C was taken in high amounts (2 grams every hour for 12 hours) (South Med Surg 1949; 111:210-14; Pauling, L. Vitamin C, the common cold, and the flu. San Francisco, WH Freeman & Co. 1976 [review]) , however high dosing should be supervised. Caution exists for iron overload disease, kidney-stone formers, and those with gout. Some people have a bowel tolerance to vitamin C around a gram, and experience diarrhea past that amount. Calcium (as chelate) is essential for cellular metabolism. When the metabolism is revved up during an infection, and when an enormous amount of energy is being used just to produce antibodies for viral invaders, calcium is in high demand for metabolic processes. One of the theories of the purpose of fever is that the increased body temperature draws calcium from the bones out into the system, where it is needed for biochemical reactions and clearing of infection. Magnesium (as chelate) like calcium, is an essential co-factor for biochemical reactions. It helps to maintain the body’s pH and help produce the energy needed for antibody production and immune defenses, along with aiding in the production of DNA and RNA for protein synthesis. Both magnesium and calcium bind to heavy metals, which can be part of the problem of a lowered immune system. Zinc (as chelate) enhances immune function and increases white blood cell activity. Zinc is a powerful antioxidant that can protect against the metal poisoning that lowers immune function. When a sore throat is involved, zinc lozenges bathe epithelial cells in the throat and provide increased protection. Manganese (as chelate) is an important mineral for activating enzymes in the many processes of infection fighting. It helps to maintain cellular integrity, and is essential for utilization of vitamin C. Colostrum is breast milk, and as such confers immunity onto offspring by the transfer of antibodies and other immune factors. Bovine colostrum has been used as a nutritional supplement to confer these factors of immunity onto humans. Unlike bovine milk, which may contain allergens, the bovine colostrum is a different substance, which is thought to have immunomodulatory activity. One study notes that colostrum, “contains factors that are protective for the neonate and may be a source of immunomodulatory molecules that positively influence the immune status of the neonate (Vet Immunol Immunopathol 2000 Oct 31; 76(3-4): 183-190). Astragalus (root) is a Chinese herb that has been shown to restore T-cell counts to relatively normal ranges. It contains a wide variety of phytochemicals to support antiviral functions. The results of one study even suggest that astragalus increased natural killer cell activity, and exerted an anticarcinogenic effect in carcinogen-treated mice (Cancer Invest 1999; 17(1): 30-5). Astragalus contains triterpene glycoside compounds, nineteen of which have shown immunostimulatory effects (Biol Pharm Bull 2000 Jul; 23(7): 834-7) . Inositol (as hexaphosphate) has been touted lately as a strong immune nutrient, offering particular support for natural killer cells. IP-6 is a naturally occurring plant fiber, otherwise known as phytate. It is present in legumes and whole grains, especially wheat bran. As with some other plant fibers, IP-6 appears to have a beneficial effect on blood sugar control. It seems to possess several beneficial health properties, including antioxidant (Free Rad Biol Med1990; 8:61-9) and anticancer (Life Sci 1997; 61:343-54) properties, showing particular results in the event of colon cancer (animal study; Nutr Canc 1993; 19:11-19) and breast cancer (animal/pilot study, Canc Lett 1993; 75:95-102) . In the animal/pilot study conducted on pure IP-6, significant results were obtained, however these results were not obtained when IP-6 was given in the form of wheat bran (Nutr Canc 1997; 28(1): 7-13) . IP-6 injected into mice with cancerous tumors has resulted in partial regression of the tumors (Anticancer Res 1998; 18:4091-96) . IP-6 has also been used in the protocol for kidney stones. Phytate is a substance associated with reported reduced mineral absorption, iron in particular (Am J Clin Nutr 1999; 70:240-46) , and as such is recommended to be taken at least an hour away from meals. Maitake (mushroom) is full of phytonutrients that stimulate white blood cells and trigger an enhanced immune response. It has been mostly researched for its role in maintaining healthy blood pressure, and has also been researched in cancer studies. It has been used for a long time in Chinese medicine as an adaptogen (nutrient which brings systems back into homeostasis). Maitake has complex polysaccharides in its structure, one of the primary ones being beta-D-glucan. Beta glucan is currently being studied for it immune properties, specifically the prevention and treatment of cancer, and support for HIV infection (Chemotherapy 1990; 38:790; Nanba, H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b 1-6 glucans extracted from maitake mushrooms. VIII International Conference on Aids, Amsterdam, 1992) . Animal studies have indicated that maitake may lower blood lipids and blood pressure (Biol Pharm Bull 1997; 20:781-785; Chem Pharm Bull 1998; 36:1000-06) . Green Tea Extract contains catechins, one of the most widely investigated flavonoids. It has been in the news lately for its reported ability to boost immune function. For example, a recent review in Sept. 2000 reports that, “Catechin and its gallate are major ingredients in green tea and their antioxidant and cancer preventive effects have been widely investigated. A Phase I study of green tea extract has been conducted in adult patients with solid tumors” (Wang HK. The therapeutic potential of flavonoids. Expert Opin Investig Drugs 2000 Sep; 9(9): 2103-19). A report in Epidemiology stated that the antioxidant compounds found in tea, wine, fruits and vegetables may lower the risk of having a non-fatal heart attack for some men (Epidemiology January, 2000) . Antioxidants combat the effects of free radicals, which are naturally-occurring particles that can contribute to chronic disease and aging when they are produced in excess. Glandulars can be an important part of any immune protocol. They target immune glands (such as Lymph (bovine), Spleen (bovine), Parotid (bovine) and Thymus (bovine)) and help repair tissues by supplying amino acids that are essential building blocks. They are believed to repair damaged or deteriorated glands, and help restore them to normal function (homeostasis). The thymus is the organ that produces T-cells; the lymph supports white blood cells and toxin removal, and the spleen produces and stores antibodies and phagocytes, and filters toxins from the blood. Pomegranate (fruit) is a fruit containing ellagic acid, the same compound found in wine that has been identified as a strong antioxidant with healthful properties. Some studies have shown pomegranate to be strong enough to protect against cell mutation. Lycopene is a carotenoid that has gotten a lot of press lately as one of the newly discovered potent antioxidants. Found in tomatoes in high concentration, lycopene is such a strong immune nutrient that it has been found to have protective qualities against cancer, most notably prostate cancer. One study, which looked at the correlation of tomato consumption and decreased risk for prostate cancer suggested that even pizza could lower the risk because of its tomato content. Some people took this as a green light to have massive amounts of pizza, which is high in refined carbohydrates and saturated fat (similar to justifying chocolate when we heard it contains flavonoids!) One doesn’t want to raise the risk for other diseases (such as heart disease) while lowering risk for prostate cancer. Which means that the lycopene in tomatoes may be making a difference, but that organic tomatoes consumed without the “junk food” would foster an even healthier scenario.
Contraindications: Caution exists for high levels of vitamin C and iron overload disease, kidney-stone formers, and those with gout. Some people have a bowel tolerance to vitamin C around a gram, and experience diarrhea past that amount. However, only a small amount of vitamin C is utilized in this synergistic formula.
Ingredients: Each Tablet Contains: Vitamin A (as cod liver oil) 225 mcg, Vitamin C (as ascorbic acid) 50 mg, Vitamin B- 6 (as pyridoxine hydrochloride) 10 mg, Calcium (as chelate) 34 mg, Magnesium (as chelate) 20 mg, Zinc (as chelate) 8 mg, Manganese (as chelate) 2 mg. Proprietary blend 382.5 mg* of: Colostrum, Astragalus (root), Inositol (as hexaphosphate), Maitake (mushroom), Green Tea Extract, Lymph (bovine), Spleen (bovine), Thymus (bovine), Parotid (bovine), Pomegranate (fruit), Lycopene.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Total Probiotics (120) (2405A)

Supportive Function: In an age where the human body is subjected to numerous immune insults, from environmental toxins to endogenous parasites, it is imperative to remember the balance of friendly flora in the large intestine. A healthy balance supports immune function and decreases colony populations of harmful bacteria. Total Probiotics contains FOS, molecules, which attract bifidobacteria in the gut, and are especially helpful when populations of flora have been decreased from antibiotic use. When are Probiotics helpful? A high-potency, probiotic combination is necessary to rebuild the "good bacteria" in the gastrointestinal tract. Can be helpful for intestinal integrity, candida, dysbiosis, parasites, intestinal complaints.
Clinical Applications Research: Jerusalem Artichoke (Helianthus Tuberosus)(bark) is a rich source of fructooligosaccharides (FOS). The human body does not metabolize FOS. Bifidobacterium in the presence of FOS is the primary source of biotin production in infants. FOS helps promote the growth of friendly bacteria, especially bifidobacteria and lactobacilli, while decreasing the amount of bad bacteria. FOS also increases butyrate production (short-chain fatty acids), enhances liver function and increases elimination of toxic substances. Onions, garlic and asparagus are also natural sources of FOS (Murray, M., Encyclopedia of Nutritional Supplements, Prima Publishing, Rocklin, CA, 1996, p. 362) . Acerola Extract (Malpighia Glabra)(fruit) is a natural source of vitamin C and bioflavonoids, which have powerful effects on the immune system. Rose Hips (Rosa Canina)(fruit) are a natural source of vitamin C and bioflavonoids, which have powerful effects on the immune system. Cellulase is composed of hydrolytic food enzymes that aid in the breakdown and assimilation of nutrients. Lactobacillus Acidophilus provides protection for the intestinal wall by enhancing antigen-specific immune defense. Lactobacilli produce a variety of substances that inhibit bad bacteria and inhibit the production of toxins by pathogenic species. Lactobacillus acidophilus "has been found to inhibit Candida albicans" (Microbios, 1990; 62 (250): 37-46) . Bifidobacterium Bifidum and Bifidobacterium Longum prevents pathogenic enterobacteria from colonizing the gut. In particular, research has shown that nitrite-producing organisms are specifically inhibited by these probiotics. Protease, Lipase and Amylase: Protease is a protein-digesting enzyme, lipase is a fat-digesting enzyme, and amylase is a carbohydrate-digesting enzyme. Lactobacillus Casei creates a desirable microbial balance and controls the production of toxins upon vital organs and body cells. Lactobacillus casei contributes to intestinal peristalsis and elimination of harmful amines from amino acids. It coats the intestinal mucosa and protects against invasion and activities of harmful organisms (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997) . Lactobacillus Plantarum produces a high percentage of lactic acid, which acts to inhibit harmful microorganisms (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997) . Lactobacillus Rueteri has been shown to stabilize the intestinal flora and is used with acidophilus and bifidobacteria as extra support. It promotes additional benefits such as protection against pathogens, provision of certain nutrients and enzymatic reactions, involvement in tissue morphogenesis, peristalsis activity and interaction with the immune and endocrine systems (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997) . Lactobacillus Salvarius has been shown to produce alpha-galactosidase, which can help reduce flatulence. In addition, Lactobacillus Salivarius has been shown to be highly resistant to tetracycline and other types of antibiotics (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997) .
Contraindications: None known
Ingredients: Each Capsule Contains: Zinc (as gluconate) 0.7 mg, Manganese (as gluconate) 0.6 mg. Proprietary blend 255 mg* of: Jerusalem Artichoke (Helianthus Tuberosus)(bark), Acerola Extract (Malpighia Glabra)(fruit), Rose Hips (Rosa Canina)(fruit), Beet (Beta Vulgaris)(root). Probiotic Blend (70 billion CFU) 176 mg*: Cellulase (1200 CU*), Lactobacillus Acidophilus 400 Million*, Bifidobacterium Bifidum 200 Million*, Bifidobacterium Longum 200 Million*, Protease (7500 HUT*), Lipase (52 LU*), Lactobacillus Casei 100 Million*, Lactobacillus Plantarum 100 Million*, Lactobacillus Rueteri 100 Million*, Lactobacillus Salivarius 100 Million*, Amylase (275 DU*).
Vegetarian: Yes
Suggested Dosage: 1 capsule daily or as directed
Pack: 120 Capsules
Product:

Total Probiotics (60) (2405)

Supportive Function: In an age where the human body is subjected to numerous immune insults, from environmental toxins to endogenous parasites, it is imperative to remember the balance of friendly flora in the large intestine. A healthy balance supports immune function and decreases colony populations of harmful bacteria. Total Probiotics contains FOS, molecules, which attract bifidobacteria in the gut, and are especially helpful when populations of flora have been decreased from antibiotic use. When are Probiotics helpful? A high-potency, probiotic combination is necessary to rebuild the "good bacteria" in the gastrointestinal tract. Can be helpful for intestinal integrity, candida, dysbiosis, parasites, intestinal complaints.
Clinical Applications Research: Jerusalem Artichoke (Helianthus Tuberosus)(bark) is a rich source of fructooligosaccharides (FOS). The human body does not metabolize FOS. Bifidobacterium in the presence of FOS is the primary source of biotin production in infants. FOS helps promote the growth of friendly bacteria, especially bifidobacteria and lactobacilli, while decreasing the amount of bad bacteria. FOS also increases butyrate production (short-chain fatty acids), enhances liver function and increases elimination of toxic substances. Onions, garlic and asparagus are also natural sources of FOS (Murray, M., Encyclopedia of Nutritional Supplements, Prima Publishing, Rocklin, CA, 1996, p. 362).  Acerola Extract (Malpighia Glabra)(fruit) is a natural source of vitamin C and bioflavonoids, which have powerful effects on the immune system.  Rose Hips (Rosa Canina)(fruit) are a natural source of vitamin C and bioflavonoids, which have powerful effects on the immune system.  Cellulase is composed of hydrolytic food enzymes that aid in the breakdown and assimilation of nutrients.  Lactobacillus Acidophilus provides protection for the intestinal wall by enhancing antigen-specific immune defense. Lactobacilli produce a variety of substances that inhibit bad bacteria and inhibit the production of toxins by pathogenic species. Lactobacillus acidophilus "has been found to inhibit Candida albicans" (Microbios, 1990; 62 (250): 37-46).  Bifidobacterium Bifidum and Bifidobacterium Longum prevents pathogenic enterobacteria from colonizing the gut. In particular, research has shown that nitrite-producing organisms are specifically inhibited by these probiotics.  Protease, Lipase and Amylase: Protease is a protein-digesting enzyme, lipase is a fat-digesting enzyme, and amylase is a carbohydrate-digesting enzyme.  Lactobacillus Casei creates a desirable microbial balance and controls the production of toxins upon vital organs and body cells. Lactobacillus casei contributes to intestinal peristalsis and elimination of harmful amines from amino acids. It coats the intestinal mucosa and protects against invasion and activities of harmful organisms (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997).  Lactobacillus Plantarum produces a high percentage of lactic acid, which acts to inhibit harmful microorganisms (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997).  Lactobacillus Rueteri has been shown to stabilize the intestinal flora and is used with acidophilus and bifidobacteria as extra support. It promotes additional benefits such as protection against pathogens, provision of certain nutrients and enzymatic reactions, involvement in tissue morphogenesis, peristalsis activity and interaction with the immune and endocrine systems (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997).  Lactobacillus Salvarius has been shown to produce alpha-galactosidase, which can help reduce flatulence. In addition, Lactobacillus Salivarius has been shown to be highly resistant to tetracycline and other types of antibiotics (Dr. Lynn Toohey, PhD, Paper presented on Total Probiotic, 1997).
Contraindications: None known
Ingredients: Each Capsule Contains: Zinc (as gluconate) 0.7 mg, Manganese (as gluconate) 0.6 mg. Proprietary blend 255 mg* of: Jerusalem Artichoke (Helianthus Tuberosus)(bark), Acerola Extract (Malpighia Glabra)(fruit), Rose Hips (Rosa Canina)(fruit), Beet (Beta Vulgaris)(root). Probiotic Blend (70 billion CFU) 176 mg*: Cellulase (1200 CU*), Lactobacillus Acidophilus 400 Million*, Bifidobacterium Bifidum 200 Million*, Bifidobacterium Longum 200 Million*, Protease (7500 HUT*), Lipase (52 LU*), Lactobacillus Casei 100 Million*, Lactobacillus Plantarum 100 Million*, Lactobacillus Rueteri 100 Million*, Lactobacillus Salivarius 100 Million*, Amylase (275 DU*).
Vegetarian: Yes
Suggested Dosage: 1 capsule daily or as directed
Pack: 60 Capsules
Product:

Total Protect (2734F)

Supportive Function: This formula provides comprehensive nutritional support for a healthy immune system. An array of powerful phytochemicals facilitate the detoxification of harmful substances both by supporting phase I liver detox (cytochrome P450 system), and also phase 2 liver detox (conjugation) . When is Phytochemical Support helpful? Challenged immune systems, cancer support, intense support of toxic clearance, protection against toxic insult and tissue damage.
Clinical Applications Research: Soy Isoflavones (Genistin, Genistein, Daidzin, Daidzein, Glycitin, Glycitein) are found in abundance in the traditional diets of populations of Africans and Asians who experience very few menopause symptoms, very few transitional problems through menopause, low incidence of cardiovascular disease, colon, breast, and prostate cancer. Average intake of isoflavonoids in traditional diets are estimated at 27.8mg (of daidzein 12.02, glycitein 2.3mg, and genistein 13.48mg) per day. In a study of 177 postmenopausal women, genistin and daidzin significantly reduced symptoms of hot flashes. Daidzin, genistin, and glycitin have been shown to significantly prevent bone loss, and lower total cholesterol and triglyceride levels. In an animal study, Genistin and daidzin have been demonstrated to significantly reduce eosinophilia in lung tissue and reduce asthma symptoms. Soy isoflavones have antioxidant properties that help prevent LDL cholesterol oxidation and protect against cell damage in vascular tissues. Soy isoflavones have shown protective actions on bladder cells and protective effects on angiogenic neovasculature without negative effects on normal tissue (Aldercreutz H et al, “Dietary phytoestrogens and the menopause in Japan,” (Lancet May 1992;339(8803):1233; Aldercreutz et al), “Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional diet,” (Am J of Clin Nutri 1991; 54(6): 1093-1100; Nakamura Y et al) , “Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake,” (J AOAC Int May-Jun 2000;83(3):635-50; Upmalis DH et al) , “Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study,” (Menopause Jul-Aug 2000;7(4):213-4; Uesugi T et al) , “Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin,” (Biol Pharm Bull Apr 2001;24(4):368-72; Regal JF et al) , “Dietary phytoestrogens have anti-inflammatory activity in a guinea pig model of asthma,” (Proc Soc Exp Biol Med Apr 2000;223(4):372-8; Kapiotis S et al) , “Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL,”  (Arterioscler Thromb Vasc Biol Nov 1997;17(11):2868-74; Zhou JR et al) , “Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis,” (Cancer Res Nov 1998 15;58(22):5231-8) . Cordyceps helps relax bronchial passages, facilitate breathing, and increase blood flow to muscles (Stamets P & C Dusty Wu Yao, “Medicinal Mushrooms,”) (TLfD&P June 1998:162) .Yamaguchi et al, 1990, found that cordycepts was an immune stimulant “Augmentation of various immune activities of tumor-bearing hosts with an extract of Cordyceps sinensis,” (Biotherapy 2(3):199-205). Liu et al, 1992) , showed that cordycepts enhanced Natural Killer Cell activity “Effects of Cordyceps sinensis (CS) on in vitro natural killer cells,” (Chung Kuo Chung His I Cheih Ho Tsa Chih 12(5):267-9,259) . Zhou & Lin, 1995), demonstrated that cordycepts could restore normal cellular immunological function “Effect of Jinshubao capsule on the immunological function of 36 patients with advanced cancer,” (Chung Kuo Chung His I Ho Tsa Chih Aug: 15(8):476-8) . Artemisia Annua (herb) is rich in protective phytochemicals. Its capillarisin has protective effects against freeradical damage to liver and lung cells. Fifteen protective phytochemical compounds have shown antiplatelet aggregation activity and three other compounds appear to inhibit viral replication. Its scoparone phytochemical compound appears to have an anti-anginal effect, improving coronary blood flow. Artemesia has shown chemoprotective effects on liver cells. (Chu CY) , “Protective effects of capillarisin on tert-butylhydroperoxideinduced oxidative damage in rat primary hepatocytes,” (Arch Toxicol Jun-Jul 1999;73(4-5):263-8; Wu TS et al) , “New constituents and antiplatelet aggregation and anti-HIV principles of artemesia capillaris,” (Bioorg Med Chem Jan 2001;9(1):77-83; Yamahara J et al) , “The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug artemisiae capillaris flos, on the heart,” (Chem Pharm Bull May 1989;37(5):1297-9; Hu YQ) , “Apoptosis in human hepatoma cell line SMMC-7721 induced by water-soluble macromolecular components of Artemisia capillaris Thunberg,”  (Jpn J Cancer Res Jan 2000;91(1):113-7) . DIM (Diindolylmethane) is a normal metabolic product of ingesting indole-3-carbinol from cruciferous vegetables. It has potent chemoprotective effects on the cells and tissues of the larynx, cervix, endometrium, and breast. (Chen DZ et al, “Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16- transgenic preneoplastic cervical epithelium,”J Nutr Dec 2001;131(12):3294-302; Hong C et al) , “Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM)in human breast cancer cells,” (Biochem Pharmacol Mar 15 2002;63(6):1085-97; Leong H et al) , “Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression,” (Carcinogenesis Nov 2001;22(11):1809-17) . Indole-3-Carbinol is a protective phytochemical found in cruciferous vegetables. It is a powerful free-radical scavenger, protects against the potentially damaging chemicals in cigarette smoke, and helps remove them from the body. Indole-3-carbinol protects cells from damage by pesticides. It has hormone balancing and protective effects on the cells and tissues of the larynx, breast, cervix, colon, and liver. Indole-3-carbinol helps improve estrogen metabolism and helps protect estrogen-sensitive tissues. (Chen DZ et al, Ibid; Lord RS et al) , “Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites,” (Altern Med Rev Apr 2002;7(2):112-29; Arnao MB et al) , “Indole-3-carbinol as a scavenger of free radicals,” (Biochem Mol Biol Int Aug 1996;39(6):1125-34; Taioli E et al) , “Effects of indole-3-carbinol on the metabolism of 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers,” (Cancer Epidemiol Biomarkers Prev Jul 1997;6(7):517-22); Agrawal RC, Mehrotra N, “Assessment of mutagenic potential of propoxur and its modulation by indole-3-carbinol,” (Food Chem Toxicol Oct-Nov 1997;35(10-11):1081-4; Xu M et al) , “Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole- 3-carbinol: dose-response studies in the rat colon,” (Carcinogenesis Nov 1997;18(11):2149-53; Manson MM et al) , “Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism,” (Carcinogenesis Sep 1997;18(9):1729-38) . Lactoferrin helps protect against harmful oxidation, has been reported to stimulate the immune system, has both antibacterial and antiviral properties, promotes protective flora in the gut, and helps regulate iron metabolism. Lactoferrin is one of the body’s protective polypeptides, called defensins. Lactoferrin is an iron binding glycoprotein that blocks unfriendly bacteria from obtaining a source of iron. Lactoferrin is found in the products of all exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, in saliva, tears, nasal secretions, and seminal plasma. In blood, lactoferrin is derived from a special group of white blood cells, the neutrophils (Levay PF, Viljoen M, “Lactoferrin: a general review,” Haemotologica 1995; 80:252-67; Reiter B) , “The biological significance of the non-immunoglobulin protective proteins in milk,” (Developments in Dairy Chemistry, vol 3, 1985: 281-336) . Organic Cauliflower (sprout): Cauliflower is a member of the cruciferous family of vegetables, including broccoli, cabbage, radish, kale, mustard, turnip, cress, horseradish, rutabaga, kohlrabi, and Brussels sprouts. Cauliflower sprouts are rich in food enzymes that protect against depletion of the body’s own enzymes and reduce stress on the body. The superoxide dismutase (SOD) enzyme in cauliflower protects against cell damage caused by one of the most dangerous free radicals, superoxide. Three-day-old sprouts of cruciferous vegetables contain 10-100 times the protective phytochemical, sulphoraphane, than do mature plants. Cauliflower’s high indole component is believed to be responsible for strengthening the immune system, enhancing detoxification, and neutralizing damaging agents in the GI tract. Population studies in Norway show that high consumption of cauliflower and other cruciferous vegetables is linked with low incidence of polyps of the colon  (Carper, 1989:160-1; Balch & Balch, 1997:45; 48; Fahey JW et al). “Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens,” (Proc Natl Acad Sci U S A Sep 16 1997; 94(19):10367-72) . Organic Broccoli (sprout) are rich in food enzymes, carotenoids, chlorophyll, indoles, glucosinolates, sulphoraphane, and dithiolthiones. Food enzymes protect against depletion of the body’s own enzymes and reduce stress on the body. Population studies link broccoli consumption with health of the esophagus, stomach, colon, lung, larynx, prostate, oral cavity, and pharynx. Three-day-old sprouts of cruciferous vegetables contain 10-100 times the protective phytochemical, sulphoraphane, than do mature plants. Biochemistry studies show sulphoraphane to be a chemoprotective agent for cells of the GI tract, liver, and breast. A Buffalo, New York study found that broccoli’s protective effects rose in a dose- dependent manner: greater consumption was associated with less risk. A 1983 population study suggested that women who ate more broccoli maintained the health of the cervix  (Carper, 1989:146-7; Balch & Balch, 1997:45; 48; Watenberg LW et al), “Inhibition of polycyclic hydrocarbon induced neoplasia by naturally occurring indoles,” (Cancer Research May 1978; 38(5):1410-13; Graham S et al), “Diet in the epidemiology of cancer of the colon and rectum,” (J of the National Cancer Institute Sept 1978; 61(3):709-14; Colditz GA et al), “Increased green and yellow vegetable intake in an elderly population,” (Am J of Clin Nutri Jan 1985; 41(1):32-6; Van Lieshout EM et al) , “Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels,” (Carcinogenesis Nov 1998;19(11):2055-7; Zhang Y, Callaway EC), “High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate,” (Biochem J May 15 2002;364(Pt 1):301-7; Fahey JW et al, Ibid) . Betaine (as hydrochloride) helps digest proteins in the stomach, reduce bacterial colonization of the stomach, and enhance the absorption of minerals and other nutrients.
Contraindications: Use with caution in conjunction with blood-thinning drugs. Take with meals to prevent stomach upset.
Ingredients: Each Tablet Contains: Selenium (as chelate) 2 mcg. Proprietary blend 167.5 mg* of: Soy Isoflavones, Cordyceps, Artemisia Annua (herb), DIM (Diindolylmethane), Indole 3 Carbinol, Lacto Ferrin, Organic Cauliflower (sprout), Organic Broccoli (sprout), Betaine (as hydrochloride).
Vegetarian: No
Suggested Dosage: 1 tablet daily with meals or as directed
Pack: 90 Tablets
Product:

Total Tri-Estro (Homeopathic) (0969)

Supportive Function: Water-Based Tri-Potent Sublingual Spray. Menopausal Symptoms.  When is Total Tri-Estro helpful? For the temporary relief of menopausal symptoms, menstrual disorders, hot flashes, depression, sleep disorders, fatigue, apathy.
Clinical Applications Research: Adrenalinum (Adrenalin): The adrenal glands make adrenalin, and they also make some of our sex hormones; in fact they take over some slack in menopause when other organs are not producing as much estrogen or progesterone. Stress plays an important role in exhausting the adrenal glands and the ability to produce these regulatory hormones. Cimifuga Racemosa (Black Cohosh) is used for its effects on many systems, including the cerebrospinal and muscular system (pain and irritation), as well as the uterus and ovaries. It is useful in rheumatic or nervous subjects with ovarian irritation, uterine cramps and/or heavy limbs. It is also used for disorders of menstruation/menopause (Henry Clarke MD, in A Dictionary of Practical Materia Medica) . Ignatia Amara is also known as St Ignatius' bean. It is utilized for sleeplessness, mood swings, anxiety, depression, emotional fragility, etc. It is used for relief of headaches, extreme sensitivity to pain and noise, cramps, constipation due to emotional issues, crying jags, and inability to work. A scientific study using homeopathic remedies that contained Ignatia Amara showed “substantial improvement in psychological and psychosomatic symptoms…Climacteric complaints diminished or disappeared completely in the majority of women (95.7% by patient evaluation and 96.2% by physician evaluation)” (Wasilewski BW. Homeopathic remedies as placebo alternatives--verification on the example of treatment of menopause-related vegetative and emotional disturbances. Sci Eng Ethics. 2004 Jan;10(1):179-88). Nicotinamidum is part of nicotinamide adenine dinucleotide (NAD), and the reduced form of the enzyme, NADH. NAD and NADH are powerful enzymes used for biochemical reactions, many of which have effects on hormonal balance (David Riley MD, J of the Am Inst of Homeopathy. 1994;87(2) . Lecithinum homeopathic is traditionally used for a forgetful, dull, confused mind, ovarian insufficiency, weak sexual power, low libido, aching, lack of energy, and scanty urine with phosphates, sugar or albumin (a percentage of testosterone and estrogens circulate in the blood while bound to albumin) (Boericke's Materia Medica) . Lecithin is important in the vital processes of life; it is an integral component of cell membranes. Lecithin has a favorable influence upon the nutritive conditions and especially upon the blood; it increases the red corpuscle count and hemoglobin in the blood. Oophorinum: Henry Clarke MD, in A Dictionary of Practical Materia Medica, reports that oophorinum has been used with much success in cases of suffering following removal of the ovaries, and for menopausal symptoms, ovarian cysts, nervousness, eczema, acne rosacea (and other skin disorders of menopause), and adiposity. Sepia is referenced as one of the “classical 'great' remedies” in a scientific study (Becker-Witt C. Diagnoses and treatment in homeopathic medical practice. Forsch Komplementarmed Klass Naturheilkd. 2004 Apr;11(2):98-103). A controlled trial in 12 cows demonstrated that a homeopathic treatment with a sepia-containing formula was 100% effective in inducing cycles in anestrus cows and promoting conception (Rajkumar R et al. Effect of a Homeopathic complex on oestrus induction and hormonal profile in anoestrus cows. Homeopathy. 2006 Jul;95(3):131-5). Estradiol, Estriol, and Estrone are three varieties of estrogen found in a woman’s body. It is critical to have a balance of these estrogens, and the homeopathic essences of these hormones are used to achieve hormonal homeostasis. While estradiol and estrone have been associated with increased risk for some female cancers, estriol is actually thought to be anti-inflammatory. In fact, estriol, known as the pregnancy hormone, has been studied as a possible therapeutic agent for MS. In a study where estriol was found to decrease inflammatory cytokines, researchers discovered that, “Estriol is a potent regulator for T cell functions”, and “The protective role of pregnancy in autoimmune conditions, such as multiple sclerosis (MS), is potentially associated with immune regulation by sex hormones produced during pregnancy (estriol)” (Zang YC, Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B. J Neuroimmunol. 2002 Mar;124(1-2):106-14). In fact, “The decrease in disease severity during late pregnancy appears to be due at least in part to high levels of estriol” (Voskuhl RR, Palaszynski K. Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neuroscientist. 2001 Jun;7(3):258-70).
Contraindications: WARNING: STOP USE AND CALL A DOCTOR, IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING, CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN.
Ingredients: Active Ingredients: Contains equal volumes of each ingredient in 10X, 30X, and LM1 potencies: Adrenalinum, Cimicifuga, Ignatia, Lecithin, Nicotinamidum, Oophorinum, Sepia. Inactive Ingredients: Citric Acid, Potassium Sorbate, Purified Water.
Vegetarian: No
Suggested Dosage: Take 2 pump sprays 3 times daily or as directed. Hold under tongue for 30 seconds before swallowing. More frequent dosages may be used according to symptomatic needs. For Adults Only.
Pack: 1 oz Liquid Spray
Product:

Total Upper GI (2701)

Supportive Function: The stomach is where the processes of digestion really begins (minimal starch digestion in saliva), which in turn will determine how effectively we extract vital nutrients from our food. Upper GI was formulated in an effort to completely support these sensitive, all-important cells of digestion and includes soothing herbals and nutrition for healthy maintenance. When are Upper GI Nutrients helpful? Heartburn and gastrointestinal distress and complaints.
Clinical Applications Research: Vitamin A (as palmitate) is considered to be an essential immune vitamin. It is necessary to cellular growth, repair, and regeneration. Its role in regenerating epithelial tissue is vital to immune organs. It has been known for a long time that a lack of vitamin A in the diet will result in reduced resistance to infection. Folate (as folic acid) is essential to the growth and repair of cells. It plays an integral role in DNA/RNA replication, and is required whenever there is a large turnover of cells, such as when the stomach lining has been injured and is in need of cellular repair. Deglycyrrhizinated Licorice (root) increases the integrity of the mucous\bicarbonate-producing cells in the stomach. A natural licorice extract, deglycyrrhizinated licorice (DGL), has been found to increase the life span of the intestinal cells, improve the quality of protective substances, and improve blood supply of nutrients (Glick L. Lancet ii: 817,1982). DGL has been effective in treating both gastric and duodenal ulcers, and can reduce the gastric bleeding caused by aspirin (Rees WDW et al. Scand J Gastroenterol 14:605-7.1979) . When DGL was compared to antacids and H2 receptor antagonists in over 800 patients, all had a high healing rate. DGL, however, had a significantly lower relapse rate (Kassir ZA Irish Med J 78:153-56, 1985) , probably because of its ability to inhibit helicobacter pylori, the bacteria suspected of causing over 90% of ulcers. L-Glutamine : Glutamine is the main fuel that the intestinal cells need for maintenance and repair (they slough off every three days). Glutamine reinforces the immune system, and there is considerable evidence that glutamine can enhance the barrier function of the gut against viral, bacterial, and food antigen invaders (Hall JC et al. Br J Surg 1996 Mar; 83(3): 305-312) . Glutamine has been proven to stimulate intestinal cell growth while reducing cell injury and infection. It also stimulates mucosal cells, which are highly protective against the damage seen in ulcers. In Japan, glutamine is known as the most popular anti-ulcer treatment. N-Acetyl Glucosamine (NAG) is important to the extra cellular matrix that helps to comprise our, “cellular cement." NAG is needed for synthesis of the chondroitin proteoglycans (big building blocks of connective tissue) (Biochem J. 1991 Jan; 273(Pt 2): 283-88) . It provides the extra cellular layer of cells, which forms a protective layer over the stomach lining. Slippery Elm (bark) calms the inflamed mucous membranes of the stomach (Balch JF Presc for Nutr Healing 1990, Garden City, NY) . In addition to a soothing texture that coats the stomach lining, slippery elm contains the fiber- rich ingredient mucilage that stimulates mucous secretion (protective against ulcers). Bromelain has been documented in over 200 studies as being a potent anti-inflammatory agent. Additionally, double blind studies have shown that bromelaine can combat infection by affecting mucosal inflammation (Headache 1967; 7:13-17; Acta Obstet Gynaecol Jpn 1972; 19:147-153). Okra (fruit) has beneficial phytochemicals, and as mucilage is capable of covering the stomach lining and  protecting cells. Its soothing effect on the lining helps the healing process. Cabbage (leaf) is reported to heal ulcers; it has a high glutamine content (glutamine is involved in the synthesis of the mucoproteins present in the mucous secretions). Cabbage is defined in the Merck index as “vitamin U," named so because of its powerful antiulcer properties. Glandulars are thought to provide precursor substances that the body can use to support and enhance the function of a specific gland. They may provide the potential “life force” the body needs to enhance function of a specific organ or gland. Glandulars are tissue concentrates, usually of a bovine source, which stimulate their respective glands.
Contraindications: None known
Ingredients: Each Tablet Contains: Vitamin A (as palmitate) 450 mcg, Folate (as folic acid) 250 mcg, Magnesium (as chelate) 15 mg. Proprietary blend 610 mg* of: Deglycyrrhizinated Licorice (root), Stomach (porcine), Duodenum (porcine), L-Glutamine, N-Acetyl Glucosamine, Slippery Elm (bark), Bromelain, Okra (fruit), Cabbage (leaf), Parotid (bovine).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed.
Product:

Total VR-X (120) (2704A)

Supportive Function: Immune support for maintenance of defenses against attack from viral organisms. A uniquely orchestrated combination of powerful phytochemicals and nutrients make up this formula, which includes the highly active components in olive leaf (such as oleuropein). When are Immune Nutrients helpful? Decreased immune function, infections
Clinical Applications Research: Vitamin A (as palmitate) 40% as Beta Carotene) is considered to be an essential immune vitamin. It is necessary to cellular growth, repair, and regeneration. Its role in regenerating epithelial tissue is vital to immune organs. It has been known for a long time that a lack of vitamin A in the diet will result in reduced resistance to infection. Beta-Carotene is a precursor, which is made into vitamin A, as the body needs it. Beta-carotene has also been found to specifically enhance the immune system, and is a potent antioxidant (vitamin A is not an antioxidant form). Vitamin C (as ascorbic acid) is one of the most important vitamins, which builds the immune system. It creates strong, healthy tissues that line immune organs, and it is carried in the immune-fighting lymphocytes (white blood cells). Vitamin C helps mobilize the lymphocytes (immune-fighting cells) and increases the speed with which they can reach a site of infection. When there is an infection, vitamin C is carried to the site quickly, and it is used up quickly. Zinc (as chelate) is another important immune vitamin. It has a vital role in regenerating epithelial tissue and so is highly important when viral infection calls for cellular repair. Zinc shortens colds and reduces symptoms, theoretically by inhibiting viral replication (Landis R. Herbal Defense. 1997 Warner Books, NY, NY) . Selenium is an antioxidant, it’s a cofactor in glutathione peroxidase and Selenium SOD antioxidant enzymes, and its ability to strengthen the immune system has been widely documented. Epidemiological studies suggest that many diseases are higher in areas where selenium is depleted in the soil. For instance, cultivating garlic and onion in selenium reduced total tumors up to 75% (Carcinogenesis 1994; 15(9): 1881-5) . Echinacea Purpurea (root) is an herb that has been used for centuries because of its profound effect on the immune system. Supplementary treatment of echinacea has been reported to protect cells and enhance antibody (B lymphocytes) and cell-mediated immune response (T lymphocytes) (Vet Clin North Am Food Anim Pract. 1988) . L-Lysine (as hydrochloride) is an amino acid with antiviral properties; it is especially effective against the herpes simplex virus. While lysine and lysine-rich foods are recommended for herpes and related viruses, large amounts of arginine and arginine-rich foods (including chocolate, nuts, dairy and meat) should be avoided. Olive (leaf) Powder and Olive (leaf) Extract has been recently researched because of the discovery of the high quantity of active phytochemicals in this plant. The olive branch dates back to ancient times as a symbol of rebirth and growth. Now, an extract from the leaves of the olive branch has gained interest, due to a phytochemical called, "oleuropein." 329 In addition to the oleuropein contained in olive leaf extract, other powerful bioflavonoids are present, including rutin, Hesperidin, and other flavones. These ingredients work synergistically together, and are responsible for the reputation that the extract is building for purported medicinal properties, including: antibacterial, antimicrobial, antiviral, antifungal, antioxidant, antiarrhythmic, hypoglycemic, hypolipidemic, hypouricemic, hypocholesterolemic, and hypotensive. Numerous scientific tests are now starting to confirm the potency of this plant’s actions. Elderberry (flower) and Elderberry Extract (sambucus nigra)(fruit) is high in phytochemical content, especially proanthocyanidins, which have potent cell-protecting ability. Elderberry has been used traditionally for its antiviral effects. Astragalus (root) has been traditionally used by the Chinese to fight viral infections. A clinical trial with 10 patients suffering from a coxsackie B viral infection showed improved natural killer cell activity in patients treated with astragalus (Chin Med J 1990; 103:304-307) . Research has demonstrated an ability of astragalus to correct deficient T cell (immune-fighting cell) function in cancer patients (J Clin Lab Immunnol 1988; 25:119-123) .
Contraindications: Contraindicated in pregnancy. Echinacea contains sugars in its cell membrane which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (I.e. 8 weeks on, 1 week off).
Ingredients: Vitamin A (as palmitate) (40% as Beta Carotene) 1250 mcg, Vitamin C (as ascorbic acid) 25 mg, Zinc (as chelate) 1 mg, Selenium (as chelate) 50 mcg. Proprietary blend 455 mg* of: Echinacea Purpurea (root), L-Lysine (as hydrochloride), Olive (leaf) Powder, Elderberry (flower), Astragalus (root), Elderberry Extract (sambucus nigra)(fruit), Glycerol Monolaurate, Olive (leaf) Extract. (leaf) Extract.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 120 Tablets
Product:

Total VR-X (60) (2704)

Supportive Function: Immune support for maintenance of defenses against attack from viral organisms. A uniquely orchestrated combination of powerful phytochemicals and nutrients make up this formula, which includes the highly active components in olive leaf (such as oleuropein). When are Immune Nutrients helpful? Decreased immune function, infections
Clinical Applications Research: Vitamin A (as palmitate) 40% as Beta Carotene) is considered to be an essential immune vitamin. It is necessary to cellular growth, repair, and regeneration. Its role in regenerating epithelial tissue is vital to immune organs. It has been known for a long time that a lack of vitamin A in the diet will result in reduced resistance to infection. Beta-Carotene is a precursor, which is made into vitamin A, as the body needs it. Beta-carotene has also been found to specifically enhance the immune system, and is a potent antioxidant (vitamin A is not an antioxidant form).  Vitamin C (as ascorbic acid) is one of the most important vitamins, which builds the immune system. It creates strong, healthy tissues that line immune organs, and it is carried in the immune-fighting lymphocytes (white blood cells). Vitamin C helps mobilize the lymphocytes (immune-fighting cells) and increases the speed with which they can reach a site of infection. When there is an infection, vitamin C is carried to the site quickly, and it is used up quickly.  Zinc (as chelate) is another important immune vitamin. It has a vital role in regenerating epithelial tissue and so is highly important when viral infection calls for cellular repair. Zinc shortens colds and reduces symptoms, theoretically by inhibiting viral replication (Landis R. Herbal Defense. 1997 Warner Books, NY, NY).  Selenium is an antioxidant, it’s a cofactor in glutathione peroxidase and Selenium SOD antioxidant enzymes, and its ability to strengthen the immune system has been widely documented. Epidemiological studies suggest that many diseases are higher in areas where selenium is depleted in the soil. For instance, cultivating garlic and onion in selenium reduced total tumors up to 75% (Carcinogenesis 1994; 15(9): 1881-5).  Echinacea Purpurea (root) is an herb that has been used for centuries because of its profound effect on the immune system. Supplementary treatment of echinacea has been reported to protect cells and enhance antibody (B lymphocytes) and cell-mediated immune response (T lymphocytes) (Vet Clin North Am Food Anim Pract. 1988).  L-Lysine (as hydrochloride) is an amino acid with antiviral properties; it is especially effective against the herpes simplex virus. While lysine and lysine-rich foods are recommended for herpes and related viruses, large amounts of arginine and arginine-rich foods (including chocolate, nuts, dairy and meat) should be avoided.  Olive (leaf) Powder and Olive (leaf) Extract has been recently researched because of the discovery of the high quantity of active phytochemicals in this plant. The olive branch dates back to ancient times as a symbol of rebirth and growth. Now, an extract from the leaves of the olive branch has gained interest, due to a phytochemical called, "oleuropein." 329 In addition to the oleuropein contained in olive leaf extract, other powerful bioflavonoids are present, including rutin, Hesperidin, and other flavones. These ingredients work synergistically together, and are responsible for the reputation that the extract is building for purported medicinal properties, including: antibacterial, antimicrobial, antiviral, antifungal, antioxidant, antiarrhythmic, hypoglycemic, hypolipidemic, hypouricemic, hypocholesterolemic, and hypotensive. Numerous scientific tests are now starting to confirm the potency of this plant’s actions.  Elderberry (flower) and Elderberry Extract (sambucus nigra)(fruit) is high in phytochemical content, especially proanthocyanidins, which have potent cell-protecting ability. Elderberry has been used traditionally for its antiviral effects.  Astragalus (root) has been traditionally used by the Chinese to fight viral infections. A clinical trial with 10 patients suffering from a coxsackie B viral infection showed improved natural killer cell activity in patients treated with astragalus (Chin Med J 1990; 103:304-307). Research has demonstrated an ability of astragalus to correct deficient T cell (immune-fighting cell) function in cancer patients (J Clin Lab Immunnol 1988; 25:119-123).
Contraindications: Contraindicated in pregnancy. Echinacea contains sugars in its cell membrane which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (I.e. 8 weeks on, 1 week off).
Ingredients: Each Tablet Contains: Vitamin A (as palmitate) (40% as Beta Carotene) 1250 mcg, Vitamin C (as ascorbic acid) 25 mg, Zinc (as chelate) 1 mg, Selenium (as chelate) 50 mcg. Proprietary blend 455 mg* of: Echinacea Purpurea (root), L-Lysine (as hydrochloride), Olive (leaf) Powder, Elderberry (flower), Astragalus (root), Elderberry Extract (sambucus nigra)(fruit), Glycerol Monolaurate, Olive (leaf) Extract. (leaf) Extract.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Total Yst Redux (2710)

Supportive Function: Total Yst-Redux is a special formulation of herbs, vitamins and minerals, which is nutritionally helpful against fungal infections, candida and yeast. When is Yeast Support helpful? Candidiasis and related symptoms, including food allergies, PMS, lowered immune reactions, lethargy, headaches, and overall sick feeling; candidiasis causes a toxin overload that can be manifested in a lot of different diseases.
Clinical Applications Research: Oregon Grape (root) acts as a tonic on the liver and gallbladder, and can remedy systemic imbalances. Caprylic Acid is listed in the Merck index as an antifungal. It is effective in the treatment of candida, and is described by a leading authority on candida as, “a short chain, saturated fatty acid found to have anti-fungal activity, whose efficacy approaches that of nystatin” (Crook, W. MD. The Yeast Connection. 1983. Professional Books, Jackson, Tenn. pp. 352-53) . Garlic (bulb) fights a broad range of infectious organisms, including candida, viruses, bacteria, protozoa, and parasites. Garlic is so effective that, “Neither Nystatin, nor amphotericin B... displayed such a high activity as garlic juice (against Candida)” (Crook, W. MD. The Yeast Connection. Professional Books, Jackson, Tenn. pp. 355-356) . Garlic’s antibacterial characteristics have been tested even against drug-resistant varieties, and shown to have therapeutic activity (Indian J Med Res 1991; 93:33-6) . Lactobacillus Acidophilus is good bacteria. They keep bad bacteria and fungal organisms like candida at bay.
Contraindications: Garlic and grape seed extract in large quantities are contraindicated with anticoagulant drugs (only a small amount of each are used in this synergistic formula). Do not use during pregnancy.
Ingredients: Each Tablet Contains: Proprietary blend 300 mg* of: Orange (seed) Extract, Oregon Grape (root), Caprylic Acid, Garlic (bulb), Lactobacillus Acidophilus
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

UR-KID (#12) (DH12)

Supportive Function: Kidney, bladder and urinary support.
Contraindications: Contraindicated during pregnancy.
Ingredients: Each Tablet Contains: Proprietary blend 391.5 mg* of: Juniper(fruit), Parsley (leaf), Uva Ursi (leaf), Ginger (root), Corn (silk),Cleavers (leaf).
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 100 Tablets
Product:

Uro-Bac (2010)

Supportive Function: Uro Bac is the supreme answer to helping maintain a healthy, protective barrier against organism assault in the urinary tract, a major elimination pathway. Nutrients and glandulars unite to build immune support. Enzymes facilitate nutrient breakdown for rapid absorption, and also work on clearing both internal and external toxic debris when taken away from food. When is Urinary Tract Support helpful? Water balance, detoxification, urination support, bowel dysfunction
Clinical Applications Research: Vitamin C (as sago palm): Extra addition of vitamin C supports the immune system by increasing cellular immune functions and stimulating neutrophils. Patients receiving 1 gram of vitamin C daily had improved neutrophil activity, resulting in a dramatic reduction of attacks from foreign invaders (Anderson, R. Int J Vitam Nutr Res. Suppl. 23:23-34, 1982; Patrone, R, Dallegri, F, Bonvivi, E, et al. Acta Vitaminol Enzymol. 4:163- 68, 1982) . According to a report in Allergy and Imm. (Feb. 1993) , Vitamin C has a “special influence” on supporting the immune response and warding off invaders. Glandulars: Provides the amino acid sequencing to support the organ during repair. Enzymes: Provide support for maintaining a healthy, non-inflammatory cellular environment. Propolis: Research has shown propolis to have strong properties. Propolis supports the immune system and fortifies the body’s natural resistance to foreign invasion. Propolis supports the natural process of phagocytosis (bacteria-engulfing by immune cells). A major scientific journal reports that, “Propolis, a honey bee hive product, is thought to exhibit a broad spectrum of activities” (Chemical and Biological Interactions, 1992, 84:277-90) .
Contraindications: High dosages of vitamin C (>1000 mg.) should not be taken by gout patients or by kidney stone formers. Vitamin C is contraindicated in iron overload disease.
Ingredients: Each Tablet Contains: Vitamin C (as sago palm) 75 mg, Vitamin D3 (as cholecalciferol) 1 mcg, Calcium (aslactate, aspartate) 30 mg, Magnesium (as aspartate, citrate) 8 mg. Proprietary blend 559 mg* of: Kidney(bovine), Thymus (bovine), Ox Bile, Pancreatin (porcine), Papain, Rutin, Bromelain, Lemon Bioflavonoid,Hesperidin (as complex), Trypsin, Pancrelipase (porcine), Amylase, Lymph (bovine), Spleen (bovine), Parotid,Propolis.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Vana-Chrom (2400)

Supportive Function: A scientifically advanced formula takes advantage of a long list of nutrients that are reported to support normal glucose regulation. Those with concerns with sugar imbalance often choose Vana- Chrom. When is Blood Sugar Support helpful? Blood sugar imbalances
Clinical Applications Research: Thiamine (as hydrochloride) (B-1) has a Co-enzyme form as thiamine pyrophosphate (TPP). Riboflavin (B-2) is the component of two major energy enzymes - flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), and Niacin (as niacinamide)(B-3) functions in over fifty metabolic reactions. The B Vitamins are involved in all aspects of glucose (blood sugar) metabolism. Vitamin B-6 (as pyridoxine hydrochloride) is also important in glucose metabolism. Vitamin B-12 (as cyanocobalamin) is an integral vitamin for the metabolism of carbohydrate, protein and fat. Proper DNA replication is dependent on the function of Co-enzyme B-12. Biotin is involved in reactions specific for release of energy from carbohydrates. Magnesium (as aspartate) is a cofactor for the reactions that metabolize carbohydrate in the Kreb's cycle, and is also needed for ATP (energy production). All reactions using vitamin B-1 are dependent on magnesium. Zinc (as picolinate) is important in normal insulin function - synthesis, secretion, and utilization (Free Rad in Res and Comm 1991; 14:289-96). Zinc deficiency is suspected as having a possible role in the development of diabetes  (AJCN 1987; 45:877-895) . Zinc supplements have helped in the healing of resistant leg ulcers in diabetics (Diabetes. A dietary approach. 1992; 3:1-2) . Manganese (as aspartate) is a cofactor for many carbohydrate metabolism enzymes. Chromium (as picolinate): Chromium is known for its effects on blood sugar control mechanisms (Mertz, W. Chromium in human nutrition: a review. J Nutr 1993; 123:626-633) . It most likely exerts these effects because of its important role in making up the GTF (glucose tolerance factor) of the body. Vanadyl Sulfate: The functions of vanadium are still being researched. It appears that vanadium is very important for its role in glucose metabolism (mimics insulin), and its role in lipid metabolism. Recent research indicates that vanadium was able to partially preserve pancreatic beta-cells in rats, and that this preservation was, “both critical and sufficient for a long-term reversal of the diabetic state” (Cam MC et al. Partial preservation of pancreatic beta-cells by vanadium: evidence for long-term amelioration of diabetes (Metabolism 1997; 46:769-778).
Contraindications: Do not use in cases of extremely low blood sugar.
Ingredients: Each Tablet Contains: Vitamin C (as calcium ascorbate) 89 mg, Thiamine (as hydrochloride) 10 mg, Riboflavin 5 mg, Niacin (as niacinamide) 26 mg, Vitamin B-6 (as pyridoxine hydrochloride) 5 mg, Folate (as folic acid) 200 mcg, Vitamin B-12 (as cyanocobalamin) 10 mcg, Biotin 500 mcg, Pantothenic Acid (as calcium pantothenate) 20 mg, Magnesium (as aspartate) 20 mg, Zinc (as picolinate) 1 mg, Selenium (as chelate) 30 mcg, Manganese (as aspartate) 0.400 mg, Chromium (as picolinate) 200 mcg. Vanadyl Sulfate 3 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed.
Product:

Vitamin A Emulsion (1211)

Supportive Function: Vitamin A acts to support the growth of epithelium tissues and is a vital ingredient necessary for a healthy immune system. Vitamin A is specifically beneficial in foreign attack. Vitamin A prompts secretion of gastric juices necessary for proper digestion of proteins, builds strong bones and teeth, maintains good eyesight (the vitamin A in rhodopsin, located in the rods of the cell, transmits light signals by changing its configuration), and aids in the manufacturing of red blood cells. Vitamin E: Vitamin A Emulsion is emulsified with small amounts of vitamin E, which has many functions. Vitamin E is the main lipid antioxidant in the body. When is Vitamin A Effective? Eye health, frequent foreign attack, immune system maintenance, skin health, aiding normal healing processes, nerve support, acne, tooth enamel, sinus support, cell cycle regulation, abnormal cell growth, allergies, kidney and bladder support; people who can’t convert beta-carotene to vitamin A, emulsification beneficial for gallbladder digestion/absorption issues.
Clinical Applications Research: Supports the mucous linings especially of the GI tract. It also appears to support antibody response and white blood cell function. Vitamin A is specifically beneficial support for the upper respiratory area. Skin: Has many beneficial effects on the skin and is helpful in the normal healing process. It may be helpful support for acne. Antioxidant Function: The precursor of vitamin A, beta-carotene, is a powerful antioxidant. It protects against pollutants, stress, smoke and chemical exposure. Vitamin A itself is not technically an antioxidant. To be an antioxidant, the substance has to be able to donate an extra electron to a free radical to neutralize it. Menorrhagia (heavy menstrual flow): Vitamin A deficiency has been noted in menorrhagia. Intestinal Problems: Vitamin A is needed to repair the intestinal cells. Immune Support: Supplementary treatment of vitamin A is reported by some investigators to be beneficial support for the immune response (Levis WR & Emden RG. Proc. Am Assoc. Can. Res. 1976; 17:112; Cohen BE & Cohen IK. J. Immunol.1976; 111:1376) . Vitamin A Emulsion is great for lymphatic drainage, especially those with antro and retrograde problems. . Occiput Fixations: Occiput fixations that are found with bilateral weakness of the psoas muscles can strengthen as vitamin A is one of the nutrients used for the psoas muscle. The Pec Major Sternal muscle that relates to the liver responds well to Vitamin A Emulsion.
Contraindications: Vitamin A is fat-soluble and can become toxic in acute or chronic doses. Acute toxicity can occur in doses > 200 mg or 660,000 IU (adults) or chronic toxicity can occur in doses > 100 mg or 333,000 IU (children). Symptoms can include nausea, vomiting and headache. Doses greater than 10,000 IU during pregnancy can be teratogenic (causing birth defects). Drug/Nutrient Interactions: The acne medicine Accutane is related to vitamin A and should not be taken together. Laxatives and cholesterol medicines (i.e. bile acid sequestrants, such as Questran) can interfere with the absorption of vitamin A and the other fat-soluble vitamins.
Ingredients: Each Drop Contains: Vitamin A (as palmitate) 5000 IU, Vitamin E (as d-alpha tocopherol acetate) 5 IU. Shake well before using.
Vegetarian: Yes
Suggested Dosage: 1 DROP (squeezed from the dropper, NOT one dropperful) daily or as directed. Do Not Exceed Recommendation.
Pack: 30cc Liquid
Product:

Vitamin B-12 Lozenges (1321)

Supportive Function: An easily assimilated form of Vitamin B-12 (with complementary folic acid) dissolves under the tongue, entering the bloodstream directly without having to hook up with intrinsic factor (usually required for absorption in the small intestine). Vitamin B-12 functions in red blood cell formation, nervous system function, and RNA and DNA synthesis. When is B-12/Folic Acid helpful? Fatigue, pernicious anemia, red blood cell formation, asthma, nervous system function, macronutrient metabolism, mood changes, menstrual problems, heart disease (homocysteine reduction), diabetic neuropathy, hepatitis, urticaria, pregnancy, dermatitis and bursitis.
Clinical Applications Research: Vitamin B-12 (as cyanocobalamin) is essential in nervous system function, helps to build healthy red blood cells, increases energy level, stimulates utilization of carbohydrates, fats and proteins, and is important in DNA and RNA synthesis (the material that makes up our genetic code). The intrinsic factor, which is made in the stomach, is necessary for the absorption of B-12 into the small intestine. People who have low levels of HCL (hydrochloric acid is produced from the same cells that produce intrinsic factor) are at higher risk for inadequate B-12 absorption. People who do not biologically produce the intrinsic factor must get B-12 injections, which shoots the vitamin directly into the bloodstream, eliminating the need for intrinsic factor. Taking B-12 sublingually (under the tongue) also bypasses the small intestine and the need for intrinsic factor, so this method is also used for rapid absorption of B-12. Folic acid complements the actions of B-12 and synergistically boosts its activity, especially in red blood cell formation and homocysteine reduction. NOTE : Vitamin B-12 deficiency can arise due to conditions that interfere with B-12 absorption, such as inflammatory bowel disease, or gastric surgery. Folic Acid (as folic acid) : Clinical applications: fatigue, stress, adrenal gland support, psoriasis, folic acid deficiency anemia, depression, heart disease (lowers homocysteine) and cervical tissue support. Folic acid functions as a Co-enzyme that is important for cell reproduction. Its functions are similar to vitamin B-12. It aids in red blood cell (RBC) production, protein utilization, RNA and DNA synthesis, and is important in pregnancy since it is needed for the division of cells in the body. Fortification of foods with folate, starting Jan 1, 1998, emphasizes the newly recognized value of this B vitamin. Tidbit : B-12 needs to be combined with intrinsic factor in the stomach to be able to be absorbed in the small intestine, but the lozenge bypasses digestion and absorbs directly in to the bloodstream sublingually.
Contraindications: Vitamin B-12 is non-toxic, even in doses that have exceeded the RDA by 10,000 times. Being water-soluble, excesses are excreted in the urine. Folic acid should not be given if a B-12 deficiency is suspected, because it can mask the symptoms. A rare congenital defect prevents the metabolism of cyancobalamin. Medicinal amounts of any vitamin, mineral or specialty nutrient should only be taken with the advice of a trained licensed healthcare professional.
Ingredients: Vitamin B-12 (as cyanocobalamin) 1,000 mcg, Folic Acid (as folic acid) 400 mcg. Proprietary blend 20 mg* of: Liver (bovine), Stomach (porcine). Natural spearmint added for flavor.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Vitamin B-6 (1320)

Supportive Function: Vitamin B-6, or pyridoxine, is involved in many reactions such as amino acid synthesis into protein and the production of hydrochloric acid in the stomach. It is a food supplement used often by premenstrual women.  Essential for a healthy nervous system.
Contraindications: Vitamin B-6 in amounts > 200 mg/day can possibly cause symptoms of neuropathy.
Ingredients: Each Tablet Contains: Vitamin B-6 (as pyridoxine hydrochloride)200 mg.
Vegetarian: No
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets
Product:

Whole System EEP (Homeopathic) (0208)

Supportive Function: For the temporary relief of Depression, Energy Loss and Anxiety
Contraindications: WARNING: STOP USE AND CALL A DOCTOR IF SYMPTOMS PERSIST OR WORSEN. IF PREGNANT OR BREAST-FEEDING,CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE. KEEP OUT OF REACH OF CHILDREN. CONTAINS ALCOHOL: IN CASE OF ACCIDENTAL OVERDOSE, CONSULT A POISON CONTROL CENTRE IMMEDIATELY.
Ingredients: Active Ingredients: Belladonna 1M, Berber vulg 12X, Causticum 5M, Ceanothus 6X, Chelidonium maj 3X, Cinchona 5M, Coffea cruda 1M, Condurango 3X, Graphites 2M, Hydrastis 3X, Hyoscyaminum 10M, Ignatia 200X, Lilium 5M, Lycopodium 12X, Merc corros 12X, Nux vom 10M, Pancreas suis 12X, Scrophularia nodosa 15X, Senna 3X, Spongia 6X, Zinc met 3M. Inactive Ingredients: Alcohol (20% v/v), Purified Water.
Vegetarian: No
Suggested Dosage: 10 drops daily or as directed
Pack: 1 oz Liquid
Product:

Yst-Dysbio-Cleanz (2500F)

Supportive Function: The detrimental effect of harmful microorganisms such as yeast and their toxic excretions should be avoided whenever possible. This formula supports an environment of intestinal health. When is Yeast Support helpful? Candidiasis and related symptoms, including food allergies, PMS, lowered immune reactions, lethargy, headaches, and overall sick feeling; candidiasis causes a toxin overload that can be manifested in a lot of different diseases.
Clinical Applications Research: Citrus (seed) Extract is effective in treating patients with giardiasis and some other intestinal parasites. Leo Galland, MD., states that grapefruit extract is very effective in treating Candida related complex.(1)  Oregon Grape (root) "acts as a tonic on the liver and gallbladder, and can remedy systemic imbalances" (Scalzo R. Naturopathic Handbook of Herbal Formulas, 3rd ed. 1994, Kivaki Press, Durango, Co. p. 96). Oregon Grape (root) is recommended for impure blood conditions, psoriasis, etc.(2)  Total health starts in the GI tract. Yst-Dysbio Cleanz is a probiotic enhancer especially formulated to complement our gastric nutritional support program.  The gastrointestinal ecosystem consists of trillions of micro-organisms; many are beneficial to the human host. Microbial balance is the key factor that determines whether substances in the intestines are converted into compounds that are beneficial or detrimental to the host. The result in a healthy individual is an optimally functioning intestinal system.  Provided with food and shelter by the human host, the probiotic intestinal flora reciprocate by providing the body with useful metabolic products. Microflora helps to metabolize vitamins, nutrients and hormones. The beneficial bacteria also compete for food and lodging with the non-beneficial, potentially damaging microorganisms. As long as the probiotic or friendly bacteria can dominate, the human host can maintain optimum health; if the unfriendly flora takes over or dominates, imbalance or dysbiosis can occur.  The villus is the functional unit of the intestines. The fragile structure is lined by a solo layer of cells that must regulate digestion, produces digestive enzymes, and absorb the digested nutrients. The functional and structural integrity of the villi is related to the beneficial contributions in the form of metabolites from the probiotic flora attached to the villus lining. The villi become more susceptible to damage when deprived of the presence of the probiotics. As a result, breaks can develop in the intestinal lining that may allow partially digested food and macro molecules to enter into the blood stream.  The “Leaky Gut” scenarios are suspected to facilitate auto-antibody formations and certain food intolerances. They have also been linked to overgrowths of certain, unfriendly intestinal bacteria, Candida albicans, and to persistent protozoa. Yst-Dysbio Cleanz is a state of the art herbal formula for moderating intestinal dysbiosis and for broad spectrum nutritional support for the gastrointestinal tract. Yeast problems and intestinal bacteria imbalances must be considered with patients with chronic complaints. Since yeast can be non-viable when outside the human host it is possible to get a negative stool culture and have a yeast overgrowth.  Remember clinical experience is the gold standard on which treatment protocol should be based. Yst-Dysbio Cleanz consists of 2 ingredients: Citrus (seed) Extract and Oregon Grape (root). Leo Galland, MD., states that grapefruit extract is very effective in treating Candida related complex.(1)  In addition, grapefruit seed extract is also effective in treating patients with giardiasis and some other intestinal parasites. Oregon grape is a source of berberine. Berberines possess antimicrobial activity against a wide variety of micro-organisms. Oregon Grape (root) also has a high proportion of berberine. "Oregon Grape (root) is recommended for impure blood conditions, psoriasis, etc".(2) Yst-Dysbio Cleanz will strengthen a weak tensor fascia lata quadriceps or abdominal muscle upon insalivations if the above imbalances are present.  References  (1) Dr Leo Gallard, Medical Director of Great Smokies Lab.  (2) A Modern Herbal Vol.1.
Contraindications: Contraindicated in pregnancy. Large amounts of grapefruit seed extract should not be combined with anticoagulants (150 mg is not a large amount).
Ingredients: Each Tablet Contains: Proprietary blend 375 mg* of: Citrus (seed) Extract, Oregon Grape (root).
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 60 Tablets
Product:

Zinc-S (1300)

Supportive Function: Chelated to enhance bioavailability of this elemental nutrient. Zinc is needed as a cofactor in many reactions. Required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, acne carbonic anhydrase.
Contraindications: It has been suggested that zinc in excess of 150 mg/day may depress immune function.
Ingredients: Each Tablet Contains: Zinc (as chelate) 15 mg.
Vegetarian: Yes
Suggested Dosage: 1 tablet daily or as directed
Pack: 90 Tablets


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